High-level expression of human beta-defensin-2 gene with rare codons in E. coli cell-free system.

abstract：:Hepatitis C virus and related viruses in the Flaviviridae family (such as dengue virus, yellow fever virus or West Nile virus) are amongst the most important human pathogens, causing substantial morbidity and mortality world-wide. The production of viral progeny in Flaviviridae is orchestrated by the small, multifunct...

journal_title：Protein and peptide letters

authors： Ivanyi-Nagy R,Darlix JL

更新日期：2010-08-01 00:00:00

abstract：:The present study dealt with the isolation, identification and characterization of pigments from red snow samples of the Quito coastal front glacier (S 62º 27,217', W 059º 45,960') in Greenwich, Archipelago South Shetland, Antarctica, during summer 2013. As a strain of Shewanella was found to be the most common and ab...

journal_title：Protein and peptide letters

authors： Martín-Cerezo ML,García-López E,Cid C

更新日期：2015-01-01 00:00:00

abstract：:The reaction between Arg-Gly-Asp (RGD) and Lys-Gly-Asp (KGD) derivatives with 3,4',5-trihydroxy-trans-stilbene (resveratrol) was investigated. Knowing that resveratrol, RGD as well as KGD analogues inhibit human platelet aggregation in vitro, it was tempting for us to examine whether their coupling products present en...

journal_title：Protein and peptide letters

authors： Koutsas C,Sarigiannis Y,Stavropoulos G,Liakopoulou-Kyriakides M

更新日期：2007-01-01 00:00:00

abstract：:Cinnamomin is a type II ribosome-inactivating protein (RIP) and its A-chain (CTA) is a RNA N-glycosidase. It is observed that modification of tyrosine residues by N-acetylimidazole (N-AI) causes almost complete loss of CTA activity. Adenine partially protects tyrosine residues from modification by N-AI. It is proposed...

journal_title：Protein and peptide letters

authors： Xu H,Liu WY

更新日期：2003-10-01 00:00:00

abstract：:Kallikrein-related peptidases (KLKs) are trypsin-like and chymotrypsin-like serine proteases which are expressed in several tissues. Their activity is tightly controlled by inhibitors including members of the serine protease Kazal-type (SPINK) family. These enzymes are promising targets for the treatment of skin desqu...

journal_title：Protein and peptide letters

authors： Assis DM,Zalazar L,Juliano MA,De Castro R,Cesari A

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Protealysin, a zinc metalloprotease of Serratia proteamaculans, is the prototype of a new group within the peptidase family M4. Protealysin-like proteases (PLPs) are widely spread in bacteria but are also found in fungi and archaea. The biological functions of PLPs have not been well studied, but published d...

journal_title：Protein and peptide letters

authors： Chukhontseva KN,Salnikov VV,Morenkov OS,Kostrov SV,Demidyuk IV

更新日期：2019-01-01 00:00:00

abstract：:The identification of interfaces in protein complexes is effective for the elucidation of protein function and helps us to understand their roles in biological processes. With the exponentially growing amount of protein sequence data, an exploration of new methods that predict protein interaction sites based solely on...

journal_title：Protein and peptide letters

authors： Huang J,Deng R,Wang J,Wu H,Xiong Y,Wang X

更新日期：2013-02-01 00:00:00

abstract：:Allergy prevalence has increased worldwide over the last 25 years along with industrialization and westernized lifestyles. Indoor allergens are primarily responsible for the sensitization and development of atopic diseases. The main indoor allergens are known to be derived from various arthropods which account for up ...

journal_title：Protein and peptide letters

authors： Jeong KY,Hong CS,Yong TS

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Multiple Sequence Alignment (MSA) is a fundamental task in bioinformatics and is required for many biological analysis tasks. The more accurate the alignments are, the more credible the downstream analyses. Most protein MSA algorithms realign an alignment to refine it by dividing it into two groups horizonta...

journal_title：Protein and peptide letters

authors： Zhan Q,Fu Y,Jiang Q,Liu B,Peng J,Wang Y

更新日期：2020-01-01 00:00:00

abstract：:Hop is a tetratricopeptide repeat domain (TPR)-containing co-chaperone that is able to directly associate with both Hsp70 and Hsp90. Previous data showed that the TPR2A-domain is the primary site for dimerization and that the TPR2B-domain may also play a role in dimerization. We present Hop-D456G, a mutant within the ...

journal_title：Protein and peptide letters

authors： Gonçalves DC,Gava LM,Ramos CH

更新日期：2010-04-01 00:00:00

abstract：:In the development of cell-hybrid biomaterials, the functional activity of cells depends on the selective binding of cells to artificial ligands on the biomaterials. The extracellular matrix (ECM) is the most important ligand for cell activity. ECM is known to contain collagen, one of whose constituents is gelatin. Al...

journal_title：Protein and peptide letters

authors： Miyamoto K,Chinzei H,Komai T

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:Uterine Leiomyoma is mainly widespread non-malignant tumor. Around more than 80% woman have these particular tumor among them only 30% of them are detected. Integrin-ᵦ1 is one of the up regulated biomarkers during tumorigenesis which is also associated with structural disordered. Intrinsically disordered pro...

journal_title：Protein and peptide letters

authors： Maulik U,Uversky VN,Sen S

更新日期：2018-01-01 00:00:00

abstract：:In mammals the M1 aminopeptidase family consists of nine different proteins, five of which are integral membrane proteins. The aminopeptidases are defined by two motifs in the catalytic domain; a zinc binding motif HEXXH-(X18)-E and an exopeptidase motif GXMEN. Aminopeptidases of this family are able to cleave a broad...

journal_title：Protein and peptide letters

authors： Albiston AL,Ye S,Chai SY

更新日期：2004-10-01 00:00:00

abstract：:Current advancements in biological protein discovery utilize bi-partite methods of fluorescence detection where chromophore and scaffold are uncoupled. One such technology, called fluorogen-activating proteins (FAPs), consists of single-chain-variable-fragments (scFvs) selected against small organic molecules (fluorog...

journal_title：Protein and peptide letters

authors： Gallo E,Wienbar S,Snyder AC,Vasilev KV,Armitage BA,Jarvik JW

更新日期：2014-01-01 00:00:00

abstract：:Protein palmitoylation is an important and common post-translational lipid modification of proteins and plays a critical role in various cellular processes. Identification of Palmitoylation sites is fundamental to decipher the mechanisms of these biological processes. However, experimental determination of palmitoylat...

journal_title：Protein and peptide letters

authors： Li YX,Shao YH,Deng NY

更新日期：2011-02-01 00:00:00

abstract：:Behcet's disease (BD) is a recurrent pathema with a typical symptom of inflammation involved in many organs. Previous report indicated that the serum of Korean patients with BD stimulates membrane expression of hnRNP A2/B1 in endothelial cells. In this study, the target 35 kDa recombinant human hnRNP A2/B1 were over-e...

journal_title：Protein and peptide letters

authors： Liang J,Yang W,Meng X,Chen P,Du H

更新日期：2015-01-01 00:00:00

abstract：:Numerous small molecules including cytokines primarily associated with immune response have been shown to play a role in normal mesenchymal stem cells (MSC) and tumour cells' communication. One characteristic that distinguishes MSC from fibroblast and other cells of mesenchymal origin is their pro-tumour migratory beh...

journal_title：Protein and peptide letters

authors： Motaln H,Turnsek TL

更新日期：2015-01-01 00:00:00

abstract：:Red blood cell (RBC) encapsulated L-asparaginase is a novel therapeutic for the treatment of asparagine auxotrophic malignancies. The enzyme-loaded red blood cells function as bioreactors to deplete bloodstream substrate. This delivery system provides improved pharmacodynamics with protection from circulating proteoly...

journal_title：Protein and peptide letters

authors： Agrawal V,Woo JH,Borthakur G,Kantarjian H,Frankel AE

更新日期：2013-04-01 00:00:00

abstract：:Migraine is a common neurologic condition marked by recurrent episodes of headache. Its pathophysiology is highly complex involving neuronal, inflammatory and vascular mechanisms. The Renin-Angiotensin System (RAS) can modulate all these mechanism, being a potential pharmacological target for migraine treatment. We ca...

journal_title：Protein and peptide letters

authors： Sassi KLM,Martins LB,de Miranda AS,Teixeira AL

更新日期：2020-01-01 00:00:00

abstract：:The superoxide anion radical is a highly reactive toxic species produced during the metabolic processes. A number of copper (II) complexes with amino acids and peptides are known to show superoxide dismutase (SOD) like activity. The design and application of synthetic low molecular weight metal complexes as SOD mimics...

journal_title：Protein and peptide letters

authors： Singh RK,Srivastava VC,Singh UP

更新日期：2011-12-01 00:00:00

abstract：:We used a de novo designed, beta-hairpin forming T1 peptide as a model to investigate the kinetics of peptide fibrogenesis by a combination of light scattering (LS), circular dichroism (CD), fluorescence, and atomic force microscopy (AFM). The results demonstrate that the T1 fibrogenesis undergoes a consecutive stepwi...

journal_title：Protein and peptide letters

authors： Wang C,Sha Y

更新日期：2010-04-01 00:00:00

abstract：UNLABELLED:In this investigation a novel approach based on mucoadhesive superporous hydrogel hybrids (SPHHs) for topi- cal vaginal drug delivery for Metronidazole was tried. METHOD:SPHHs were synthesized by solution polymerization tech- nique. The synthesized SPHHs were characterized for tensile strength, swelling beh...

journal_title：Protein and peptide letters

authors： Chavda H,Chavada G,Patel J,Rangpadiya K,Patel C

更新日期：2014-01-01 00:00:00

abstract：:Human endophilin 1 (hEndo1) is a multifunctional protein that was found to bind a wide spectrum of prolinerich endocytic proteins through its Src homology 3 (SH3) domain. In order to elucidate the unknown biological functions of hEndo1, it is essential to find out the cytoplasmic components that hEndo1 recognizes and ...

journal_title：Protein and peptide letters

authors： Wu G,Zhang ZL,Fu CJ,Lv FL,Tian FF

更新日期：2012-10-01 00:00:00

abstract：:The description of protein backbone was recently improved with a group of structural fragments called Structural Alphabets instead of the regular three states (Helix, Sheet and Coil) secondary structure description. Protein Blocks is one of the Structural Alphabets used to describe each and every region of protein bac...

journal_title：Protein and peptide letters

authors： Suresh V,Ganesan K,Parthasarathy S

更新日期：2013-03-01 00:00:00

abstract：:Quantum mechanical fragment molecular orbital calculations have been performed for receptor binding of the hemagglutinin protein of the recently pandemic influenza 2009 H1N1, A/swine/Iowa/1930, and A/Puerto Rico/8/1934 viruses to α2-6 linked sialyloligosaccharides, as analogs of human receptors. The strongest receptor...

journal_title：Protein and peptide letters

authors： Fukuzawa K,Omagari K,Nakajima K,Nobusawa E,Tanaka S

更新日期：2011-05-01 00:00:00

abstract：:From the extensive analysis, we identified three highly conserved sequence segments in HCV NS5A proteins and one binding motif in human proteins. The binding motif of human proteins often forms a full helix or an extended strand-loop structure, and is in good agreement with the experimental findings of previous studie...

journal_title：Protein and peptide letters

authors： Zhang GZ,Han K

更新日期：2008-01-01 00:00:00

abstract：:A method for seed proteome analysis using MALDI-TOF mass spectrometry is described. The data were used to estimate the genetic diversity degree among twelve genotypes of pepper (Capsicum). The resulting spectra were converted into a binary matrix consisting of 23 protein data sets, and genetic similarity values were c...

journal_title：Protein and peptide letters

authors： de Pinho Pessoa Filho MA,Bloch Junior C,da Silva Filho DF,Galdino AS,da Cunha RM,Alves MA,Grangeiro TB

更新日期：2004-02-01 00:00:00

abstract：:Nucleobindin-2 is a 420 amino acid EF-hand Ca²⁺ binding protein that can be further processed to generate an 82 amino terminal peptide termed Nesfatin-1. To examine the function of secreted Nucleobindin-2 in adipocyte differentiation, cultured 3T3-L1 cells were incubated with either 0 or 100 nM of GST, GST-Nucleobindi...

journal_title：Protein and peptide letters

authors： Tagaya Y,Osaki A,Miura A,Okada S,Ohshima K,Hashimoto K,Yamada M,Satoh T,Shimizu H,Mori M

更新日期：2012-09-01 00:00:00

abstract：:Two cell-penetrating peptides, a Pro-rich peptide derivative, acetyl-(Val-Arg-Leu-Pro-Pro-Pro)(3)-Gly-Cys amide, and an octaarginine derivative, acetyl-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Cys amide, were prepared by the solid phase method. Each peptide was coupled to the heterobifunctional cross-linking reagent, 6-mal...

journal_title：Protein and peptide letters

authors： Kida S,Eto Y,Yoshioka Y,Nakagawa S,Kawasaki K,Maeda M

更新日期：2010-02-01 00:00:00

abstract：:Porins are integral membrane proteins found in the outer membrane of bacteria, mitochondria and chloroplasts. Herein, we have reviewed sequence and structural understanding about bacterial porins. The first porin structure from Rhodobacter capsulatus at 1.8 Å resolution in 1991 till the recent structural advancement, ...

journal_title：Protein and peptide letters

authors： Kumar A,Bhandari A,Krishnaswamy S

更新日期：2015-01-01 00:00:00