Abstract:
:Phytotoxic compounds produced by plant pathogens are often crucial determinants of plant disease. Knowledge of them provides insights into disease syndromes and may be exploited by conventional breeding and biotechnology to obtain resistant crops.
journal_name
Nat Prod Repjournal_title
Natural product reportsauthors
Strange RNdoi
10.1039/b513232ksubject
Has Abstractpub_date
2007-02-01 00:00:00pages
127-44issue
1eissn
0265-0568issn
1460-4752journal_volume
24pub_type
杂志文章,评审abstract::A key property of metallo-proteins and -enzymes is the affinity of metal ion M for protein ligand P as defined by the dissociation constant KD = [M][P]/[MP]. Its accurate determination is essential for a quantitative understanding of metal selection and speciation. However, the surfaces of proteins are defined by the ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b906690j
更新日期:2010-05-01 00:00:00
abstract::Discovering molecular components and their functionality is key to the development of hypotheses concerning the organization and regulation of metabolic networks. The iterative experimental testing of such hypotheses is the trajectory that can ultimately enable accurate computational modelling and prediction of metabo...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c3np20111b
更新日期:2013-04-01 00:00:00
abstract::This Highlight describes some of the recent synthetic work on imidazole-containing alkaloids isolated from marine sponges. Target molecules have been chosen which demonstrate synthetic strategies leading towards metabolites containing intact imidazole moieties as well as systems bearing modified imidazole rings. ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b700206h
更新日期:2007-10-01 00:00:00
abstract::Dinoflagellates produce unique polyketides characterized by their size and complexity. The biosynthesis of a limited number of such metabolites has been reported, with studies largely hampered by the low yield of compounds and the severe scrambling of label in the isotopically-labeled precursors. Nonetheless, of the s...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c4np00016a
更新日期:2014-09-01 00:00:00
abstract::2,5-Disubstituted tetrahydrofurans constitute the core skeleton of several natural products and are pivotal synthetic analogues of medicinal importance that exhibit remarkable bioactivities. Oxasqualenoid natural products are implicated as potent biologically active molecules, particularly with regard to demonstrating...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c4np00029c
更新日期:2014-09-01 00:00:00
abstract::The aim of the present review is to summarise the knowledge about newly isolated acetogenins (ACGs) in the last six years. It will also report the total syntheses that have allowed either the confirmation or the revision of some structures, together with the biological activities and mechanism of action of such intere...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b500186m
更新日期:2005-04-01 00:00:00
abstract::Covering: 1989 up to 2019 Ahp-cyclodepsipeptides (also known as Ahp-containing cyclodepsipeptides, cyanopeptolins, micropeptins, microginines, and lyngbyastatins, and by many other names) are a family of non-ribosomal peptide synthesis (NRPS)-derived natural products with potent serine protease inhibitory properties. ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c9np00033j
更新日期:2020-02-26 00:00:00
abstract::This review covers the structure and function of heparin and heparan sulfate glycosaminoglycans. Their chemical structures are discussed, including recently developed methods for sequencing picomole to nanomole quantities of heparin- and heparan sulfate-derived oligosaccharides. The biosynthesis of heparin and heparan...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b100916h
更新日期:2002-06-01 00:00:00
abstract::Covering: up to 2019As abundant natural products, isoprenoids have many useful industrial applications in the manufacturing of drugs, fragrances, food additives, colorants, rubber and advanced biofuels. The microbial production of isoprenoids has received much attention in recent years. Metabolic engineering approache...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c9np00016j
更新日期:2020-01-01 00:00:00
abstract::This review covers the morphology, isolation, total synthesis and biological activity of the naturally occurring alkaloids isolated from the Amaryllidaceae family, as well as the structurally related Sceletium alkaloids. ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b316106b
更新日期:2005-02-01 00:00:00
abstract::The biosynthesis of peptidoglycan is essential for all bacteria and has no counterpart in eukaryotic cells. It is one of the prime targets for antibiotic chemotherapy, especially phospho-MurNAc-pentapeptide translocase (translocase I) is a fascinating target in which there is no commercial antibiotic. In this review w...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b202149h
更新日期:2003-04-01 00:00:00
abstract::This review covers the recent marine chemical ecology literature for benthic cyanobacteria, macroalgae, sponges, octocorals, molluscs, other benthic invertebrates, fish and seabirds. ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b702742g
更新日期:2008-08-01 00:00:00
abstract::Covering: up to September 2015. Meroterpenoids are hybrid natural products that partially originate from the terpenoid pathway. The meroterpenoids derived from fungi display quite diverse structures, with a wide range of biological properties. This review summarizes the molecular bases for their biosyntheses, which we...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c5np00090d
更新日期:2016-01-01 00:00:00
abstract::Novel organic reactions drive the advance of chemical synthesis in the same way that enabling technologies drive new scientific discoveries. One area of organic methodology that has undergone significant growth during the last decade is that of homogeneous gold-catalyzed transformations. This trend has been further en...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c3np70075e
更新日期:2014-04-01 00:00:00
abstract::The diastereoselective addition of organometallic reagents to α-chloroaldehydes was first reported in 1959 and occupies a historically significant role as the prototypical reaction for Cornforth's model of stereoinduction. Despite clear synthetic potential for these reagents, difficulties associated with producing ena...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c2np20108a
更新日期:2013-02-01 00:00:00
abstract::Covering: July 2012 to December 2019Over the last seven years, expanding research efforts focused on sesterterpenoids has led to the isolation, identification, and characterization of numerous structurally novel and biologically active sesterterpenoids. These newly reported sesterterpenoids provide diverse structures ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/d0np00070a
更新日期:2020-12-22 00:00:00
abstract::This Highlight describes factors that contribute to an ideal synthesis, including economies (step, time, atom, solvent, energy) and orientations (target, diversity, safety, function), and the role of synthesis-informed design directed at function in advancing synthesis and its impact on science. ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c4np00013g
更新日期:2014-04-01 00:00:00
abstract::Covering: up to the end of 2018 Piperazic acid is a cyclic hydrazine and a non-proteinogenic amino acid found in diverse non-ribosomal peptide (NRP) and hybrid NRP-polyketide (PK) structures. Piperazic acid was first identified as a residue in the monamycins in 1959. Since then, the piperazic acid residue has been fou...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c8np00076j
更新日期:2019-12-11 00:00:00
abstract::Sesterterpenoids account for many bioactive natural products, often with unusual and complex structural features, which makes them attractive targets for synthetic chemists. This review surveys efforts undertaken toward the synthesis of sesterterpenoids, focusing on completed total syntheses and covering ca. 50 natura...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c2np20005h
更新日期:2012-07-01 00:00:00
abstract::Silybin, a secondary metabolite isolated from the seeds of the blessed milk thistle (Silybum marianum) was discovered as the first member of a new family of natural compounds called flavonolignans in 1959. Over the years it has received the research attention of many organic chemists. This research has resulted in a n...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c3np70122k
更新日期:2014-09-01 00:00:00
abstract::We compiled a data set of the compounds that terrestrial vertebrates (amniotes) use to send chemical signals, and searched for relationships between signal compound properties and signal function. Overall, relationships were scarce and formed only small-scale patterns. Terrestrial vertebrate signalling compounds are i...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c5np00029g
更新日期:2015-07-01 00:00:00
abstract::Covering: 2008 to 2016The total synthesis of natural products and their derivatives continues to inspire organic chemists to identify and test new synthetic strategies and develop and explore novel methodology. In recent years, visible light photoredox catalysis has risen to prominence as a powerful technology that en...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c6np00070c
更新日期:2016-10-26 00:00:00
abstract::This review summarizes the state of knowledge on D-glucosamine-6P synthesis catalyzed by glucosamine-6P synthase. The mechanisms of L-glutamine hydrolysis, ammonia transfer and fructose-6P conversion into D-glucosamine-6P are analyzed with the E. coli enzyme in light of recent X-ray structures. With 92 references this...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b103713g
更新日期:2002-02-01 00:00:00
abstract::This review will detail progress made in the previous decade on the chemistry and bioactivity of birch bark extractive products. Current and future applications of birch bark natural products in pharmaceuticals, cosmetics, and dietary supplements for the prevention and treatment of cancer, HIV,and other human pathogen...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b606816b
更新日期:2006-12-01 00:00:00
abstract::This Highlight describes synthetic methods that have enabled new strategic approaches to the synthesis of natural product targets as well as libraries of compounds for unbiased screening experiments. The structural differences of the compounds produced by both efforts are illustrated. ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b814468k
更新日期:2009-01-01 00:00:00
abstract::Covering: 1997 to 2010. The angucycline group is the largest group of type II PKS-engineered natural products, rich in biological activities and chemical scaffolds. This stimulated synthetic creativity and biosynthetic inquisitiveness. The synthetic studies used five different strategies, involving Diels-Alder reactio...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c1np00068c
更新日期:2012-02-01 00:00:00
abstract::Covering up to December 2013. Oligosaccharide natural products target a wide spectrum of biological processes including disruption of cell wall biosynthesis, interference of bacterial translation, and inhibition of human α-amylase. Correspondingly, oligosaccharides possess the potential for development as treatments o...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c3np70128j
更新日期:2014-08-01 00:00:00
abstract::This review focuses on recent developments in the use of natural products as therapeutics for Alzheimer's disease. The compounds span a diverse array of structural classes and are organized according to their mechanism of action, with the focus primarily on the major hypotheses. Overall, the review discusses more than...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c0np00027b
更新日期:2011-01-01 00:00:00
abstract::The cyclic depsipeptide largazole from a cyanobacterium of the genus Symploca is a marine natural product with a novel chemical scaffold and potently inhibits class I histone deacetylases (HDACs). Largazole possesses highly differential growth-inhibitory activity, preferentially targeting transformed over non-transfor...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c2np00066k
更新日期:2012-04-01 00:00:00
abstract::The mangrove flora is a diverse group of salt-tolerant plants growing in tropical and subtropical intertidal estuarine zones. This review summarizes the source, chemistry and bioactivities of natural products from true mangrove species worldwide. It includes 349 metabolites and 150 references. The molecular phylogeny ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b807365a
更新日期:2008-10-01 00:00:00