Phenotypic taxonomy and metabolite profiling in microbial drug discovery.

Abstract:

:Microorganisms and in particular actinomycetes and microfungi are known to produce a vast number of bioactive secondary metabolites. For industrially important fungal genera such as Penicillium and Aspergillus the production of these compounds has been demonstrated to be very consistent at the species level. This means that direct metabolite profiling techniques such as direct injection mass spectrometry or NMR can easily be used for chemotyping/metabolomics of strains from both culture collections and natural samples using modern informatics tools. In this review we discuss chemotyping/metabolomics as part of intelligent screening and highlight how it can be used for identification and classification of filamentous fungi and for the discovery of novel compounds when used in combination with modern methods for dereplication. In our opinion such approaches will be important for future effective drug discovery strategies, especially for dereplication of culture collections in order to avoid redundancy in the selection of species. This will maximize the chemical diversity of the microbial natural product libraries that can be generated from fungal collections.

journal_name

Nat Prod Rep

journal_title

Natural product reports

authors

Larsen TO,Smedsgaard J,Nielsen KF,Hansen ME,Frisvad JC

doi

10.1039/b404943h

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

672-95

issue

6

eissn

0265-0568

issn

1460-4752

journal_volume

22

pub_type

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