Abstract:
:This review summarizes the state of knowledge on D-glucosamine-6P synthesis catalyzed by glucosamine-6P synthase. The mechanisms of L-glutamine hydrolysis, ammonia transfer and fructose-6P conversion into D-glucosamine-6P are analyzed with the E. coli enzyme in light of recent X-ray structures. With 92 references this paper covers the literature up to June 2001 and emphasizes the potential implication of the mammalian glucosamine-6P synthase in type 2 diabetes.
journal_name
Nat Prod Repjournal_title
Natural product reportsauthors
Teplyakov A,Leriche C,Obmolova G,Badet B,Badet-Denisot MAdoi
10.1039/b103713gsubject
Has Abstractpub_date
2002-02-01 00:00:00pages
60-9issue
1eissn
0265-0568issn
1460-4752journal_volume
19pub_type
杂志文章,评审abstract::In the recent past, macromolecular crystallography has gone through substantial methodological and technological development. The purpose of this review is to provide a general overview of structural biology and its impact on enzyme structure/function analysis and illustrate how it is modifying the focus of research r...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c2np20057k
更新日期:2012-10-01 00:00:00
abstract::Covering: up to September 2015. Meroterpenoids are hybrid natural products that partially originate from the terpenoid pathway. The meroterpenoids derived from fungi display quite diverse structures, with a wide range of biological properties. This review summarizes the molecular bases for their biosyntheses, which we...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c5np00090d
更新日期:2016-01-01 00:00:00
abstract::This review covers the structure and function of heparin and heparan sulfate glycosaminoglycans. Their chemical structures are discussed, including recently developed methods for sequencing picomole to nanomole quantities of heparin- and heparan sulfate-derived oligosaccharides. The biosynthesis of heparin and heparan...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b100916h
更新日期:2002-06-01 00:00:00
abstract::Covering up to December 2013. Oligosaccharide natural products target a wide spectrum of biological processes including disruption of cell wall biosynthesis, interference of bacterial translation, and inhibition of human α-amylase. Correspondingly, oligosaccharides possess the potential for development as treatments o...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c3np70128j
更新日期:2014-08-01 00:00:00
abstract::Nature has yielded numerous classes of chemically distinct microtubule stabilizers. Several of these, including paclitaxel (Taxol) and docetaxel (Taxotere), are important drugs used in the treatment of cancer. New microtubule stabilizers and novel formulations of these agents continue to provide advances in cancer the...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c3np70092e
更新日期:2014-03-01 00:00:00
abstract::Covering: up to January 2017Cytochrome P450 enzymes (P450s) are some of the most exquisite and versatile biocatalysts found in nature. In addition to their well-known roles in steroid biosynthesis and drug metabolism in humans, P450s are key players in natural product biosynthetic pathways. Natural products, the most ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c7np00034k
更新日期:2017-08-30 00:00:00
abstract::This review covers the literature on simple indole alkaloids and those with a nonrearranged monoterpenoid unit from the beginning of 2012 up to the end of 2013, which includes newly isolated alkaloids, structure determinations, total syntheses and biological activities. ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c5np00032g
更新日期:2015-09-23 00:00:00
abstract::The fungal genus Trichoderma has various applications in industry and in medicine, and several species have economic importance as sources of enzymes, antibiotics, plant growth promoters, decomposers of xenobiotics, and as commercial biofungicides. Peptaibiotics and peptaibols are a class of linear peptides synthesize...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b618086h
更新日期:2007-10-01 00:00:00
abstract::Covering: up to June 2018 Understanding the biosynthetic mechanisms that generate the astounding structural complexity and variety of fungal secondary metabolites (FSMs) remains a challenge. As an example, the biogenesis of the Monascus azaphilone pigments (MonAzPs) has remained obscure until recently despite the sign...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c8np00060c
更新日期:2019-04-17 00:00:00
abstract::From the basic export of unwanted metal ions in simple organisms to the complex orchestration of metal handling and usage in higher eukaryotes, cellular systems are based on a variety of molecular mechanisms that constrain the right metal to bind to the right protein partner at the right time when needed. A failure to...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b906678k
更新日期:2010-05-01 00:00:00
abstract::The article reviews the progress in the chemistry of the steroids that was published between January and December, 2001. The reactions and partial syntheses of estrogens, androgens, pregnanes, cholic acid derivatives, cholestanes and vitamin D analogues are covered. There are 184 references. ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b212061p
更新日期:2003-06-01 00:00:00
abstract::Covering: 1972 to 2011. This review covers the literature of prenylated quinone, hydroquinone and naphthoquinone marine natural products with reported cytotoxic and/or antioxidant properties. The structures, biological activity and, where applicable, the syntheses of 159 cytotoxic/antioxidant compounds, isolated from ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c2np00086e
更新日期:2012-05-01 00:00:00
abstract::This review covers the isolation and structure determination of triterpenoids reported during 2012 including squalene derivatives, lanostanes, holostanes, cycloartanes, cucurbitanes, dammaranes, euphanes, tirucallanes, tetranortriterpenoids, quassinoids, lupanes, oleananes, friedelanes, ursanes, hopanes, serratanes, i...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c4np00101j
更新日期:2015-02-01 00:00:00
abstract::This review covers the morphology, isolation, total synthesis and biological activity of the naturally occurring alkaloids isolated from the Amaryllidaceae family, as well as the structurally related Sceletium alkaloids. ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b316106b
更新日期:2005-02-01 00:00:00
abstract::Although natural products have been marginalized by major pharmaceutical companies over the last 20-30 years, the changing landscape of drug discovery now favors a greatly enhanced role for Nature's privileged structures. Screening for drug leads in phenotypic screens provides the best opportunity to realize the value...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c1np00033k
更新日期:2011-10-01 00:00:00
abstract::Blue flower colors are primarily due to anthocyanin, a flavonoid pigment. Anthocyanin itself is purple in neutral aqueous solutions, ans its color is very unstable and quickly fades. Therefore, the mechanism of blue color development in living flower petals is one of the most intriguing problems in natural product che...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b800165k
更新日期:2009-07-01 00:00:00
abstract::This review covers the biosynthesis of aliphatic and aromatic polyketides as well as mixed polyketide/NRPS metabolites, and discusses the molecular genetics and enzymology of the proteins responsible for their formation. ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b301028g
更新日期:2006-04-01 00:00:00
abstract::This review focuses on recent developments in the use of natural products as therapeutics for Alzheimer's disease. The compounds span a diverse array of structural classes and are organized according to their mechanism of action, with the focus primarily on the major hypotheses. Overall, the review discusses more than...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c0np00027b
更新日期:2011-01-01 00:00:00
abstract::Covering: up to early 2018 The Nonribosomal Peptide Synthetases (NRPSs) and Polyketide Synthases (PKSs) are families of modular enzymes that produce a tremendous diversity of natural products, with antibacterial, antifungal, immunosuppressive, and anticancer activities. Both enzymes utilize a fascinating modular archi...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c8np00044a
更新日期:2018-11-14 00:00:00
abstract::Covering: up to 2018 The Haemodoraceae family is a monocotyledonous family in the order Commelinales consisting of 14 genera. Many species from the family are endemic to Australia and their use by the Aboriginal People of Australia as both pigments or remedies has been ethnobotanically documented. Phenylphenalenones a...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c8np00067k
更新日期:2019-05-22 00:00:00
abstract::Microorganisms and in particular actinomycetes and microfungi are known to produce a vast number of bioactive secondary metabolites. For industrially important fungal genera such as Penicillium and Aspergillus the production of these compounds has been demonstrated to be very consistent at the species level. This mean...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b404943h
更新日期:2005-12-01 00:00:00
abstract::Silybin, a secondary metabolite isolated from the seeds of the blessed milk thistle (Silybum marianum) was discovered as the first member of a new family of natural compounds called flavonolignans in 1959. Over the years it has received the research attention of many organic chemists. This research has resulted in a n...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c3np70122k
更新日期:2014-09-01 00:00:00
abstract::Dinoflagellates produce unique polyketides characterized by their size and complexity. The biosynthesis of a limited number of such metabolites has been reported, with studies largely hampered by the low yield of compounds and the severe scrambling of label in the isotopically-labeled precursors. Nonetheless, of the s...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c4np00016a
更新日期:2014-09-01 00:00:00
abstract::A detailed overview is presented of recent total synthesis approaches to four different diterpenoids--the ginkgolides, tonantzitlolone, ingenol and eleutherobin. Due to their structural complexity, all pose major challenges for total synthesis, guaranteeing diverse strategic tours de force and a rich synthetic chemist...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b705652b
更新日期:2008-04-01 00:00:00
abstract::Naturally-occurring nitro compounds display great structural diversity, and a wide range of biological activities. This review summarizes current information on the structures of naturally-occurring nitro compounds and on the biosynthesis of the nitro group. ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c0np00024h
更新日期:2011-01-01 00:00:00
abstract::The biosynthesis of peptidoglycan is essential for all bacteria and has no counterpart in eukaryotic cells. It is one of the prime targets for antibiotic chemotherapy, especially phospho-MurNAc-pentapeptide translocase (translocase I) is a fascinating target in which there is no commercial antibiotic. In this review w...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b202149h
更新日期:2003-04-01 00:00:00
abstract::Covering: 1989 up to 2019 Ahp-cyclodepsipeptides (also known as Ahp-containing cyclodepsipeptides, cyanopeptolins, micropeptins, microginines, and lyngbyastatins, and by many other names) are a family of non-ribosomal peptide synthesis (NRPS)-derived natural products with potent serine protease inhibitory properties. ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c9np00033j
更新日期:2020-02-26 00:00:00
abstract::A key property of metallo-proteins and -enzymes is the affinity of metal ion M for protein ligand P as defined by the dissociation constant KD = [M][P]/[MP]. Its accurate determination is essential for a quantitative understanding of metal selection and speciation. However, the surfaces of proteins are defined by the ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b906690j
更新日期:2010-05-01 00:00:00
abstract::Covering: up to 2018 β-Lactones are strained rings that are useful organic synthons and pharmaceutical warheads. Over 30 core scaffolds of β-lactone natural products have been described to date, many with potent bioactivity against bacteria, fungi, or human cancer cell lines. β-Lactone natural products are chemically ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c8np00052b
更新日期:2019-03-20 00:00:00
abstract::This Highlight describes some of the recent synthetic work on imidazole-containing alkaloids isolated from marine sponges. Target molecules have been chosen which demonstrate synthetic strategies leading towards metabolites containing intact imidazole moieties as well as systems bearing modified imidazole rings. ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b700206h
更新日期:2007-10-01 00:00:00