Long-term deficits in motion detection thresholds and spike count variability after unilateral vestibular lesion.

abstract：:We have found new evidence for gamma-aminobutyric acid (GABA)-induced intrinsic optical changes associated with a voltage-sensitive dye signal in the early embryonic chick brain stem slice. The slices were prepared from 8-day-old embryos, and they were stained with a voltage-sensitive dye (NK2761). Pressure ejection o...

journal_title：Journal of neurophysiology

authors： Momose-Sato Y,Sato K,Hirota A,Kamino K

更新日期：1998-04-01 00:00:00

abstract：:The R6/2 mouse is the most frequently used model for experimental and preclinical drug trials in Huntington's disease (HD). When the R6/2 mouse was first developed, it carried exon 1 of the huntingtin gene with ~150 cytosine-adenine-guanine (CAG) repeats. The model presented with a rapid and aggressive phenotype that ...

journal_title：Journal of neurophysiology

authors： Cummings DM,Alaghband Y,Hickey MA,Joshi PR,Hong SC,Zhu C,Ando TK,André VM,Cepeda C,Watson JB,Levine MS

更新日期：2012-01-01 00:00:00

abstract：:People naturally direct their gaze to visible hand movement goals. Doing so improves reach accuracy through use of signals related to gaze position and visual feedback of the hand. Here, we studied where people naturally look when acting on remembered target locations. Four targets were presented on a screen, in perip...

journal_title：Journal of neurophysiology

authors： Flanagan JR,Terao Y,Johansson RS

更新日期：2008-09-01 00:00:00

abstract：:Field potential recording was used to investigate properties of synaptic transmission and long-term potentiation (LTP) at Schaffer collateral-CA1 synapses in both hippocampal slices of mutant mice in which the alpha-subunit of the olfactory cyclic nucleotide-gated channel (alpha3/OCNC)1 was rendered null and also in s...

journal_title：Journal of neurophysiology

authors： Parent A,Schrader K,Munger SD,Reed RR,Linden DJ,Ronnett GV

更新日期：1998-06-01 00:00:00

abstract：:This study considers the possibility of using coherence analysis for detection and measurement of synchrony (correlations) in large neural populations, applied to activities that are relatively easy to record in parallel. Mathematical analysis and computer simulations are used to examine the behavior of the coherence ...

journal_title：Journal of neurophysiology

authors： Christakos CN

更新日期：1997-12-01 00:00:00

abstract：:Glutamate-receptor-mediated synaptic transmission was studied in morphologically identified hippocampal dentate granule cells (DGCs; n = 31) with the use of whole cell patch-clamp recording and intracellular injection of biocytin or Lucifer yellow in slices prepared from surgically removed medial temporal lobe specime...

journal_title：Journal of neurophysiology

authors： Isokawa M,Levesque M,Fried I,Engel J Jr

更新日期：1997-06-01 00:00:00

abstract：:The scratch reflex is a motor task exhibited by the hindlimb of a turtle after complete transection of the spinal cord just posterior to the forelimb enlargement. The scratch is elicited by applying gentle tactile stimulation to a site innervated by spinal segments caudal to the level of the transection. During the sc...

journal_title：Journal of neurophysiology

authors： Mortin LI,Keifer J,Stein PS

更新日期：1985-06-01 00:00:00

abstract：:1. Transmission at electrical synapses is modulated by a variety of physiological signals, and this modulation is a potentially general mechanism for regulating signal integration in neural circuits and networks. In the outer plexiform layer of the retina, modulation of horizontal-cell electrical coupling by dopamine ...

journal_title：Journal of neurophysiology

authors： McMahon DG,Brown DR

更新日期：1994-11-01 00:00:00

abstract：:Ablation and single-unit studies in primates have shown that inferior temporal (IT) cortex is important for pattern discrimination. The first paper in this series suggested that single units in IT cortex of alert monkeys respond to a set of two-dimensional patterns with complex temporal modulation of their spike train...

journal_title：Journal of neurophysiology

authors： Optican LM,Richmond BJ

更新日期：1987-01-01 00:00:00

abstract：:ALS (amyotrophic lateral sclerosis) is an adult-onset and deadly neurodegenerative disease characterized by a progressive and selective loss of motoneurons. Transgenic mice overexpressing a mutated human gene (G93A) coding for the enzyme SOD1 (Cu/Zn superoxide dismutase) develop a motoneuron disease resembling ALS in ...

journal_title：Journal of neurophysiology

authors： Kuo JJ,Schonewille M,Siddique T,Schults AN,Fu R,Bär PR,Anelli R,Heckman CJ,Kroese AB

更新日期：2004-01-01 00:00:00

abstract：:The dorsolateral pontine nucleus (DLPN) and nucleus reticularis tegmenti pontis (NRTP) comprise obligatory links in the cortico-ponto-cerebellar system supporting smooth pursuit eye movements. We examined the response properties of DLPN and rNRTP neurons during step-ramp smooth pursuit of a small target moving across ...

journal_title：Journal of neurophysiology

authors： Ono S,Das VE,Economides JR,Mustari MJ

更新日期：2005-01-01 00:00:00

abstract：:Sensory cortical neurons display substantial receptive field dynamics during and after persistent sensory drive. Because a cell's response properties are determined by the inputs it receives, receptive field dynamics are likely to involve changes in the relative efficacy of different inputs to the cell. To test this h...

journal_title：Journal of neurophysiology

authors： Kohn A,Metz C,Tommerdahl MA,Whitsel BL

更新日期：2002-12-01 00:00:00

abstract：:1. In chronically prepared, freely moving rats, electrical stimulation was applied to the angular bundle, and responses were recorded extracellularly at a variety of sites in the ipsilateral hippocampal formation. At each recording site the stimulus-response relationship was tested during four different behavioral sta...

journal_title：Journal of neurophysiology

authors： Winson J,Abzug C

更新日期：1978-05-01 00:00:00

abstract：:1. Recent immunocytochemical and receptor binding data have demonstrated a transient somatotopic patterning of serotonin (5-HT)-immunoreactive fibers in the primary somatosensory cortex of developing rats and a transient expression of 5-HT1B receptors on thalamocortical axons from the ventral posteromedial thalamic nu...

journal_title：Journal of neurophysiology

authors： Rhoades RW,Bennett-Clarke CA,Shi MY,Mooney RD

更新日期：1994-11-01 00:00:00

abstract：:Adaptive processes are crucial in maintaining the accuracy of body movements and rely on error storage and processing mechanisms. Although classically studied with adaptation paradigms, evidence of these ongoing error-correction mechanisms should also be detectable in other movements. Despite this connection, current ...

journal_title：Journal of neurophysiology

authors： Wong AL,Shelhamer M

更新日期：2014-05-01 00:00:00

abstract：:In contrast to hand movements, the existence of a neural representation of saccade kinematics is unclear. Saccade kinematics is typically thought to be specified by motor error/desired displacement and generated by brain stem circuits that are not penetrable to voluntary control. We studied the influence of instructed...

journal_title：Journal of neurophysiology

authors： Gopal A,Jana S,Murthy A

更新日期：2017-09-01 00:00:00

abstract：:Purinoreceptors of the P2 family contribute strongly to signaling in the cochlea, but little is known about the effects of purinergic neurotransmission in the central auditory system. Here we examine P2 receptor-mediated signaling in the large spherical bushy cells (SBCs) of Mongolian gerbils around the onset of acous...

journal_title：Journal of neurophysiology

authors： Milenkovic I,Rinke I,Witte M,Dietz B,Rübsamen R

更新日期：2009-09-01 00:00:00

abstract：:Nerve injury induces a reorganization of subcortical and cortical sensory or motor maps in mammals. A similar process, vestibular plasticity 2 mo after unilateral section of the ramus anterior of N. VIII was examined in this study in adult frogs. The brain was isolated with the branches of both N. VIII attached. Monos...

journal_title：Journal of neurophysiology

authors： Goto F,Straka H,Dieringer N

更新日期：2001-06-01 00:00:00

abstract：:Phasic and tonic motor neurons of crustaceans differ strikingly in their junctional synaptic physiology. Tonic neurons generally produce small excitatory postsynaptic potentials (EPSPs) that facilitate strongly as stimulation frequency is increased, and normally show no synaptic depression. In contrast, phasic neurons...

journal_title：Journal of neurophysiology

authors： Nguyen PV,Marin L,Atwood HL

更新日期：1997-07-01 00:00:00

abstract：:1. The proton-gated current was investigated in whole-cell configuration of the neurons isolated from bullfrog heart parasympathetic ganglia with the use of the "concentration-clamp" technique, which combines intracellular perfusion and extremely rapid exchange of external solution within 1-2 ms, under a single-electr...

journal_title：Journal of neurophysiology

authors： Kim DK,Tateishi N,Akaike N

更新日期：1990-05-01 00:00:00

abstract：:The role of GAT-3 transporters in regulating GABA(A) receptor-mediated inhibition was examined in the rat neocortex using an in vitro slice preparation. Pharmacologically isolated GABA(A) receptor-mediated responses were recorded from layer V neocortical pyramidal cells, and the effects of SNAP-5114, a GAT-3 GABA tran...

journal_title：Journal of neurophysiology

authors： Kinney GA

更新日期：2005-12-01 00:00:00

abstract：:Electrical stimulation has been delivered to the basal ganglia (BG) to treat intractable symptoms of a variety of clinical disorders. However, it is still unknown how such treatments improve behavioral symptoms. A difficulty of this problem is that artificial signals created by electrical stimulation interact with int...

journal_title：Journal of neurophysiology

authors： Watanabe M,Munoz DP

更新日期：2013-07-01 00:00:00

abstract：:Multiple studies have demonstrated that brain-derived neurotrophic factor (BDNF) is a potent modulator of neuronal structure and function in the hippocampus. However, the majority of studies to date have relied on the application of recombinant BDNF. We herein report that endogenous BDNF, released via theta burst stim...

journal_title：Journal of neurophysiology

authors： Li Y,Calfa G,Inoue T,Amaral MD,Pozzo-Miller L

更新日期：2010-05-01 00:00:00

abstract：:1. A variety of pharmacological tests indicate that the neuromuscular junction between the salivary burster neuron (SB) and the salivary duct muscle (SD) in the terrestrial mollusk Limax maximus is cholinergic. These include the effects of curare, atropine, and hexamethonium. 2. Exogenously applied choline can act bot...

journal_title：Journal of neurophysiology

authors： Barry SR,Gelperin A

更新日期：1982-08-01 00:00:00

abstract：:Long-term potentiation (LTP) in rat spinal dorsal horn neurons was induced by electrical high-frequency stimulation (HFS) of afferent C fibers. LTP is generally assumed to be a key mechanism of spinal sensitization. To determine the contribution of skin and muscle afferents to LTP induction, the sural nerve (SU, pure ...

journal_title：Journal of neurophysiology

authors： Zhang J,Hoheisel U,Klein T,Magerl W,Mense S,Treede RD

更新日期：2016-02-01 00:00:00

abstract：:Seminal work in animals indicates that learning a motor task results in long-term potentiation (LTP) in primary motor cortex (M1) and a subsequent occlusion of LTP induction (Rioult-Pedotti et al. J Neurophysiol 98: 3688-3695, 2007). Using various forms of noninvasive brain stimulation in conjunction with a motor lear...

journal_title：Journal of neurophysiology

authors： Hinder MR,Reissig P,Fujiyama H

更新日期：2014-03-01 00:00:00

abstract：:During auditory stimulation with several frequency components, distortion products (DPs) are generated as byproduct of nonlinear cochlear amplification. After generated, DP energy is reemitted into the ear channel where it can be measured as DP otoacoustic emission (DPOAE), and it also induces an excitatory response a...

journal_title：Journal of neurophysiology

authors： Abel C,Kössl M

更新日期：2009-03-01 00:00:00

abstract：:Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are responsible for the functional hyperpolarization-activated current (I(h)) in dorsal root ganglion (DRG) neurons, playing an important role in pain processing. We found that the known analgesic loperamide inhibited I(h) channels in rat DRG neurons. ...

journal_title：Journal of neurophysiology

authors： Vasilyev DV,Shan Q,Lee Y,Mayer SC,Bowlby MR,Strassle BW,Kaftan EJ,Rogers KE,Dunlop J

更新日期：2007-05-01 00:00:00

abstract：:Understanding how whisker-based tactile information is represented in the nervous system requires quantification of sensory input and observation of neural activity during whisking and whisker touch. Chronic electrophysiological methods have long been available to study neural responses in awake and behaving animals; ...

journal_title：Journal of neurophysiology

authors： Voigts J,Sakmann B,Celikel T

更新日期：2008-07-01 00:00:00

abstract：:1. A task was used by Posner (1980) to measure shifts of attention that occurred covertly, in the absence of an eye movement or other orienting response. This paradigm was used here to assess the nature of covert attentional orienting in monkeys to develop an animal model for neurophysiological studies. Shifts of atte...

journal_title：Journal of neurophysiology

authors： Bowman EM,Brown VJ,Kertzman C,Schwarz U,Robinson DL

更新日期：1993-07-01 00:00:00