Abstract:
:Low-intensity alternating electric fields applied to the scalp are capable of modulating cortical activity and brain functions, but the underlying mechanisms remain largely unknown. Here, we report two distinct components of voltage-sensitive dye signals induced by low-intensity, alternating electric fields in rodent cortical slices: a "passive component," which corresponds to membrane potential changes directly induced by the electric field; and an "active component," which is a widespread depolarization that is dependent on excitatory synaptic transmission. The passive component is stationary, with amplitude and phase accurately reflecting the cortical cytoarchitecture. In contrast, the active component is initiated from a local "hot spot" of activity and spreads to a large population as a propagating wave with rich local dynamics. The propagation of the active component may play a role in modulating large-scale cortical activity by spreading a low level of excitation from a small initiation point to a vast neuronal population.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Xu W,Wolff BS,Wu JYdoi
10.1152/jn.00740.2013subject
Has Abstractpub_date
2014-11-15 00:00:00pages
2446-56issue
10eissn
0022-3077issn
1522-1598pii
jn.00740.2013journal_volume
112pub_type
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