Recent advances and perspectives in the design and development of polymyxins.

abstract：:In this study, the biological properties of natural abietane-type diterpenoids with an aromatic C ring are reviewed. An overview of the synthetic studies of this group of abietanes, including dehydroabietic acid, callitrisic acid and ferruginol, is presented. The review contains about 160 references. ...

journal_title：Natural product reports

authors： González MA

更新日期：2015-05-01 00:00:00

abstract：:Covering: 2014-2019We review recent progress on natural products that target cytoskeletal components, including microtubules, actin, intermediate filaments, and septins and highlight their demonstrated and potential utility in the treatment of human disease. The anticancer efficacy of microtubule targeted agents ident...

journal_title：Natural product reports

authors： Risinger AL,Du L

更新日期：2020-05-01 00:00:00

abstract：:This review covers the morphology, isolation, total synthesis and biological activity of the naturally occurring alkaloids isolated from the Amaryllidaceae family, as well as the structurally related Sceletium alkaloids. ...

journal_title：Natural product reports

authors： Jin Z

更新日期：2005-02-01 00:00:00

abstract：:Covering: up to September 2015. Meroterpenoids are hybrid natural products that partially originate from the terpenoid pathway. The meroterpenoids derived from fungi display quite diverse structures, with a wide range of biological properties. This review summarizes the molecular bases for their biosyntheses, which we...

journal_title：Natural product reports

authors： Matsuda Y,Abe I

更新日期：2016-01-01 00:00:00

abstract：:Covering: up to early 2018 Polyketides and nonribosomal peptides are two major families of natural product with a broad range of biological activities. Polyketide synthases (PKSs) assemble small acetic acid-type acyl building blocks into polyketides through C-C bonds, and nonribosomal peptide synthetases (NRPSs) assem...

journal_title：Natural product reports

authors： Miyanaga A,Kudo F,Eguchi T

更新日期：2018-11-14 00:00:00

abstract：:Covering: 1997 to 2010. The angucycline group is the largest group of type II PKS-engineered natural products, rich in biological activities and chemical scaffolds. This stimulated synthetic creativity and biosynthetic inquisitiveness. The synthetic studies used five different strategies, involving Diels-Alder reactio...

journal_title：Natural product reports

authors： Kharel MK,Pahari P,Shepherd MD,Tibrewal N,Nybo SE,Shaaban KA,Rohr J

更新日期：2012-02-01 00:00:00

abstract：:This review covers the literature on simple indole alkaloids and those with a nonrearranged monoterpenoid unit from the beginning of 2012 up to the end of 2013, which includes newly isolated alkaloids, structure determinations, total syntheses and biological activities. ...

journal_title：Natural product reports

authors： Ishikura M,Abe T,Choshi T,Hibino S

更新日期：2015-09-23 00:00:00

abstract：:The fungal genus Trichoderma has various applications in industry and in medicine, and several species have economic importance as sources of enzymes, antibiotics, plant growth promoters, decomposers of xenobiotics, and as commercial biofungicides. Peptaibiotics and peptaibols are a class of linear peptides synthesize...

journal_title：Natural product reports

authors： Daniel JF,Filho ER

更新日期：2007-10-01 00:00:00

abstract：:This review covers the recent marine chemical ecology literature for benthic cyanobacteria, macroalgae, sponges, octocorals, molluscs, other benthic invertebrates, fish and seabirds. ...

journal_title：Natural product reports

authors： Paul VJ,Ritson-Williams R

更新日期：2008-08-01 00:00:00

abstract：:Microorganisms and in particular actinomycetes and microfungi are known to produce a vast number of bioactive secondary metabolites. For industrially important fungal genera such as Penicillium and Aspergillus the production of these compounds has been demonstrated to be very consistent at the species level. This mean...

journal_title：Natural product reports

authors： Larsen TO,Smedsgaard J,Nielsen KF,Hansen ME,Frisvad JC

更新日期：2005-12-01 00:00:00

abstract：:The diastereoselective addition of organometallic reagents to α-chloroaldehydes was first reported in 1959 and occupies a historically significant role as the prototypical reaction for Cornforth's model of stereoinduction. Despite clear synthetic potential for these reagents, difficulties associated with producing ena...

journal_title：Natural product reports

authors： Britton R,Kang B

更新日期：2013-02-01 00:00:00

abstract：:Nature has yielded numerous classes of chemically distinct microtubule stabilizers. Several of these, including paclitaxel (Taxol) and docetaxel (Taxotere), are important drugs used in the treatment of cancer. New microtubule stabilizers and novel formulations of these agents continue to provide advances in cancer the...

journal_title：Natural product reports

authors： Rohena CC,Mooberry SL

更新日期：2014-03-01 00:00:00

abstract：:Natural products have evolved, at least in part, to bind to biological macromolecules, particularly proteins. As a result, natural products are able to interact with many specific targets within the cell. Indeed for many years this has been central in the drug development process. Today, however, natural products are ...

journal_title：Natural product reports

authors： Dixon N,Wong LS,Geerlings TH,Micklefield J

更新日期：2007-12-01 00:00:00

abstract：:Blue flower colors are primarily due to anthocyanin, a flavonoid pigment. Anthocyanin itself is purple in neutral aqueous solutions, ans its color is very unstable and quickly fades. Therefore, the mechanism of blue color development in living flower petals is one of the most intriguing problems in natural product che...

journal_title：Natural product reports

authors： Yoshida K,Mori M,Kondo T

更新日期：2009-07-01 00:00:00

abstract：:This review will detail progress made in the previous decade on the chemistry and bioactivity of birch bark extractive products. Current and future applications of birch bark natural products in pharmaceuticals, cosmetics, and dietary supplements for the prevention and treatment of cancer, HIV,and other human pathogen...

journal_title：Natural product reports

authors： Krasutsky PA

更新日期：2006-12-01 00:00:00

abstract：:The article reviews the progress in the chemistry of the steroids that was published between January and December, 2001. The reactions and partial syntheses of estrogens, androgens, pregnanes, cholic acid derivatives, cholestanes and vitamin D analogues are covered. There are 184 references. ...

journal_title：Natural product reports

authors： Hanson JR

更新日期：2003-06-01 00:00:00

abstract：:Antibiotics are a therapeutic class that, once deployed, select for resistant bacterial pathogens and so shorten their useful life cycles. As a consequence new versions of antibiotics are constantly needed. Among the antibiotic natural products, morphed peptide scaffolds, converting conformationally mobile, short-live...

journal_title：Natural product reports

authors： Walsh CT

更新日期：2017-07-01 00:00:00

abstract：:This Viewpoint article provides a personal viewpoint of research in the area of fungal polyketide biosynthesis. It spans the period from the first applications and subsequent development of modern stable-isotope labelling methods, the isolation, sequencing and expression of PKS genes, biochemical and structural charac...

journal_title：Natural product reports

authors： Simpson TJ

更新日期：2014-10-01 00:00:00

abstract：:Covering: up to January 2017Cytochrome P450 enzymes (P450s) are some of the most exquisite and versatile biocatalysts found in nature. In addition to their well-known roles in steroid biosynthesis and drug metabolism in humans, P450s are key players in natural product biosynthetic pathways. Natural products, the most ...

journal_title：Natural product reports

authors： Rudolf JD,Chang CY,Ma M,Shen B

更新日期：2017-08-30 00:00:00

abstract：:Aristolactams, having a phenanthrene chromophore are a small group of compounds mainly found in the Aristolochiaceae together with the aristolochic acids and 4,5-dioxoaporphines. In this report, these three important classes of natural products are reviewed and classified on the basis of their oxygenation pattern. In ...

journal_title：Natural product reports

authors： Kumar V,Poonam,Prasad AK,Parmar VS

更新日期：2003-12-01 00:00:00

abstract：:The biosynthesis of peptidoglycan is essential for all bacteria and has no counterpart in eukaryotic cells. It is one of the prime targets for antibiotic chemotherapy, especially phospho-MurNAc-pentapeptide translocase (translocase I) is a fascinating target in which there is no commercial antibiotic. In this review w...

journal_title：Natural product reports

authors： Kimura K,Bugg TD

更新日期：2003-04-01 00:00:00

abstract：:In the search for new drugs and natural remedies, medicinal plants or herbs used in folk and traditional medicines are promising candidates. For the naturally rare and slowly growing plant species, plant tissue culture in bioreactors provides a cost-effective, sustainable and well-controlled means for mass production ...

journal_title：Natural product reports

authors： Zhou LG,Wu JY

更新日期：2006-10-01 00:00:00

abstract：:From the basic export of unwanted metal ions in simple organisms to the complex orchestration of metal handling and usage in higher eukaryotes, cellular systems are based on a variety of molecular mechanisms that constrain the right metal to bind to the right protein partner at the right time when needed. A failure to...

journal_title：Natural product reports

authors： Banci L,Bertini I,McGreevy KS,Rosato A

更新日期：2010-05-01 00:00:00

abstract：:Covering: 2000 to 2008. Previous review: D. L. Wright and C. R. Whitehead, Org. Prep. Proced. Int., 2000, 32, 309-330. An overview of synthetic efforts toward cyathane diterpenoid natural products from the year 2000 to present is provided. The emphasis of this review is the various ring-constructing and stereoforming ...

journal_title：Natural product reports

authors： Enquist JA Jr,Stoltz BM

更新日期：2009-05-01 00:00:00

abstract：:In the recent past, macromolecular crystallography has gone through substantial methodological and technological development. The purpose of this review is to provide a general overview of structural biology and its impact on enzyme structure/function analysis and illustrate how it is modifying the focus of research r...

journal_title：Natural product reports

authors： Panjikar S,Stoeckigt J,O'Connor S,Warzecha H

更新日期：2012-10-01 00:00:00

abstract：:Covering: 2000 up to 2020 Few classes of natural products have inspired as many chemists and biologists as have the iboga alkaloids. This family of monoterpenoid indole alkaloids includes the anti-addictive compound ibogaine as well as catharanthine, a precursor to the chemotherapeutic vinblastine. Despite being known...

journal_title：Natural product reports

authors： Iyer RN,Favela D,Zhang G,Olson DE

更新日期：2020-08-14 00:00:00

abstract：:Dinoflagellates produce unique polyketides characterized by their size and complexity. The biosynthesis of a limited number of such metabolites has been reported, with studies largely hampered by the low yield of compounds and the severe scrambling of label in the isotopically-labeled precursors. Nonetheless, of the s...

journal_title：Natural product reports

authors： Van Wagoner RM,Satake M,Wright JL

更新日期：2014-09-01 00:00:00

abstract：:Covering: 2008 to 2016The total synthesis of natural products and their derivatives continues to inspire organic chemists to identify and test new synthetic strategies and develop and explore novel methodology. In recent years, visible light photoredox catalysis has risen to prominence as a powerful technology that en...

journal_title：Natural product reports

authors： Nicholls TP,Leonori D,Bissember AC

更新日期：2016-10-26 00:00:00

abstract：:Venomous marine cone snails harbour a variety of small disulfide-rich peptides called conotoxins, which target a broad range of ion channels, membrane receptors, and transporters. More than 700 species of Conus are thought to exist, each expressing a wide array of different peptides. Within this large repertoire of to...

journal_title：Natural product reports

authors： Halai R,Craik DJ

更新日期：2009-04-01 00:00:00

abstract：:Bracken (Pteridium spp.) is a ubiquitous fern which has been described as one of the five most common plants on the earth. The toxic effects of bracken on livestock have been recorded since the end of the 19th century, and extensive and intensive investigations for the bracken toxin(s) led to the isolation of ptaquilo...

journal_title：Natural product reports

authors： Yamada K,Ojika M,Kigoshi H

更新日期：2007-08-01 00:00:00