Biosynthesis of polyketides by trans-AT polyketide synthases.

abstract：:The diastereoselective addition of organometallic reagents to α-chloroaldehydes was first reported in 1959 and occupies a historically significant role as the prototypical reaction for Cornforth's model of stereoinduction. Despite clear synthetic potential for these reagents, difficulties associated with producing ena...

journal_title：Natural product reports

authors： Britton R,Kang B

更新日期：2013-02-01 00:00:00

abstract：:From the basic export of unwanted metal ions in simple organisms to the complex orchestration of metal handling and usage in higher eukaryotes, cellular systems are based on a variety of molecular mechanisms that constrain the right metal to bind to the right protein partner at the right time when needed. A failure to...

journal_title：Natural product reports

authors： Banci L,Bertini I,McGreevy KS,Rosato A

更新日期：2010-05-01 00:00:00

abstract：:We compiled a data set of the compounds that terrestrial vertebrates (amniotes) use to send chemical signals, and searched for relationships between signal compound properties and signal function. Overall, relationships were scarce and formed only small-scale patterns. Terrestrial vertebrate signalling compounds are i...

journal_title：Natural product reports

authors： Apps PJ,Weldon PJ,Kramer M

更新日期：2015-07-01 00:00:00

abstract：:This Highlight describes factors that contribute to an ideal synthesis, including economies (step, time, atom, solvent, energy) and orientations (target, diversity, safety, function), and the role of synthesis-informed design directed at function in advancing synthesis and its impact on science. ...

journal_title：Natural product reports

authors： Wender PA

更新日期：2014-04-01 00:00:00

abstract：:Covering: up to the end of 2015.Peptides are naturally occurring compounds that play an important role in all living systems and are responsible for a range of essential functions. Peptide receptors have been implicated in disease states such as oncology, metabolic disorders and cardiovascular disease. Therefore, natu...

journal_title：Natural product reports

authors： Charron CL,Hickey JL,Nsiama TK,Cruickshank DR,Turnbull WL,Luyt LG

更新日期：2016-06-02 00:00:00

abstract：:This review deals with the isolation and structure elucidation of meroterpenoids (natural products of mixed biosynthetic origin which are partially derived from terpenoids) from higher and lower fungi, and discusses biosynthetic studies and biological activities as appropriate. It describes 333 fungal meroterpenoids a...

journal_title：Natural product reports

authors： Geris R,Simpson TJ

更新日期：2009-08-01 00:00:00

abstract：:This Highlight describes synthetic methods that have enabled new strategic approaches to the synthesis of natural product targets as well as libraries of compounds for unbiased screening experiments. The structural differences of the compounds produced by both efforts are illustrated. ...

journal_title：Natural product reports

authors： Shaw JT

更新日期：2009-01-01 00:00:00

abstract：:Discovering molecular components and their functionality is key to the development of hypotheses concerning the organization and regulation of metabolic networks. The iterative experimental testing of such hypotheses is the trajectory that can ultimately enable accurate computational modelling and prediction of metabo...

journal_title：Natural product reports

authors： Hur M,Campbell AA,Almeida-de-Macedo M,Li L,Ransom N,Jose A,Crispin M,Nikolau BJ,Wurtele ES

更新日期：2013-04-01 00:00:00

abstract：:Venomous marine cone snails harbour a variety of small disulfide-rich peptides called conotoxins, which target a broad range of ion channels, membrane receptors, and transporters. More than 700 species of Conus are thought to exist, each expressing a wide array of different peptides. Within this large repertoire of to...

journal_title：Natural product reports

authors： Halai R,Craik DJ

更新日期：2009-04-01 00:00:00

abstract：:Vitamin B12, or cobalamin, is one of the most structurally complex small molecules made in Nature. Major progress has been made over the past decade in understanding how this synthesis is accomplished. This review covers some of the most important findings that have been made and provides the reader with a complete de...

journal_title：Natural product reports

authors： Warren MJ,Raux E,Schubert HL,Escalante-Semerena JC

更新日期：2002-08-01 00:00:00

abstract：:This review article provides an overview on the current state of research in the area of microtubule-stabilizing agents from natural sources, with a primary focus on the biochemistry, biology, and pharmacology associated with these compounds. A variety of natural products have been discovered over the last decade to i...

journal_title：Natural product reports

authors： Altmann KH,Gertsch J

更新日期：2007-04-01 00:00:00

abstract：:This review will detail progress made in the previous decade on the chemistry and bioactivity of birch bark extractive products. Current and future applications of birch bark natural products in pharmaceuticals, cosmetics, and dietary supplements for the prevention and treatment of cancer, HIV,and other human pathogen...

journal_title：Natural product reports

authors： Krasutsky PA

更新日期：2006-12-01 00:00:00

abstract：:Aristolactams, having a phenanthrene chromophore are a small group of compounds mainly found in the Aristolochiaceae together with the aristolochic acids and 4,5-dioxoaporphines. In this report, these three important classes of natural products are reviewed and classified on the basis of their oxygenation pattern. In ...

journal_title：Natural product reports

authors： Kumar V,Poonam,Prasad AK,Parmar VS

更新日期：2003-12-01 00:00:00

abstract：:Natural products have evolved, at least in part, to bind to biological macromolecules, particularly proteins. As a result, natural products are able to interact with many specific targets within the cell. Indeed for many years this has been central in the drug development process. Today, however, natural products are ...

journal_title：Natural product reports

authors： Dixon N,Wong LS,Geerlings TH,Micklefield J

更新日期：2007-12-01 00:00:00

abstract：:Covering: up to 2017This review covers the biosynthetic and evolutionary aspects of lincosamide antibiotics, antitumour pyrrolobenzodiazepines (PBDs) and the quorum-sensing molecule hormaomycin. These structurally and functionally diverse groups of complex natural products all incorporate rarely occurring 4-alkyl-l-pr...

journal_title：Natural product reports

authors： Janata J,Kamenik Z,Gazak R,Kadlcik S,Najmanova L

更新日期：2018-03-01 00:00:00

abstract：:The article reviews the progress in the chemistry of the steroids that was published between January and December, 2001. The reactions and partial syntheses of estrogens, androgens, pregnanes, cholic acid derivatives, cholestanes and vitamin D analogues are covered. There are 184 references. ...

journal_title：Natural product reports

authors： Hanson JR

更新日期：2003-06-01 00:00:00

abstract：:In this study, the biological properties of natural abietane-type diterpenoids with an aromatic C ring are reviewed. An overview of the synthetic studies of this group of abietanes, including dehydroabietic acid, callitrisic acid and ferruginol, is presented. The review contains about 160 references. ...

journal_title：Natural product reports

authors： González MA

更新日期：2015-05-01 00:00:00

abstract：:Covering: up to early 2018 The Nonribosomal Peptide Synthetases (NRPSs) and Polyketide Synthases (PKSs) are families of modular enzymes that produce a tremendous diversity of natural products, with antibacterial, antifungal, immunosuppressive, and anticancer activities. Both enzymes utilize a fascinating modular archi...

journal_title：Natural product reports

authors： Gulick AM,Aldrich CC

更新日期：2018-11-14 00:00:00

abstract：:This review focuses on recent developments in the use of natural products as therapeutics for Alzheimer's disease. The compounds span a diverse array of structural classes and are organized according to their mechanism of action, with the focus primarily on the major hypotheses. Overall, the review discusses more than...

journal_title：Natural product reports

authors： Williams P,Sorribas A,Howes MJ

更新日期：2011-01-01 00:00:00

abstract：:Covering: July 2012 to December 2019Over the last seven years, expanding research efforts focused on sesterterpenoids has led to the isolation, identification, and characterization of numerous structurally novel and biologically active sesterterpenoids. These newly reported sesterterpenoids provide diverse structures ...

journal_title：Natural product reports

authors： Li K,Gustafson KR

更新日期：2020-12-22 00:00:00

abstract：:A diverse array of secondary metabolites have been isolated and characterized from marine-derived fungi. The structures and biological activities of these metabolites are presented. Additionally, some basic principles of mycology are covered. Overall, 273 structures are presented and the review contains 162 references...

journal_title：Natural product reports

authors： Bugni TS,Ireland CM

更新日期：2004-02-01 00:00:00

abstract：:Natural products and their derivatives are mainstays of our antibiotic drugs, but they are increasingly in peril. The combination of widespread multidrug resistance in once susceptible bacterial pathogens, disenchantment with natural products as sources of new drugs, lack of success using synthetic compounds and targe...

journal_title：Natural product reports

authors： Wright GD

更新日期：2017-07-01 00:00:00

abstract：:Dinoflagellates produce unique polyketides characterized by their size and complexity. The biosynthesis of a limited number of such metabolites has been reported, with studies largely hampered by the low yield of compounds and the severe scrambling of label in the isotopically-labeled precursors. Nonetheless, of the s...

journal_title：Natural product reports

authors： Van Wagoner RM,Satake M,Wright JL

更新日期：2014-09-01 00:00:00

abstract：:This review covers the isolation and structure determination of triterpenoids reported during 2012 including squalene derivatives, lanostanes, holostanes, cycloartanes, cucurbitanes, dammaranes, euphanes, tirucallanes, tetranortriterpenoids, quassinoids, lupanes, oleananes, friedelanes, ursanes, hopanes, serratanes, i...

journal_title：Natural product reports

authors： Hill RA,Connolly JD

更新日期：2015-02-01 00:00:00

abstract：:In the search for new drugs and natural remedies, medicinal plants or herbs used in folk and traditional medicines are promising candidates. For the naturally rare and slowly growing plant species, plant tissue culture in bioreactors provides a cost-effective, sustainable and well-controlled means for mass production ...

journal_title：Natural product reports

authors： Zhou LG,Wu JY

更新日期：2006-10-01 00:00:00

abstract：:This review covers the isolation, structure determination, synthesis, chemical transformations and biological activity of indolizidine and quinolizidine alkaloids. Included in the review are the hydroxylated indolizidines lentiginosine, swainsonine, castanospermine and their analogues; alkaloids from animal sources, i...

journal_title：Natural product reports

authors： Michael JP

更新日期：2008-02-01 00:00:00

abstract：:A key property of metallo-proteins and -enzymes is the affinity of metal ion M for protein ligand P as defined by the dissociation constant KD = [M][P]/[MP]. Its accurate determination is essential for a quantitative understanding of metal selection and speciation. However, the surfaces of proteins are defined by the ...

journal_title：Natural product reports

authors： Xiao Z,Wedd AG

更新日期：2010-05-01 00:00:00

abstract：:Covering up to December 2013. Oligosaccharide natural products target a wide spectrum of biological processes including disruption of cell wall biosynthesis, interference of bacterial translation, and inhibition of human α-amylase. Correspondingly, oligosaccharides possess the potential for development as treatments o...

journal_title：Natural product reports

authors： McCranie EK,Bachmann BO

更新日期：2014-08-01 00:00:00

abstract：:The mangrove flora is a diverse group of salt-tolerant plants growing in tropical and subtropical intertidal estuarine zones. This review summarizes the source, chemistry and bioactivities of natural products from true mangrove species worldwide. It includes 349 metabolites and 150 references. The molecular phylogeny ...

journal_title：Natural product reports

authors： Wu J,Xiao Q,Xu J,Li MY,Pan JY,Yang MH

更新日期：2008-10-01 00:00:00

abstract：:Silybin, a secondary metabolite isolated from the seeds of the blessed milk thistle (Silybum marianum) was discovered as the first member of a new family of natural compounds called flavonolignans in 1959. Over the years it has received the research attention of many organic chemists. This research has resulted in a n...

journal_title：Natural product reports

authors： Biedermann D,Vavříková E,Cvak L,Křen V

更新日期：2014-09-01 00:00:00