Detection of antibodies to both M. leprae PGL-I and MMP-II to recognize leprosy patients at an early stage of disease progression.

Abstract:

:Antibodies to phenolic glycolipid (PGL)-I and major membrane protein (MMP)-II were evaluated for serodiagnosis of leprosy in Southwest China, and the role in predicting the occurrence of the disease in household contacts (HHCs) of leprosy was examined. Using PGL-I (natural disaccharide-octyl-bovine serum albumin) antigen-based diagnosis (IgM antibodies), we could detect 94.9% of multibacillary (MB) leprosy and 38.9% paucibacillary (PB) leprosy patients, whereas using MMP-II (IgG antibody), 88.1% of MB and 61.1% of PB patients were positive. By combining the 2 tests and considering either test positive as positive, 100% of MB patients and 72.2% of PB patients were found to test positive. Of the HHCs of leprosy, 28.3% and 30% had positive levels of PGL-I and MMP-II Abs, respectively. Seven out of 21 HHCs, who had high Ab titer to either antigen, developed leprosy during the follow-up period of 3 years. These data suggest that the measurement of both anti-PGL-I as well as anti-MMP-II antibodies could facilitate early detection of leprosy.

authors

Wang H,Liu W,Jin Y,Yu M,Jiang H,Tamura T,Maeda Y,Makino M

doi

10.1016/j.diagmicrobio.2015.07.012

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

274-7

issue

3

eissn

0732-8893

issn

1879-0070

pii

S0732-8893(15)00238-2

journal_volume

83

pub_type

杂志文章
  • Changes in the balance between Treg and Th17 cells in patients with chronic hepatitis B.

    abstract::The purpose of this study was to explore the role of Treg cells, Th17 cells and cytokines associated with Treg/Th17 differentiation in the occurrence, development and outcome of chronic hepatitis B (CHB). To do so, we detected populations of Treg and Th17 cells and their associated cytokines in the peripheral blood of...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章

    doi:10.1016/j.diagmicrobio.2013.04.026

    authors: Su ZJ,Yu XP,Guo RY,Ming DS,Huang LY,Su ML,Deng Y,Lin ZZ

    更新日期:2013-08-01 00:00:00

  • Prevalence and risk factors for carriage of extended-spectrum β-lactamase-producing Enterobacteriaceae among patients prior to bowel surgery.

    abstract::Prophylactic antibiotics are an important measure in preventing perioperative infection, Failure to cover multidrug-resistant pathogens may place carriers at increased risk of infection. We conducted a prospective, cross-sectional study in patients prior to bowel surgery to measure the carriage prevalence of extended-...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章

    doi:10.1016/j.diagmicrobio.2016.04.002

    authors: Pfeffer I,Zemel M,Kariv Y,Mishali H,Adler A,Braun T,Klein A,Matalon MK,Klausner J,Carmeli Y,Schwaber MJ

    更新日期:2016-07-01 00:00:00

  • Evaluation of the in vitro activity of cefepime compared to other broad-spectrum cephalosporins against clinical isolates from eighteen Brazilian hospitals by using the Etest.

    abstract::The in vitro activity of cefepime was compared to that of ceftazidime, ceftriaxone, and cefotaxime in a multicenter study involving 10 clinical microbiology laboratories and clinical isolates from 18 Brazilian hospitals from 7 cities (4 states). A total of 982 isolates consecutively collected between December 1995 and...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章

    doi:10.1016/s0732-8893(97)00015-1

    authors: Sader HS,Mimiça I,Rossi F,Zoccoli C,Montelli AC,Sampaio JL,Segura AJ,Magalhães M,Nowakonski A,Mendes CM

    更新日期:1997-06-01 00:00:00

  • Evaluation of the fully automated AIX1000 rapid plasma reagin system compared to a manual plasma reagin testing method for the diagnosis of syphilis.

    abstract::The analytical performance of the FDA-cleared AIX1000 automated RPR testing platform was evaluated in comparison to manual RPR card testing. Eight hundred thirty-three patient serum samples were analyzed, 87 samples were positive by the AIX1000, 108 were positive by the manual test method; overall agreement between me...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章

    doi:10.1016/j.diagmicrobio.2020.115081

    authors: Pyden A,Kang AD,Amato S,Dutta S,Berg G,Riedel S

    更新日期:2020-08-01 00:00:00

  • T2 Candida versus beta-D-glucan to facilitate antifungal discontinuation in the intensive care unit.

    abstract::T2 Magnetic Resonance Candida Panel (T2MR) detects Candida directly in blood. Rapid turnaround time and high negative predictive value make it a useful diagnostic test to support antifungal discontinuation. This retrospective quasi-experiment compared empiric anidulafungin days of therapy (DOTs) in intensive care unit...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章

    doi:10.1016/j.diagmicrobio.2019.04.016

    authors: Gill CM,Kenney RM,Hencken L,Mlynarek ME,Alangaden GJ,Samuel LP,Davis SL

    更新日期:2019-10-01 00:00:00

  • Erysipelothrix bacteremia without endocarditis: rare event or under-reported occurrence?

    abstract::A patient presented with inflamed hands and Erysipelothrix rhusiopathiae bacteremia. Because a high incidence of endocarditis has been reported with this organism, a transesophageal echocardiogram was obtained, which was normal. Treatment with oral moxifloxacin resolved all manifestations of illness. The association b...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章

    doi:10.1016/j.diagmicrobio.2013.07.002

    authors: Drekonja DM

    更新日期:2013-11-01 00:00:00

  • Detection of enteroviruses using subgenomic probes of Coxsackie virus B4 by hybridization.

    abstract::The objective of this research was to develop group- and type-specific probes for the detection of enteroviruses. Coxsackie virus B4 RNA was cloned, and a series of subgenomic clones were generated. Six of these clones, containing sequences from the 3' end or the 5' end of the genome, were tested for their ability to ...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章

    doi:10.1016/0732-8893(88)90014-4

    authors: Chatterjee NK,Kaehler M,Deibel R

    更新日期:1988-11-01 00:00:00

  • The importance of volume of blood cultured in the detection of bacteremia and fungemia.

    abstract::An analysis was made on the basis of 5,389 isolates from 5,008 positive blood cultures of the relative yields from 10, 20, and 30 ml of blood. Average yields from cultures of 20 and 30 ml of blood were, respectively, 38 and 61% greater than that from 10 ml of blood. ...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章

    doi:10.1016/0732-8893(83)90039-1

    authors: Ilstrup DM,Washington JA 2nd

    更新日期:1983-06-01 00:00:00

  • Group-C beta-hemolytic streptococcal bacteremia.

    abstract::Group-C beta-hemolytic streptococci (GCBHS) is an uncommon cause of bacteremia. In a 5-year period, GCBHS accounted for 0.28% of positive blood cultures and 0.35% of bacteremias documented at our hospital. The incidence of GCBHS bacteremia was 0.05 episodes per 1000 admissions. We were able to analyze clinical data of...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章

    doi:10.1016/0732-8893(92)90040-z

    authors: Berenguer J,Sampedro I,Cercenado E,Baraia J,Rodríguez-Créixems M,Bouza E

    更新日期:1992-02-01 00:00:00

  • The effect of fecal turbidity on norovirus detection by reverse transcriptase polymerase chain reaction.

    abstract::A 10-min fecal preparation results in greater specimen turbidity than a 45-min protocol, but reverse transcriptase polymerase chain reaction (RT-PCR) norovirus test sensitivity is essentially the same. Feces processed so that particle size does not exceed approximately 560 nm do not display greater norovirus RT-PCR in...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章

    doi:10.1016/j.diagmicrobio.2008.08.006

    authors: Witlox KJ,Karapanagiotidis T,Bruggink LD,Marshall JA

    更新日期:2010-02-01 00:00:00

  • Bacterial pathogens isolated from patients with skin and soft tissue infections: frequency of occurrence and antimicrobial susceptibility patterns from the SENTRY Antimicrobial Surveillance Program (United States and Canada, 1997). SENTRY Study Group (Nor

    abstract::As part of the SENTRY Antimicrobial Surveillance Program, 1562 bacterial isolates were recovered from hospitalized patients with skin and soft tissue infections (SSTIs) in 30 United States (U.S.) and 8 Canadian medical centers between October and December, 1997. The overall rank order of recovery of the six most commo...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章,多中心研究

    doi:10.1016/s0732-8893(98)00162-x

    authors: Doern GV,Jones RN,Pfaller MA,Kugler KC,Beach ML

    更新日期:1999-05-01 00:00:00

  • Quantification and identification of polyomavirus DNA in blood and urine of renal transplant recipients.

    abstract::A cohort of 201 kidney transplant recipients (KTR) including 7 patients with evidence of renal function deterioration (as defined by creatinine levels >20% over baseline values) was analyzed for polyomavirus DNA in blood and urine samples by a new quantitative polymerase chain reaction method. Of 201 patients, 14 (6.9...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章

    doi:10.1016/j.diagmicrobio.2006.08.006

    authors: Baldanti F,Fogazzi GB,Furione M,Saglimbeni L,Rovida F,Gatti M,Paolucci S,Tarantino A,Gerna G

    更新日期:2007-03-01 00:00:00

  • Efficacy of fluconazole in cryptococcal meningitis.

    abstract::In this clinical trial, oral fluconazole was used to treat cryptococcal meningitis in 32 patients with Acquired Immune Deficiency Syndrome (AIDS). In 11 patients who received 200 to 400 mg/day of fluconazole as primary therapy, a favorable clinical response was obtained in 67% of all evaluable patients. A negative cer...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 临床试验,杂志文章

    doi:10.1016/0732-8893(89)90142-9

    authors: Jones PD,Marriott D,Speed BR

    更新日期:1989-07-01 00:00:00

  • A new causative bacteria of infective endocarditis, Bergeyella cardium sp. nov.

    abstract::The first cases of infective endocarditis due to a new species of Bergeyella, Bergeyella cardium sp. nov., are reported. Two strains, 13-07(T) (= JCM 30115(T) = NCCP 15908(T)) and 13-16, were independently isolated from 2 patients in different hospitals in Korea. Initially, the isolates were identified as Brevundimona...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章

    doi:10.1016/j.diagmicrobio.2014.12.001

    authors: Sohn KM,Huh K,Baek JY,Kim YS,Kang CI,Peck KR,Lee NY,Song JH,Ko KS,Chung DR

    更新日期:2015-03-01 00:00:00

  • Human infections with Actinomyces pyogenes (Corynebacterium pyogenes).

    abstract::Actinomyces pyogenes (Corynebacterium pyogenes), a well-known pathogen in many animals, was isolated from 11 Danish patients since 1968. Bacteriologic characteristics and clinical pictures of the patients are described. Ability to hydrolyze gelatine, to produce beta-glucuronidase, to reach with antisera against group-...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章,评审

    doi:10.1016/0732-8893(92)90022-l

    authors: Gahrn-Hansen B,Frederiksen W

    更新日期:1992-05-01 00:00:00

  • Comparative in vitro pharmacodynamics of imipenem and meropenem against ATCC strains of Escherichia coli, Staphylococcus aureus and Bacteroides fragilis.

    abstract::We evaluated the pharmacodynamics of imipenem and meropenem, utilizing time-kill studies over a concentration/MIC (C/MIC) range of 0.0625-1024 for E. coli ATCC 35218 (EC) and S. aureus ATCC 29213 (SA) and from 0.125-512 for B. fragilis ATCC 25285 (BF). Area under the time-kill curves were converted to percent response...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章

    doi:10.1016/s0732-8893(00)00219-4

    authors: White RL,Friedrich LV,Manduru M,Mihm LB,Bosso JA

    更新日期:2001-01-01 00:00:00

  • Extended spectrum beta-lactamase production and fluorquinolone resistance in pathogens associated with community acquired urinary tract infection.

    abstract::We have evaluated the susceptibility of 199 pathogens isolated in pure culture from consecutive urine samples submitted from the community. Rates of susceptibility for all organisms were ampicillin, 48%; amoxycillin/clavulanic acid, 88%; cephalothin, 57%; cefuroxime axetil, 74%; nalidixic acid, 85%; ciprofloxacin, 99%...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章

    doi:10.1016/s0732-8893(98)00113-8

    authors: Cormican M,Morris D,Corbett-Feeeney G,Flynn J

    更新日期:1998-12-01 00:00:00

  • Proteolytic activity of Candida albicans and other yeasts.

    abstract::Clinical isolates of C. albicans (75 strains) and other yeasts (20 strains) were evaluated for their ability to produce a carboxyl acid proteinase in an effort to assess its potential role as a virulence factor. Yeasts were categorized as to the infectious process present in the patient: (1) isolates from patients wit...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章

    doi:10.1016/0732-8893(85)90060-4

    authors: Schreiber B,Lyman CA,Gurevich J,Needham CA

    更新日期:1985-01-01 00:00:00

  • Evaluation of Brucella dipstick assay for the diagnosis of acute brucellosis.

    abstract::The diagnostic value of the dipstick assay was evaluated by comparison with Rose Bengal (RB), serum aglutination tests (SAT) and 2 mercaptoethanol test (2-ME) on consecutive serum samples submitted because of suspicion of brucellosis. Serum samples of 232 patients with suspected brucellosis that were submitted for lab...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章

    doi:10.1016/s0732-8893(02)00456-x

    authors: Altuglu I,Zeytinoğlu A,Bilgic A,Kamcioglu S,Karakartal G,Smits H

    更新日期:2002-11-01 00:00:00

  • Evaluation of immuno-1 toxoplasma IgG assay in the prenatal screening of toxoplasmosis.

    abstract::We evaluated the Immuno-1 (Bayer Diagnostics, Tarrytown, New York, USA) and IMx (Abbott Laboratories, Chicago, Illinois, USA) toxoplasma IgG assays in 298 (223 fresh in-house prenatal + 75 supplied by Bayer) specimens over 15 days. Discordant results were resolved by indirect fluorescence assay (Gull Laboratories, Sal...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章

    doi:10.1016/s0732-8893(96)00215-5

    authors: Rao LV,James OA,Mann LM,Mohammad AA,Okorodudu AO,Bissell MG,Petersen JR

    更新日期:1997-01-01 00:00:00

  • Isolation of agent associated with cat scratch disease bacillus from pretibial biopsy.

    abstract::We describe the isolation and cultural characteristics of a Gram-negative bacillus that is very similar to the presumed etiologic agent of cat scratch disease. The organism was isolated from a tibial lesion of a male patient who had been hospitalized for severe necrotizing pancreatitis. The significance of the isolate...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章

    doi:10.1016/0732-8893(91)90009-5

    authors: Hall GS,Pratt-Rippin K,Washington JA

    更新日期:1991-11-01 00:00:00

  • Identification by 16S ribosomal RNA gene sequencing of an Enterobacteriaceae species with ambiguous biochemical profile from a renal transplant recipient.

    abstract::Traditional ways of identification of bacteria by phenotypic characteristics cannot be used for non-cultivable organisms and organisms with unusual biochemical profiles. In this study, an Enterobacteriaceae was isolated in pure growth from the mid-stream urine of a 67-year old renal transplant recipient with urinary t...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章

    doi:10.1016/s0732-8893(01)00206-1

    authors: Woo PC,Cheung EY,Leung K,Yuen K

    更新日期:2001-02-01 00:00:00

  • Corynebacterium macginleyi isolation from conjunctival swab in Italy.

    abstract::Corynebacterium macginleyi was isolated from conjunctival swabs of a farmer suffering from purulent conjunctivitis. This species has only recently been reported in Switzerland and Germany to be exclusively isolated from ocular surfaces. This represents the first isolation of C. macginleyi in Italy indicating that its ...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章

    doi:10.1016/s0732-8893(02)00438-8

    authors: Giammanco GM,Di Marco V,Priolo I,Intrivici A,Grimont F,Grimont PA

    更新日期:2002-10-01 00:00:00

  • A study on producing monoclonal antibody with one diagnostic marker screened electrophoretically from the urine of individuals infected with Schistosoma japonicum.

    abstract::One diagnostic marker (a glycoprotein with 30kDa) from the urine of individuals infected with S. japonicum was screened with electrophoresis, and used as antigen to produce McAbs. Two lines of McAbs, named NP56 and NP54,were obtained. McAb NP56 was of better immunoreactivity and its immunoglobulin isotype was IgG(2b.)...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章

    doi:10.1016/s0732-8893(00)00207-8

    authors: Zhu C,Tian H,Lu L,Li Y,Feng Z,Ma L,Guan X

    更新日期:2000-12-01 00:00:00

  • Polymicrobial candidemia.

    abstract::We conducted a retrospective review of the clinical data on patients with polymicrobial candidemia during a nine-year period (1992-2000) at our tertiary care University Hospital. Also, the clinical features of patients with polymicrobial vs monomicrobial candidemia were compared. There were 16 (5.2%) patients with mul...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章,评审

    doi:10.1016/s0732-8893(02)00460-1

    authors: Pulimood S,Ganesan L,Alangaden G,Chandrasekar P

    更新日期:2002-12-01 00:00:00

  • Reproducibility of positive results for rare pathogens on the FilmArray GI Panel.

    abstract::Though the FilmArray GI Panel has a reported aggregate specificity and reproducibility of >97% and > 99%, respectively, the reproducibility is less understood in clinical practice. We measured the reproducibility of positive results for low-prevalence pathogens. Samples with positive results for selected targets were ...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章

    doi:10.1016/j.diagmicrobio.2019.03.013

    authors: Hitchcock MM,Hogan CA,Budvytiene I,Banaei N

    更新日期:2019-09-01 00:00:00

  • Susceptibility of clinical isolates of Candida spp. to terconazole and other azole antifungal agents.

    abstract::Terconazole is a triazole ketal derivative with potent, broad-spectrum antifungal activity. We investigated the in vitro activity of terconazole, miconazole, and clotrimazole, against 94 clinical isolates of Candida spp.: C. albicans (n = 68), C. tropicalis (n = 18), and C. parapsilosis (n = 8). In vitro susceptibilit...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章

    doi:10.1016/0732-8893(89)90079-5

    authors: Pfaller MA,Gerarden T

    更新日期:1989-11-01 00:00:00

  • In vitro activity of tigecycline against isolates collected from complicated skin and skin structure infections and intra-abdominal infections in Africa and Middle East countries: TEST 2007-2012.

    abstract::Complicated skin and skin structure infections (cSSSIs) and intra-abdominal infections (IAIs) are problematic due to decreasing therapeutic options available against multidrug-resistant pathogens common among these types of infections. A total of 2245 isolates from African and the Middle Eastern (AfME) countries were ...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章

    doi:10.1016/j.diagmicrobio.2014.01.017

    authors: Renteria MI,Biedenbach DJ,Bouchillon SK,Hoban DJ,Raghubir N,Sajben P,Mokaddas E

    更新日期:2014-05-01 00:00:00

  • Adaptation of a commercially available indirect fluorescent antibody slide test for measuring measles-specific immunoglobulins.

    abstract::A commercially available indirect fluorescent antibody (IFA) test was evaluated for the determination of measles-specific immunoglobulins G and M (MIgG, MIgM). The IFA test detected fourfold rises of MIgG in 34 of 35 (97%) cases of measles confirmed by complement fixation or hemagglutination inhibition. In determining...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章

    doi:10.1016/0732-8893(86)90068-4

    authors: Kleiman MB,Bockhold CA,Zimmerman SE,Griffin C,French ML,Barrett C

    更新日期:1986-04-01 00:00:00

  • Clinical characteristics of bacteremia caused by hypermucoviscous Klebsiella pneumoniae at a tertiary hospital.

    abstract::This study aimed to assess the predictive factors of bacteremia due to hypermucoviscous Klebsiella pneumoniae (hvKP), as well as the mortality. The medical records of 114 patients with K. pneumoniae bacteremia who were divided into the hvKP (n = 24) and non-hvKP (n = 90) groups and were retrospectively reviewed. The m...

    journal_title:Diagnostic microbiology and infectious disease

    pub_type: 杂志文章

    doi:10.1016/j.diagmicrobio.2019.04.008

    authors: Namikawa H,Yamada K,Sakiyama A,Imoto W,Yamairi K,Shibata W,Yoshii N,Niki M,Nakaie K,Oinuma KI,Tsubouchi T,Niki M,Tochino Y,Takemoto Y,Kaneko Y,Shuto T,Kakeya H

    更新日期:2019-09-01 00:00:00