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The influence of macrophages on mesenchymal stromal cell therapy: passive or aggressive agents?

Abstract：

:Mesenchymal stromal cells (MSC) have emerged as promising cell therapies for multiple conditions based on demonstrations of their potent immunomodulatory and regenerative capacities in models of inflammatory disease. Understanding the effects of MSC on T cells has dominated the majority of work carried out in this field to date; recently, however, a number of studies have shown that the therapeutic effect of MSC requires the presence of macrophages. It is timely to review the mechanisms and manner by which MSC modulate macrophage populations in order to design more effective MSC therapies and clinical studies. A complex cross-talk exists through which MSC and macrophages communicate, a communication that is not controlled exclusively by MSC. Here, we examine the evidence that suggests that MSC not only respond to inflammatory macrophages and adjust their secretome accordingly, but also that macrophages respond to encounters with MSC, creating a feedback loop which contributes to the immune regulation observed following MSC therapy. Future studies examining the effects of MSC on macrophages should consider the antagonistic role that macrophages play in this exchange.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Carty F,Mahon BP,English K

doi

10.1111/cei.12929

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

1-11

issue

1

eissn

0009-9104

issn

1365-2249

journal_volume

188

pub_type

杂志文章,评审

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