Abstract:
:Covering: 1989 up to 2019 Ahp-cyclodepsipeptides (also known as Ahp-containing cyclodepsipeptides, cyanopeptolins, micropeptins, microginines, and lyngbyastatins, and by many other names) are a family of non-ribosomal peptide synthesis (NRPS)-derived natural products with potent serine protease inhibitory properties. Here, we review their isolation and structural elucidation from natural sources as well as studies of their biosynthesis, molecular mode of action, and use in drug discovery efforts. Accordingly, this summary aims to provide a comprehensive overview of the current state-of-the-art Ahp-cyclodepsipeptide research.
journal_name
Nat Prod Repjournal_title
Natural product reportsauthors
Köcher S,Resch S,Kessenbrock T,Schrapp L,Ehrmann M,Kaiser Mdoi
10.1039/c9np00033jsubject
Has Abstractpub_date
2020-02-26 00:00:00pages
163-174issue
2eissn
0265-0568issn
1460-4752journal_volume
37pub_type
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