Abstract：
:Iron-binding transcription factors are widespread throughout the bacterial world and to date are known to bind several types of cofactors, such as Fe2+, heme, or iron-sulfur clusters. The known chemistry of these cofactors is exploited by transcription factors, including Fur, FNR, and NsrR, to sense molecules such as Fe2+, gases (e.g. oxygen and nitric oxide), or reactive oxygen species. New structural data and information generated by genome-wide analysis studies have provided additional details about the mechanism and function of iron-binding transcription factors that act as sensors.
journal_name
Curr Opin Chem Bioljournal_title
Current opinion in chemical biologyauthors
Fleischhacker AS,Kiley PJdoi
10.1016/j.cbpa.2011.01.006subject
Has Abstractpub_date
2011-04-01 00:00:00pages
335-41issue
2eissn
1367-5931issn
1879-0402pii
S1367-5931(11)00005-6journal_volume
15pub_type
杂志文章,评审abstract：:Some therapeutic monoclonal antibodies function by focusing the killing power of the immune system on particular cellular targets, a process known as antibody-dependent cell-mediated cytotoxicity (ADCC). There is considerable interest in developing small-molecule therapeutics that utilize this mechanism of action and ...
journal_title：Current opinion in chemical biology
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journal_title：Current opinion in chemical biology
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journal_title：Current opinion in chemical biology
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journal_title：Current opinion in chemical biology
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journal_title：Current opinion in chemical biology
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journal_title：Current opinion in chemical biology
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journal_title：Current opinion in chemical biology
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journal_title：Current opinion in chemical biology
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journal_title：Current opinion in chemical biology
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journal_title：Current opinion in chemical biology
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journal_title：Current opinion in chemical biology
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journal_title：Current opinion in chemical biology
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