Toward the ideal synthesis and molecular function through synthesis-informed design.


:This Highlight describes factors that contribute to an ideal synthesis, including economies (step, time, atom, solvent, energy) and orientations (target, diversity, safety, function), and the role of synthesis-informed design directed at function in advancing synthesis and its impact on science.


Nat Prod Rep


Natural product reports


Wender PA




Has Abstract


2014-04-01 00:00:00












  • Biosynthesis and chemical diversity of β-lactone natural products.

    abstract::Covering: up to 2018 β-Lactones are strained rings that are useful organic synthons and pharmaceutical warheads. Over 30 core scaffolds of β-lactone natural products have been described to date, many with potent bioactivity against bacteria, fungi, or human cancer cell lines. β-Lactone natural products are chemically ...

    journal_title:Natural product reports

    pub_type: 杂志文章,评审


    authors: Robinson SL,Christenson JK,Wackett LP

    更新日期:2019-03-20 00:00:00

  • The challenges of determining metal-protein affinities.

    abstract::A key property of metallo-proteins and -enzymes is the affinity of metal ion M for protein ligand P as defined by the dissociation constant KD = [M][P]/[MP]. Its accurate determination is essential for a quantitative understanding of metal selection and speciation. However, the surfaces of proteins are defined by the ...

    journal_title:Natural product reports

    pub_type: 杂志文章,评审


    authors: Xiao Z,Wedd AG

    更新日期:2010-05-01 00:00:00

  • Natural products from true mangrove flora: source, chemistry and bioactivities.

    abstract::The mangrove flora is a diverse group of salt-tolerant plants growing in tropical and subtropical intertidal estuarine zones. This review summarizes the source, chemistry and bioactivities of natural products from true mangrove species worldwide. It includes 349 metabolites and 150 references. The molecular phylogeny ...

    journal_title:Natural product reports

    pub_type: 杂志文章,评审


    authors: Wu J,Xiao Q,Xu J,Li MY,Pan JY,Yang MH

    更新日期:2008-10-01 00:00:00

  • Synthetic endeavours towards oxasqualenoid natural products containing 2,5-disubstituted tetrahydrofurans--eurylene and teurilene.

    abstract::2,5-Disubstituted tetrahydrofurans constitute the core skeleton of several natural products and are pivotal synthetic analogues of medicinal importance that exhibit remarkable bioactivities. Oxasqualenoid natural products are implicated as potent biologically active molecules, particularly with regard to demonstrating...

    journal_title:Natural product reports

    pub_type: 杂志文章,评审


    authors: Sheikh NS

    更新日期:2014-09-01 00:00:00

  • Marine-derived fungi: a chemically and biologically diverse group of microorganisms.

    abstract::A diverse array of secondary metabolites have been isolated and characterized from marine-derived fungi. The structures and biological activities of these metabolites are presented. Additionally, some basic principles of mycology are covered. Overall, 273 structures are presented and the review contains 162 references...

    journal_title:Natural product reports

    pub_type: 杂志文章,评审


    authors: Bugni TS,Ireland CM

    更新日期:2004-02-01 00:00:00

  • The iboga enigma: the chemistry and neuropharmacology of iboga alkaloids and related analogs.

    abstract::Covering: 2000 up to 2020 Few classes of natural products have inspired as many chemists and biologists as have the iboga alkaloids. This family of monoterpenoid indole alkaloids includes the anti-addictive compound ibogaine as well as catharanthine, a precursor to the chemotherapeutic vinblastine. Despite being known...

    journal_title:Natural product reports

    pub_type: 杂志文章,评审


    authors: Iyer RN,Favela D,Zhang G,Olson DE

    更新日期:2020-08-14 00:00:00

  • The biosynthesis of adenosylcobalamin (vitamin B12).

    abstract::Vitamin B12, or cobalamin, is one of the most structurally complex small molecules made in Nature. Major progress has been made over the past decade in understanding how this synthesis is accomplished. This review covers some of the most important findings that have been made and provides the reader with a complete de...

    journal_title:Natural product reports

    pub_type: 杂志文章,评审


    authors: Warren MJ,Raux E,Schubert HL,Escalante-Semerena JC

    更新日期:2002-08-01 00:00:00

  • From dolastatin 13 to cyanopeptolins, micropeptins, and lyngbyastatins: the chemical biology of Ahp-cyclodepsipeptides.

    abstract::Covering: 1989 up to 2019 Ahp-cyclodepsipeptides (also known as Ahp-containing cyclodepsipeptides, cyanopeptolins, micropeptins, microginines, and lyngbyastatins, and by many other names) are a family of non-ribosomal peptide synthesis (NRPS)-derived natural products with potent serine protease inhibitory properties. ...

    journal_title:Natural product reports

    pub_type: 杂志文章,评审


    authors: Köcher S,Resch S,Kessenbrock T,Schrapp L,Ehrmann M,Kaiser M

    更新日期:2020-02-26 00:00:00

  • Recent advances of metabolic engineering strategies in natural isoprenoid production using cell factories.

    abstract::Covering: up to 2019As abundant natural products, isoprenoids have many useful industrial applications in the manufacturing of drugs, fragrances, food additives, colorants, rubber and advanced biofuels. The microbial production of isoprenoids has received much attention in recent years. Metabolic engineering approache...

    journal_title:Natural product reports

    pub_type: 杂志文章,评审


    authors: Li M,Hou F,Wu T,Jiang X,Li F,Liu H,Xian M,Zhang H

    更新日期:2020-01-01 00:00:00

  • Recent progress with microtubule stabilizers: new compounds, binding modes and cellular activities.

    abstract::Nature has yielded numerous classes of chemically distinct microtubule stabilizers. Several of these, including paclitaxel (Taxol) and docetaxel (Taxotere), are important drugs used in the treatment of cancer. New microtubule stabilizers and novel formulations of these agents continue to provide advances in cancer the...

    journal_title:Natural product reports

    pub_type: 杂志文章,评审


    authors: Rohena CC,Mooberry SL

    更新日期:2014-03-01 00:00:00

  • Some recent advances in the synthesis of polycyclic imidazole-containing marine natural products.

    abstract::This Highlight describes some of the recent synthetic work on imidazole-containing alkaloids isolated from marine sponges. Target molecules have been chosen which demonstrate synthetic strategies leading towards metabolites containing intact imidazole moieties as well as systems bearing modified imidazole rings. ...

    journal_title:Natural product reports

    pub_type: 杂志文章,评审


    authors: Weinreb SM

    更新日期:2007-10-01 00:00:00

  • Molecular recognition in copper trafficking.

    abstract::From the basic export of unwanted metal ions in simple organisms to the complex orchestration of metal handling and usage in higher eukaryotes, cellular systems are based on a variety of molecular mechanisms that constrain the right metal to bind to the right protein partner at the right time when needed. A failure to...

    journal_title:Natural product reports

    pub_type: 杂志文章,评审


    authors: Banci L,Bertini I,McGreevy KS,Rosato A

    更新日期:2010-05-01 00:00:00

  • Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function.

    abstract::Covering: up to January 2017Cytochrome P450 enzymes (P450s) are some of the most exquisite and versatile biocatalysts found in nature. In addition to their well-known roles in steroid biosynthesis and drug metabolism in humans, P450s are key players in natural product biosynthetic pathways. Natural products, the most ...

    journal_title:Natural product reports

    pub_type: 杂志文章,评审


    authors: Rudolf JD,Chang CY,Ma M,Shen B

    更新日期:2017-08-30 00:00:00

  • Protein-protein interactions in polyketide synthase-nonribosomal peptide synthetase hybrid assembly lines.

    abstract::Covering: up to early 2018 Polyketides and nonribosomal peptides are two major families of natural product with a broad range of biological activities. Polyketide synthases (PKSs) assemble small acetic acid-type acyl building blocks into polyketides through C-C bonds, and nonribosomal peptide synthetases (NRPSs) assem...

    journal_title:Natural product reports

    pub_type: 杂志文章,评审


    authors: Miyanaga A,Kudo F,Eguchi T

    更新日期:2018-11-14 00:00:00

  • Marine chemical ecology.

    abstract::This review covers the recent marine chemical ecology literature for benthic cyanobacteria, macroalgae, sponges, octocorals, molluscs, other benthic invertebrates, fish and seabirds. ...

    journal_title:Natural product reports

    pub_type: 杂志文章,评审


    authors: Paul VJ,Ritson-Williams R

    更新日期:2008-08-01 00:00:00

  • Naturally occurring aristolactams, aristolochic acids and dioxoaporphines and their biological activities.

    abstract::Aristolactams, having a phenanthrene chromophore are a small group of compounds mainly found in the Aristolochiaceae together with the aristolochic acids and 4,5-dioxoaporphines. In this report, these three important classes of natural products are reviewed and classified on the basis of their oxygenation pattern. In ...

    journal_title:Natural product reports

    pub_type: 杂志文章,评审


    authors: Kumar V,Poonam,Prasad AK,Parmar VS

    更新日期:2003-12-01 00:00:00

  • Bioactive oligosaccharide natural products.

    abstract::Covering up to December 2013. Oligosaccharide natural products target a wide spectrum of biological processes including disruption of cell wall biosynthesis, interference of bacterial translation, and inhibition of human α-amylase. Correspondingly, oligosaccharides possess the potential for development as treatments o...

    journal_title:Natural product reports

    pub_type: 杂志文章,评审


    authors: McCranie EK,Bachmann BO

    更新日期:2014-08-01 00:00:00

  • Indolizidine and quinolizidine alkaloids.

    abstract::This review covers the isolation, structure determination, synthesis, chemical transformations and biological activity of indolizidine and quinolizidine alkaloids. Included in the review are the hydroxylated indolizidines lentiginosine, swainsonine, castanospermine and their analogues; alkaloids from animal sources, i...

    journal_title:Natural product reports

    pub_type: 杂志文章,评审


    authors: Michael JP

    更新日期:2008-02-01 00:00:00

  • Expanding the roles for 2-oxoglutarate-dependent oxygenases in plant metabolism.

    abstract::Covering: up to 2018 2-Oxoglutarate-dependent oxygenases (2ODOs) comprise a large enzyme superfamily in plant genomes, second in size only to the cytochromes P450 monooxygenase (CYP) superfamily. 2ODOs participate in both primary and specialized plant pathways, and their occurrence across all life kingdoms points to a...

    journal_title:Natural product reports

    pub_type: 杂志文章,评审


    authors: Hagel JM,Facchini PJ

    更新日期:2018-08-15 00:00:00

  • Birch bark research and development.

    abstract::This review will detail progress made in the previous decade on the chemistry and bioactivity of birch bark extractive products. Current and future applications of birch bark natural products in pharmaceuticals, cosmetics, and dietary supplements for the prevention and treatment of cancer, HIV,and other human pathogen...

    journal_title:Natural product reports

    pub_type: 杂志文章,评审


    authors: Krasutsky PA

    更新日期:2006-12-01 00:00:00

  • Are highly morphed peptide frameworks lurking silently in microbial genomes valuable as next generation antibiotic scaffolds?

    abstract::Antibiotics are a therapeutic class that, once deployed, select for resistant bacterial pathogens and so shorten their useful life cycles. As a consequence new versions of antibiotics are constantly needed. Among the antibiotic natural products, morphed peptide scaffolds, converting conformationally mobile, short-live...

    journal_title:Natural product reports

    pub_type: 杂志文章,评审


    authors: Walsh CT

    更新日期:2017-07-01 00:00:00

  • Simple indole alkaloids and those with a nonrearranged monoterpenoid unit.

    abstract::This review covers the literature on simple indole alkaloids and those with a nonrearranged monoterpenoid unit from the beginning of 2012 up to the end of 2013, which includes newly isolated alkaloids, structure determinations, total syntheses and biological activities. ...

    journal_title:Natural product reports

    pub_type: 杂志文章,评审


    authors: Ishikura M,Abe T,Choshi T,Hibino S

    更新日期:2015-09-23 00:00:00

  • Meroterpenoids produced by fungi.

    abstract::This review deals with the isolation and structure elucidation of meroterpenoids (natural products of mixed biosynthetic origin which are partially derived from terpenoids) from higher and lower fungi, and discusses biosynthetic studies and biological activities as appropriate. It describes 333 fungal meroterpenoids a...

    journal_title:Natural product reports

    pub_type: 杂志文章,评审


    authors: Geris R,Simpson TJ

    更新日期:2009-08-01 00:00:00

  • The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life.

    abstract::Covering: up to 2013. Although holo-acyl carrier protein synthase, AcpS, a phosphopantetheinyl transferase (PPTase), was characterized in the 1960s, it was not until the publication of the landmark paper by Lambalot et al. in 1996 that PPTases garnered wide-spread attention being classified as a distinct enzyme superf...

    journal_title:Natural product reports

    pub_type: 杂志文章,评审


    authors: Beld J,Sonnenschein EC,Vickery CR,Noel JP,Burkart MD

    更新日期:2014-01-01 00:00:00

  • On ovothiol biosynthesis and biological roles: from life in the ocean to therapeutic potential.

    abstract::Covering: up to 2018 Ovothiols are sulfur-containing natural products biosynthesized by marine invertebrates, microalgae, and bacteria. These compounds are characterized by unique chemical properties suggestive of numerous cellular functions. For example, ovothiols may be cytoprotectants against oxidative stress, serv...

    journal_title:Natural product reports

    pub_type: 杂志文章,评审


    authors: Castellano I,Seebeck FP

    更新日期:2018-12-12 00:00:00

  • Biosynthesis of fungal meroterpenoids.

    abstract::Covering: up to September 2015. Meroterpenoids are hybrid natural products that partially originate from the terpenoid pathway. The meroterpenoids derived from fungi display quite diverse structures, with a wide range of biological properties. This review summarizes the molecular bases for their biosyntheses, which we...

    journal_title:Natural product reports

    pub_type: 杂志文章,评审


    authors: Matsuda Y,Abe I

    更新日期:2016-01-01 00:00:00

  • Biosynthesis of pantothenate.

    abstract::Pantothenate is an essential metabolite for all biological systems, however, the biosynthetic pathway is limited to plants, eubacteria and archaea. This suggests that the pathway is a strong candidate for the discovery of novel antibiotic and herbicidal compounds. The enzymology of this short pathway in both bacteria ...

    journal_title:Natural product reports

    pub_type: 杂志文章,评审


    authors: Webb ME,Smith AG,Abell C

    更新日期:2004-12-01 00:00:00

  • Ptaquiloside, the major toxin of bracken, and related terpene glycosides: chemistry, biology and ecology.

    abstract::Bracken (Pteridium spp.) is a ubiquitous fern which has been described as one of the five most common plants on the earth. The toxic effects of bracken on livestock have been recorded since the end of the 19th century, and extensive and intensive investigations for the bracken toxin(s) led to the isolation of ptaquilo...

    journal_title:Natural product reports

    pub_type: 杂志文章,评审


    authors: Yamada K,Ojika M,Kigoshi H

    更新日期:2007-08-01 00:00:00

  • Synthetic efforts toward cyathane diterpenoid natural products.

    abstract::Covering: 2000 to 2008. Previous review: D. L. Wright and C. R. Whitehead, Org. Prep. Proced. Int., 2000, 32, 309-330. An overview of synthetic efforts toward cyathane diterpenoid natural products from the year 2000 to present is provided. The emphasis of this review is the various ring-constructing and stereoforming ...

    journal_title:Natural product reports

    pub_type: 杂志文章,评审


    authors: Enquist JA Jr,Stoltz BM

    更新日期:2009-05-01 00:00:00

  • Aromatic abietane diterpenoids: their biological activity and synthesis.

    abstract::In this study, the biological properties of natural abietane-type diterpenoids with an aromatic C ring are reviewed. An overview of the synthetic studies of this group of abietanes, including dehydroabietic acid, callitrisic acid and ferruginol, is presented. The review contains about 160 references. ...

    journal_title:Natural product reports

    pub_type: 杂志文章,评审


    authors: González MA

    更新日期:2015-05-01 00:00:00