Abstract：
:Computational fluid dynamics (CFD) simulations quantifying thoracic aortic flow patterns have not included disturbances from the aortic valve (AoV). 80% of patients with aortic coarctation (CoA) have a bicuspid aortic valve (BAV) which may cause adverse flow patterns contributing to morbidity. Our objectives were to develop a method to account for the AoV in CFD simulations, and quantify its impact on local hemodynamics. The method developed facilitates segmentation of the AoV, spatiotemporal interpolation of segments, and anatomic positioning of segments at the CFD model inlet. The AoV was included in CFD model examples of a normal (tricuspid AoV) and a post-surgical CoA patient (BAV). Velocity, turbulent kinetic energy (TKE), time-averaged wall shear stress (TAWSS), and oscillatory shear index (OSI) results were compared to equivalent simulations using a plug inlet profile. The plug inlet greatly underestimated TKE for both examples. TAWSS differences extended throughout the thoracic aorta for the CoA BAV, but were limited to the arch for the normal example. OSI differences existed mainly in the ascending aorta for both cases. The impact of AoV can now be included with CFD simulations to identify regions of deleterious hemodynamics thereby advancing simulations of the thoracic aorta one step closer to reality.
journal_name
Med Eng Physjournal_title
Medical engineering & physicsauthors
Wendell DC,Samyn MM,Cava JR,Ellwein LM,Krolikowski MM,Gandy KL,Pelech AN,Shadden SC,LaDisa JF Jrdoi
10.1016/j.medengphy.2012.07.015subject
Has Abstractpub_date
2013-06-01 00:00:00pages
723-35issue
6eissn
1350-4533issn
1873-4030pii
S1350-4533(12)00211-1journal_volume
35pub_type
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