Abstract:
:Covering: 2011-2017Radical cyclizations have a rich history in organic chemistry and have been particularly generous to the field of natural product synthesis. Owing to their ability to operate in highly congested molecular quarters, and with significant functional group compatibility, these transformations have enabled the synthesis of numerous polycyclic terpenoid natural products over the past several decades. Moreover, when programmed accordingly into a synthetic plan, radical cascade processes can be used to rapidly assemble molecular complexity, much in the same way nature rapidly constructs terpene frameworks through cationic cyclization pathways. This review highlights recent total syntheses of complex terpenoids (from 2011-2017) employing C-C bond-forming radical cascade sequences.
journal_name
Nat Prod Repjournal_title
Natural product reportsauthors
Hung K,Hu X,Maimone TJdoi
10.1039/c7np00065ksubject
Has Abstractpub_date
2018-02-21 00:00:00pages
174-202issue
2eissn
0265-0568issn
1460-4752journal_volume
35pub_type
杂志文章,评审abstract::Novel organic reactions drive the advance of chemical synthesis in the same way that enabling technologies drive new scientific discoveries. One area of organic methodology that has undergone significant growth during the last decade is that of homogeneous gold-catalyzed transformations. This trend has been further en...
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更新日期:2002-02-01 00:00:00
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doi:10.1039/c8np00045j
更新日期:2018-12-12 00:00:00
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pub_type: 杂志文章,评审
doi:10.1039/c2np00066k
更新日期:2012-04-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1039/c0np00024h
更新日期:2011-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1039/c0np00047g
更新日期:2011-06-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2017-05-10 00:00:00
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pub_type: 杂志文章,评审
doi:10.1039/c0np00027b
更新日期:2011-01-01 00:00:00
abstract::Oligo-, polysaccharides, and glycoconjugates are a relevant part of the bioactive components of the natural products exploited in therapeutics, diagnostics, food additives, and biomaterials. Glycans are directly involved in important biological processes, such as immunostimulation, anti-inflammatory, antioxidant, and ...
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pub_type: 杂志文章,评审
doi:10.1039/c2np20032e
更新日期:2012-06-01 00:00:00
abstract::This review covers the literature on simple indole alkaloids and those with a nonrearranged monoterpenoid unit from the beginning of 2012 up to the end of 2013, which includes newly isolated alkaloids, structure determinations, total syntheses and biological activities. ...
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pub_type: 杂志文章,评审
doi:10.1039/c5np00032g
更新日期:2015-09-23 00:00:00
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pub_type: 杂志文章,评审
doi:10.1039/b606816b
更新日期:2006-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2020-08-14 00:00:00
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更新日期:2020-05-01 00:00:00
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pub_type: 杂志文章,评审
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abstract::2,5-Disubstituted tetrahydrofurans constitute the core skeleton of several natural products and are pivotal synthetic analogues of medicinal importance that exhibit remarkable bioactivities. Oxasqualenoid natural products are implicated as potent biologically active molecules, particularly with regard to demonstrating...
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更新日期:2014-09-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1039/b316419p
更新日期:2004-12-01 00:00:00
abstract::Covering: up to the end of 2015.Peptides are naturally occurring compounds that play an important role in all living systems and are responsible for a range of essential functions. Peptide receptors have been implicated in disease states such as oncology, metabolic disorders and cardiovascular disease. Therefore, natu...
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pub_type: 杂志文章,评审
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更新日期:2016-06-02 00:00:00
abstract::Covering: 1972 to 2011. This review covers the literature of prenylated quinone, hydroquinone and naphthoquinone marine natural products with reported cytotoxic and/or antioxidant properties. The structures, biological activity and, where applicable, the syntheses of 159 cytotoxic/antioxidant compounds, isolated from ...
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pub_type: 杂志文章,评审
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abstract::This review covers the isolation and structure determination of triterpenoids reported during 2012 including squalene derivatives, lanostanes, holostanes, cycloartanes, cucurbitanes, dammaranes, euphanes, tirucallanes, tetranortriterpenoids, quassinoids, lupanes, oleananes, friedelanes, ursanes, hopanes, serratanes, i...
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更新日期:2015-02-01 00:00:00