The iboga enigma: the chemistry and neuropharmacology of iboga alkaloids and related analogs.

abstract：:A detailed overview is presented of recent total synthesis approaches to four different diterpenoids--the ginkgolides, tonantzitlolone, ingenol and eleutherobin. Due to their structural complexity, all pose major challenges for total synthesis, guaranteeing diverse strategic tours de force and a rich synthetic chemist...

journal_title：Natural product reports

authors： Busch T,Kirschning A

更新日期：2008-04-01 00:00:00

abstract：:In the recent past, macromolecular crystallography has gone through substantial methodological and technological development. The purpose of this review is to provide a general overview of structural biology and its impact on enzyme structure/function analysis and illustrate how it is modifying the focus of research r...

journal_title：Natural product reports

authors： Panjikar S,Stoeckigt J,O'Connor S,Warzecha H

更新日期：2012-10-01 00:00:00

abstract：:This Viewpoint article provides a personal viewpoint of research in the area of fungal polyketide biosynthesis. It spans the period from the first applications and subsequent development of modern stable-isotope labelling methods, the isolation, sequencing and expression of PKS genes, biochemical and structural charac...

journal_title：Natural product reports

authors： Simpson TJ

更新日期：2014-10-01 00:00:00

abstract：:This review article provides an overview on the current state of research in the area of microtubule-stabilizing agents from natural sources, with a primary focus on the biochemistry, biology, and pharmacology associated with these compounds. A variety of natural products have been discovered over the last decade to i...

journal_title：Natural product reports

authors： Altmann KH,Gertsch J

更新日期：2007-04-01 00:00:00

abstract：:Aristolactams, having a phenanthrene chromophore are a small group of compounds mainly found in the Aristolochiaceae together with the aristolochic acids and 4,5-dioxoaporphines. In this report, these three important classes of natural products are reviewed and classified on the basis of their oxygenation pattern. In ...

journal_title：Natural product reports

authors： Kumar V,Poonam,Prasad AK,Parmar VS

更新日期：2003-12-01 00:00:00

abstract：:This review covers the structure and function of heparin and heparan sulfate glycosaminoglycans. Their chemical structures are discussed, including recently developed methods for sequencing picomole to nanomole quantities of heparin- and heparan sulfate-derived oligosaccharides. The biosynthesis of heparin and heparan...

journal_title：Natural product reports

authors： Rabenstein DL

更新日期：2002-06-01 00:00:00

abstract：:Covering: up to February 2019Actinomycetes are Gram positive bacteria of the phylum Actinobacteria. These organisms are one of the most important sources of structurally diverse, clinically used antibiotics and other valuable bioactive products, as well as biotechnologically relevant enzymes. Most strains were discove...

journal_title：Natural product reports

authors： Musiol-Kroll EM,Tocchetti A,Sosio M,Stegmann E

更新日期：2019-09-01 00:00:00

abstract：:This review focuses on recent developments in the use of natural products as therapeutics for Alzheimer's disease. The compounds span a diverse array of structural classes and are organized according to their mechanism of action, with the focus primarily on the major hypotheses. Overall, the review discusses more than...

journal_title：Natural product reports

authors： Williams P,Sorribas A,Howes MJ

更新日期：2011-01-01 00:00:00

abstract：:This review discusses the biosynthesis of natural products that are generated by trans-AT polyketide synthases, a family of catalytically versatile enzymes that represents one of the major group of proteins involved in the production of bioactive polyketides. The article includes 609 references and covers the literatu...

journal_title：Natural product reports

authors： Helfrich EJ,Piel J

更新日期：2016-02-01 00:00:00

abstract：:Microorganisms and in particular actinomycetes and microfungi are known to produce a vast number of bioactive secondary metabolites. For industrially important fungal genera such as Penicillium and Aspergillus the production of these compounds has been demonstrated to be very consistent at the species level. This mean...

journal_title：Natural product reports

authors： Larsen TO,Smedsgaard J,Nielsen KF,Hansen ME,Frisvad JC

更新日期：2005-12-01 00:00:00

abstract：:Covering: Early 2008 until the end of 2019Microorganisms which survive (extreme-tolerant) or even prefer (extremophilic) living at the limits of pH, temperature, salinity and pressure found on earth have proven to be a rich source of novel structures. In this update we summarise the wide variety of new molecules which...

journal_title：Natural product reports

authors： Wilson ZE,Brimble MA

更新日期：2020-07-16 00:00:00

abstract：:The aim of the present review is to summarise the knowledge about newly isolated acetogenins (ACGs) in the last six years. It will also report the total syntheses that have allowed either the confirmation or the revision of some structures, together with the biological activities and mechanism of action of such intere...

journal_title：Natural product reports

authors： Bermejo A,Figadere B,Zafra-Polo MC,Barrachina I,Estornell E,Cortes D

更新日期：2005-04-01 00:00:00

abstract：:Covering: up to 2018 Ovothiols are sulfur-containing natural products biosynthesized by marine invertebrates, microalgae, and bacteria. These compounds are characterized by unique chemical properties suggestive of numerous cellular functions. For example, ovothiols may be cytoprotectants against oxidative stress, serv...

journal_title：Natural product reports

authors： Castellano I,Seebeck FP

更新日期：2018-12-12 00:00:00

abstract：:Blue flower colors are primarily due to anthocyanin, a flavonoid pigment. Anthocyanin itself is purple in neutral aqueous solutions, ans its color is very unstable and quickly fades. Therefore, the mechanism of blue color development in living flower petals is one of the most intriguing problems in natural product che...

journal_title：Natural product reports

authors： Yoshida K,Mori M,Kondo T

更新日期：2009-07-01 00:00:00

abstract：:The mangrove flora is a diverse group of salt-tolerant plants growing in tropical and subtropical intertidal estuarine zones. This review summarizes the source, chemistry and bioactivities of natural products from true mangrove species worldwide. It includes 349 metabolites and 150 references. The molecular phylogeny ...

journal_title：Natural product reports

authors： Wu J,Xiao Q,Xu J,Li MY,Pan JY,Yang MH

更新日期：2008-10-01 00:00:00

abstract：:Covering: up to 2019This review covers the current status of the quantum mechanical prediction of chiroptical properties, such as electronic CD and optical rotation, as needed for stereochemical assignments in new natural products. The reliability of the prediction of chiroptical properties is steadily increasing, wit...

journal_title：Natural product reports

authors： Grauso L,Teta R,Esposito G,Menna M,Mangoni A

更新日期：2019-07-01 00:00:00

abstract：:This review covers the recent marine chemical ecology literature for benthic cyanobacteria, macroalgae, sponges, octocorals, molluscs, other benthic invertebrates, fish and seabirds. ...

journal_title：Natural product reports

authors： Paul VJ,Ritson-Williams R

更新日期：2008-08-01 00:00:00

abstract：:Dinoflagellates produce unique polyketides characterized by their size and complexity. The biosynthesis of a limited number of such metabolites has been reported, with studies largely hampered by the low yield of compounds and the severe scrambling of label in the isotopically-labeled precursors. Nonetheless, of the s...

journal_title：Natural product reports

authors： Van Wagoner RM,Satake M,Wright JL

更新日期：2014-09-01 00:00:00

abstract：:Novel organic reactions drive the advance of chemical synthesis in the same way that enabling technologies drive new scientific discoveries. One area of organic methodology that has undergone significant growth during the last decade is that of homogeneous gold-catalyzed transformations. This trend has been further en...

journal_title：Natural product reports

authors： Zhang Y,Luo T,Yang Z

更新日期：2014-04-01 00:00:00

abstract：:This review covers the isolation and structure determination of triterpenoids reported during 2012 including squalene derivatives, lanostanes, holostanes, cycloartanes, cucurbitanes, dammaranes, euphanes, tirucallanes, tetranortriterpenoids, quassinoids, lupanes, oleananes, friedelanes, ursanes, hopanes, serratanes, i...

journal_title：Natural product reports

authors： Hill RA,Connolly JD

更新日期：2015-02-01 00:00:00

abstract：:Covering: up to 2013. Although holo-acyl carrier protein synthase, AcpS, a phosphopantetheinyl transferase (PPTase), was characterized in the 1960s, it was not until the publication of the landmark paper by Lambalot et al. in 1996 that PPTases garnered wide-spread attention being classified as a distinct enzyme superf...

journal_title：Natural product reports

authors： Beld J,Sonnenschein EC,Vickery CR,Noel JP,Burkart MD

更新日期：2014-01-01 00:00:00

abstract：:2,5-Disubstituted tetrahydrofurans constitute the core skeleton of several natural products and are pivotal synthetic analogues of medicinal importance that exhibit remarkable bioactivities. Oxasqualenoid natural products are implicated as potent biologically active molecules, particularly with regard to demonstrating...

journal_title：Natural product reports

authors： Sheikh NS

更新日期：2014-09-01 00:00:00

abstract：:Covering: up to early 2018 Polyketides and nonribosomal peptides are two major families of natural product with a broad range of biological activities. Polyketide synthases (PKSs) assemble small acetic acid-type acyl building blocks into polyketides through C-C bonds, and nonribosomal peptide synthetases (NRPSs) assem...

journal_title：Natural product reports

authors： Miyanaga A,Kudo F,Eguchi T

更新日期：2018-11-14 00:00:00

abstract：:This review covers the biosynthesis of aliphatic and aromatic polyketides as well as mixed polyketide/NRPS metabolites, and discusses the molecular genetics and enzymology of the proteins responsible for their formation. ...

journal_title：Natural product reports

authors： Hill AM

更新日期：2006-04-01 00:00:00

abstract：:Although natural products have been marginalized by major pharmaceutical companies over the last 20-30 years, the changing landscape of drug discovery now favors a greatly enhanced role for Nature's privileged structures. Screening for drug leads in phenotypic screens provides the best opportunity to realize the value...

journal_title：Natural product reports

authors： Carter GT

更新日期：2011-10-01 00:00:00

abstract：:In this study, the biological properties of natural abietane-type diterpenoids with an aromatic C ring are reviewed. An overview of the synthetic studies of this group of abietanes, including dehydroabietic acid, callitrisic acid and ferruginol, is presented. The review contains about 160 references. ...

journal_title：Natural product reports

authors： González MA

更新日期：2015-05-01 00:00:00

abstract：:Covering: 1997 to 2010. The angucycline group is the largest group of type II PKS-engineered natural products, rich in biological activities and chemical scaffolds. This stimulated synthetic creativity and biosynthetic inquisitiveness. The synthetic studies used five different strategies, involving Diels-Alder reactio...

journal_title：Natural product reports

authors： Kharel MK,Pahari P,Shepherd MD,Tibrewal N,Nybo SE,Shaaban KA,Rohr J

更新日期：2012-02-01 00:00:00

abstract：:Contact chemosensation, or tasting, is a complex process governed by nonvolatile phytochemicals that tell host-seeking insects whether they should accept or reject a plant. During this process, insect gustatory receptors (GRs) contribute to deciphering a host plant's metabolic code. GRs recognise many different classe...

journal_title：Natural product reports

authors： Pentzold S,Burse A,Boland W

更新日期：2017-05-10 00:00:00

abstract：:Covering: 1989 up to 2019 Ahp-cyclodepsipeptides (also known as Ahp-containing cyclodepsipeptides, cyanopeptolins, micropeptins, microginines, and lyngbyastatins, and by many other names) are a family of non-ribosomal peptide synthesis (NRPS)-derived natural products with potent serine protease inhibitory properties. ...

journal_title：Natural product reports

authors： Köcher S,Resch S,Kessenbrock T,Schrapp L,Ehrmann M,Kaiser M

更新日期：2020-02-26 00:00:00

abstract：:Oligo-, polysaccharides, and glycoconjugates are a relevant part of the bioactive components of the natural products exploited in therapeutics, diagnostics, food additives, and biomaterials. Glycans are directly involved in important biological processes, such as immunostimulation, anti-inflammatory, antioxidant, and ...

journal_title：Natural product reports

authors： Cobucci-Ponzano B,Moracci M

更新日期：2012-06-01 00:00:00