Abstract:
:Medico-legal experts are increasingly enlisted to assess the methamphetamine and amphetamine serum concentrations after a criminal offense. However, since criminal users rarely provide useful information to medico-legal experts regarding the substances abused, when the substance(s) was/were used, dose of ingestion tools are needed to interpret the analytical data, which can be used as objective evidence in such cases. A comparative series of methamphetamine and amphetamine serum concentrations were used to analyze the frequency of concentrations, to determine methamphetamine/amphetamine concentration ratios, and prove them as a tool to distinguish pure methamphetamine from mixed amphetamine/methamphetamine ingestion. Additionally, two cases of survived accidental methamphetamine intoxication, resulting from ingestion smuggling which was longitudinally monitored, and pharmacokinetic parameters were assessed. In a series of 628 samples where the most frequent concentration of methamphetamine exceeded the therapeutic level, there was a strong correlation suggesting pure methamphetamine consumption, when the ratios of methamphetamine/amphetamine concentrations were within the range between 3 and 10. In the two cases of methamphetamine bodypacking, the relevant serum concentrations of methamphetamine and amphetamine, which could be measured up to 9 days after ingestion, indicated a decrease of the methamphetamine/amphetamine ratios in an exponential manner. However, the ratios were not always within the range between 3 and 10. Lastly, the course of the serum concentrations suggested an increase of the apparent elimination half-life of methamphetamine. In terms of the objective evidence required in criminal law, calculating methamphetamine/amphetamine concentration ratio is not a suitable to means to distinguish pure methamphetamine intake and that of mixed amphetamine/methamphetamine abuse in an individual case. Instead, methamphetamine high serum concentrations and the possible increase in apparent elimination half-life suggest that an extended detection period may be used to distinguish between "illicit use" as compared to "therapeutic use" of methamphetamine.
journal_name
Int J Legal Medjournal_title
International journal of legal medicineauthors
Weber M,Lessig R,Richter C,Ritter AP,Weiß Idoi
10.1007/s00414-017-1607-5subject
Has Abstractpub_date
2017-09-01 00:00:00pages
1253-1260issue
5eissn
0937-9827issn
1437-1596pii
10.1007/s00414-017-1607-5journal_volume
131pub_type
杂志文章abstract::One of the most common conditions during fetal development is anencephaly, which often involves many identification difficulties in the context of physical anthropology, as it causes severe skull challenges. In this paper, we describe the alterations found in the skulls of two perinatal individuals with anencephaly fr...
journal_title:International journal of legal medicine
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journal_title:International journal of legal medicine
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journal_title:International journal of legal medicine
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journal_title:International journal of legal medicine
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journal_title:International journal of legal medicine
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journal_title:International journal of legal medicine
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journal_title:International journal of legal medicine
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journal_title:International journal of legal medicine
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journal_title:International journal of legal medicine
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journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-016-1469-2
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journal_title:International journal of legal medicine
pub_type: 杂志文章,meta分析,评审
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abstract::In the last decade, increasing knowledge of epigenetics has led to the development of DNA methylation-based models to predict age, which have shown high predictive accuracy. However, despite the value of teeth as forensic samples, few studies have focused on this source of DNA. This study used bisulfite pyrosequencing...
journal_title:International journal of legal medicine
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journal_title:International journal of legal medicine
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更新日期:2017-09-01 00:00:00
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journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s004140050073
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journal_title:International journal of legal medicine
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journal_title:International journal of legal medicine
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journal_title:International journal of legal medicine
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journal_title:International journal of legal medicine
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journal_title:International journal of legal medicine
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:International journal of legal medicine
pub_type: 杂志文章
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journal_title:International journal of legal medicine
pub_type: 杂志文章
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journal_title:International journal of legal medicine
pub_type: 杂志文章
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journal_title:International journal of legal medicine
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journal_title:International journal of legal medicine
pub_type: 杂志文章
doi:10.1007/s00414-019-02036-x
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