Challenges and advances in genetic manipulation of filamentous actinomycetes - the remarkable producers of specialized metabolites.

abstract：:Covering: 2000 to 2008. Previous review: D. L. Wright and C. R. Whitehead, Org. Prep. Proced. Int., 2000, 32, 309-330. An overview of synthetic efforts toward cyathane diterpenoid natural products from the year 2000 to present is provided. The emphasis of this review is the various ring-constructing and stereoforming ...

journal_title：Natural product reports

authors： Enquist JA Jr,Stoltz BM

更新日期：2009-05-01 00:00:00

abstract：:A detailed overview is presented of recent total synthesis approaches to four different diterpenoids--the ginkgolides, tonantzitlolone, ingenol and eleutherobin. Due to their structural complexity, all pose major challenges for total synthesis, guaranteeing diverse strategic tours de force and a rich synthetic chemist...

journal_title：Natural product reports

authors： Busch T,Kirschning A

更新日期：2008-04-01 00:00:00

abstract：:Covering: 1997 to 2010. The angucycline group is the largest group of type II PKS-engineered natural products, rich in biological activities and chemical scaffolds. This stimulated synthetic creativity and biosynthetic inquisitiveness. The synthetic studies used five different strategies, involving Diels-Alder reactio...

journal_title：Natural product reports

authors： Kharel MK,Pahari P,Shepherd MD,Tibrewal N,Nybo SE,Shaaban KA,Rohr J

更新日期：2012-02-01 00:00:00

abstract：:The cyclic depsipeptide largazole from a cyanobacterium of the genus Symploca is a marine natural product with a novel chemical scaffold and potently inhibits class I histone deacetylases (HDACs). Largazole possesses highly differential growth-inhibitory activity, preferentially targeting transformed over non-transfor...

journal_title：Natural product reports

authors： Hong J,Luesch H

更新日期：2012-04-01 00:00:00

abstract：:Covering: 1947-early 2017, particularly from 2005-early 2017The rise of bacterial pathogens with acquired resistance to almost all available antibiotics is becoming a serious public health issue. Polymyxins, antibiotics that were mostly abandoned a few decades ago because of toxicity concerns, are ultimately considere...

journal_title：Natural product reports

authors： Rabanal F,Cajal Y

更新日期：2017-07-06 00:00:00

abstract：:Covering: up to 2017This review covers the biosynthetic and evolutionary aspects of lincosamide antibiotics, antitumour pyrrolobenzodiazepines (PBDs) and the quorum-sensing molecule hormaomycin. These structurally and functionally diverse groups of complex natural products all incorporate rarely occurring 4-alkyl-l-pr...

journal_title：Natural product reports

authors： Janata J,Kamenik Z,Gazak R,Kadlcik S,Najmanova L

更新日期：2018-03-01 00:00:00

abstract：:Covering: up to 2018 The Haemodoraceae family is a monocotyledonous family in the order Commelinales consisting of 14 genera. Many species from the family are endemic to Australia and their use by the Aboriginal People of Australia as both pigments or remedies has been ethnobotanically documented. Phenylphenalenones a...

journal_title：Natural product reports

authors： Norman EO,Lever J,Brkljača R,Urban S

更新日期：2019-05-22 00:00:00

abstract：:Covering: up to 2019As abundant natural products, isoprenoids have many useful industrial applications in the manufacturing of drugs, fragrances, food additives, colorants, rubber and advanced biofuels. The microbial production of isoprenoids has received much attention in recent years. Metabolic engineering approache...

journal_title：Natural product reports

authors： Li M,Hou F,Wu T,Jiang X,Li F,Liu H,Xian M,Zhang H

更新日期：2020-01-01 00:00:00

abstract：:Covering: July 2012 to December 2019Over the last seven years, expanding research efforts focused on sesterterpenoids has led to the isolation, identification, and characterization of numerous structurally novel and biologically active sesterterpenoids. These newly reported sesterterpenoids provide diverse structures ...

journal_title：Natural product reports

authors： Li K,Gustafson KR

更新日期：2020-12-22 00:00:00

abstract：:Novel organic reactions drive the advance of chemical synthesis in the same way that enabling technologies drive new scientific discoveries. One area of organic methodology that has undergone significant growth during the last decade is that of homogeneous gold-catalyzed transformations. This trend has been further en...

journal_title：Natural product reports

authors： Zhang Y,Luo T,Yang Z

更新日期：2014-04-01 00:00:00

abstract：:Covering: up to 2013. Although holo-acyl carrier protein synthase, AcpS, a phosphopantetheinyl transferase (PPTase), was characterized in the 1960s, it was not until the publication of the landmark paper by Lambalot et al. in 1996 that PPTases garnered wide-spread attention being classified as a distinct enzyme superf...

journal_title：Natural product reports

authors： Beld J,Sonnenschein EC,Vickery CR,Noel JP,Burkart MD

更新日期：2014-01-01 00:00:00

abstract：:Covering: up to 2018 β-Lactones are strained rings that are useful organic synthons and pharmaceutical warheads. Over 30 core scaffolds of β-lactone natural products have been described to date, many with potent bioactivity against bacteria, fungi, or human cancer cell lines. β-Lactone natural products are chemically ...

journal_title：Natural product reports

authors： Robinson SL,Christenson JK,Wackett LP

更新日期：2019-03-20 00:00:00

abstract：:Covering: up to the end of 2015.Peptides are naturally occurring compounds that play an important role in all living systems and are responsible for a range of essential functions. Peptide receptors have been implicated in disease states such as oncology, metabolic disorders and cardiovascular disease. Therefore, natu...

journal_title：Natural product reports

authors： Charron CL,Hickey JL,Nsiama TK,Cruickshank DR,Turnbull WL,Luyt LG

更新日期：2016-06-02 00:00:00

abstract：:Covering: 2000 up to 2020 Few classes of natural products have inspired as many chemists and biologists as have the iboga alkaloids. This family of monoterpenoid indole alkaloids includes the anti-addictive compound ibogaine as well as catharanthine, a precursor to the chemotherapeutic vinblastine. Despite being known...

journal_title：Natural product reports

authors： Iyer RN,Favela D,Zhang G,Olson DE

更新日期：2020-08-14 00:00:00

abstract：:Contact chemosensation, or tasting, is a complex process governed by nonvolatile phytochemicals that tell host-seeking insects whether they should accept or reject a plant. During this process, insect gustatory receptors (GRs) contribute to deciphering a host plant's metabolic code. GRs recognise many different classe...

journal_title：Natural product reports

authors： Pentzold S,Burse A,Boland W

更新日期：2017-05-10 00:00:00

abstract：:Covering: up to 2018 Ovothiols are sulfur-containing natural products biosynthesized by marine invertebrates, microalgae, and bacteria. These compounds are characterized by unique chemical properties suggestive of numerous cellular functions. For example, ovothiols may be cytoprotectants against oxidative stress, serv...

journal_title：Natural product reports

authors： Castellano I,Seebeck FP

更新日期：2018-12-12 00:00:00

abstract：:Covering: 1972 to 2011. This review covers the literature of prenylated quinone, hydroquinone and naphthoquinone marine natural products with reported cytotoxic and/or antioxidant properties. The structures, biological activity and, where applicable, the syntheses of 159 cytotoxic/antioxidant compounds, isolated from ...

journal_title：Natural product reports

authors： Sunassee SN,Davies-Coleman MT

更新日期：2012-05-01 00:00:00

abstract：:Nature has yielded numerous classes of chemically distinct microtubule stabilizers. Several of these, including paclitaxel (Taxol) and docetaxel (Taxotere), are important drugs used in the treatment of cancer. New microtubule stabilizers and novel formulations of these agents continue to provide advances in cancer the...

journal_title：Natural product reports

authors： Rohena CC,Mooberry SL

更新日期：2014-03-01 00:00:00

abstract：:The aim of the present review is to summarise the knowledge about newly isolated acetogenins (ACGs) in the last six years. It will also report the total syntheses that have allowed either the confirmation or the revision of some structures, together with the biological activities and mechanism of action of such intere...

journal_title：Natural product reports

authors： Bermejo A,Figadere B,Zafra-Polo MC,Barrachina I,Estornell E,Cortes D

更新日期：2005-04-01 00:00:00

abstract：:This review covers the morphology, isolation, total synthesis and biological activity of the naturally occurring alkaloids isolated from the Amaryllidaceae family, as well as the structurally related Sceletium alkaloids. ...

journal_title：Natural product reports

authors： Jin Z

更新日期：2005-02-01 00:00:00

abstract：:Aristolactams, having a phenanthrene chromophore are a small group of compounds mainly found in the Aristolochiaceae together with the aristolochic acids and 4,5-dioxoaporphines. In this report, these three important classes of natural products are reviewed and classified on the basis of their oxygenation pattern. In ...

journal_title：Natural product reports

authors： Kumar V,Poonam,Prasad AK,Parmar VS

更新日期：2003-12-01 00:00:00

abstract：:Blue flower colors are primarily due to anthocyanin, a flavonoid pigment. Anthocyanin itself is purple in neutral aqueous solutions, ans its color is very unstable and quickly fades. Therefore, the mechanism of blue color development in living flower petals is one of the most intriguing problems in natural product che...

journal_title：Natural product reports

authors： Yoshida K,Mori M,Kondo T

更新日期：2009-07-01 00:00:00

abstract：:This Viewpoint article provides a personal viewpoint of research in the area of fungal polyketide biosynthesis. It spans the period from the first applications and subsequent development of modern stable-isotope labelling methods, the isolation, sequencing and expression of PKS genes, biochemical and structural charac...

journal_title：Natural product reports

authors： Simpson TJ

更新日期：2014-10-01 00:00:00

abstract：:Covering: up to 2018 2-Oxoglutarate-dependent oxygenases (2ODOs) comprise a large enzyme superfamily in plant genomes, second in size only to the cytochromes P450 monooxygenase (CYP) superfamily. 2ODOs participate in both primary and specialized plant pathways, and their occurrence across all life kingdoms points to a...

journal_title：Natural product reports

authors： Hagel JM,Facchini PJ

更新日期：2018-08-15 00:00:00

abstract：:This review covers the recent marine chemical ecology literature for benthic cyanobacteria, macroalgae, sponges, octocorals, molluscs, other benthic invertebrates, fish and seabirds. ...

journal_title：Natural product reports

authors： Paul VJ,Ritson-Williams R

更新日期：2008-08-01 00:00:00

abstract：:A diverse array of secondary metabolites have been isolated and characterized from marine-derived fungi. The structures and biological activities of these metabolites are presented. Additionally, some basic principles of mycology are covered. Overall, 273 structures are presented and the review contains 162 references...

journal_title：Natural product reports

authors： Bugni TS,Ireland CM

更新日期：2004-02-01 00:00:00

abstract：:Covering: up to January 2017Cytochrome P450 enzymes (P450s) are some of the most exquisite and versatile biocatalysts found in nature. In addition to their well-known roles in steroid biosynthesis and drug metabolism in humans, P450s are key players in natural product biosynthetic pathways. Natural products, the most ...

journal_title：Natural product reports

authors： Rudolf JD,Chang CY,Ma M,Shen B

更新日期：2017-08-30 00:00:00

abstract：:Microorganisms and in particular actinomycetes and microfungi are known to produce a vast number of bioactive secondary metabolites. For industrially important fungal genera such as Penicillium and Aspergillus the production of these compounds has been demonstrated to be very consistent at the species level. This mean...

journal_title：Natural product reports

authors： Larsen TO,Smedsgaard J,Nielsen KF,Hansen ME,Frisvad JC

更新日期：2005-12-01 00:00:00

abstract：:A key property of metallo-proteins and -enzymes is the affinity of metal ion M for protein ligand P as defined by the dissociation constant KD = [M][P]/[MP]. Its accurate determination is essential for a quantitative understanding of metal selection and speciation. However, the surfaces of proteins are defined by the ...

journal_title：Natural product reports

authors： Xiao Z,Wedd AG

更新日期：2010-05-01 00:00:00

abstract：:From the basic export of unwanted metal ions in simple organisms to the complex orchestration of metal handling and usage in higher eukaryotes, cellular systems are based on a variety of molecular mechanisms that constrain the right metal to bind to the right protein partner at the right time when needed. A failure to...

journal_title：Natural product reports

authors： Banci L,Bertini I,McGreevy KS,Rosato A

更新日期：2010-05-01 00:00:00