Hypoxic Exercise Training Promotes apelin/APJ Expression in Skeletal Muscles of High Fat Diet-Induced Obese Mice.

abstract：:Tumor vasculatures express high levels of α(V)β(3)/α(V)β(5) and α(5)β(1) integrins. Peptide containing the RGD (Arg-Gly-Asp) sequence, which is present in ligands of integrins, is effective in targeting therapeutic reagents to tumor vascular endothelium. In this study, we investigated whether the biological activity o...

journal_title：Protein and peptide letters

authors： Zhang HT,Li HC,Li ZW,Guo CH,Chen YJ

更新日期：2011-06-15 00:00:00

abstract：:ROS, including (.)OH, is now recognized as the hallmark of inflammation and damage to the anti-proteinase barrier has been implicated in a number of pathophysiological conditions. We have previously shown that O2( -) and H2O2/HOCl are physiologically relevant inactivators of alpha 2M, a key anti-proteinase. Here, we s...

journal_title：Protein and peptide letters

authors： Khan SA,Khan FH

更新日期：2009-01-01 00:00:00

abstract：:A new galactose-specific lectin, named BBL, was purified from seeds of Bauhinia bauhinioides by precipitation with ammonium sulfate, followed by two steps of ion exchange chromatography. BBL haemagglutinated rabbit erythrocytes (native and treated with proteolytic enzymes) showing stability even after exposure to 60 °...

journal_title：Protein and peptide letters

authors： Silva HC,Bari AU,Pereira-Jénior FN,Simões RC,Barroso-Neto IL,Nobre CB,Pereira MG,Nascimento KS,Rocha BA,Delatorre P,Nagano CS,Assreuy AM,Cavada BS

更新日期：2011-04-01 00:00:00

abstract：:To investigate the function of plant plasma membrane, proteins of rice plasma membrane were analyzed and the proteins changed by cold stress were identified. Plasma membrane proteins were purified with an aqueous two-phase partitioning method from root of rice seedlings, and activity of specific H(+)-ATPase localized ...

journal_title：Protein and peptide letters

authors： Hashimoto M,Toorchi M,Matsushita K,Iwasaki Y,Komatsu S

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:The heterologous production of antimicrobial peptides in bacterial models can produce insoluble proteins due to the lack of proper folding. Fusion proteins have been used to increase the expression and solubility of these types of proteins with varying degrees of success. OBJECTIVES:Here, we demonstrate the...

journal_title：Protein and peptide letters

authors： Montfort-Gardeazabal JM,Claudio PCM,Casillas-Vega NG,Zarate X

更新日期：2020-06-10 00:00:00

abstract：:We used a de novo designed, beta-hairpin forming T1 peptide as a model to investigate the kinetics of peptide fibrogenesis by a combination of light scattering (LS), circular dichroism (CD), fluorescence, and atomic force microscopy (AFM). The results demonstrate that the T1 fibrogenesis undergoes a consecutive stepwi...

journal_title：Protein and peptide letters

authors： Wang C,Sha Y

更新日期：2010-04-01 00:00:00

abstract：:In the last few decades, novel drug delivery strategies have been a big priority to the formulation scientists. Peptides and proteins have drawn a special attention for their wide scope in the area. Serum albumin, transferrin, recom- binant proteins, virus capsids etc. are used as carrier for drug and biomolecules. Co...

journal_title：Protein and peptide letters

authors： Mukherjee B,Karmakar SD,Hossain CM,Bhattacharya S

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Protein-carbohydrate interactions play vital roles in several biological processes in living organisms. The comparative analysis of binding site residues along with stabilizing residues in protein-carbohydrate complexes provides ample insights to understand the structure, function and recognition mechanism. ...

journal_title：Protein and peptide letters

authors： Shanmugam NRS,Selvin JFA,Veluraja K,Gromiha MM

更新日期：2018-01-01 00:00:00

abstract：:The reaction between Arg-Gly-Asp (RGD) and Lys-Gly-Asp (KGD) derivatives with 3,4',5-trihydroxy-trans-stilbene (resveratrol) was investigated. Knowing that resveratrol, RGD as well as KGD analogues inhibit human platelet aggregation in vitro, it was tempting for us to examine whether their coupling products present en...

journal_title：Protein and peptide letters

authors： Koutsas C,Sarigiannis Y,Stavropoulos G,Liakopoulou-Kyriakides M

更新日期：2007-01-01 00:00:00

abstract：:The role of interaction between Asn259 (catalytic domain) with Gln821 (C-terminal domain) in PeptidaseN was investigated. The k(cat) of PeptidaseN containing Asn259Asp or Gln821Glu is enhanced whereas it is suppressed in Asn259AspGln821Glu. Structural analysis shows this interaction to change the relative disposition ...

journal_title：Protein and peptide letters

authors： Kumar A,Reddy S,Srinivasan N,Nandi D

更新日期：2009-01-01 00:00:00

abstract：:Kallikrein-related peptidases (KLKs) are trypsin-like and chymotrypsin-like serine proteases which are expressed in several tissues. Their activity is tightly controlled by inhibitors including members of the serine protease Kazal-type (SPINK) family. These enzymes are promising targets for the treatment of skin desqu...

journal_title：Protein and peptide letters

authors： Assis DM,Zalazar L,Juliano MA,De Castro R,Cesari A

更新日期：2013-10-01 00:00:00

abstract：:VML is a lectin from Vatairea macrocarpa seeds that has various biological activities. Here, we describe three new lectin isoforms from V. macrocarpa identified through genomic DNA analysis. One of these isoforms has high similarity to VML, while another that has noteworthy differences. We have denoted the new isoform...

journal_title：Protein and peptide letters

authors： Alves Filho JG,do Nascimento AS,Gondim AC,Pereira RH,da Cunha RM,Nagano CS,Teixeira EH,Nascimento KS,Cavada BS

更新日期：2013-11-01 00:00:00

abstract：:Adenoregulin is a 33 amino acid antibiotic peptide who belongs to dermaseptin family which is the first vertebrate family to show lethal effects against filamentous fungi, as well as a broad spectrum of pathogenic microorganisms. Synthetic adenoregulin gene was cloned in 2, 4 and 6 tandem repeats and subcloned in pET3...

journal_title：Protein and peptide letters

authors： Zhou Y,Cao W,Wang J,Ma Y,Wei D

更新日期：2005-05-01 00:00:00

abstract：:We report the stepwise transformation of a linear peptide epitope recognized by the anti-transforming growth factor alpha monoclonal antibody Tab2 into peptomers and finally into peptoid analogs. The key experiment in this study is the substitution analysis in which each position of the peptide is exchanged by a set o...

journal_title：Protein and peptide letters

authors： Hoffmann B,Ast T,Polakowski T,Reineke U,Volkmer R

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Bursa of Fabricius plays the vital functions on B cell development and antibody production in poultry. The bursal-derived peptide plays the essential roles on avian immature B cell development. OBJECTIVES:Here we explored the functions of the recently reported bursal nonapeptide (BP9) on the antibody produc...

journal_title：Protein and peptide letters

authors： Zheng Y,Zong MM,Chen BY,Zhou XH,Liu ZN,Zhou GF,Chen PY,Feng XL

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Laminin, a member of the Extracellular Matrix (ECM), is a glycoprotein that is used as a factor that affects cell adhesion, proliferation, survival, and differentiation. Of these, five globular domains (LG domains) of the alpha chain play an important role in influencing the cell by binding to the integrin. ...

journal_title：Protein and peptide letters

authors： Kim JE,Seo HJ,Lee S,Jang JH

更新日期：2019-01-01 00:00:00

abstract：:With a huge amount of protein sequence data, the computational method for protein-protein interaction (PPI) prediction using only the protein sequences information have drawn increasing interest. In this article, we propose a sequence-based method based on a novel representation of local protein sequence descriptors. ...

journal_title：Protein and peptide letters

authors： Yang L,Xia JF,Gui J

更新日期：2010-09-01 00:00:00

abstract：:The aim of this study was to design and develop stable nanoemulsion formulations containing IFN-γ to probe their use as an immunomodulating agent. The nanoemulsions comprising distilled water, triglycerides of capric acid/caprylic, sobitan-oleate (SP), polysorbate 80 (TW) and propylene glycol (PG) were prepared throug...

journal_title：Protein and peptide letters

authors： Ribeiro EB,Honorio-França AC,França EL,Soler MA

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Breast cancer demands safe adjuvant to overcome the side effects of standard drug tamoxifen. Diet derived bioactive compounds are reported to exhibit modulation of cancer growth leading to cell death. Chickpea is a protein rich edible legume with several bioactive compounds that includes lectin as well. Char...

journal_title：Protein and peptide letters

authors： Gupta N,Bisen PS,Bhagyawant SS

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Multiple Sequence Alignment (MSA) is a fundamental task in bioinformatics and is required for many biological analysis tasks. The more accurate the alignments are, the more credible the downstream analyses. Most protein MSA algorithms realign an alignment to refine it by dividing it into two groups horizonta...

journal_title：Protein and peptide letters

authors： Zhan Q,Fu Y,Jiang Q,Liu B,Peng J,Wang Y

更新日期：2020-01-01 00:00:00

abstract：:A halophilic nucleoside diphosphate kinase from a moderate halophile, Halomonas sp. 593 (593NDK), was found to be resistant to heat treatment, as indicated by the high level of activity recovery after heating at high temperatures. This is due to reversibility of thermal unfolding, not the high melting temperature, of ...

journal_title：Protein and peptide letters

authors： Tokunaga H,Oda Y,Yonezawa Y,Arakawa T,Tokunaga M

更新日期：2006-01-01 00:00:00

abstract：:The search for potential inhibitors that target so far unexplored bacterial enzyme mono-N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) has stimulated a development of methodology for quick and efficient preparation of mono-N-acylated 2,6-diaminopimelic acid (DAP) derivatives bearing the different carboxyl gro...

journal_title：Protein and peptide letters

authors： Vanek V,Pícha J,Budesínský M,Sanda M,Jirácek J,Holz RC,Hlavácek J

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Nε-acetyl L-α lysine is an unusual acetylated di-amino acid synthesized and accumulated by certain halophiles under osmotic stress. Osmolytes are generally known to protect proteins and other cellular components under various stress conditions. OBJECTIVE:The structural and functional stability imparted by N...

journal_title：Protein and peptide letters

authors： Joghee NN,Jayaraman G,Selladurai M

更新日期：2020-01-01 00:00:00

abstract：:Prediction of protein structure from its amino acid sequence is still a challenging problem. The complete physicochemical understanding of protein folding is essential for the accurate structure prediction. Knowledge of residue solvent accessibility gives useful insights into protein structure prediction and function ...

journal_title：Protein and peptide letters

authors： Pugalenthi G,Kandaswamy KK,Chou KC,Vivekanandan S,Kolatkar P

更新日期：2012-01-01 00:00:00

abstract：:The catalytic regions of Protein Kinases are known to have similarity in primary chains. However, it is not known whether there is a signature profile specific to a particular catalytic region? Whether the signature profile, if any, is unique to a protein kinases family in a particular species or in a group of species...

journal_title：Protein and peptide letters

authors： Joshi RR,Manda C

更新日期：2007-01-01 00:00:00

abstract：:S-adenosyl-l-homocysteine hydrolase from a malaria parasite Plasmodium falciparum (PfSAHH) has been crystallized by the vapor diffusion method. The crystals belong to an orthorhombic space group P212121 with the cell dimensions of a = 76.66 A, b = 86.31 A, and c = 335.6 A. There are four subunits (one tetramer) per as...

journal_title：Protein and peptide letters

authors： Tanaka N,Kusakabe Y,Shiraiwa K,Sakamoto Y,Nakanishi M,Kitade Y,Nakamura KT

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:The biocatalytic oxidation of UDP-glucose in the presence of NAD+ is catalyzed by UDP-glucose dehydrogenases. OBJECTIVES:The main objective of this study was the characterization of a UDP-glucose dehydrogenase (AmUGD) from Akkermansia muciniphila, a bacterium originally isolated from human faeces in an anae...

journal_title：Protein and peptide letters

authors： Wei S,Zhang XY,Sun Y,Conway LP,Liu L

更新日期：2017-01-01 00:00:00

abstract：:Zwitterionic dipeptides have recently been shown to exist in water mainly as nine conformational forms with specific combinations of backbone Psi, omega and Phi torsions, which allows conformer-specific molecular recognition of peptide ligands by proteins. Here, we show that pairs of virtual backbone torsions can also...

journal_title：Protein and peptide letters

authors： Gupta S,Grail BM,Payne JW

更新日期：2002-04-01 00:00:00

abstract：:The studies presented here explore antimicrobial peptide preferential binding behavior for a target pathogen, Escherichia coli O157:H7. A modified immunoassay and surface plasmon resonance were employed to evaluate immobilized peptide binding of whole bacterial cells. The knowledge gained may guide the rational design...

journal_title：Protein and peptide letters

authors： Soares JW,Kirby R,Morin KM,Mello CM

更新日期：2008-01-01 00:00:00

abstract：:Human beta-defensin-2 (hBD2) is A small cationic peptide with A broad range of antimicrobial activity. An E. coli cell-free system was employed to express the hBD2 fusion protein by using the hBD2 gene with 14 rare codons. The results showed that the expression level of trxA-hBD2 fusion protein was 0.35 mg/ml, which i...

journal_title：Protein and peptide letters

authors： Chen H,Xu Z,Cen P

更新日期：2006-01-01 00:00:00