Abstract:
:Covering: 2008 to 2016The total synthesis of natural products and their derivatives continues to inspire organic chemists to identify and test new synthetic strategies and develop and explore novel methodology. In recent years, visible light photoredox catalysis has risen to prominence as a powerful technology that enables the selective formation of chemical bonds under mild reaction conditions. Herein we review applications of photoredox catalysis to the synthesis of natural products and related complex molecules, showcasing a range of powerful transformations that include: reductive couplings, photocycloadditions, intermolecular C-H functionalisation processes, fragmentations, and cyclisations.
journal_name
Nat Prod Repjournal_title
Natural product reportsauthors
Nicholls TP,Leonori D,Bissember ACdoi
10.1039/c6np00070csubject
Has Abstractpub_date
2016-10-26 00:00:00pages
1248-1254issue
11eissn
0265-0568issn
1460-4752journal_volume
33pub_type
杂志文章,评审abstract::Oligo-, polysaccharides, and glycoconjugates are a relevant part of the bioactive components of the natural products exploited in therapeutics, diagnostics, food additives, and biomaterials. Glycans are directly involved in important biological processes, such as immunostimulation, anti-inflammatory, antioxidant, and ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c2np20032e
更新日期:2012-06-01 00:00:00
abstract::A detailed overview is presented of recent total synthesis approaches to four different diterpenoids--the ginkgolides, tonantzitlolone, ingenol and eleutherobin. Due to their structural complexity, all pose major challenges for total synthesis, guaranteeing diverse strategic tours de force and a rich synthetic chemist...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b705652b
更新日期:2008-04-01 00:00:00
abstract::Antibiotics are a therapeutic class that, once deployed, select for resistant bacterial pathogens and so shorten their useful life cycles. As a consequence new versions of antibiotics are constantly needed. Among the antibiotic natural products, morphed peptide scaffolds, converting conformationally mobile, short-live...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c7np00011a
更新日期:2017-07-01 00:00:00
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journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b212061p
更新日期:2003-06-01 00:00:00
abstract::2,5-Disubstituted tetrahydrofurans constitute the core skeleton of several natural products and are pivotal synthetic analogues of medicinal importance that exhibit remarkable bioactivities. Oxasqualenoid natural products are implicated as potent biologically active molecules, particularly with regard to demonstrating...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c4np00029c
更新日期:2014-09-01 00:00:00
abstract::Novel organic reactions drive the advance of chemical synthesis in the same way that enabling technologies drive new scientific discoveries. One area of organic methodology that has undergone significant growth during the last decade is that of homogeneous gold-catalyzed transformations. This trend has been further en...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c3np70075e
更新日期:2014-04-01 00:00:00
abstract::Covering: up to 2018 The Haemodoraceae family is a monocotyledonous family in the order Commelinales consisting of 14 genera. Many species from the family are endemic to Australia and their use by the Aboriginal People of Australia as both pigments or remedies has been ethnobotanically documented. Phenylphenalenones a...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c8np00067k
更新日期:2019-05-22 00:00:00
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journal_title:Natural product reports
pub_type: 杂志文章
doi:10.1039/c9np00053d
更新日期:2020-05-01 00:00:00
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journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c8np00045j
更新日期:2018-12-12 00:00:00
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journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c8np00044a
更新日期:2018-11-14 00:00:00
abstract::This review summarizes the state of knowledge on D-glucosamine-6P synthesis catalyzed by glucosamine-6P synthase. The mechanisms of L-glutamine hydrolysis, ammonia transfer and fructose-6P conversion into D-glucosamine-6P are analyzed with the E. coli enzyme in light of recent X-ray structures. With 92 references this...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b103713g
更新日期:2002-02-01 00:00:00
abstract::Heterologous expression of biosynthetic pathways is an indispensable tool in the discovery, production, engineering, and characterization of bacterial polyketides and the complex enzymology involved in their biosynthesis. Ensuring transcription of polyketide biosynthetic gene clusters in heterologous hosts is a pressi...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c3np70060g
更新日期:2013-10-11 00:00:00
abstract::The aim of the present review is to summarise the knowledge about newly isolated acetogenins (ACGs) in the last six years. It will also report the total syntheses that have allowed either the confirmation or the revision of some structures, together with the biological activities and mechanism of action of such intere...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b500186m
更新日期:2005-04-01 00:00:00
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journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b404943h
更新日期:2005-12-01 00:00:00
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journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c7np00047b
更新日期:2018-03-01 00:00:00
abstract::Covering: up to January 2017Cytochrome P450 enzymes (P450s) are some of the most exquisite and versatile biocatalysts found in nature. In addition to their well-known roles in steroid biosynthesis and drug metabolism in humans, P450s are key players in natural product biosynthetic pathways. Natural products, the most ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c7np00034k
更新日期:2017-08-30 00:00:00
abstract::Covering: up to early 2018 Polyketides and nonribosomal peptides are two major families of natural product with a broad range of biological activities. Polyketide synthases (PKSs) assemble small acetic acid-type acyl building blocks into polyketides through C-C bonds, and nonribosomal peptide synthetases (NRPSs) assem...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c8np00022k
更新日期:2018-11-14 00:00:00
abstract::Covering: 1947-early 2017, particularly from 2005-early 2017The rise of bacterial pathogens with acquired resistance to almost all available antibiotics is becoming a serious public health issue. Polymyxins, antibiotics that were mostly abandoned a few decades ago because of toxicity concerns, are ultimately considere...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c7np00023e
更新日期:2017-07-06 00:00:00
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journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c9np00018f
更新日期:2019-07-01 00:00:00
abstract::A diverse array of secondary metabolites have been isolated and characterized from marine-derived fungi. The structures and biological activities of these metabolites are presented. Additionally, some basic principles of mycology are covered. Overall, 273 structures are presented and the review contains 162 references...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b301926h
更新日期:2004-02-01 00:00:00
abstract::Naturally-occurring nitro compounds display great structural diversity, and a wide range of biological activities. This review summarizes current information on the structures of naturally-occurring nitro compounds and on the biosynthesis of the nitro group. ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c0np00024h
更新日期:2011-01-01 00:00:00
abstract::This review covers the morphology, isolation, total synthesis and biological activity of the naturally occurring alkaloids isolated from the Amaryllidaceae family, as well as the structurally related Sceletium alkaloids. ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b316106b
更新日期:2005-02-01 00:00:00
abstract::Dinoflagellates produce unique polyketides characterized by their size and complexity. The biosynthesis of a limited number of such metabolites has been reported, with studies largely hampered by the low yield of compounds and the severe scrambling of label in the isotopically-labeled precursors. Nonetheless, of the s...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c4np00016a
更新日期:2014-09-01 00:00:00
abstract::Covering: up to 2018 2-Oxoglutarate-dependent oxygenases (2ODOs) comprise a large enzyme superfamily in plant genomes, second in size only to the cytochromes P450 monooxygenase (CYP) superfamily. 2ODOs participate in both primary and specialized plant pathways, and their occurrence across all life kingdoms points to a...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c7np00060j
更新日期:2018-08-15 00:00:00
abstract::This Highlight describes factors that contribute to an ideal synthesis, including economies (step, time, atom, solvent, energy) and orientations (target, diversity, safety, function), and the role of synthesis-informed design directed at function in advancing synthesis and its impact on science. ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c4np00013g
更新日期:2014-04-01 00:00:00
abstract::This Highlight describes synthetic methods that have enabled new strategic approaches to the synthesis of natural product targets as well as libraries of compounds for unbiased screening experiments. The structural differences of the compounds produced by both efforts are illustrated. ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b814468k
更新日期:2009-01-01 00:00:00
abstract::Natural products and their derivatives are mainstays of our antibiotic drugs, but they are increasingly in peril. The combination of widespread multidrug resistance in once susceptible bacterial pathogens, disenchantment with natural products as sources of new drugs, lack of success using synthetic compounds and targe...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c7np00019g
更新日期:2017-07-01 00:00:00
abstract::This review covers the isolation, structural determination, synthesis and chemical and microbiological transformations of natural sesquiterpenoids. The literature from January to December 2003 is reviewed, and 389 references are cited. ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b407376m
更新日期:2004-10-01 00:00:00
abstract::The diastereoselective addition of organometallic reagents to α-chloroaldehydes was first reported in 1959 and occupies a historically significant role as the prototypical reaction for Cornforth's model of stereoinduction. Despite clear synthetic potential for these reagents, difficulties associated with producing ena...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c2np20108a
更新日期:2013-02-01 00:00:00
abstract::This Viewpoint article provides a personal viewpoint of research in the area of fungal polyketide biosynthesis. It spans the period from the first applications and subsequent development of modern stable-isotope labelling methods, the isolation, sequencing and expression of PKS genes, biochemical and structural charac...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c4np00065j
更新日期:2014-10-01 00:00:00