A comparative study of patients' knowledge about hepatitis C in the United States and in urban and rural China.

Abstract:

BACKGROUND:Hepatitis C (HCV) is the predominant cause of chronic liver disease in the USA and is increasingly recognized as a common cause of liver disease in China. Studies of HCV patients in the US found major gaps in knowledge but little is known about HCV knowledge among patients in China. METHODS:We conducted a survey in three cohorts of HCV patients in Ann Arbor, MI, US, and in Beijing and Hebei, China, between April and November 2012 to compare patient knowledge about HCV in the US and in urban and rural China. RESULTS:A total of 525 patients (US 186; Beijing 186; Hebei 153) were enrolled. Mean ages of the three cohorts ranged from 52-56 years; 63% of US and 47% of Chinese patients were males; 63% of US and 39% of Beijing patients had college or postgraduate education compared to 0.7% in Hebei. More than half of the US and Beijing patients but only 13% of Hebei patients had received HCV treatment. The average HCV knowledge score out of a total of 16 in the US, Beijing, and Hebei was 12.7, 11.7, and 6.4, respectively (p < 0.001). Study site, education, gender, and prior HCV treatment were independent predictors of HCV knowledge. CONCLUSIONS:Knowledge about HCV in the US and Beijing patients was similar and significantly better than in Hebei patients. Our data show that efforts to improve HCV knowledge are necessary for all three cohorts and should be tailored to the education level and health literacy of the patients.

journal_name

Hepatol Int

journal_title

Hepatology international

authors

Wu E,Chen X,Guan Z,Cao C,Rao H,Feng B,Chan M,Fu S,Lin A,Wei L,Lok AS

doi

10.1007/s12072-014-9559-z

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

58-66

issue

1

eissn

1936-0533

issn

1936-0541

journal_volume

9

pub_type

杂志文章
  • Thy1-positive bone marrow stem cells express liver-specific genes in vitro and can mature into hepatocytes in vivo.

    abstract::The bone marrow contains stem cells that have the potential to differentiate into a variety of organ-specific mature cells, including the liver and the pancreas. Recently, the origin of hepatic progenitors and hepatocytes was identified to be the bone marrow. However, evidence that describes which cells, among all bon...

    journal_title:Hepatology international

    pub_type: 杂志文章

    doi:10.1007/s12072-007-9031-4

    authors: Bae SH,Choi JY,Yoon SK,Oh IH,Yoon KH,Park ST,Kim GD,Oh SH,Petersen BE

    更新日期:2008-03-01 00:00:00

  • Feasibility of liver graft procurement with donor gallbladder preservation in living donor liver transplantation.

    abstract:OBJECTIVE:Cholecystectomy is routinely performed at most transplant centers during living donor liver transplantation (LDLT). This study was performed to evaluate the feasibility of liver graft procurement with donor gallbladder preservation in LDLT. METHODS:Eighty-nine LDLTs (from June 2006 to Dec 2012) were retrospe...

    journal_title:Hepatology international

    pub_type: 杂志文章

    doi:10.1007/s12072-015-9628-y

    authors: Dong JH,Ye S,Duan WD,Ji WB,Liang YR

    更新日期:2015-10-01 00:00:00

  • Effect of hepatitis B surface antibody in patients with core antibody-positive liver transplantation: a systematic review and meta-analysis.

    abstract:BACKGROUND AND AIM:There is an increased awareness of de novo hepatitis B virus (HBV) infection (DNH) in hepatitis B surface antigen (HBsAg)-negative recipients receiving hepatitis B core antibody (HBcAb)-positive liver organ. Whether hepatitis B surface antibody (HBsAb) has positive result on preventing the occurrence...

    journal_title:Hepatology international

    pub_type: 杂志文章,meta分析

    doi:10.1007/s12072-020-10021-5

    authors: Yang Y,Huang A,Zhao Y

    更新日期:2020-03-01 00:00:00

  • Liver stiffness measurement in the risk assessment of hepatocellular carcinoma for patients with chronic hepatitis.

    abstract:BACKGROUND/AIMS:[corrected] The risk of hepatocellular carcinoma (HCC) increased with progression of hepatic fibrosis as assessed by liver stiffness measurement (LSM). This study used LSM to assess the risk of HCC presence in patients with chronic hepatitis. METHODS:The patients with liver tumor or chronic hepatitis i...

    journal_title:Hepatology international

    pub_type: 杂志文章

    doi:10.1007/s12072-010-9223-1

    authors: Kuo YH,Lu SN,Hung CH,Kee KM,Chen CH,Hu TH,Lee CM,Changchien CS,Wang JH

    更新日期:2010-10-08 00:00:00

  • Renal function and severity of bright liver. Relationship with insulin resistance, intrarenal resistive index, and glomerular filtration rate.

    abstract:AIMS:Relationships of renal function and liver disease are described in acute and chronic liver failure. The aim of the study is to investigate which relationship, if any, is present between severity of non-alcoholic fatty liver disease (NAFLD), assessed by bright liver score (BLS) versus mild-moderate renal insufficie...

    journal_title:Hepatology international

    pub_type: 杂志文章

    doi:10.1007/s12072-011-9254-2

    authors: Catalano D,Trovato GM,Martines GF,Pirri C,Trovato FM

    更新日期:2011-09-01 00:00:00

  • A comparison of hepatitis B viral markers of patients in different clinical stages of chronic infection.

    abstract:PURPOSE:Hepatitis B viral markers may be useful for predicting outcomes such as liver-related deaths or development of hepatocellular carcinoma. We determined the frequency of these markers in different clinical stages of chronic hepatitis B infection. METHODS:We compared baseline hepatitis B viral markers in 317 pati...

    journal_title:Hepatology international

    pub_type: 杂志文章

    doi:10.1007/s12072-010-9179-1

    authors: Tong MJ,Hsu L,Hsien C,Kao JH,Durazo FA,Saab S,Blatt LM

    更新日期:2010-04-07 00:00:00

  • Significant decrease in Faecalibacterium among gut microbiota in nonalcoholic fatty liver disease: a large BMI- and sex-matched population study.

    abstract:BACKGROUND:Compositional changes of the gut microbiota are known to occur in patients with nonalcoholic fatty liver disease (NAFLD); however, the changes did not corroborate between the studies. We evaluated the gut microbiota between NAFLD and non-NAFLD participants, excluding the influence of obesity and sex in this ...

    journal_title:Hepatology international

    pub_type: 杂志文章

    doi:10.1007/s12072-019-09987-8

    authors: Iino C,Endo T,Mikami K,Hasegawa T,Kimura M,Sawada N,Nakaji S,Fukuda S

    更新日期:2019-11-01 00:00:00

  • Viscoelastic test-based bleeding risk score reliably predicts coagulopathic bleeding in decompensated cirrhosis and ACLF patients.

    abstract:BACKGROUND AND AIMS:Coagulopathic bleeding risk prediction is challenging in decompensated cirrhosis (DC) by conventional assays. Viscoelastic tests (VETs) are likely to be more useful for assessing coagulation status in these patients. We investigated whether the VET (Sonoclot) parameters with fibrinogen could predict...

    journal_title:Hepatology international

    pub_type: 杂志文章

    doi:10.1007/s12072-020-10036-y

    authors: Bihari C,Patil A,Shasthry SM,Baweja S,Kumar G,Sarin SK

    更新日期:2020-07-01 00:00:00

  • Validation of graft and standard liver size predictions in right liver living donor liver transplantation.

    abstract:PURPOSE:To assess the accuracy of a formula derived from 159 living liver donors to estimate the liver size of a normal subject: standard liver weight (g) = 218 + body weight (kg) × 12.3 + 51 (if male). Standard liver volume (SLV) is attained by a conversion factor of 1.19 mL/g. METHODS:The total liver volume (TLV) of...

    journal_title:Hepatology international

    pub_type: 杂志文章

    doi:10.1007/s12072-011-9264-0

    authors: Chan SC,Lo CM,Chok KS,Sharr WW,Cheung TT,Tsang SH,Chan AC,Fan ST

    更新日期:2011-03-26 00:00:00

  • Liver failure determines the outcome in patients of acute-on-chronic liver failure (ACLF): comparison of APASL ACLF research consortium (AARC) and CLIF-SOFA models.

    abstract:BACKGROUND AND AIMS:Acute-on-chronic liver failure (ACLF) is a progressive disease associated with rapid clinical worsening and high mortality. Early prediction of mortality and intervention can improve patient outcomes. We aimed to develop a dynamic prognostic model and compare it with the existing models. METHODS:A ...

    journal_title:Hepatology international

    pub_type: 杂志文章

    doi:10.1007/s12072-017-9816-z

    authors: Choudhury A,Jindal A,Maiwall R,Sharma MK,Sharma BC,Pamecha V,Mahtab M,Rahman S,Chawla YK,Taneja S,Tan SS,Devarbhavi H,Duan Z,Yu C,Ning Q,Jia JD,Amarapurkar D,Eapen CE,Goel A,Hamid SS,Butt AS,Jafri W,Kim DJ,G

    更新日期:2017-09-01 00:00:00

  • Treatment of chronic hepatitis C genotype 3 with Sofosbuvir-based therpy: a real-life study.

    abstract:BACKGROUND AND AIMS:Recently, Sofosbuvir was launched in India at affordable cost. We conducted a real-life study to determine the efficacy and safety of Sofosbuvir plus Ribavirin, with and without peginterferon-alfa 2a, in patients with chronic hepatitis C (CHC) genotype 3, the commonest genotype in South Asia. METHO...

    journal_title:Hepatology international

    pub_type: 杂志文章

    doi:10.1007/s12072-017-9794-1

    authors: Sidhu SS,Malhi NS,Goyal O,Singh R,Dutta U,Grover R,Sidhu JS,Nanda V,Saluja H,Bansal A,Singh G,Sehgal A,Kishore H,Sidhu S

    更新日期:2017-05-01 00:00:00

  • Genetic and epigenetic mechanisms of NASH.

    abstract::Along with the obesity epidemic, the prevalence of nonalcoholic fatty liver disease (NAFLD) has increased exponentially. The histological disease spectrum of NAFLD ranges from bland fatty liver (hepatic steatosis), to the concomitant presence of inflammation and ballooning which defines nonalcoholic steatohepatitis (N...

    journal_title:Hepatology international

    pub_type: 杂志文章,评审

    doi:10.1007/s12072-015-9689-y

    authors: Eslam M,George J

    更新日期:2016-05-01 00:00:00

  • The prevalence of occult HBV infection in immunized children with HBsAg-positive parents: a hospital-based analysis.

    abstract:BACKGROUND AND OBJECT:The risk of occult HBV infection (OBI) in children whose mothers are HBV carriers has received more widespread attention, but there were few reports to focus on the children with HBsAg-positive parents. In this study, we aimed to investigate the prevalence of OBI in immunized children with HBsAg-p...

    journal_title:Hepatology international

    pub_type: 杂志文章

    doi:10.1007/s12072-020-10055-9

    authors: Zhuge S,Ge C,Yang Y,Cui Y,Yue X,Zhang Z,Xu H,Huang A,Zhao Y

    更新日期:2020-07-01 00:00:00

  • New drugs for NAFLD: lessons from basic models to the clinic.

    abstract::The term nonalcoholic fatty liver disease (NAFLD) comprises a spectrum of increasingly harmful conditions ranging from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH) to liver fibrosis and end-stage cirrhosis. NAFLD is the currently most common form of chronic liver disease in both adults and ch...

    journal_title:Hepatology international

    pub_type: 杂志文章,评审

    doi:10.1007/s12072-019-10001-4

    authors: Reimer KC,Wree A,Roderburg C,Tacke F

    更新日期:2020-01-01 00:00:00

  • New therapeutic targets in alcoholic hepatitis.

    abstract::Alcoholic liver disease (ALD) is a leading cause of liver-related morbidity and mortality worldwide. ALD encompasses a spectrum of disorders including asymptomatic steatosis, steatohepatitis, fibrosis, cirrhosis and its related complications, and the acute-on-chronic state of alcoholic hepatitis. While multidisciplina...

    journal_title:Hepatology international

    pub_type: 杂志文章,评审

    doi:10.1007/s12072-015-9701-6

    authors: Arsene D,Farooq O,Bataller R

    更新日期:2016-07-01 00:00:00

  • Etiopathogenesis of primary biliary cirrhosis: an overview of recent developments.

    abstract::Substantial advancements in the field of primary biliary cirrhosis (PBC) research have broadened our understanding of this enigmatic disease. Genome-wide studies have identified several new candidate genes involved in the immunoregulatory process, particularly those responsible for antigen presentation and lymphocyte ...

    journal_title:Hepatology international

    pub_type: 杂志文章

    doi:10.1007/s12072-012-9362-7

    authors: Trivedi PJ,Cullen S

    更新日期:2013-03-01 00:00:00

  • Immunological cure of HBV infection.

    abstract::Chronic hepatitis B virus (HBV) infection is a major global health burden and cure is rarely achieved by current antiviral therapies. Therefore, there is an urgent need for new therapeutic options. Immune modulation with the goal to restore dysfunctional HBV-specific immunity is an interesting target for new therapeut...

    journal_title:Hepatology international

    pub_type: 杂志文章,评审

    doi:10.1007/s12072-018-9912-8

    authors: Lang J,Neumann-Haefelin C,Thimme R

    更新日期:2019-03-01 00:00:00

  • End-stage liver disease patients with MELD >40 have higher waitlist mortality compared to Status 1A patients.

    abstract:BACKGROUND AND AIMS:Status 1A patients are prioritized over end-stage liver disease (ESLD) for liver transplantation (LT). ESLD patients with high MELD may have higher waitlist mortality than Status 1A patients, and may require LT more urgently. METHODS:Using United Network for Organ Sharing registry data, we retrospe...

    journal_title:Hepatology international

    pub_type: 杂志文章

    doi:10.1007/s12072-016-9735-4

    authors: Ahn J,Bhuket T,Mosadeghi S,Frenette C,Liu B,Wong RJ

    更新日期:2016-09-01 00:00:00

  • Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update.

    abstract::Worldwide, some 240 million people have chronic hepatitis B virus (HBV), with the highest rates of infection in Africa and Asia. Our understanding of the natural history of HBV infection and the potential for therapy of the resultant disease is continuously improving. New data have become available since the previous ...

    journal_title:Hepatology international

    pub_type: 杂志文章,实务指引

    doi:10.1007/s12072-015-9675-4

    authors: Sarin SK,Kumar M,Lau GK,Abbas Z,Chan HL,Chen CJ,Chen DS,Chen HL,Chen PJ,Chien RN,Dokmeci AK,Gane E,Hou JL,Jafri W,Jia J,Kim JH,Lai CL,Lee HC,Lim SG,Liu CJ,Locarnini S,Al Mahtab M,Mohamed R,Omata M,Park J,

    更新日期:2016-01-01 00:00:00

  • Hepatitis B virus reactivation in patients receiving cancer chemotherapy: natural history, pathogenesis, and management.

    abstract::Chronic hepatitis B virus (HBV) infection is endemic in the Asian-Pacific region, and reactivation of HBV post-cancer chemotherapy has become an emerging clinical challenge. Patients with detectable serum HBV DNA before chemotherapy and those receiving intensive chemotherapy are particularly at a risk of HBV reactivat...

    journal_title:Hepatology international

    pub_type: 杂志文章

    doi:10.1007/s12072-011-9279-6

    authors: Liu CJ,Chen PJ,Chen DS,Kao JH

    更新日期:2013-06-01 00:00:00

  • Acute kidney injury in hepatitis B-related acute-on-chronic liver failure without preexisting liver cirrhosis.

    abstract:BACKGROUND AND AIM:Acute kidney injury (AKI), as defined by the Acute Kidney Injury Network, has been widely investigated in decompensated liver cirrhosis patients. AKI is frequently progressive and independently associated with mortality in these patients. However, in the Asia-Pacific region, the majority of cases of ...

    journal_title:Hepatology international

    pub_type: 杂志文章

    doi:10.1007/s12072-015-9636-y

    authors: Huang Z,Lin C,Fang J,Wang N,Zhou R,Pan C

    更新日期:2015-07-01 00:00:00

  • Prognostic analysis of pulmonary metastases from hepatocellular carcinoma.

    abstract:PURPOSE:To analyze the prognostic factors for the patients with lung metastases from hepatocellular carcinoma (HCC). METHODS AND MATERIALS:One hundred and five patients with lung metastases from HCC were analyzed retrospectively. We analyzed the impact factors, including the gender, age, liver function, serum AFP and ...

    journal_title:Hepatology international

    pub_type: 杂志文章

    doi:10.1007/s12072-008-9052-7

    authors: Zhang SM,Zeng ZC,Tang ZY,Sun J,Cheng JM,Liu R,Wang P,Zhang BH

    更新日期:2008-06-01 00:00:00

  • Current status and perspectives for computer-aided ultrasonic diagnosis of liver lesions using deep learning technology.

    abstract::An ultrasound (US) examination is a common noninvasive technique widely applied for diagnosis of a variety of diseases. Based on the rapid development of US equipment, many US images have been accumulated and are now available and ready for the preparation of a database for the development of computer-aided US diagnos...

    journal_title:Hepatology international

    pub_type: 杂志文章,评审

    doi:10.1007/s12072-019-09937-4

    authors: Nishida N,Yamakawa M,Shiina T,Kudo M

    更新日期:2019-07-01 00:00:00

  • Hepatitis B reactivation after chemotherapy: two decades of clinical research.

    abstract::Hepatitis due to hepatitis B virus reactivation after cytotoxic or immunosuppressive therapy is a serious cause of liver-related morbidity and mortality. With the characterization of the underlying pathogenesis, much progress in the management of this important clinical problem has been made in the past 2 decades. By ...

    journal_title:Hepatology international

    pub_type: 杂志文章

    doi:10.1007/s12072-008-9056-3

    authors: Lau GK

    更新日期:2008-06-01 00:00:00

  • CSH guidelines for the diagnosis and treatment of drug-induced liver injury.

    abstract::Drug-induced liver injury (DILI) is an important clinical problem, which has received more attention in recent decades. It can be induced by small chemical molecules, biological agents, traditional Chinese medicines (TCM), natural medicines (NM), health products (HP), and dietary supplements (DS). Idiosyncratic DILI i...

    journal_title:Hepatology international

    pub_type: 社论

    doi:10.1007/s12072-017-9793-2

    authors: Yu YC,Mao YM,Chen CW,Chen JJ,Chen J,Cong WM,Ding Y,Duan ZP,Fu QC,Guo XY,Hu P,Hu XQ,Jia JD,Lai RT,Li DL,Liu YX,Lu LG,Ma SW,Ma X,Nan YM,Ren H,Shen T,Wang H,Wang JY,Wang TL,Wang XJ,Wei L,Xie Q,Xie W,

    更新日期:2017-05-01 00:00:00

  • The therapeutic response of antiviral therapy in HBsAg-positive renal transplant recipients and a long-term follow-up.

    abstract:BACKGROUND:Early prediction of lamivudine (LAM) response by individualized monitoring of serum HBV DNA like roadmap concept, and investigation of the outcome after LAM discontinuation in renal transplant recipients (RTRs) with chronic hepatitis B (CHB). METHODS:We conducted a study on 19 RTRs with HBV infection receiv...

    journal_title:Hepatology international

    pub_type: 杂志文章

    doi:10.1007/s12072-011-9295-6

    authors: Hu TH,Tsai MC,Chen YT,Chien YS,Hung CH,Chen TC,Tseng PL,Chang KC,Yen YH

    更新日期:2012-04-01 00:00:00

  • Cytokine gene polymorphisms in acute cellular rejection following living donor liver transplantation: analysis of 155 donor-recipient pairs.

    abstract:PURPOSE:Despite improvements in immunosuppressive therapy, acute cellular rejection (ACR) remains an important cause of graft loss in patients undergoing liver transplantation. Recently, associations between cytokine gene polymorphisms in recipients and the occurrence of ACR have been reported. However, most studies di...

    journal_title:Hepatology international

    pub_type: 杂志文章

    doi:10.1007/s12072-013-9443-2

    authors: Kamei H,Masuda S,Nakamura T,Ishigami M,Fujimoto Y,Ogura Y,Oike F,Takada Y,Hamajima N

    更新日期:2013-07-01 00:00:00

  • A comparison of 4-year entecavir efficacy in nucleos(t)ide analog-naïve and -experienced adult Taiwanese chronic hepatitis B patients.

    abstract:PURPOSE:To compare the efficacy of entecavir (ETV) monotherapy up to 4 years in nucleos(t)ide analog (NA)-experienced and -naïve subjects. METHODS:One hundred sixty NA-experienced and 282 naïve chronic hepatitis B patients who were treated with ETV were enrolled. Of the 160 NA-experienced patients, 49 had prior lamivu...

    journal_title:Hepatology international

    pub_type: 杂志文章

    doi:10.1007/s12072-013-9440-5

    authors: Chen CH,Hu TH,Hung CH,Lu SN,Wang JH,Chang MH,Changchien CS,Lee CM

    更新日期:2013-07-01 00:00:00

  • Reversal of NASH fibrosis with pharmacotherapy.

    abstract::NAFLD is a spectrum of liver disease starting with fatty liver at one end of the spectrum and cirrhosis or liver cancer at the other end. Worldwide, NAFLD has become one of the most common liver diseases and it has also become one of the leading indications for liver transplantation. Our understanding of the NAFLD epi...

    journal_title:Hepatology international

    pub_type: 杂志文章,评审

    doi:10.1007/s12072-019-09970-3

    authors: Alukal JJ,Thuluvath PJ

    更新日期:2019-09-01 00:00:00

  • p53 codon 72 polymorphism and hepatocellular carcinoma: a meta-analysis.

    abstract:BACKGROUND:Hepatocellular carcinoma (HCC) is one of the most common malignant neoplasms worldwide. The p53 gene is frequently mutated in some histological subtypes of HCC. The role of p53 mutations and polymorphic variant of codon 72 in the prognosis of disease is still unclear. The p53 tumor suppressor gene Arg72Pro p...

    journal_title:Hepatology international

    pub_type: 杂志文章

    doi:10.1007/s12072-012-9389-9

    authors: Jia S,Tang W,Luo Y

    更新日期:2013-06-01 00:00:00