Abstract:
:In this review the names, structures and occurrence of all new drimanes and rearranged drimanes which have been published between January 1990 and January 2003 have been collected. Subjects that have been treated are biosynthesis, analysis, biological activities, with special attention to cytotoxic activity and antifeedant and insecticidal activity and mode of action. An important part of the review deals with the synthesis of drimanes. This part has been subdivided into syntheses by transformation of natural products, syntheses starting from chiral compounds obtained by enzymatic resolution, syntheses by cationic polyolefin cyclizations, syntheses from trans-decalones, syntheses by radical cyclizations and syntheses by cycloaddition reactions. The review contains about 350 references.
journal_name
Nat Prod Repjournal_title
Natural product reportsauthors
Jansen BJ,de Groot Adoi
10.1039/b311170asubject
Has Abstractpub_date
2004-08-01 00:00:00pages
449-77issue
4eissn
0265-0568issn
1460-4752journal_volume
21pub_type
杂志文章,评审abstract::2,5-Disubstituted tetrahydrofurans constitute the core skeleton of several natural products and are pivotal synthetic analogues of medicinal importance that exhibit remarkable bioactivities. Oxasqualenoid natural products are implicated as potent biologically active molecules, particularly with regard to demonstrating...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c4np00029c
更新日期:2014-09-01 00:00:00
abstract::Covering: 1947-early 2017, particularly from 2005-early 2017The rise of bacterial pathogens with acquired resistance to almost all available antibiotics is becoming a serious public health issue. Polymyxins, antibiotics that were mostly abandoned a few decades ago because of toxicity concerns, are ultimately considere...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c7np00023e
更新日期:2017-07-06 00:00:00
abstract::Aristolactams, having a phenanthrene chromophore are a small group of compounds mainly found in the Aristolochiaceae together with the aristolochic acids and 4,5-dioxoaporphines. In this report, these three important classes of natural products are reviewed and classified on the basis of their oxygenation pattern. In ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b303648k
更新日期:2003-12-01 00:00:00
abstract::Covering: up to the end of 2018 Piperazic acid is a cyclic hydrazine and a non-proteinogenic amino acid found in diverse non-ribosomal peptide (NRP) and hybrid NRP-polyketide (PK) structures. Piperazic acid was first identified as a residue in the monamycins in 1959. Since then, the piperazic acid residue has been fou...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c8np00076j
更新日期:2019-12-11 00:00:00
abstract::Blue flower colors are primarily due to anthocyanin, a flavonoid pigment. Anthocyanin itself is purple in neutral aqueous solutions, ans its color is very unstable and quickly fades. Therefore, the mechanism of blue color development in living flower petals is one of the most intriguing problems in natural product che...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b800165k
更新日期:2009-07-01 00:00:00
abstract::Pantothenate is an essential metabolite for all biological systems, however, the biosynthetic pathway is limited to plants, eubacteria and archaea. This suggests that the pathway is a strong candidate for the discovery of novel antibiotic and herbicidal compounds. The enzymology of this short pathway in both bacteria ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b316419p
更新日期:2004-12-01 00:00:00
abstract::Covering: 1997 to 2010. The angucycline group is the largest group of type II PKS-engineered natural products, rich in biological activities and chemical scaffolds. This stimulated synthetic creativity and biosynthetic inquisitiveness. The synthetic studies used five different strategies, involving Diels-Alder reactio...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c1np00068c
更新日期:2012-02-01 00:00:00
abstract::This review covers the literature on simple indole alkaloids and those with a nonrearranged monoterpenoid unit from the beginning of 2012 up to the end of 2013, which includes newly isolated alkaloids, structure determinations, total syntheses and biological activities. ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c5np00032g
更新日期:2015-09-23 00:00:00
abstract::Natural products have evolved, at least in part, to bind to biological macromolecules, particularly proteins. As a result, natural products are able to interact with many specific targets within the cell. Indeed for many years this has been central in the drug development process. Today, however, natural products are ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b616808f
更新日期:2007-12-01 00:00:00
abstract::Covering: up to January 2017Cytochrome P450 enzymes (P450s) are some of the most exquisite and versatile biocatalysts found in nature. In addition to their well-known roles in steroid biosynthesis and drug metabolism in humans, P450s are key players in natural product biosynthetic pathways. Natural products, the most ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c7np00034k
更新日期:2017-08-30 00:00:00
abstract::In the recent past, macromolecular crystallography has gone through substantial methodological and technological development. The purpose of this review is to provide a general overview of structural biology and its impact on enzyme structure/function analysis and illustrate how it is modifying the focus of research r...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c2np20057k
更新日期:2012-10-01 00:00:00
abstract::The mangrove flora is a diverse group of salt-tolerant plants growing in tropical and subtropical intertidal estuarine zones. This review summarizes the source, chemistry and bioactivities of natural products from true mangrove species worldwide. It includes 349 metabolites and 150 references. The molecular phylogeny ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b807365a
更新日期:2008-10-01 00:00:00
abstract::We compiled a data set of the compounds that terrestrial vertebrates (amniotes) use to send chemical signals, and searched for relationships between signal compound properties and signal function. Overall, relationships were scarce and formed only small-scale patterns. Terrestrial vertebrate signalling compounds are i...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c5np00029g
更新日期:2015-07-01 00:00:00
abstract::Bracken (Pteridium spp.) is a ubiquitous fern which has been described as one of the five most common plants on the earth. The toxic effects of bracken on livestock have been recorded since the end of the 19th century, and extensive and intensive investigations for the bracken toxin(s) led to the isolation of ptaquilo...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b614160a
更新日期:2007-08-01 00:00:00
abstract::In the search for new drugs and natural remedies, medicinal plants or herbs used in folk and traditional medicines are promising candidates. For the naturally rare and slowly growing plant species, plant tissue culture in bioreactors provides a cost-effective, sustainable and well-controlled means for mass production ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b610767b
更新日期:2006-10-01 00:00:00
abstract::This review covers the isolation, structural determination, synthesis and chemical and microbiological transformations of natural sesquiterpenoids. The literature from January to December 2003 is reviewed, and 389 references are cited. ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b407376m
更新日期:2004-10-01 00:00:00
abstract::Covering: up to June 2018 Understanding the biosynthetic mechanisms that generate the astounding structural complexity and variety of fungal secondary metabolites (FSMs) remains a challenge. As an example, the biogenesis of the Monascus azaphilone pigments (MonAzPs) has remained obscure until recently despite the sign...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c8np00060c
更新日期:2019-04-17 00:00:00
abstract::Microorganisms and in particular actinomycetes and microfungi are known to produce a vast number of bioactive secondary metabolites. For industrially important fungal genera such as Penicillium and Aspergillus the production of these compounds has been demonstrated to be very consistent at the species level. This mean...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b404943h
更新日期:2005-12-01 00:00:00
abstract::Oligo-, polysaccharides, and glycoconjugates are a relevant part of the bioactive components of the natural products exploited in therapeutics, diagnostics, food additives, and biomaterials. Glycans are directly involved in important biological processes, such as immunostimulation, anti-inflammatory, antioxidant, and ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c2np20032e
更新日期:2012-06-01 00:00:00
abstract::A key property of metallo-proteins and -enzymes is the affinity of metal ion M for protein ligand P as defined by the dissociation constant KD = [M][P]/[MP]. Its accurate determination is essential for a quantitative understanding of metal selection and speciation. However, the surfaces of proteins are defined by the ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b906690j
更新日期:2010-05-01 00:00:00
abstract::From the basic export of unwanted metal ions in simple organisms to the complex orchestration of metal handling and usage in higher eukaryotes, cellular systems are based on a variety of molecular mechanisms that constrain the right metal to bind to the right protein partner at the right time when needed. A failure to...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b906678k
更新日期:2010-05-01 00:00:00
abstract::A diverse array of secondary metabolites have been isolated and characterized from marine-derived fungi. The structures and biological activities of these metabolites are presented. Additionally, some basic principles of mycology are covered. Overall, 273 structures are presented and the review contains 162 references...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b301926h
更新日期:2004-02-01 00:00:00
abstract::Covering: up to 2019This review covers the current status of the quantum mechanical prediction of chiroptical properties, such as electronic CD and optical rotation, as needed for stereochemical assignments in new natural products. The reliability of the prediction of chiroptical properties is steadily increasing, wit...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c9np00018f
更新日期:2019-07-01 00:00:00
abstract::The biosynthesis of peptidoglycan is essential for all bacteria and has no counterpart in eukaryotic cells. It is one of the prime targets for antibiotic chemotherapy, especially phospho-MurNAc-pentapeptide translocase (translocase I) is a fascinating target in which there is no commercial antibiotic. In this review w...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b202149h
更新日期:2003-04-01 00:00:00
abstract::Covering: 2008 to 2016The total synthesis of natural products and their derivatives continues to inspire organic chemists to identify and test new synthetic strategies and develop and explore novel methodology. In recent years, visible light photoredox catalysis has risen to prominence as a powerful technology that en...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c6np00070c
更新日期:2016-10-26 00:00:00
abstract::Covering up to December 2013. Oligosaccharide natural products target a wide spectrum of biological processes including disruption of cell wall biosynthesis, interference of bacterial translation, and inhibition of human α-amylase. Correspondingly, oligosaccharides possess the potential for development as treatments o...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c3np70128j
更新日期:2014-08-01 00:00:00
abstract::A detailed overview is presented of recent total synthesis approaches to four different diterpenoids--the ginkgolides, tonantzitlolone, ingenol and eleutherobin. Due to their structural complexity, all pose major challenges for total synthesis, guaranteeing diverse strategic tours de force and a rich synthetic chemist...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b705652b
更新日期:2008-04-01 00:00:00
abstract::This review covers the isolation, structure determination, synthesis, chemical transformations and biological activity of indolizidine and quinolizidine alkaloids. Included in the review are the hydroxylated indolizidines lentiginosine, swainsonine, castanospermine and their analogues; alkaloids from animal sources, i...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b612166g
更新日期:2008-02-01 00:00:00
abstract::Covering: up to the end of 2015.Peptides are naturally occurring compounds that play an important role in all living systems and are responsible for a range of essential functions. Peptide receptors have been implicated in disease states such as oncology, metabolic disorders and cardiovascular disease. Therefore, natu...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c5np00083a
更新日期:2016-06-02 00:00:00
abstract::Covering: up to 2018 β-Lactones are strained rings that are useful organic synthons and pharmaceutical warheads. Over 30 core scaffolds of β-lactone natural products have been described to date, many with potent bioactivity against bacteria, fungi, or human cancer cell lines. β-Lactone natural products are chemically ...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c8np00052b
更新日期:2019-03-20 00:00:00