Recent advances in the total synthesis of pharmaceutically relevant diterpenes.

abstract：:Covering: 1997 to 2010. The angucycline group is the largest group of type II PKS-engineered natural products, rich in biological activities and chemical scaffolds. This stimulated synthetic creativity and biosynthetic inquisitiveness. The synthetic studies used five different strategies, involving Diels-Alder reactio...

journal_title：Natural product reports

authors： Kharel MK,Pahari P,Shepherd MD,Tibrewal N,Nybo SE,Shaaban KA,Rohr J

更新日期：2012-02-01 00:00:00

abstract：:Covering up to December 2013. Oligosaccharide natural products target a wide spectrum of biological processes including disruption of cell wall biosynthesis, interference of bacterial translation, and inhibition of human α-amylase. Correspondingly, oligosaccharides possess the potential for development as treatments o...

journal_title：Natural product reports

authors： McCranie EK,Bachmann BO

更新日期：2014-08-01 00:00:00

abstract：:Covering: up to September 2015. Meroterpenoids are hybrid natural products that partially originate from the terpenoid pathway. The meroterpenoids derived from fungi display quite diverse structures, with a wide range of biological properties. This review summarizes the molecular bases for their biosyntheses, which we...

journal_title：Natural product reports

authors： Matsuda Y,Abe I

更新日期：2016-01-01 00:00:00

abstract：:Covering: 1947-early 2017, particularly from 2005-early 2017The rise of bacterial pathogens with acquired resistance to almost all available antibiotics is becoming a serious public health issue. Polymyxins, antibiotics that were mostly abandoned a few decades ago because of toxicity concerns, are ultimately considere...

journal_title：Natural product reports

authors： Rabanal F,Cajal Y

更新日期：2017-07-06 00:00:00

abstract：:Covering: up to 2019This review covers the current status of the quantum mechanical prediction of chiroptical properties, such as electronic CD and optical rotation, as needed for stereochemical assignments in new natural products. The reliability of the prediction of chiroptical properties is steadily increasing, wit...

journal_title：Natural product reports

authors： Grauso L,Teta R,Esposito G,Menna M,Mangoni A

更新日期：2019-07-01 00:00:00

abstract：:This review focuses on recent developments in the use of natural products as therapeutics for Alzheimer's disease. The compounds span a diverse array of structural classes and are organized according to their mechanism of action, with the focus primarily on the major hypotheses. Overall, the review discusses more than...

journal_title：Natural product reports

authors： Williams P,Sorribas A,Howes MJ

更新日期：2011-01-01 00:00:00

abstract：:Novel organic reactions drive the advance of chemical synthesis in the same way that enabling technologies drive new scientific discoveries. One area of organic methodology that has undergone significant growth during the last decade is that of homogeneous gold-catalyzed transformations. This trend has been further en...

journal_title：Natural product reports

authors： Zhang Y,Luo T,Yang Z

更新日期：2014-04-01 00:00:00

abstract：:Fungi have emerged worldwide as increasingly frequent causes of healthcare-associated infections, but fungal infections have generally been considered curable, and thus the demand for new antifungal agents has been very low. Although superficial fungal infections of the skin and nails are common and are for the most p...

journal_title：Natural product reports

authors： Di Santo R

更新日期：2010-07-01 00:00:00

abstract：:Naturally-occurring nitro compounds display great structural diversity, and a wide range of biological activities. This review summarizes current information on the structures of naturally-occurring nitro compounds and on the biosynthesis of the nitro group. ...

journal_title：Natural product reports

authors： Parry R,Nishino S,Spain J

更新日期：2011-01-01 00:00:00

abstract：:Covering: July 2012 to December 2019Over the last seven years, expanding research efforts focused on sesterterpenoids has led to the isolation, identification, and characterization of numerous structurally novel and biologically active sesterterpenoids. These newly reported sesterterpenoids provide diverse structures ...

journal_title：Natural product reports

authors： Li K,Gustafson KR

更新日期：2020-12-22 00:00:00

abstract：:Natural products and their derivatives are mainstays of our antibiotic drugs, but they are increasingly in peril. The combination of widespread multidrug resistance in once susceptible bacterial pathogens, disenchantment with natural products as sources of new drugs, lack of success using synthetic compounds and targe...

journal_title：Natural product reports

authors： Wright GD

更新日期：2017-07-01 00:00:00

abstract：:From the basic export of unwanted metal ions in simple organisms to the complex orchestration of metal handling and usage in higher eukaryotes, cellular systems are based on a variety of molecular mechanisms that constrain the right metal to bind to the right protein partner at the right time when needed. A failure to...

journal_title：Natural product reports

authors： Banci L,Bertini I,McGreevy KS,Rosato A

更新日期：2010-05-01 00:00:00

abstract：:Covering: Early 2008 until the end of 2019Microorganisms which survive (extreme-tolerant) or even prefer (extremophilic) living at the limits of pH, temperature, salinity and pressure found on earth have proven to be a rich source of novel structures. In this update we summarise the wide variety of new molecules which...

journal_title：Natural product reports

authors： Wilson ZE,Brimble MA

更新日期：2020-07-16 00:00:00

abstract：:Contact chemosensation, or tasting, is a complex process governed by nonvolatile phytochemicals that tell host-seeking insects whether they should accept or reject a plant. During this process, insect gustatory receptors (GRs) contribute to deciphering a host plant's metabolic code. GRs recognise many different classe...

journal_title：Natural product reports

authors： Pentzold S,Burse A,Boland W

更新日期：2017-05-10 00:00:00

abstract：:Covering: up to February 2019Actinomycetes are Gram positive bacteria of the phylum Actinobacteria. These organisms are one of the most important sources of structurally diverse, clinically used antibiotics and other valuable bioactive products, as well as biotechnologically relevant enzymes. Most strains were discove...

journal_title：Natural product reports

authors： Musiol-Kroll EM,Tocchetti A,Sosio M,Stegmann E

更新日期：2019-09-01 00:00:00

abstract：:The mangrove flora is a diverse group of salt-tolerant plants growing in tropical and subtropical intertidal estuarine zones. This review summarizes the source, chemistry and bioactivities of natural products from true mangrove species worldwide. It includes 349 metabolites and 150 references. The molecular phylogeny ...

journal_title：Natural product reports

authors： Wu J,Xiao Q,Xu J,Li MY,Pan JY,Yang MH

更新日期：2008-10-01 00:00:00

abstract：:In this review the names, structures and occurrence of all new drimanes and rearranged drimanes which have been published between January 1990 and January 2003 have been collected. Subjects that have been treated are biosynthesis, analysis, biological activities, with special attention to cytotoxic activity and antife...

journal_title：Natural product reports

authors： Jansen BJ,de Groot A

更新日期：2004-08-01 00:00:00

abstract：:The fungal genus Trichoderma has various applications in industry and in medicine, and several species have economic importance as sources of enzymes, antibiotics, plant growth promoters, decomposers of xenobiotics, and as commercial biofungicides. Peptaibiotics and peptaibols are a class of linear peptides synthesize...

journal_title：Natural product reports

authors： Daniel JF,Filho ER

更新日期：2007-10-01 00:00:00

abstract：:This review deals with the isolation and structure elucidation of meroterpenoids (natural products of mixed biosynthetic origin which are partially derived from terpenoids) from higher and lower fungi, and discusses biosynthetic studies and biological activities as appropriate. It describes 333 fungal meroterpenoids a...

journal_title：Natural product reports

authors： Geris R,Simpson TJ

更新日期：2009-08-01 00:00:00

abstract：:This review covers the isolation, structural determination, synthesis and chemical and microbiological transformations of natural sesquiterpenoids. The literature from January to December 2003 is reviewed, and 389 references are cited. ...

journal_title：Natural product reports

authors： Fraga BM

更新日期：2004-10-01 00:00:00

abstract：:A key property of metallo-proteins and -enzymes is the affinity of metal ion M for protein ligand P as defined by the dissociation constant KD = [M][P]/[MP]. Its accurate determination is essential for a quantitative understanding of metal selection and speciation. However, the surfaces of proteins are defined by the ...

journal_title：Natural product reports

authors： Xiao Z,Wedd AG

更新日期：2010-05-01 00:00:00

abstract：:Covering: 2011-2017Radical cyclizations have a rich history in organic chemistry and have been particularly generous to the field of natural product synthesis. Owing to their ability to operate in highly congested molecular quarters, and with significant functional group compatibility, these transformations have enabl...

journal_title：Natural product reports

authors： Hung K,Hu X,Maimone TJ

更新日期：2018-02-21 00:00:00

abstract：:The aim of the present review is to summarise the knowledge about newly isolated acetogenins (ACGs) in the last six years. It will also report the total syntheses that have allowed either the confirmation or the revision of some structures, together with the biological activities and mechanism of action of such intere...

journal_title：Natural product reports

authors： Bermejo A,Figadere B,Zafra-Polo MC,Barrachina I,Estornell E,Cortes D

更新日期：2005-04-01 00:00:00

abstract：:Dinoflagellates produce unique polyketides characterized by their size and complexity. The biosynthesis of a limited number of such metabolites has been reported, with studies largely hampered by the low yield of compounds and the severe scrambling of label in the isotopically-labeled precursors. Nonetheless, of the s...

journal_title：Natural product reports

authors： Van Wagoner RM,Satake M,Wright JL

更新日期：2014-09-01 00:00:00

abstract：:Vitamin B12, or cobalamin, is one of the most structurally complex small molecules made in Nature. Major progress has been made over the past decade in understanding how this synthesis is accomplished. This review covers some of the most important findings that have been made and provides the reader with a complete de...

journal_title：Natural product reports

authors： Warren MJ,Raux E,Schubert HL,Escalante-Semerena JC

更新日期：2002-08-01 00:00:00

abstract：:Covering: 1972 to 2011. This review covers the literature of prenylated quinone, hydroquinone and naphthoquinone marine natural products with reported cytotoxic and/or antioxidant properties. The structures, biological activity and, where applicable, the syntheses of 159 cytotoxic/antioxidant compounds, isolated from ...

journal_title：Natural product reports

authors： Sunassee SN,Davies-Coleman MT

更新日期：2012-05-01 00:00:00

abstract：:Covering: up to 2013. Although holo-acyl carrier protein synthase, AcpS, a phosphopantetheinyl transferase (PPTase), was characterized in the 1960s, it was not until the publication of the landmark paper by Lambalot et al. in 1996 that PPTases garnered wide-spread attention being classified as a distinct enzyme superf...

journal_title：Natural product reports

authors： Beld J,Sonnenschein EC,Vickery CR,Noel JP,Burkart MD

更新日期：2014-01-01 00:00:00

abstract：:Covering: up to 2018 Ovothiols are sulfur-containing natural products biosynthesized by marine invertebrates, microalgae, and bacteria. These compounds are characterized by unique chemical properties suggestive of numerous cellular functions. For example, ovothiols may be cytoprotectants against oxidative stress, serv...

journal_title：Natural product reports

authors： Castellano I,Seebeck FP

更新日期：2018-12-12 00:00:00

abstract：:This review article focuses on how nature sometimes solves the same problem in the biosynthesis of small molecules but using very different approaches. Four examples, involving isopentenyl diphosphate, menaquinone, lysine, and aromatic polyketides, are highlighted that represent different strategies in convergent meta...

journal_title：Natural product reports

authors： Dairi T,Kuzuyama T,Nishiyama M,Fujii I

更新日期：2011-06-01 00:00:00

abstract：:Silybin, a secondary metabolite isolated from the seeds of the blessed milk thistle (Silybum marianum) was discovered as the first member of a new family of natural compounds called flavonolignans in 1959. Over the years it has received the research attention of many organic chemists. This research has resulted in a n...

journal_title：Natural product reports

authors： Biedermann D,Vavříková E,Cvak L,Křen V

更新日期：2014-09-01 00:00:00