Abstract:
:The fermentation of synthesis gas (including carbon monoxide, carbon dioxide, and hydrogen) with anaerobic acetogens is an established biotechnological process that has recently been transferred to a commercial scale. The natural product spectrum of acetogens is natively restricted to acetate, ethanol, and 2,3-butanediol but is rapidly expanding to heterologous products. Syngas fermentation can achieve high carbon-efficiencies; however, the underlying metabolism is operating at a thermodynamic limit. This necessitates special enzymatic properties for energy conservation by acetogens. Therefore, the availability of cellular energy is considered to restrain the efficient production of energy-intense products with complex production pathways. The optimization of the feed-gas composition and other process parameters, genetic engineering, and integration with other biotechnologies is required to overcome this limitation.
journal_name
Curr Opin Chem Bioljournal_title
Current opinion in chemical biologyauthors
Molitor B,Marcellin E,Angenent LTdoi
10.1016/j.cbpa.2017.10.003subject
Has Abstractpub_date
2017-12-01 00:00:00pages
84-92eissn
1367-5931issn
1879-0402pii
S1367-5931(17)30056-Xjournal_volume
41pub_type
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journal_title:Current opinion in chemical biology
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