Naturally-occurring nitro compounds.

abstract：:Covering: up to 2018 Ovothiols are sulfur-containing natural products biosynthesized by marine invertebrates, microalgae, and bacteria. These compounds are characterized by unique chemical properties suggestive of numerous cellular functions. For example, ovothiols may be cytoprotectants against oxidative stress, serv...

journal_title：Natural product reports

authors： Castellano I,Seebeck FP

更新日期：2018-12-12 00:00:00

abstract：:Discovering molecular components and their functionality is key to the development of hypotheses concerning the organization and regulation of metabolic networks. The iterative experimental testing of such hypotheses is the trajectory that can ultimately enable accurate computational modelling and prediction of metabo...

journal_title：Natural product reports

authors： Hur M,Campbell AA,Almeida-de-Macedo M,Li L,Ransom N,Jose A,Crispin M,Nikolau BJ,Wurtele ES

更新日期：2013-04-01 00:00:00

abstract：:Covering: July 2012 to December 2019Over the last seven years, expanding research efforts focused on sesterterpenoids has led to the isolation, identification, and characterization of numerous structurally novel and biologically active sesterterpenoids. These newly reported sesterterpenoids provide diverse structures ...

journal_title：Natural product reports

authors： Li K,Gustafson KR

更新日期：2020-12-22 00:00:00

abstract：:This review covers the structure and function of heparin and heparan sulfate glycosaminoglycans. Their chemical structures are discussed, including recently developed methods for sequencing picomole to nanomole quantities of heparin- and heparan sulfate-derived oligosaccharides. The biosynthesis of heparin and heparan...

journal_title：Natural product reports

authors： Rabenstein DL

更新日期：2002-06-01 00:00:00

abstract：:Nature has yielded numerous classes of chemically distinct microtubule stabilizers. Several of these, including paclitaxel (Taxol) and docetaxel (Taxotere), are important drugs used in the treatment of cancer. New microtubule stabilizers and novel formulations of these agents continue to provide advances in cancer the...

journal_title：Natural product reports

authors： Rohena CC,Mooberry SL

更新日期：2014-03-01 00:00:00

abstract：:Oligo-, polysaccharides, and glycoconjugates are a relevant part of the bioactive components of the natural products exploited in therapeutics, diagnostics, food additives, and biomaterials. Glycans are directly involved in important biological processes, such as immunostimulation, anti-inflammatory, antioxidant, and ...

journal_title：Natural product reports

authors： Cobucci-Ponzano B,Moracci M

更新日期：2012-06-01 00:00:00

abstract：:Covering: 1997 to 2010. The angucycline group is the largest group of type II PKS-engineered natural products, rich in biological activities and chemical scaffolds. This stimulated synthetic creativity and biosynthetic inquisitiveness. The synthetic studies used five different strategies, involving Diels-Alder reactio...

journal_title：Natural product reports

authors： Kharel MK,Pahari P,Shepherd MD,Tibrewal N,Nybo SE,Shaaban KA,Rohr J

更新日期：2012-02-01 00:00:00

abstract：:From the basic export of unwanted metal ions in simple organisms to the complex orchestration of metal handling and usage in higher eukaryotes, cellular systems are based on a variety of molecular mechanisms that constrain the right metal to bind to the right protein partner at the right time when needed. A failure to...

journal_title：Natural product reports

authors： Banci L,Bertini I,McGreevy KS,Rosato A

更新日期：2010-05-01 00:00:00

abstract：:Covering: 2008 to 2016The total synthesis of natural products and their derivatives continues to inspire organic chemists to identify and test new synthetic strategies and develop and explore novel methodology. In recent years, visible light photoredox catalysis has risen to prominence as a powerful technology that en...

journal_title：Natural product reports

authors： Nicholls TP,Leonori D,Bissember AC

更新日期：2016-10-26 00:00:00

abstract：:The cyclic depsipeptide largazole from a cyanobacterium of the genus Symploca is a marine natural product with a novel chemical scaffold and potently inhibits class I histone deacetylases (HDACs). Largazole possesses highly differential growth-inhibitory activity, preferentially targeting transformed over non-transfor...

journal_title：Natural product reports

authors： Hong J,Luesch H

更新日期：2012-04-01 00:00:00

abstract：:Silybin, a secondary metabolite isolated from the seeds of the blessed milk thistle (Silybum marianum) was discovered as the first member of a new family of natural compounds called flavonolignans in 1959. Over the years it has received the research attention of many organic chemists. This research has resulted in a n...

journal_title：Natural product reports

authors： Biedermann D,Vavříková E,Cvak L,Křen V

更新日期：2014-09-01 00:00:00

abstract：:Microorganisms and in particular actinomycetes and microfungi are known to produce a vast number of bioactive secondary metabolites. For industrially important fungal genera such as Penicillium and Aspergillus the production of these compounds has been demonstrated to be very consistent at the species level. This mean...

journal_title：Natural product reports

authors： Larsen TO,Smedsgaard J,Nielsen KF,Hansen ME,Frisvad JC

更新日期：2005-12-01 00:00:00

abstract：:This review covers the recent marine chemical ecology literature for benthic cyanobacteria, macroalgae, sponges, octocorals, molluscs, other benthic invertebrates, fish and seabirds. ...

journal_title：Natural product reports

authors： Paul VJ,Ritson-Williams R

更新日期：2008-08-01 00:00:00

abstract：:This review covers the isolation and structure determination of triterpenoids reported during 2012 including squalene derivatives, lanostanes, holostanes, cycloartanes, cucurbitanes, dammaranes, euphanes, tirucallanes, tetranortriterpenoids, quassinoids, lupanes, oleananes, friedelanes, ursanes, hopanes, serratanes, i...

journal_title：Natural product reports

authors： Hill RA,Connolly JD

更新日期：2015-02-01 00:00:00

abstract：:Covering: up to June 2018 Understanding the biosynthetic mechanisms that generate the astounding structural complexity and variety of fungal secondary metabolites (FSMs) remains a challenge. As an example, the biogenesis of the Monascus azaphilone pigments (MonAzPs) has remained obscure until recently despite the sign...

journal_title：Natural product reports

authors： Chen W,Feng Y,Molnár I,Chen F

更新日期：2019-04-17 00:00:00

abstract：:Covering: up to 2018 The Haemodoraceae family is a monocotyledonous family in the order Commelinales consisting of 14 genera. Many species from the family are endemic to Australia and their use by the Aboriginal People of Australia as both pigments or remedies has been ethnobotanically documented. Phenylphenalenones a...

journal_title：Natural product reports

authors： Norman EO,Lever J,Brkljača R,Urban S

更新日期：2019-05-22 00:00:00

abstract：:The aim of the present review is to summarise the knowledge about newly isolated acetogenins (ACGs) in the last six years. It will also report the total syntheses that have allowed either the confirmation or the revision of some structures, together with the biological activities and mechanism of action of such intere...

journal_title：Natural product reports

authors： Bermejo A,Figadere B,Zafra-Polo MC,Barrachina I,Estornell E,Cortes D

更新日期：2005-04-01 00:00:00

abstract：:This review covers the biosynthesis of aliphatic and aromatic polyketides as well as mixed polyketide/NRPS metabolites, and discusses the molecular genetics and enzymology of the proteins responsible for their formation. ...

journal_title：Natural product reports

authors： Hill AM

更新日期：2006-04-01 00:00:00

abstract：:Covering: 1958 to June 2018 Phenyl-γ-valerolactones (PVLs) and their related phenylvaleric acids (PVAs) are the main metabolites of flavan-3-ols, the major class of flavonoids in the human diet. Despite their presumed importance, these gut microbiota-derived compounds have, to date, in terms of biological activity, be...

journal_title：Natural product reports

authors： Mena P,Bresciani L,Brindani N,Ludwig IA,Pereira-Caro G,Angelino D,Llorach R,Calani L,Brighenti F,Clifford MN,Gill CIR,Crozier A,Curti C,Del Rio D

更新日期：2019-05-22 00:00:00

abstract：:Natural products have evolved, at least in part, to bind to biological macromolecules, particularly proteins. As a result, natural products are able to interact with many specific targets within the cell. Indeed for many years this has been central in the drug development process. Today, however, natural products are ...

journal_title：Natural product reports

authors： Dixon N,Wong LS,Geerlings TH,Micklefield J

更新日期：2007-12-01 00:00:00

abstract：:Covering: up to 2019As abundant natural products, isoprenoids have many useful industrial applications in the manufacturing of drugs, fragrances, food additives, colorants, rubber and advanced biofuels. The microbial production of isoprenoids has received much attention in recent years. Metabolic engineering approache...

journal_title：Natural product reports

authors： Li M,Hou F,Wu T,Jiang X,Li F,Liu H,Xian M,Zhang H

更新日期：2020-01-01 00:00:00

abstract：:The diastereoselective addition of organometallic reagents to α-chloroaldehydes was first reported in 1959 and occupies a historically significant role as the prototypical reaction for Cornforth's model of stereoinduction. Despite clear synthetic potential for these reagents, difficulties associated with producing ena...

journal_title：Natural product reports

authors： Britton R,Kang B

更新日期：2013-02-01 00:00:00

abstract：:This review covers the morphology, isolation, total synthesis and biological activity of the naturally occurring alkaloids isolated from the Amaryllidaceae family, as well as the structurally related Sceletium alkaloids. ...

journal_title：Natural product reports

authors： Jin Z

更新日期：2005-02-01 00:00:00

abstract：:This review deals with the isolation and structure elucidation of meroterpenoids (natural products of mixed biosynthetic origin which are partially derived from terpenoids) from higher and lower fungi, and discusses biosynthetic studies and biological activities as appropriate. It describes 333 fungal meroterpenoids a...

journal_title：Natural product reports

authors： Geris R,Simpson TJ

更新日期：2009-08-01 00:00:00

abstract：:The article reviews the progress in the chemistry of the steroids that was published between January and December, 2001. The reactions and partial syntheses of estrogens, androgens, pregnanes, cholic acid derivatives, cholestanes and vitamin D analogues are covered. There are 184 references. ...

journal_title：Natural product reports

authors： Hanson JR

更新日期：2003-06-01 00:00:00

abstract：:A detailed overview is presented of recent total synthesis approaches to four different diterpenoids--the ginkgolides, tonantzitlolone, ingenol and eleutherobin. Due to their structural complexity, all pose major challenges for total synthesis, guaranteeing diverse strategic tours de force and a rich synthetic chemist...

journal_title：Natural product reports

authors： Busch T,Kirschning A

更新日期：2008-04-01 00:00:00

abstract：:This Highlight describes synthetic methods that have enabled new strategic approaches to the synthesis of natural product targets as well as libraries of compounds for unbiased screening experiments. The structural differences of the compounds produced by both efforts are illustrated. ...

journal_title：Natural product reports

authors： Shaw JT

更新日期：2009-01-01 00:00:00

abstract：:Covering: up to January 2017Cytochrome P450 enzymes (P450s) are some of the most exquisite and versatile biocatalysts found in nature. In addition to their well-known roles in steroid biosynthesis and drug metabolism in humans, P450s are key players in natural product biosynthetic pathways. Natural products, the most ...

journal_title：Natural product reports

authors： Rudolf JD,Chang CY,Ma M,Shen B

更新日期：2017-08-30 00:00:00

abstract：:Covering: 1972 to 2011. This review covers the literature of prenylated quinone, hydroquinone and naphthoquinone marine natural products with reported cytotoxic and/or antioxidant properties. The structures, biological activity and, where applicable, the syntheses of 159 cytotoxic/antioxidant compounds, isolated from ...

journal_title：Natural product reports

authors： Sunassee SN,Davies-Coleman MT

更新日期：2012-05-01 00:00:00

abstract：:Covering: 1947-early 2017, particularly from 2005-early 2017The rise of bacterial pathogens with acquired resistance to almost all available antibiotics is becoming a serious public health issue. Polymyxins, antibiotics that were mostly abandoned a few decades ago because of toxicity concerns, are ultimately considere...

journal_title：Natural product reports

authors： Rabanal F,Cajal Y

更新日期：2017-07-06 00:00:00