Abstract：
:A number of challenges for developing a protective pre-pandemic influenza A vaccine exists including predicting the target influenza strain and designing the vaccine for an immunologically naïve population. Manufacturing and supply of the vaccine would also require implementing ways to increase coverage for the largest number of people through dose-sparing methods, while not compromising the potency of the vaccine. Previously, our group described a novel hemagglutinin (HA) for H5N1 influenza derived from a methodology termed computationally optimized broadly reactive antigen (COBRA). This report describes a strategy combining a COBRA-based HA vaccine with an oil-in-water emulsion, resulting in a dose-sparing, immunologically broadened, and protective response against multiple H5N1 isolates. Here, we show that an emulsion-based adjuvant enhances the magnitude and breadth of antibody responses with both a wild-type H5HA (H5N1 WT) and the H5N1 COBRA HA VLP vaccines. The H5N1 COBRA HA VLP, combined with an emulsion adjuvant, elicited HAI specific antibodies against a larger panel of H5N1 viruses that resulted in protection against challenge as efficiently as the homologous, matched vaccine.
journal_name
Vaccinejournal_title
Vaccineauthors
Allen JD,Owino SO,Carter DM,Crevar CJ,Reese VA,Fox CB,Coler RN,Reed SG,Baldwin SL,Ross TMdoi
10.1016/j.vaccine.2017.07.107subject
Has Abstractpub_date
2017-09-12 00:00:00pages
5209-5216issue
38eissn
0264-410Xissn
1873-2518pii
S0264-410X(17)31043-5journal_volume
35pub_type
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