Low-intensity electric fields induce two distinct response components in neocortical neuronal populations.

Abstract:

:Low-intensity alternating electric fields applied to the scalp are capable of modulating cortical activity and brain functions, but the underlying mechanisms remain largely unknown. Here, we report two distinct components of voltage-sensitive dye signals induced by low-intensity, alternating electric fields in rodent cortical slices: a "passive component," which corresponds to membrane potential changes directly induced by the electric field; and an "active component," which is a widespread depolarization that is dependent on excitatory synaptic transmission. The passive component is stationary, with amplitude and phase accurately reflecting the cortical cytoarchitecture. In contrast, the active component is initiated from a local "hot spot" of activity and spreads to a large population as a propagating wave with rich local dynamics. The propagation of the active component may play a role in modulating large-scale cortical activity by spreading a low level of excitation from a small initiation point to a vast neuronal population.

journal_name

J Neurophysiol

authors

Xu W,Wolff BS,Wu JY

doi

10.1152/jn.00740.2013

subject

Has Abstract

pub_date

2014-11-15 00:00:00

pages

2446-56

issue

10

eissn

0022-3077

issn

1522-1598

pii

jn.00740.2013

journal_volume

112

pub_type

杂志文章
  • Oculomotor task switching: alternating from a nonstandard to a standard response yields the unidirectional prosaccade switch-cost.

    abstract::The completion of an antisaccade (i.e., a nonstandard task) lengthens the reaction time (RT) of a subsequent prosaccade: a behavioral phenomenon termed the unidirectional prosaccade switch-cost. One explanation for the unidirectional prosaccade switch-cost is suppressing a stimulus-driven prosaccade during the precedi...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00352.2014

    authors: Weiler J,Heath M

    更新日期:2014-11-01 00:00:00

  • Intraspinal microstimulation excites multisegmental sensory afferents at lower stimulus levels than local alpha-motoneuron responses.

    abstract::Microstimulation within the motor regions of the spinal cord is often assumed to activate motoneurons and propriospinal neurons close to the electrode tip. However, previous work has shown that intraspinal microstimulation (ISMS) in the gray matter activates sensory afferent axons as well as alpha-motoneurons (MNs). H...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00061.2006

    authors: Gaunt RA,Prochazka A,Mushahwar VK,Guevremont L,Ellaway PH

    更新日期:2006-12-01 00:00:00

  • Localized adenosine signaling provides fine-tuned negative feedback over a wide dynamic range of neocortical network activities.

    abstract::Although the patterns of activity produced by neocortical networks are now better understood, how these states are activated, sustained, and terminated still remains unclear. Negative feedback by the endogenous neuromodulator adenosine may potentially play an important role, as it can be released by activity and there...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00620.2014

    authors: Wall MJ,Richardson MJ

    更新日期:2015-02-01 00:00:00

  • Lag structure in resting-state fMRI.

    abstract::The discovery that spontaneous fluctuations in blood oxygen level-dependent (BOLD) signals contain information about the functional organization of the brain has caused a paradigm shift in neuroimaging. It is now well established that intrinsic brain activity is organized into spatially segregated resting-state networ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00804.2013

    authors: Mitra A,Snyder AZ,Hacker CD,Raichle ME

    更新日期:2014-06-01 00:00:00

  • Effect of cerebellar inactivation by lidocaine microdialysis on the vestibuloocular reflex in goldfish.

    abstract::Vestibuloocular reflex performance and adaptation were examined during vestibulocerebellar inactivation by localized lidocaine microdialysis or injection in goldfish. In the light, eye velocity perfectly compensated for head velocity (Vis-VOR) during sinusoidal yaw rotation (1/8 Hz +/- 20 degrees). In the dark, the re...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.79.3.1286

    authors: McElligott JG,Beeton P,Polk J

    更新日期:1998-03-01 00:00:00

  • Permeation properties of the hair cell mechanotransducer channel provide insight into its molecular structure.

    abstract::Mechanoelectric transducer (MET) channels, located near stereocilia tips, are opened by deflecting the hair bundle of sensory hair cells. Defects in this process result in deafness. Despite this critical function, the molecular identity of MET channels remains a mystery. Inherent channel properties, particularly those...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01178.2011

    authors: Pan B,Waguespack J,Schnee ME,LeBlanc C,Ricci AJ

    更新日期:2012-05-01 00:00:00

  • Early and late beta-band power reflect audiovisual perception in the McGurk illusion.

    abstract::The McGurk illusion is a prominent example of audiovisual speech perception and the influence that visual stimuli can have on auditory perception. In this illusion, a visual speech stimulus influences the perception of an incongruent auditory stimulus, resulting in a fused novel percept. In this high-density electroen...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00783.2014

    authors: Roa Romero Y,Senkowski D,Keil J

    更新日期:2015-04-01 00:00:00

  • Hand-held tools with complex kinematics are efficiently incorporated into movement planning and online control.

    abstract::Certain hand-held tools alter the mapping between hand motion and motion of the tool end point that must be controlled in order to perform a task. For example, when using a pool cue, the motion of the cue tip is reversed relative to the hand. Previous studies have shown that the time required to initiate a reaching mo...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00157.2012

    authors: Baugh LA,Hoe E,Flanagan JR

    更新日期:2012-10-01 00:00:00

  • Long-term deficits in motion detection thresholds and spike count variability after unilateral vestibular lesion.

    abstract::The vestibular system operates in a push-pull fashion using signals from both labyrinths and an intricate bilateral organization. Unilateral vestibular lesions cause well-characterized motor deficits that are partially compensated over time and whose neural correlates have been traced in the mean response modulation o...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00280.2014

    authors: Yu XJ,Thomassen JS,Dickman JD,Newlands SD,Angelaki DE

    更新日期:2014-08-15 00:00:00

  • Correlated firing of cat retinal ganglion cells. I. Spontaneously active inputs to X- and Y-cells.

    abstract::1. The shared inputs to cat retinal ganglion cells have been investigated by studying correlations in the maintained firing of neighboring ganglion cells. The firing of one cell was recorded from its axon in the optic tract, while that of a neighboring cell was simultaneously recorded with a second electrode in the re...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1983.49.2.303

    authors: Mastronarde DN

    更新日期:1983-02-01 00:00:00

  • Intersegmental coordination: influence of a single walking leg on the neighboring segments in the stick insect walking system.

    abstract::A key element of walking is the coordinated interplay of multiple limbs to achieve a stable locomotor pattern that is adapted to the environment. We investigated intersegmental coordination of walking in the stick insect, Carausius morosus by examining the influence a single stepping leg has on the motoneural activity...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00291.2007

    authors: Borgmann A,Scharstein H,Büschges A

    更新日期:2007-09-01 00:00:00

  • Innocuous warming enhances peripheral serotonergic itch signaling and evokes enhanced responses in serotonin-responsive dorsal horn neurons in the mouse.

    abstract::Itch is often triggered by warming the skin in patients with itchy dermatitis, but the underlying mechanism is largely unknown. We presently investigated if warming the skin enhances histamine- or serotonin (5-HT)-evoked itch behavior or responses of sensory dorsal root ganglion (DRG) cells, and if responses of superf...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00703.2016

    authors: Akiyama T,Nagamine M,Davoodi A,Ivanov M,Carstens MI,Carstens E

    更新日期:2017-01-01 00:00:00

  • Electrophysiological properties of vestibular sensory and supporting cells in the labyrinth slice before and during regeneration.

    abstract::The whole cell patch-clamp technique in combination with the slice preparation was used to investigate the electrophysiological properties of pigeon semicircular canal sensory and supporting cells. These properties were also characterized in regenerating neuroepithelia of pigeons preinjected with streptomycin to kill ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1997.78.4.1913

    authors: Masetto S,Correia MJ

    更新日期:1997-10-01 00:00:00

  • Possible network interactions indicated by bilaterally coherent fast rhythms in expiratory recurrent laryngeal nerve discharges.

    abstract::1. In a search for correlated fast rhythms in recurrent laryngeal (RL) expiratory (E) activities, we performed spectral and coherence analysis on bilateral RL nerve discharges in 54 midcollicular decerebrate, paralyzed cats. 2. Inspiratory (I) RL activities showed in almost all cases high-frequency oscillations (HFO, ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1993.70.5.2192

    authors: Huang WX,Christakos CN,Cohen MI,He Q

    更新日期:1993-11-01 00:00:00

  • Postural adjustments for online corrections of arm movements in standing humans.

    abstract::The aim of this study was to investigate how humans correct ongoing arm movements while standing. Specifically, we sought to understand whether the postural adjustments in the legs required for online corrections of arm movements are predictive or rely on feedback from the moving limb. To answer this question we measu...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00944.2010

    authors: Leonard JA,Gritsenko V,Ouckama R,Stapley PJ

    更新日期:2011-05-01 00:00:00

  • Developmental changes in evoked Purkinje cell complex spike responses.

    abstract::The development of synaptic interconnections between the cerebellum and inferior olive, the sole source of climbing fibers, could contribute to the ontogeny of certain forms of motor learning (e.g., eyeblink conditioning). Purkinje cell complex spikes are produced exclusively by climbing fibers and exhibit short- and ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00481.2003

    authors: Nicholson DA,Freeman JH Jr

    更新日期:2003-10-01 00:00:00

  • Further morphological and electrophysiological studies on snake muscle spindles.

    abstract::1. Electron microscope studies using ruthenium red, horseradish peroxidase, and colloidal lanthanum disclosed a feature characteristic of the snake spindle capsule: it consists of a single layer of flattened cells connected in series, each of which forms a cylinder enclosing the intrafusal fiber. 2. In intact spindles...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1982.47.5.810

    authors: Fukami Y

    更新日期:1982-05-01 00:00:00

  • Dynamics of receptive field size in primary visual cortex.

    abstract::Recent studies have shown that the initial responses evoked by a stimulus in neurons of primary visual cortex are dominated by low spatial frequency information in the image, whereas finer spatial scales dominate later in the response. Such phenomena could arise from the dynamics of receptive field (RF) size at early ...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00830.2006

    authors: Malone BJ,Kumar VR,Ringach DL

    更新日期:2007-01-01 00:00:00

  • Role of the oculomotor vermis in generating pursuit and saccades: effects of microstimulation.

    abstract::We studied the eye movements evoked by applying small amounts of current (2-50 microA) within the oculomotor vermis of two monkeys. We first compared the eye movements evoked by microstimulation applied either during maintained pursuit or during fixation. Smooth, pursuitlike changes in eye velocity caused by the micro...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1998.80.4.2046

    authors: Krauzlis RJ,Miles FA

    更新日期:1998-10-01 00:00:00

  • Closed-loop, ultraprecise, automated craniotomies.

    abstract::A large array of neuroscientific techniques, including in vivo electrophysiology, two-photon imaging, optogenetics, lesions, and microdialysis, require access to the brain through the skull. Ideally, the necessary craniotomies could be performed in a repeatable and automated fashion, without damaging the underlying br...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.01055.2014

    authors: Pak N,Siegle JH,Kinney JP,Denman DJ,Blanche TJ,Boyden ES

    更新日期:2015-06-01 00:00:00

  • Wide dynamic range but not nociceptive-specific neurons encode multidimensional features of prolonged repetitive heat pain.

    abstract::1. To better characterize temporal and spatial mechanisms involved in the coding of prolonged nociceptive stimuli in the spinal cord, the responses of dorsal horn wide dynamic range (WDR) and nociceptive-specific (NS) neurons to prolonged, repetitive noxious heat stimuli (45-49 degrees C) were examined in unanesthetiz...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1993.69.3.703

    authors: Coghill RC,Mayer DJ,Price DD

    更新日期:1993-03-01 00:00:00

  • Extracellular stimulation of central neurons: influence of stimulus waveform and frequency on neuronal output.

    abstract::The objective of this project was to examine the influence of stimulus waveform and frequency on extracellular stimulation of neurons with their cell bodies near the electrode (local cells) and fibers of passage in the CNS. Detailed computer-based models of CNS cells and axons were developed that accurately reproduced...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2002.88.4.1592

    authors: McIntyre CC,Grill WM

    更新日期:2002-10-01 00:00:00

  • Neural representation of target distance in auditory cortex of the echolocating bat Myotis lucifugus.

    abstract::1. Single- and multiunit recordings were obtained from neurons in the auditory cortex of the echolocating bat Myotis lucifugus, while trains of stimuli designed to simulate the bat's frequency-modulated (FM) orientation pulse and its returning echo were delivered. It was found that many neurons in the cortex responded...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1982.48.4.1011

    authors: Sullivan WE 3rd

    更新日期:1982-10-01 00:00:00

  • Auditory modulation of spiking activity and local field potentials in area MT does not appear to underlie an audiovisual temporal illusion.

    abstract::The timing of brief stationary sounds has been shown to alter the perceived speed of visual apparent motion (AM), presumably by altering the perceived timing of the individual frames of the AM stimuli and/or the duration of the interstimulus intervals (ISIs) between those frames. To investigate the neural correlates o...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00835.2017

    authors: Kafaligonul H,Albright TD,Stoner GR

    更新日期:2018-09-01 00:00:00

  • Cholinergic and electrical motoneuron-to-motoneuron synapses contribute to on-cycle excitation during swimming in Xenopus embryos.

    abstract::1. We have previously shown that Xenopus spinal motoneurons make both chemical and electrical synapses with neighboring motoneurons. Because motoneurons are active during swimming, these synapses would be expected to contribute excitation to their neighbors. The significance of central motoneuron to motoneuron synapse...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.1995.73.3.1005

    authors: Perrins R,Roberts A

    更新日期:1995-03-01 00:00:00

  • A modified Sindbis vector for prolonged gene expression in neurons.

    abstract::Sindbis viruses have been widely used in neurobiology to express a variety of genes in cultured neurons, in cultured slices, and in vivo. They provide fast onset and high levels of expression of foreign genes, but the expression is limited to a short time window due to a shut-off of host protein synthesis. We have use...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00464.2003

    authors: Jeromin A,Yuan LL,Frick A,Pfaffinger P,Johnston D

    更新日期:2003-10-01 00:00:00

  • Localizing visual discrimination processes in time and space.

    abstract::Previous studies of visual processing in humans using event-related potentials (ERPs) have demonstrated that task-related modulations of an early component called the "N1" wave (140-200 ms) reflect the operation of a voluntary discrimination process. Specifically, this component is larger in tasks requiring target dis...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.2002.88.4.2088

    authors: Hopf JM,Vogel E,Woodman G,Heinze HJ,Luck SJ

    更新日期:2002-10-01 00:00:00

  • Selectivity for space and time in early areas of the auditory dorsal stream in the rhesus monkey.

    abstract::The respective roles of ventral and dorsal cortical processing streams are still under discussion in both vision and audition. We characterized neural responses in the caudal auditory belt cortex, an early dorsal stream region of the macaque. We found fast neural responses with elevated temporal precision as well as n...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00436.2013

    authors: Kusmierek P,Rauschecker JP

    更新日期:2014-04-01 00:00:00

  • Interpreting the electrophysiological power spectrum.

    abstract::Recent experimental findings suggest that there may be rich physiological information embedded within the power spectrum of neurophysiological recordings, which, in addition to power in specific oscillatory frequencies, can be extracted with the appropriate model. This article reviews previous empirical and modeling r...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章,评审

    doi:10.1152/jn.00722.2015

    authors: Gao R

    更新日期:2016-02-01 00:00:00

  • Spontaneous waves in the dentate gyrus of slices from the ventral hippocampus.

    abstract::Spontaneous negative-going potentials occurring at an average frequency of 0.7 Hz were recorded from the dentate gyrus of slices prepared from the temporal hippocampus of young adult rats. These events (here termed "dentate waves") in several respects resembled the dentate spikes described for freely moving rats durin...

    journal_title:Journal of neurophysiology

    pub_type: 杂志文章

    doi:10.1152/jn.00478.2004

    authors: Colgin LL,Kubota D,Brucher FA,Jia Y,Branyan E,Gall CM,Lynch G

    更新日期:2004-12-01 00:00:00