Chemistry of silybin.

abstract：:Covering: 2008 to 2016The total synthesis of natural products and their derivatives continues to inspire organic chemists to identify and test new synthetic strategies and develop and explore novel methodology. In recent years, visible light photoredox catalysis has risen to prominence as a powerful technology that en...

journal_title：Natural product reports

authors： Nicholls TP,Leonori D,Bissember AC

更新日期：2016-10-26 00:00:00

abstract：:Covering: 1997 to 2010. The angucycline group is the largest group of type II PKS-engineered natural products, rich in biological activities and chemical scaffolds. This stimulated synthetic creativity and biosynthetic inquisitiveness. The synthetic studies used five different strategies, involving Diels-Alder reactio...

journal_title：Natural product reports

authors： Kharel MK,Pahari P,Shepherd MD,Tibrewal N,Nybo SE,Shaaban KA,Rohr J

更新日期：2012-02-01 00:00:00

abstract：:Venomous marine cone snails harbour a variety of small disulfide-rich peptides called conotoxins, which target a broad range of ion channels, membrane receptors, and transporters. More than 700 species of Conus are thought to exist, each expressing a wide array of different peptides. Within this large repertoire of to...

journal_title：Natural product reports

authors： Halai R,Craik DJ

更新日期：2009-04-01 00:00:00

abstract：:This review covers the isolation and structure determination of triterpenoids reported during 2012 including squalene derivatives, lanostanes, holostanes, cycloartanes, cucurbitanes, dammaranes, euphanes, tirucallanes, tetranortriterpenoids, quassinoids, lupanes, oleananes, friedelanes, ursanes, hopanes, serratanes, i...

journal_title：Natural product reports

authors： Hill RA,Connolly JD

更新日期：2015-02-01 00:00:00

abstract：:This Highlight describes factors that contribute to an ideal synthesis, including economies (step, time, atom, solvent, energy) and orientations (target, diversity, safety, function), and the role of synthesis-informed design directed at function in advancing synthesis and its impact on science. ...

journal_title：Natural product reports

authors： Wender PA

更新日期：2014-04-01 00:00:00

abstract：:This review focuses on recent developments in the use of natural products as therapeutics for Alzheimer's disease. The compounds span a diverse array of structural classes and are organized according to their mechanism of action, with the focus primarily on the major hypotheses. Overall, the review discusses more than...

journal_title：Natural product reports

authors： Williams P,Sorribas A,Howes MJ

更新日期：2011-01-01 00:00:00

abstract：:This review article focuses on how nature sometimes solves the same problem in the biosynthesis of small molecules but using very different approaches. Four examples, involving isopentenyl diphosphate, menaquinone, lysine, and aromatic polyketides, are highlighted that represent different strategies in convergent meta...

journal_title：Natural product reports

authors： Dairi T,Kuzuyama T,Nishiyama M,Fujii I

更新日期：2011-06-01 00:00:00

abstract：:In this review the names, structures and occurrence of all new drimanes and rearranged drimanes which have been published between January 1990 and January 2003 have been collected. Subjects that have been treated are biosynthesis, analysis, biological activities, with special attention to cytotoxic activity and antife...

journal_title：Natural product reports

authors： Jansen BJ,de Groot A

更新日期：2004-08-01 00:00:00

abstract：:Covering: up to January 2017Cytochrome P450 enzymes (P450s) are some of the most exquisite and versatile biocatalysts found in nature. In addition to their well-known roles in steroid biosynthesis and drug metabolism in humans, P450s are key players in natural product biosynthetic pathways. Natural products, the most ...

journal_title：Natural product reports

authors： Rudolf JD,Chang CY,Ma M,Shen B

更新日期：2017-08-30 00:00:00

abstract：:Novel organic reactions drive the advance of chemical synthesis in the same way that enabling technologies drive new scientific discoveries. One area of organic methodology that has undergone significant growth during the last decade is that of homogeneous gold-catalyzed transformations. This trend has been further en...

journal_title：Natural product reports

authors： Zhang Y,Luo T,Yang Z

更新日期：2014-04-01 00:00:00

abstract：:Covering up to December 2013. Oligosaccharide natural products target a wide spectrum of biological processes including disruption of cell wall biosynthesis, interference of bacterial translation, and inhibition of human α-amylase. Correspondingly, oligosaccharides possess the potential for development as treatments o...

journal_title：Natural product reports

authors： McCranie EK,Bachmann BO

更新日期：2014-08-01 00:00:00

abstract：:Natural products have evolved, at least in part, to bind to biological macromolecules, particularly proteins. As a result, natural products are able to interact with many specific targets within the cell. Indeed for many years this has been central in the drug development process. Today, however, natural products are ...

journal_title：Natural product reports

authors： Dixon N,Wong LS,Geerlings TH,Micklefield J

更新日期：2007-12-01 00:00:00

abstract：:Fungi have emerged worldwide as increasingly frequent causes of healthcare-associated infections, but fungal infections have generally been considered curable, and thus the demand for new antifungal agents has been very low. Although superficial fungal infections of the skin and nails are common and are for the most p...

journal_title：Natural product reports

authors： Di Santo R

更新日期：2010-07-01 00:00:00

abstract：:A key property of metallo-proteins and -enzymes is the affinity of metal ion M for protein ligand P as defined by the dissociation constant KD = [M][P]/[MP]. Its accurate determination is essential for a quantitative understanding of metal selection and speciation. However, the surfaces of proteins are defined by the ...

journal_title：Natural product reports

authors： Xiao Z,Wedd AG

更新日期：2010-05-01 00:00:00

abstract：:The fungal genus Trichoderma has various applications in industry and in medicine, and several species have economic importance as sources of enzymes, antibiotics, plant growth promoters, decomposers of xenobiotics, and as commercial biofungicides. Peptaibiotics and peptaibols are a class of linear peptides synthesize...

journal_title：Natural product reports

authors： Daniel JF,Filho ER

更新日期：2007-10-01 00:00:00

abstract：:Covering: 1947-early 2017, particularly from 2005-early 2017The rise of bacterial pathogens with acquired resistance to almost all available antibiotics is becoming a serious public health issue. Polymyxins, antibiotics that were mostly abandoned a few decades ago because of toxicity concerns, are ultimately considere...

journal_title：Natural product reports

authors： Rabanal F,Cajal Y

更新日期：2017-07-06 00:00:00

abstract：:This review covers the recent marine chemical ecology literature for benthic cyanobacteria, macroalgae, sponges, octocorals, molluscs, other benthic invertebrates, fish and seabirds. ...

journal_title：Natural product reports

authors： Paul VJ,Ritson-Williams R

更新日期：2008-08-01 00:00:00

abstract：:Covering: 1958 to June 2018 Phenyl-γ-valerolactones (PVLs) and their related phenylvaleric acids (PVAs) are the main metabolites of flavan-3-ols, the major class of flavonoids in the human diet. Despite their presumed importance, these gut microbiota-derived compounds have, to date, in terms of biological activity, be...

journal_title：Natural product reports

authors： Mena P,Bresciani L,Brindani N,Ludwig IA,Pereira-Caro G,Angelino D,Llorach R,Calani L,Brighenti F,Clifford MN,Gill CIR,Crozier A,Curti C,Del Rio D

更新日期：2019-05-22 00:00:00

abstract：:Covering: up to February 2019Actinomycetes are Gram positive bacteria of the phylum Actinobacteria. These organisms are one of the most important sources of structurally diverse, clinically used antibiotics and other valuable bioactive products, as well as biotechnologically relevant enzymes. Most strains were discove...

journal_title：Natural product reports

authors： Musiol-Kroll EM,Tocchetti A,Sosio M,Stegmann E

更新日期：2019-09-01 00:00:00

abstract：:This review covers the isolation, structure determination, synthesis, chemical transformations and biological activity of indolizidine and quinolizidine alkaloids. Included in the review are the hydroxylated indolizidines lentiginosine, swainsonine, castanospermine and their analogues; alkaloids from animal sources, i...

journal_title：Natural product reports

authors： Michael JP

更新日期：2008-02-01 00:00:00

abstract：:Covering: up to September 2015. Meroterpenoids are hybrid natural products that partially originate from the terpenoid pathway. The meroterpenoids derived from fungi display quite diverse structures, with a wide range of biological properties. This review summarizes the molecular bases for their biosyntheses, which we...

journal_title：Natural product reports

authors： Matsuda Y,Abe I

更新日期：2016-01-01 00:00:00

abstract：:This review discusses the biosynthesis of natural products that are generated by trans-AT polyketide synthases, a family of catalytically versatile enzymes that represents one of the major group of proteins involved in the production of bioactive polyketides. The article includes 609 references and covers the literatu...

journal_title：Natural product reports

authors： Helfrich EJ,Piel J

更新日期：2016-02-01 00:00:00

abstract：:Covering: up to 2018 β-Lactones are strained rings that are useful organic synthons and pharmaceutical warheads. Over 30 core scaffolds of β-lactone natural products have been described to date, many with potent bioactivity against bacteria, fungi, or human cancer cell lines. β-Lactone natural products are chemically ...

journal_title：Natural product reports

authors： Robinson SL,Christenson JK,Wackett LP

更新日期：2019-03-20 00:00:00

abstract：:This review article provides an overview on the current state of research in the area of microtubule-stabilizing agents from natural sources, with a primary focus on the biochemistry, biology, and pharmacology associated with these compounds. A variety of natural products have been discovered over the last decade to i...

journal_title：Natural product reports

authors： Altmann KH,Gertsch J

更新日期：2007-04-01 00:00:00

abstract：:The biosynthesis of peptidoglycan is essential for all bacteria and has no counterpart in eukaryotic cells. It is one of the prime targets for antibiotic chemotherapy, especially phospho-MurNAc-pentapeptide translocase (translocase I) is a fascinating target in which there is no commercial antibiotic. In this review w...

journal_title：Natural product reports

authors： Kimura K,Bugg TD

更新日期：2003-04-01 00:00:00

abstract：:This review covers the structure and function of heparin and heparan sulfate glycosaminoglycans. Their chemical structures are discussed, including recently developed methods for sequencing picomole to nanomole quantities of heparin- and heparan sulfate-derived oligosaccharides. The biosynthesis of heparin and heparan...

journal_title：Natural product reports

authors： Rabenstein DL

更新日期：2002-06-01 00:00:00

abstract：:The aim of the present review is to summarise the knowledge about newly isolated acetogenins (ACGs) in the last six years. It will also report the total syntheses that have allowed either the confirmation or the revision of some structures, together with the biological activities and mechanism of action of such intere...

journal_title：Natural product reports

authors： Bermejo A,Figadere B,Zafra-Polo MC,Barrachina I,Estornell E,Cortes D

更新日期：2005-04-01 00:00:00

abstract：:Microorganisms and in particular actinomycetes and microfungi are known to produce a vast number of bioactive secondary metabolites. For industrially important fungal genera such as Penicillium and Aspergillus the production of these compounds has been demonstrated to be very consistent at the species level. This mean...

journal_title：Natural product reports

authors： Larsen TO,Smedsgaard J,Nielsen KF,Hansen ME,Frisvad JC

更新日期：2005-12-01 00:00:00

abstract：:Sesterterpenoids account for many bioactive natural products, often with unusual and complex structural features, which makes them attractive targets for synthetic chemists. This review surveys efforts undertaken toward the synthesis of sesterterpenoids, focusing on completed total syntheses and covering ca. 50 natura...

journal_title：Natural product reports

authors： Hog DT,Webster R,Trauner D

更新日期：2012-07-01 00:00:00

abstract：:Discovering molecular components and their functionality is key to the development of hypotheses concerning the organization and regulation of metabolic networks. The iterative experimental testing of such hypotheses is the trajectory that can ultimately enable accurate computational modelling and prediction of metabo...

journal_title：Natural product reports

authors： Hur M,Campbell AA,Almeida-de-Macedo M,Li L,Ransom N,Jose A,Crispin M,Nikolau BJ,Wurtele ES

更新日期：2013-04-01 00:00:00