Abstract:
:This study considers the possibility of using coherence analysis for detection and measurement of synchrony (correlations) in large neural populations, applied to activities that are relatively easy to record in parallel. Mathematical analysis and computer simulations are used to examine the behavior of the coherence function between both unitary and population-aggregate activity (UTA coherence) and the aggregate activities of two populations (ATA coherence). The results indicate that for a large population showing partial correlations, the UTA coherence function is almost zero at all frequencies for the uncorrelated units. However, unless the synchrony is very restricted, its value is nonzero (i.e., statistically significant by common criteria) at each frequency of synchrony for the units that show correlations to other units. Moreover, this value is indicative of the strength of synchrony for any given unit. These properties enable the identification of the correlated units in a sample of unit/population activities simultaneously recorded in a series of experiments, and hence the detection of synchrony. The extent of synchrony can then be estimated as the fraction of such units in the sample, whereas the values of the UTA coherences in the sample can be used to estimate the strength and its distribution within the population. Similarly, the ATA coherence function is generally nonzero (significant) at the frequencies where there are correlations between members of two large populations. This enables the easy detection of such correlations from simultaneously recorded population activities. However, this function is a very sensitive index of synchrony and even shows saturation effects. It may therefore be used as a general measure of synchrony only under restricted conditions.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Christakos CNdoi
10.1152/jn.1997.78.6.3453subject
Has Abstractpub_date
1997-12-01 00:00:00pages
3453-9issue
6eissn
0022-3077issn
1522-1598journal_volume
78pub_type
杂志文章abstract::Unitary excitatory (EPSP) and inhibitory (IPSP) postsynaptic potentials (PSPs) were evoked between neurons in Rexed's laminae (L)II-V of spinal slices from young hamsters (7-24 days old) at 27°C using paired whole cell recordings. Laminar differences in synaptic efficacy were observed: excitatory connections were more...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00684.2010
更新日期:2011-06-01 00:00:00
abstract::The mechanisms underlying the depression of evoked fast excitatory postsynaptic currents (EPSCs) following superfusion with medium deprived of oxygen and glucose (in vitro ischemia) for a 4-min period in hippocampal CA1 neurons were investigated in rat brain slices. The amplitude of evoked fast EPSCs decreased by 85 +...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2001.86.3.1095
更新日期:2001-09-01 00:00:00
abstract::1. The cochlear nucleus of rat brain stem slices was explored with extracellular microelectrodes to determine the distribution and characteristics of spontaneously active neurons. 2. In mapping experiments few spontaneously active neurons were found in anteroventral or posteroventral divisions of the cochlear nucleus....
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1994.71.2.467
更新日期:1994-02-01 00:00:00
abstract::We studied the eye movements evoked by applying small amounts of current (2-50 microA) within the oculomotor vermis of two monkeys. We first compared the eye movements evoked by microstimulation applied either during maintained pursuit or during fixation. Smooth, pursuitlike changes in eye velocity caused by the micro...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.80.4.2046
更新日期:1998-10-01 00:00:00
abstract::Our objective was to assess the mechanical changes associated with spasticity in elbow muscles of chronic hemiparetic stroke survivors and to compare these changes with those recorded in the ankle muscles of a similar cohort. We first characterized elbow dynamic stiffness by applying pseudorandom binary positional per...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00049.2007
更新日期:2007-08-01 00:00:00
abstract::An important new study by Kvarta, Bradbrook, Dantrassy, Bailey, and Thompson (J Neurophysiol 114: 1713-1724, 2015) examined the effects of persistent stress and excessive glucocorticoid levels on hippocampal function and emotional behavior in rodents. The authors specifically implicate the temporoammonic pathway as be...
journal_title:Journal of neurophysiology
pub_type: 杂志文章,评审
doi:10.1152/jn.01065.2015
更新日期:2017-02-01 00:00:00
abstract::Distractions affect postural control, but this mechanism is not well understood. Diversion of resources during cognitive stress may lead to decreased motor drive and postural muscle tone. This may appear as decreased postural stiffness and increased postural sway amplitude. We hypothesized that dual tasking leads to d...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00820.2009
更新日期:2010-12-01 00:00:00
abstract::Behavioral studies have shown that object recognition becomes severely impaired at fast presentation rates, indicating a limitation in temporal processing capacity. Here, we studied whether this behavioral limit in object recognition reflects limitations in the temporal processing capacity of early visual areas tuned ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00568.2006
更新日期:2007-07-01 00:00:00
abstract::Spinal neurons undergo large cyclic membrane potential oscillations during fictive locomotion in lamprey. It was investigated whether these oscillations were due only to synaptically driven excitatory and inhibitory potentials or if voltage-dependent inward conductances also contribute to the depolarizing phase by usi...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2002.87.6.2676
更新日期:2002-06-01 00:00:00
abstract::The effects of deep brain stimulation (DBS) on balance in people with Parkinson's disease (PD) are not well established. This study examined whether DBS randomized to the subthalamic nucleus (STN; n = 11) or globus pallidus interna (GPi; n = 10) improved compensatory stepping to recover balance after a perturbation. T...
journal_title:Journal of neurophysiology
pub_type: 杂志文章,随机对照试验
doi:10.1152/jn.01052.2014
更新日期:2015-09-01 00:00:00
abstract::EEG generator-a model of potentials in a volume conductor. The potential recorded over the cortex electro-corticogram (ECoG) or over the scalp [electroencephalograph (EEG)] derives from the activity of many sources known as "EEG generators." The recorded amplitude is basically a function of the unitary potential of a ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.91143.2008
更新日期:2009-11-01 00:00:00
abstract::Primates can generate accurate, smooth eye-movement responses to moving target objects of arbitrary shape and size, even in the presence of complex backgrounds and/or the extraneous motion of non-target objects. Most previous studies of pursuit have simply used a spot moving over a featureless background as the target...
journal_title:Journal of neurophysiology
pub_type: 临床试验,杂志文章
doi:10.1152/jn.00987.2001
更新日期:2002-11-01 00:00:00
abstract::1. The electrophysiological and pharmacological properties of slow afterpotentials in large layer V neurons from cat sensorimotor cortex were studied in an in vitro slice preparation using intracellular recording and single-microelectrode voltage clamp. These properties were used to assess the role of afterpotential m...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1988.59.2.450
更新日期:1988-02-01 00:00:00
abstract::The amines dopamine (DA), serotonin (5-HT), and octopamine (Oct) each elicit a distinctive motor pattern from a quiescent pyloric network in the lobster stomatogastric ganglion (STG). We previously have demonstrated that these amines alter the synaptic strength at multiple, distributed sites within the pyloric network...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1997.78.6.3210
更新日期:1997-12-01 00:00:00
abstract::Parallel recording of neuronal activity in the behaving animal is a prerequisite for our understanding of neuronal representation and storage of information. Here we describe the development of micro-machined silicon microelectrode arrays for unit and local field recordings. The two-dimensional probes with 96 or 64 re...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00116.2003
更新日期:2003-08-01 00:00:00
abstract::With each eye movement, stationary objects in the world change position on the retina, yet we perceive the world as stable. Spatial updating, or remapping, is one neural mechanism by which the brain compensates for shifts in the retinal image caused by voluntary eye movements. Remapping of a visual representation is b...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00189.2006
更新日期:2007-02-01 00:00:00
abstract::The marine mollusk Clione limacina, when swimming, can stabilize different body orientations in the gravitational field. The stabilization is based on the reflexes initiated by activation of the statocyst receptor cells and mediated by the cerebro-pedal interneurons that produce excitation of the motoneurons of the ef...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2000.83.1.367
更新日期:2000-01-01 00:00:00
abstract::The presence of a calcium-activated nonspecific cationic (CAN) current in turtle motoneurons and its involvement in plateau potentials, bistability, and wind-up was investigated by intracellular recordings in a spinal cord slice preparation. In the presence of tetraethylammonium (TEA) and tetrodotoxin (TTX), calcium a...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1999.82.2.730
更新日期:1999-08-01 00:00:00
abstract::1. We studied the effect of zinc on the gamma-aminobutyric acid-C (GABAC) receptor in acutely isolated catfish cone horizontal cells using the whole cell patch-clamp technique. 2. GABA activates the GABAC receptor with a half-activation concentration (EC50) of 2.99 microM. The Hill coefficient is 1.32. Desensitization...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1995.73.2.916
更新日期:1995-02-01 00:00:00
abstract::Activation of the medial medulla is responsible for rapid eye movement (REM) sleep atonia and cataplexy. Dysfunction can cause REM sleep behavior disorder and other motor pathologies. Here we report the behavioral effects of stimulation of the nucleus gigantocellularis (NGC) and nucleus magnocellularis (NMC) in unrest...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00528.2010
更新日期:2010-10-01 00:00:00
abstract::In many regions of the vertebrate brain, microcircuits generate local recurrent activity that aids in the processing and encoding of incoming afferent inputs. Local recurrent activity can amplify, filter, and temporally and spatially parse out incoming input. Determining how these microcircuits function is of great in...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01046.2015
更新日期:2016-03-01 00:00:00
abstract::The reflex response of the masseter muscle to the rapid unloading of a single maxillary incisor tooth was studied. Unloading of a static force of 2 N in the horizontal direction resulted in a short-latency excitation, inhibition, and long-latency excitation of masseter muscle activity occurring at latencies of approxi...
journal_title:Journal of neurophysiology
pub_type: 临床试验,杂志文章
doi:10.1152/jn.2000.84.2.1088
更新日期:2000-08-01 00:00:00
abstract::Human functional magnetic resonance imaging (fMRI) studies, as well as lesion, drug, and single-cell recording studies in animals, suggest that the striatum plays a key role in associating sensory events with rewarding actions, both by facilitating reward processing and prediction (i.e., reinforcement learning) and by...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00164.2012
更新日期:2013-10-01 00:00:00
abstract::1. The synaptic pathways underlying tectal influence over pinna movements were studied using an acute electrophysiological approach. Under pentobarbital anesthesia, postsynaptic potentials were recorded intracellularly in antidromically identified, cat facial motoneurons following electrical stimulation of the superio...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1988.60.2.769
更新日期:1988-08-01 00:00:00
abstract::Tetanus neurotoxin (TeNT) cleaves synaptobrevin, a protein involved in synaptic vesicle docking and fusion, thereby preventing neurotransmitter release and causing a functional deafferentation. We injected TeNT into the lateral rectus muscle of adult cats at 0.5 or 5 ng/kg (low and high dose, respectively). In the per...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01006.2002
更新日期:2003-04-01 00:00:00
abstract::1. The sensory responsiveness of cells in the inferior olive is known to be suppressed during certain phases of active movement. These experiments were designed to test the possibility that activity in the rubrospinal pathway contributes to this suppression. We recorded from cells sensitive to light touch located in o...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1990.64.4.1170
更新日期:1990-10-01 00:00:00
abstract::1. High-voltage-activated Ca2+ currents [ICa(HVA)] were studied in immunolabeled mouse retinal ganglion neurons (RGNs) to elucidate channel-specific components and their developmental changes in vitro. 2. Neurons were dissociated at postnatal day 5. RGNs were selected for electrophysiological measurements by vital lab...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1994.72.5.2542
更新日期:1994-11-01 00:00:00
abstract::We have addressed the source and nature of the persistent neural activity that bridges the stimulus-free gap between the conditioned stimulus (CS) and unconditioned stimulus (US) during trace eyelid conditioning. Previous work has demonstrated that this persistent activity is necessary for trace eyelid conditioning: C...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00689.2011
更新日期:2012-01-01 00:00:00
abstract::Biological gain mechanisms regulate the sensitivity and dynamics of signaling pathways at the systemic, cellular, and molecular levels. In the sympathetic nervous system, gain in sensory-motor feedback loops is essential for homeostatic regulation of blood pressure and body temperature. This study shows how synaptic c...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00470.2004
更新日期:2004-11-01 00:00:00
abstract::1. Single-unit and multiunit activities were recorded at the area 17-18 border of each cortical hemisphere in paralyzed cats anesthetized with nitrous oxide supplemented with halothane. Cross-correlation histograms (CCHs) were computed between 86 pairs of single units and 99 pairs of multiunit activities. Visually evo...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1995.74.6.2379
更新日期:1995-12-01 00:00:00