Abstract:
:Covering: 1997 to 2010. The angucycline group is the largest group of type II PKS-engineered natural products, rich in biological activities and chemical scaffolds. This stimulated synthetic creativity and biosynthetic inquisitiveness. The synthetic studies used five different strategies, involving Diels-Alder reactions, nucleophilic additions, electrophilic additions, transition-metal mediated cross-couplings and intramolecular cyclizations to generate the angucycline frames. Biosynthetic studies were particularly intriguing when unusual framework rearrangements by post-PKS tailoring oxidoreductases occurred, or when unusual glycosylation reactions were involved in decorating the benz[a]anthracene-derived cores. This review follows our previous reviews, which were published in 1992 and 1997, and covers new angucycline group antibiotics published between 1997 and 2010. However, in contrast to the previous reviews, the main focus of this article is on new synthetic approaches and biosynthetic investigations, most of which were published between 1997 and 2010, but go beyond, e.g. for some biosyntheses all the way back to the 1980s, to provide the necessary context of information.
journal_name
Nat Prod Repjournal_title
Natural product reportsauthors
Kharel MK,Pahari P,Shepherd MD,Tibrewal N,Nybo SE,Shaaban KA,Rohr Jdoi
10.1039/c1np00068csubject
Has Abstractpub_date
2012-02-01 00:00:00pages
264-325issue
2eissn
0265-0568issn
1460-4752journal_volume
29pub_type
杂志文章,评审abstract::Contact chemosensation, or tasting, is a complex process governed by nonvolatile phytochemicals that tell host-seeking insects whether they should accept or reject a plant. During this process, insect gustatory receptors (GRs) contribute to deciphering a host plant's metabolic code. GRs recognise many different classe...
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更新日期:2017-05-10 00:00:00
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更新日期:2009-04-01 00:00:00
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doi:10.1039/c5np00125k
更新日期:2016-02-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1039/b616808f
更新日期:2007-12-01 00:00:00
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更新日期:2004-10-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1039/c2np00066k
更新日期:2012-04-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1039/b906678k
更新日期:2010-05-01 00:00:00
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更新日期:2012-06-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1039/b301926h
更新日期:2004-02-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1039/b700206h
更新日期:2007-10-01 00:00:00
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doi:10.1039/c7np00023e
更新日期:2017-07-06 00:00:00
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pub_type: 杂志文章,评审
doi:10.1039/b814468k
更新日期:2009-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1039/b820413f
更新日期:2009-08-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1039/c3np70075e
更新日期:2014-04-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1039/b705652b
更新日期:2008-04-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1039/b513232k
更新日期:2007-02-01 00:00:00
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doi:10.1039/c0np00047g
更新日期:2011-06-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1039/c0np00024h
更新日期:2011-01-01 00:00:00
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doi:10.1039/c8np00067k
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doi:10.1039/c3np20111b
更新日期:2013-04-01 00:00:00
abstract::Covering up to December 2013. Oligosaccharide natural products target a wide spectrum of biological processes including disruption of cell wall biosynthesis, interference of bacterial translation, and inhibition of human α-amylase. Correspondingly, oligosaccharides possess the potential for development as treatments o...
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pub_type: 杂志文章,评审
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更新日期:2014-08-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2019-05-22 00:00:00
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更新日期:2014-04-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2008-02-01 00:00:00
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更新日期:2016-06-02 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2013-10-11 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2014-09-01 00:00:00