Abstract:
:In the recent past, macromolecular crystallography has gone through substantial methodological and technological development. The purpose of this review is to provide a general overview of structural biology and its impact on enzyme structure/function analysis and illustrate how it is modifying the focus of research relevant to alkaloid biosynthesis.
journal_name
Nat Prod Repjournal_title
Natural product reportsauthors
Panjikar S,Stoeckigt J,O'Connor S,Warzecha Hdoi
10.1039/c2np20057ksubject
Has Abstractpub_date
2012-10-01 00:00:00pages
1176-200issue
10eissn
0265-0568issn
1460-4752journal_volume
29pub_type
杂志文章,评审abstract::Covering: up to 2018 β-Lactones are strained rings that are useful organic synthons and pharmaceutical warheads. Over 30 core scaffolds of β-lactone natural products have been described to date, many with potent bioactivity against bacteria, fungi, or human cancer cell lines. β-Lactone natural products are chemically ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c8np00052b
更新日期:2019-03-20 00:00:00
abstract::A key property of metallo-proteins and -enzymes is the affinity of metal ion M for protein ligand P as defined by the dissociation constant KD = [M][P]/[MP]. Its accurate determination is essential for a quantitative understanding of metal selection and speciation. However, the surfaces of proteins are defined by the ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b906690j
更新日期:2010-05-01 00:00:00
abstract::Covering: up to 2019This review covers the current status of the quantum mechanical prediction of chiroptical properties, such as electronic CD and optical rotation, as needed for stereochemical assignments in new natural products. The reliability of the prediction of chiroptical properties is steadily increasing, wit...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c9np00018f
更新日期:2019-07-01 00:00:00
abstract::The biosynthesis of peptidoglycan is essential for all bacteria and has no counterpart in eukaryotic cells. It is one of the prime targets for antibiotic chemotherapy, especially phospho-MurNAc-pentapeptide translocase (translocase I) is a fascinating target in which there is no commercial antibiotic. In this review w...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b202149h
更新日期:2003-04-01 00:00:00
abstract::Covering: 1958 to June 2018 Phenyl-γ-valerolactones (PVLs) and their related phenylvaleric acids (PVAs) are the main metabolites of flavan-3-ols, the major class of flavonoids in the human diet. Despite their presumed importance, these gut microbiota-derived compounds have, to date, in terms of biological activity, be...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c8np00062j
更新日期:2019-05-22 00:00:00
abstract::Covering: July 2012 to December 2019Over the last seven years, expanding research efforts focused on sesterterpenoids has led to the isolation, identification, and characterization of numerous structurally novel and biologically active sesterterpenoids. These newly reported sesterterpenoids provide diverse structures ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/d0np00070a
更新日期:2020-12-22 00:00:00
abstract::This review covers the literature on simple indole alkaloids and those with a nonrearranged monoterpenoid unit from the beginning of 2012 up to the end of 2013, which includes newly isolated alkaloids, structure determinations, total syntheses and biological activities. ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c5np00032g
更新日期:2015-09-23 00:00:00
abstract::This Viewpoint article provides a personal viewpoint of research in the area of fungal polyketide biosynthesis. It spans the period from the first applications and subsequent development of modern stable-isotope labelling methods, the isolation, sequencing and expression of PKS genes, biochemical and structural charac...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c4np00065j
更新日期:2014-10-01 00:00:00
abstract::Covering: up to the end of 2018 Piperazic acid is a cyclic hydrazine and a non-proteinogenic amino acid found in diverse non-ribosomal peptide (NRP) and hybrid NRP-polyketide (PK) structures. Piperazic acid was first identified as a residue in the monamycins in 1959. Since then, the piperazic acid residue has been fou...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c8np00076j
更新日期:2019-12-11 00:00:00
abstract::Covering: up to January 2017Cytochrome P450 enzymes (P450s) are some of the most exquisite and versatile biocatalysts found in nature. In addition to their well-known roles in steroid biosynthesis and drug metabolism in humans, P450s are key players in natural product biosynthetic pathways. Natural products, the most ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c7np00034k
更新日期:2017-08-30 00:00:00
abstract::Covering: up to early 2018 The Nonribosomal Peptide Synthetases (NRPSs) and Polyketide Synthases (PKSs) are families of modular enzymes that produce a tremendous diversity of natural products, with antibacterial, antifungal, immunosuppressive, and anticancer activities. Both enzymes utilize a fascinating modular archi...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c8np00044a
更新日期:2018-11-14 00:00:00
abstract::This review will detail progress made in the previous decade on the chemistry and bioactivity of birch bark extractive products. Current and future applications of birch bark natural products in pharmaceuticals, cosmetics, and dietary supplements for the prevention and treatment of cancer, HIV,and other human pathogen...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b606816b
更新日期:2006-12-01 00:00:00
abstract::In this study, the biological properties of natural abietane-type diterpenoids with an aromatic C ring are reviewed. An overview of the synthetic studies of this group of abietanes, including dehydroabietic acid, callitrisic acid and ferruginol, is presented. The review contains about 160 references. ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c4np00110a
更新日期:2015-05-01 00:00:00
abstract::This review discusses the biosynthesis of natural products that are generated by trans-AT polyketide synthases, a family of catalytically versatile enzymes that represents one of the major group of proteins involved in the production of bioactive polyketides. The article includes 609 references and covers the literatu...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c5np00125k
更新日期:2016-02-01 00:00:00
abstract::This review covers the biosynthesis of aliphatic and aromatic polyketides as well as mixed polyketide/NRPS metabolites, and discusses the molecular genetics and enzymology of the proteins responsible for their formation. ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b301028g
更新日期:2006-04-01 00:00:00
abstract::Blue flower colors are primarily due to anthocyanin, a flavonoid pigment. Anthocyanin itself is purple in neutral aqueous solutions, ans its color is very unstable and quickly fades. Therefore, the mechanism of blue color development in living flower petals is one of the most intriguing problems in natural product che...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b800165k
更新日期:2009-07-01 00:00:00
abstract::This review covers the structure and function of heparin and heparan sulfate glycosaminoglycans. Their chemical structures are discussed, including recently developed methods for sequencing picomole to nanomole quantities of heparin- and heparan sulfate-derived oligosaccharides. The biosynthesis of heparin and heparan...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b100916h
更新日期:2002-06-01 00:00:00
abstract::Covering: up to June 2018 Understanding the biosynthetic mechanisms that generate the astounding structural complexity and variety of fungal secondary metabolites (FSMs) remains a challenge. As an example, the biogenesis of the Monascus azaphilone pigments (MonAzPs) has remained obscure until recently despite the sign...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c8np00060c
更新日期:2019-04-17 00:00:00
abstract::Discovering molecular components and their functionality is key to the development of hypotheses concerning the organization and regulation of metabolic networks. The iterative experimental testing of such hypotheses is the trajectory that can ultimately enable accurate computational modelling and prediction of metabo...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c3np20111b
更新日期:2013-04-01 00:00:00
abstract::Covering: 2008 to 2016The total synthesis of natural products and their derivatives continues to inspire organic chemists to identify and test new synthetic strategies and develop and explore novel methodology. In recent years, visible light photoredox catalysis has risen to prominence as a powerful technology that en...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c6np00070c
更新日期:2016-10-26 00:00:00
abstract::Covering: up to 2017This review covers the biosynthetic and evolutionary aspects of lincosamide antibiotics, antitumour pyrrolobenzodiazepines (PBDs) and the quorum-sensing molecule hormaomycin. These structurally and functionally diverse groups of complex natural products all incorporate rarely occurring 4-alkyl-l-pr...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c7np00047b
更新日期:2018-03-01 00:00:00
abstract::This review deals with the isolation and structure elucidation of meroterpenoids (natural products of mixed biosynthetic origin which are partially derived from terpenoids) from higher and lower fungi, and discusses biosynthetic studies and biological activities as appropriate. It describes 333 fungal meroterpenoids a...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b820413f
更新日期:2009-08-01 00:00:00
abstract::Covering: up to 2013. Although holo-acyl carrier protein synthase, AcpS, a phosphopantetheinyl transferase (PPTase), was characterized in the 1960s, it was not until the publication of the landmark paper by Lambalot et al. in 1996 that PPTases garnered wide-spread attention being classified as a distinct enzyme superf...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c3np70054b
更新日期:2014-01-01 00:00:00
abstract::Fungi have emerged worldwide as increasingly frequent causes of healthcare-associated infections, but fungal infections have generally been considered curable, and thus the demand for new antifungal agents has been very low. Although superficial fungal infections of the skin and nails are common and are for the most p...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b914961a
更新日期:2010-07-01 00:00:00
abstract::Aristolactams, having a phenanthrene chromophore are a small group of compounds mainly found in the Aristolochiaceae together with the aristolochic acids and 4,5-dioxoaporphines. In this report, these three important classes of natural products are reviewed and classified on the basis of their oxygenation pattern. In ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b303648k
更新日期:2003-12-01 00:00:00
abstract::The article reviews the progress in the chemistry of the steroids that was published between January and December, 2001. The reactions and partial syntheses of estrogens, androgens, pregnanes, cholic acid derivatives, cholestanes and vitamin D analogues are covered. There are 184 references. ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b212061p
更新日期:2003-06-01 00:00:00
abstract::Vitamin B12, or cobalamin, is one of the most structurally complex small molecules made in Nature. Major progress has been made over the past decade in understanding how this synthesis is accomplished. This review covers some of the most important findings that have been made and provides the reader with a complete de...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b108967f
更新日期:2002-08-01 00:00:00
abstract::Covering: Early 2008 until the end of 2019Microorganisms which survive (extreme-tolerant) or even prefer (extremophilic) living at the limits of pH, temperature, salinity and pressure found on earth have proven to be a rich source of novel structures. In this update we summarise the wide variety of new molecules which...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/d0np00021c
更新日期:2020-07-16 00:00:00
abstract::Bracken (Pteridium spp.) is a ubiquitous fern which has been described as one of the five most common plants on the earth. The toxic effects of bracken on livestock have been recorded since the end of the 19th century, and extensive and intensive investigations for the bracken toxin(s) led to the isolation of ptaquilo...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b614160a
更新日期:2007-08-01 00:00:00
abstract::The mangrove flora is a diverse group of salt-tolerant plants growing in tropical and subtropical intertidal estuarine zones. This review summarizes the source, chemistry and bioactivities of natural products from true mangrove species worldwide. It includes 349 metabolites and 150 references. The molecular phylogeny ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b807365a
更新日期:2008-10-01 00:00:00