Approaches to the design of catalytic metallodrugs.

Abstract:

:Metal ions are known to act as catalytic centres in metallo-enzymes. On the other hand, low-molecular-weight metal complexes are widely used as catalysts in chemical systems. However, small catalysts do not have a large protein ligand to provide substrate selectivity and minimize catalyst poisoning. Despite the challenges that the lack of a protein ligand might pose, some success in the use of metal catalysts for biochemical transformations has been reported. Here, we present a brief overview of such reports, especially involving catalytic reactions in cells. Examples include C-C bond formation, deprotection and functional group modification, degradation of biomolecules, and redox modulation. We discuss four classes of catalytic redox modulators: photosensitizers, superoxide dismutase mimics, thiol oxidants, and transfer hydrogenation catalysts. Catalytic metallodrugs offer the prospect of low-dose therapy and a challenging new design strategy for future exploration.

journal_name

Curr Opin Chem Biol

authors

Soldevila-Barreda JJ,Sadler PJ

doi

10.1016/j.cbpa.2015.01.024

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

172-83

eissn

1367-5931

issn

1879-0402

pii

S1367-5931(15)00019-8

journal_volume

25

pub_type

杂志文章,评审
  • Synthetic biology for natural product drug production and engineering.

    abstract::Natural products continue to provide privileged scaffolds for drug discovery. However, challenges in supply and structure diversification can limit development. Here, we discuss recent (2017-2020) examples of synthetic biology approaches used to address challenges in supply and contribute to structure diversification ...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.cbpa.2020.09.006

    authors: Romanowski S,Eustáquio AS

    更新日期:2020-10-01 00:00:00

  • Proteomic approaches to the characterization of protein thiol modification.

    abstract::Protein cysteine residues are central to redox signaling and to protection against oxidative damage through their interactions with reactive oxygen and nitrogen species, and electrophiles. Although there is considerable evidence for a functional role for cysteine modifications, the identity and physiological significa...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.cbpa.2010.11.003

    authors: Chouchani ET,James AM,Fearnley IM,Lilley KS,Murphy MP

    更新日期:2011-02-01 00:00:00

  • Metal regulation of metabolism.

    abstract::A broad range of biochemicals, from proteins to nucleic acids, function properly only when associated with a metal, usually a divalent cation. Not any divalent metal will do: these metals differ in their ionic radius, dissociation in water, ionization potential, and number of unpaired electrons in their outer shells, ...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.cbpa.2018.09.017

    authors: Bloom AJ

    更新日期:2019-04-01 00:00:00

  • Cross-linked enzyme crystals.

    abstract::The active site of cross-linked enzyme crystals can be further modified by chemical means, yielding a new type of chemically engineered enzyme. In the past year, the characteristics of cross-linked protein crystals as microporous materials have been studied and used as stationary phases in chromatographic separations....

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审

    doi:10.1016/s1367-5931(99)80007-6

    authors: Häring D,Schreier P

    更新日期:1999-02-01 00:00:00

  • Nitrile hydrolases.

    abstract::A number of nitrile-related enzymes have been screened over the past year for use in synthetic applications. There have also been significant advances in our understanding of the structures and modes of regulation of metal-containing nitrile hydratases. Enzyme structural characterization has provided new insights into...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审

    doi:10.1016/s1367-5931(99)00058-7

    authors: Kobayashi M,Shimizu S

    更新日期:2000-02-01 00:00:00

  • Encapsulins: microbial nanocompartments with applications in biomedicine, nanobiotechnology and materials science.

    abstract::Compartmentalization is one of the defining features of life. Cells use protein compartments to exert spatial control over their metabolism, store nutrients and create unique microenvironments needed for essential physiological processes. Encapsulins are a recently discovered class of protein nanocompartments found in...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.cbpa.2016.05.013

    authors: Giessen TW

    更新日期:2016-10-01 00:00:00

  • Ligand specificity, privileged substructures and protein druggability from fragment-based screening.

    abstract::Fragment-based screening has now become an established method for the generation of lead molecules against therapeutic targets. Fragment molecules are simple, low molecular-weight compounds with few chemical functionalities. These characteristics lead to high hit rates for fragment screening as compared to the more cl...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.cbpa.2011.02.020

    authors: Barelier S,Krimm I

    更新日期:2011-08-01 00:00:00

  • Chemical approaches to transcriptional regulation.

    abstract::Given the correlation between many human diseases and mis-regulated transcription, there is a growing need for molecules that can inhibit or mimic key interactions between transcriptional activators and their binding partners. Because transcriptional activators typically participate in many different protein-protein b...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.cbpa.2005.08.012

    authors: Majmudar CY,Mapp AK

    更新日期:2005-10-01 00:00:00

  • Directed mass spectrometry: towards hypothesis-driven proteomics.

    abstract::To date, the vast majority of the proteomic data sets collected by mass spectrometry (MS) have been generated by nondirected methods, whereby the identified precursor ions are stochastically selected for sequencing from complex sample mixtures. Recently, new MS approaches have been developed in which the mass spectrom...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.cbpa.2009.08.016

    authors: Schmidt A,Claassen M,Aebersold R

    更新日期:2009-12-01 00:00:00

  • Di-iron-tyrosyl radical ribonucleotide reductases.

    abstract::New insights have been gained into the formation of the di-iron tyrosyl radical cofactor, which is essential for nucleotide reduction in the class I ribonucleotide reductases. Recent advances include Insight into the function of the tyrosyl radical in initiation of nucleotide reduction. ...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审

    doi:10.1016/s1367-5931(03)00025-5

    authors: Stubbe J

    更新日期:2003-04-01 00:00:00

  • Activity-based sensing fluorescent probes for iron in biological systems.

    abstract::Iron is an essential nutrient for life, and its capacity to cycle between different oxidation states is required for processes spanning oxygen transport and respiration to nucleotide synthesis and epigenetic regulation. However, this same redox ability also makes iron, if not regulated properly, a potentially dangerou...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.cbpa.2017.12.010

    authors: Aron AT,Reeves AG,Chang CJ

    更新日期:2018-04-01 00:00:00

  • Peptide-based synthetic pulmonary surfactant for the treatment of respiratory distress disorders.

    abstract::KL4 (sinapultide) represents the first peptide-based replacement for surfactant protein B in pulmonary surfactant (PS) therapies approved for clinical use. Surfaxin, its formulation with PS lipids, shows the promise of synthetic PS for replacing animal-derived PS in the treatment of respiratory distress syndromes and ...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.cbpa.2016.02.012

    authors: Braide-Moncoeur O,Tran NT,Long JR

    更新日期:2016-06-01 00:00:00

  • Computational design strategies for combinatorial libraries.

    abstract::Medicinal chemistry principles are being increasingly applied to the design of smaller, high purity, information-rich libraries. Recent computational advances in statistical methodology, the design of libraries to reduce ADMET problems, targeting protein families and revisiting natural products as sources of inspirati...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审

    doi:10.1016/s1367-5931(03)00057-7

    authors: Rose S,Stevens A

    更新日期:2003-06-01 00:00:00

  • Bacterial adhesins: structural studies reveal chaperone function and pilus biogenesis.

    abstract::During the past year, remarkable progress has been made in understanding how periplasmic chaperones fold and protect protein modules that are destined for assembly into adhesive pili in Gram-negative bacteria. The first two three-dimensional structures of complexes of periplasmic chaperones with substrate pilus subuni...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审

    doi:10.1016/s1367-5931(00)00144-7

    authors: Knight SD,Berglund J,Choudhury D

    更新日期:2000-12-01 00:00:00

  • Advances in synthesis of biotin and assembly of lipoic acid.

    abstract::Although biotin and lipoic acid are two universally conserved cofactors essential for intermediary metabolism, their synthetic pathways have become known only in recent years. Both pathways have unusual features. Biotin synthesis in Escherichia coli requires a methylation that is later removed whereas lipoic acid is a...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.cbpa.2018.08.004

    authors: Cronan JE

    更新日期:2018-12-01 00:00:00

  • Advances in design of protein folds and assemblies.

    abstract::Conceptual and computational advances triggered an explosion of designed protein structures in the recent years. Various protein fold geometries have been robustly designed with atomic accuracy, including protein folds unseen in nature. The same principles and tools have been extended to design multi-chain assemblies....

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.cbpa.2017.06.020

    authors: Ljubetič A,Gradišar H,Jerala R

    更新日期:2017-10-01 00:00:00

  • Small molecules as tools to study the chemical epigenetics of lysine acetylation.

    abstract::Lysine acetylation has emerged as a key post-translational modification found at many sites throughout the cell. It plays an important role in epigenetic processes, and more generally in the regulation of protein stability and interactions. Acetyl groups are installed by lysine acetyltransferases and removed by lysine...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.cbpa.2018.06.015

    authors: Schiedel M,Conway SJ

    更新日期:2018-08-01 00:00:00

  • Enzyme (re)design: lessons from natural evolution and computation.

    abstract::The (re)design of enzymes to catalyze 'new' reactions is a topic of considerable practical and intellectual interest. Directed evolution (random mutagenesis followed by screening/selection) has been used widely to identify novel biocatalysts. However, 'rational' approaches using either natural divergent evolution or c...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.cbpa.2009.01.014

    authors: Gerlt JA,Babbitt PC

    更新日期:2009-02-01 00:00:00

  • The joys of in vitro selection: chemically dressing oligonucleotides to satiate protein targets.

    abstract::Oligonucleotide in vitro selection provides surprisingly specific aptamers to protein targets. Synthetic chemistries for modifying nucleotides have been developed to enhance aptamer binding affinity. The diversity of nucleosides amenable to either triphosphate synthesis or phosphoramidite activation is now sufficientl...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审

    doi:10.1016/s1367-5931(97)80103-2

    authors: Eaton BE

    更新日期:1997-06-01 00:00:00

  • Isotope-edited IR spectroscopy for the study of membrane proteins.

    abstract::Fourier transform infrared (FTIR) spectroscopy has long been a powerful tool for structural analysis of membrane proteins. However, because of difficulties in resolving contributions from individual residues, most of the derived measurements tend to yield average properties for the system under study. Isotope editing,...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.cbpa.2006.08.013

    authors: Arkin IT

    更新日期:2006-10-01 00:00:00

  • Fresh insight to functioning of selected enzymes of the nitrogen cycle.

    abstract::The global nitrogen cycle is the process in which different forms of environmental N are interconverted by microorganisms either for assimilation into biomass or in respiratory energy-generating pathways. This short review highlights developments over the last 5 years in our understanding of functionality of nitrogena...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.cbpa.2016.02.009

    authors: Eady RR,Antonyuk SV,Hasnain SS

    更新日期:2016-04-01 00:00:00

  • Following the Ca²⁺ roadmap to photocaged complexes for Zn²⁺ and beyond.

    abstract::The first photocaged complexes appeared in the mid-1980s specifically to complement the ongoing work studying intracellular Ca(2+) signaling with fluorescent probes. Recently, the field of biological inorganic chemistry has focused increasingly on the homeostasis mechanisms and possible signaling functions of transiti...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.cbpa.2012.11.015

    authors: Gwizdala C,Burdette SC

    更新日期:2013-04-01 00:00:00

  • Nucleic acid aptamers and enzymes as sensors.

    abstract::The function of nucleic acids has been an endless source of discovery and invention that has drastically enhanced our appreciation of DNA and RNA as multifaceted polymers. It is now widely known that nucleic acids can act as enzymes (deoxyribozymes and ribozymes) and as receptors (aptamers), and that these functional ...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.cbpa.2006.04.003

    authors: Navani NK,Li Y

    更新日期:2006-06-01 00:00:00

  • Glycan analysis by ion mobility-mass spectrometry and gas-phase spectroscopy.

    abstract::Due to the existence of numerous isomers, the in-depth analysis of glycans represents a major challenge. Currently, the majority of glycans are analysed using mass spectrometry (MS)-based techniques, which can provide information on regioisomers but usually fail to differentiate stereoisomers. A promising approach to ...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.cbpa.2017.10.021

    authors: Manz C,Pagel K

    更新日期:2018-02-01 00:00:00

  • Contemporary strategies for the stabilization of peptides in the alpha-helical conformation.

    abstract::Herein we review contemporary synthetic and protein design strategies to stabilize the alpha-helical motif in short peptides and miniature proteins. Advances in organometallic catalyst design, specifically for the olefin metathesis reaction, enable the use of hydrocarbon bridges to either crosslink side chains of spec...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.cbpa.2008.08.019

    authors: Henchey LK,Jochim AL,Arora PS

    更新日期:2008-12-01 00:00:00

  • Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases.

    abstract::Methanogenesis from trimethylamine, dimethylamine or monomethylamine is initiated by a series of corrinoid-dependent methyltransferases. The non-homologous genes encoding the full-length methyltransferases each possess an in-frame UAG (amber) codon that does not terminate translation. The amber codon is decoded by a d...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.cbpa.2004.08.012

    authors: Krzycki JA

    更新日期:2004-10-01 00:00:00

  • Visualizing glycans on single cells and tissues-Visualizing glycans on single cells and tissues.

    abstract::Metabolic oligosaccharide engineering and chemoenzymatic glycan labeling have provided powerful tools to study glycans in living systems and tissue samples. In this review article, we summarize recent advances in this field with a focus on innovative approaches for glycan imaging. The presented applications demonstrat...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.cbpa.2017.04.018

    authors: Ovryn B,Li J,Hong S,Wu P

    更新日期:2017-08-01 00:00:00

  • Epigenetic regulation by endogenous metabolite pharmacology.

    abstract::Altered metabolite levels can drive epigenetic changes critical to development and disease. However, in many cases the specific protein-metabolite interactions that underlie this process remain enigmatic. In this review, we make the case that this fundamental missing information may be discovered by applying the tools...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.cbpa.2019.02.002

    authors: Kulkarni RA,Montgomery DC,Meier JL

    更新日期:2019-08-01 00:00:00

  • The evolving capabilities of rhodopsin-based genetically encoded voltage indicators.

    abstract::Protein engineering over the past four years has made rhodopsin-based genetically encoded voltage indicators a leading candidate to achieve the task of reporting action potentials from a population of genetically targeted neurons in vivo. Rational design and large-scale screening efforts have steadily improved the dyn...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.cbpa.2015.05.006

    authors: Gong Y

    更新日期:2015-08-01 00:00:00

  • Protein epitope mimetics as anti-infectives.

    abstract::There is growing interest in the design of synthetic molecules that mimic the structures and functions of epitopes found on the surface of peptides and proteins. Epitope mimetics can provide valuable tools to probe complex biological processes, as well as interesting leads for drug and vaccine discovery. One applicati...

    journal_title:Current opinion in chemical biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.cbpa.2011.02.015

    authors: Robinson JA

    更新日期:2011-06-01 00:00:00