Trapping interactions between catalytic domains and carrier proteins of modular biosynthetic enzymes with chemical probes.

Abstract:

:Covering: up to early 2018 The Nonribosomal Peptide Synthetases (NRPSs) and Polyketide Synthases (PKSs) are families of modular enzymes that produce a tremendous diversity of natural products, with antibacterial, antifungal, immunosuppressive, and anticancer activities. Both enzymes utilize a fascinating modular architecture in which the synthetic intermediates are covalently attached to a peptidyl- or acyl-carrier protein that is delivered to catalytic domains for natural product elongation, modification, and termination. An investigation of the structural mechanism therefore requires trapping the often transient interactions between the carrier and catalytic domains. Many novel chemical probes have been produced to enable the structural and functional investigation of multidomain NRPS and PKS structures. This review will describe the design and implementation of the chemical tools that have proven to be useful in biochemical and biophysical studies of these natural product biosynthetic enzymes.

journal_name

Nat Prod Rep

journal_title

Natural product reports

authors

Gulick AM,Aldrich CC

doi

10.1039/c8np00044a

subject

Has Abstract

pub_date

2018-11-14 00:00:00

pages

1156-1184

issue

11

eissn

0265-0568

issn

1460-4752

journal_volume

35

pub_type

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