Abstract:
:The diastereoselective addition of organometallic reagents to α-chloroaldehydes was first reported in 1959 and occupies a historically significant role as the prototypical reaction for Cornforth's model of stereoinduction. Despite clear synthetic potential for these reagents, difficulties associated with producing enantiomerically enriched α-haloaldehydes limited their use in natural product synthesis through the latter half of the 20th century. In recent years, however, a variety of robust, organocatalytic processes have been reported that now provide direct access to optically enriched α-haloaldehydes and have motivated renewed interest in their use as building blocks for natural product synthesis. This Highlight summarizes the methods available for the enantioselective preparation of α-haloaldehydes and their stereoselective conversion into natural products.
journal_name
Nat Prod Repjournal_title
Natural product reportsauthors
Britton R,Kang Bdoi
10.1039/c2np20108asubject
Has Abstractpub_date
2013-02-01 00:00:00pages
227-36issue
2eissn
0265-0568issn
1460-4752journal_volume
30pub_type
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