Computational prediction of chiroptical properties in structure elucidation of natural products.

abstract：:The mangrove flora is a diverse group of salt-tolerant plants growing in tropical and subtropical intertidal estuarine zones. This review summarizes the source, chemistry and bioactivities of natural products from true mangrove species worldwide. It includes 349 metabolites and 150 references. The molecular phylogeny ...

journal_title：Natural product reports

authors： Wu J,Xiao Q,Xu J,Li MY,Pan JY,Yang MH

更新日期：2008-10-01 00:00:00

abstract：:Covering: 2011-2017Radical cyclizations have a rich history in organic chemistry and have been particularly generous to the field of natural product synthesis. Owing to their ability to operate in highly congested molecular quarters, and with significant functional group compatibility, these transformations have enabl...

journal_title：Natural product reports

authors： Hung K,Hu X,Maimone TJ

更新日期：2018-02-21 00:00:00

abstract：:Covering: up to 2019As abundant natural products, isoprenoids have many useful industrial applications in the manufacturing of drugs, fragrances, food additives, colorants, rubber and advanced biofuels. The microbial production of isoprenoids has received much attention in recent years. Metabolic engineering approache...

journal_title：Natural product reports

authors： Li M,Hou F,Wu T,Jiang X,Li F,Liu H,Xian M,Zhang H

更新日期：2020-01-01 00:00:00

abstract：:This review article provides an overview on the current state of research in the area of microtubule-stabilizing agents from natural sources, with a primary focus on the biochemistry, biology, and pharmacology associated with these compounds. A variety of natural products have been discovered over the last decade to i...

journal_title：Natural product reports

authors： Altmann KH,Gertsch J

更新日期：2007-04-01 00:00:00

abstract：:Covering: up to January 2017Cytochrome P450 enzymes (P450s) are some of the most exquisite and versatile biocatalysts found in nature. In addition to their well-known roles in steroid biosynthesis and drug metabolism in humans, P450s are key players in natural product biosynthetic pathways. Natural products, the most ...

journal_title：Natural product reports

authors： Rudolf JD,Chang CY,Ma M,Shen B

更新日期：2017-08-30 00:00:00

abstract：:The fungal genus Trichoderma has various applications in industry and in medicine, and several species have economic importance as sources of enzymes, antibiotics, plant growth promoters, decomposers of xenobiotics, and as commercial biofungicides. Peptaibiotics and peptaibols are a class of linear peptides synthesize...

journal_title：Natural product reports

authors： Daniel JF,Filho ER

更新日期：2007-10-01 00:00:00

abstract：:Covering: 1947-early 2017, particularly from 2005-early 2017The rise of bacterial pathogens with acquired resistance to almost all available antibiotics is becoming a serious public health issue. Polymyxins, antibiotics that were mostly abandoned a few decades ago because of toxicity concerns, are ultimately considere...

journal_title：Natural product reports

authors： Rabanal F,Cajal Y

更新日期：2017-07-06 00:00:00

abstract：:A detailed overview is presented of recent total synthesis approaches to four different diterpenoids--the ginkgolides, tonantzitlolone, ingenol and eleutherobin. Due to their structural complexity, all pose major challenges for total synthesis, guaranteeing diverse strategic tours de force and a rich synthetic chemist...

journal_title：Natural product reports

authors： Busch T,Kirschning A

更新日期：2008-04-01 00:00:00

abstract：:This Highlight describes synthetic methods that have enabled new strategic approaches to the synthesis of natural product targets as well as libraries of compounds for unbiased screening experiments. The structural differences of the compounds produced by both efforts are illustrated. ...

journal_title：Natural product reports

authors： Shaw JT

更新日期：2009-01-01 00:00:00

abstract：:Heterologous expression of biosynthetic pathways is an indispensable tool in the discovery, production, engineering, and characterization of bacterial polyketides and the complex enzymology involved in their biosynthesis. Ensuring transcription of polyketide biosynthetic gene clusters in heterologous hosts is a pressi...

journal_title：Natural product reports

authors： Stevens DC,Hari TP,Boddy CN

更新日期：2013-10-11 00:00:00

abstract：:The cyclic depsipeptide largazole from a cyanobacterium of the genus Symploca is a marine natural product with a novel chemical scaffold and potently inhibits class I histone deacetylases (HDACs). Largazole possesses highly differential growth-inhibitory activity, preferentially targeting transformed over non-transfor...

journal_title：Natural product reports

authors： Hong J,Luesch H

更新日期：2012-04-01 00:00:00

abstract：:From the basic export of unwanted metal ions in simple organisms to the complex orchestration of metal handling and usage in higher eukaryotes, cellular systems are based on a variety of molecular mechanisms that constrain the right metal to bind to the right protein partner at the right time when needed. A failure to...

journal_title：Natural product reports

authors： Banci L,Bertini I,McGreevy KS,Rosato A

更新日期：2010-05-01 00:00:00

abstract：:Covering: up to 2018 Ovothiols are sulfur-containing natural products biosynthesized by marine invertebrates, microalgae, and bacteria. These compounds are characterized by unique chemical properties suggestive of numerous cellular functions. For example, ovothiols may be cytoprotectants against oxidative stress, serv...

journal_title：Natural product reports

authors： Castellano I,Seebeck FP

更新日期：2018-12-12 00:00:00

abstract：:This Highlight describes factors that contribute to an ideal synthesis, including economies (step, time, atom, solvent, energy) and orientations (target, diversity, safety, function), and the role of synthesis-informed design directed at function in advancing synthesis and its impact on science. ...

journal_title：Natural product reports

authors： Wender PA

更新日期：2014-04-01 00:00:00

abstract：:Covering: up to September 2015. Meroterpenoids are hybrid natural products that partially originate from the terpenoid pathway. The meroterpenoids derived from fungi display quite diverse structures, with a wide range of biological properties. This review summarizes the molecular bases for their biosyntheses, which we...

journal_title：Natural product reports

authors： Matsuda Y,Abe I

更新日期：2016-01-01 00:00:00

abstract：:Silybin, a secondary metabolite isolated from the seeds of the blessed milk thistle (Silybum marianum) was discovered as the first member of a new family of natural compounds called flavonolignans in 1959. Over the years it has received the research attention of many organic chemists. This research has resulted in a n...

journal_title：Natural product reports

authors： Biedermann D,Vavříková E,Cvak L,Křen V

更新日期：2014-09-01 00:00:00

abstract：:Covering: up to February 2019Actinomycetes are Gram positive bacteria of the phylum Actinobacteria. These organisms are one of the most important sources of structurally diverse, clinically used antibiotics and other valuable bioactive products, as well as biotechnologically relevant enzymes. Most strains were discove...

journal_title：Natural product reports

authors： Musiol-Kroll EM,Tocchetti A,Sosio M,Stegmann E

更新日期：2019-09-01 00:00:00

abstract：:Although natural products have been marginalized by major pharmaceutical companies over the last 20-30 years, the changing landscape of drug discovery now favors a greatly enhanced role for Nature's privileged structures. Screening for drug leads in phenotypic screens provides the best opportunity to realize the value...

journal_title：Natural product reports

authors： Carter GT

更新日期：2011-10-01 00:00:00

abstract：:In the search for new drugs and natural remedies, medicinal plants or herbs used in folk and traditional medicines are promising candidates. For the naturally rare and slowly growing plant species, plant tissue culture in bioreactors provides a cost-effective, sustainable and well-controlled means for mass production ...

journal_title：Natural product reports

authors： Zhou LG,Wu JY

更新日期：2006-10-01 00:00:00

abstract：:Covering: Early 2008 until the end of 2019Microorganisms which survive (extreme-tolerant) or even prefer (extremophilic) living at the limits of pH, temperature, salinity and pressure found on earth have proven to be a rich source of novel structures. In this update we summarise the wide variety of new molecules which...

journal_title：Natural product reports

authors： Wilson ZE,Brimble MA

更新日期：2020-07-16 00:00:00

abstract：:Novel organic reactions drive the advance of chemical synthesis in the same way that enabling technologies drive new scientific discoveries. One area of organic methodology that has undergone significant growth during the last decade is that of homogeneous gold-catalyzed transformations. This trend has been further en...

journal_title：Natural product reports

authors： Zhang Y,Luo T,Yang Z

更新日期：2014-04-01 00:00:00

abstract：:Aristolactams, having a phenanthrene chromophore are a small group of compounds mainly found in the Aristolochiaceae together with the aristolochic acids and 4,5-dioxoaporphines. In this report, these three important classes of natural products are reviewed and classified on the basis of their oxygenation pattern. In ...

journal_title：Natural product reports

authors： Kumar V,Poonam,Prasad AK,Parmar VS

更新日期：2003-12-01 00:00:00

abstract：:Covering: up to 2013. Although holo-acyl carrier protein synthase, AcpS, a phosphopantetheinyl transferase (PPTase), was characterized in the 1960s, it was not until the publication of the landmark paper by Lambalot et al. in 1996 that PPTases garnered wide-spread attention being classified as a distinct enzyme superf...

journal_title：Natural product reports

authors： Beld J,Sonnenschein EC,Vickery CR,Noel JP,Burkart MD

更新日期：2014-01-01 00:00:00

abstract：:This review will detail progress made in the previous decade on the chemistry and bioactivity of birch bark extractive products. Current and future applications of birch bark natural products in pharmaceuticals, cosmetics, and dietary supplements for the prevention and treatment of cancer, HIV,and other human pathogen...

journal_title：Natural product reports

authors： Krasutsky PA

更新日期：2006-12-01 00:00:00

abstract：:Contact chemosensation, or tasting, is a complex process governed by nonvolatile phytochemicals that tell host-seeking insects whether they should accept or reject a plant. During this process, insect gustatory receptors (GRs) contribute to deciphering a host plant's metabolic code. GRs recognise many different classe...

journal_title：Natural product reports

authors： Pentzold S,Burse A,Boland W

更新日期：2017-05-10 00:00:00

abstract：:The biosynthesis of peptidoglycan is essential for all bacteria and has no counterpart in eukaryotic cells. It is one of the prime targets for antibiotic chemotherapy, especially phospho-MurNAc-pentapeptide translocase (translocase I) is a fascinating target in which there is no commercial antibiotic. In this review w...

journal_title：Natural product reports

authors： Kimura K,Bugg TD

更新日期：2003-04-01 00:00:00

abstract：:This review covers the biosynthesis of aliphatic and aromatic polyketides as well as mixed polyketide/NRPS metabolites, and discusses the molecular genetics and enzymology of the proteins responsible for their formation. ...

journal_title：Natural product reports

authors： Hill AM

更新日期：2006-04-01 00:00:00

abstract：:Discovering molecular components and their functionality is key to the development of hypotheses concerning the organization and regulation of metabolic networks. The iterative experimental testing of such hypotheses is the trajectory that can ultimately enable accurate computational modelling and prediction of metabo...

journal_title：Natural product reports

authors： Hur M,Campbell AA,Almeida-de-Macedo M,Li L,Ransom N,Jose A,Crispin M,Nikolau BJ,Wurtele ES

更新日期：2013-04-01 00:00:00

abstract：:Covering: 2008 to 2016The total synthesis of natural products and their derivatives continues to inspire organic chemists to identify and test new synthetic strategies and develop and explore novel methodology. In recent years, visible light photoredox catalysis has risen to prominence as a powerful technology that en...

journal_title：Natural product reports

authors： Nicholls TP,Leonori D,Bissember AC

更新日期：2016-10-26 00:00:00

abstract：:Venomous marine cone snails harbour a variety of small disulfide-rich peptides called conotoxins, which target a broad range of ion channels, membrane receptors, and transporters. More than 700 species of Conus are thought to exist, each expressing a wide array of different peptides. Within this large repertoire of to...

journal_title：Natural product reports

authors： Halai R,Craik DJ

更新日期：2009-04-01 00:00:00