Abstract:
:Covering: up to early 2018 Polyketides and nonribosomal peptides are two major families of natural product with a broad range of biological activities. Polyketide synthases (PKSs) assemble small acetic acid-type acyl building blocks into polyketides through C-C bonds, and nonribosomal peptide synthetases (NRPSs) assemble amino acids into peptides through amide bonds. PKS-NRPS hybrid assembly lines build structurally complex polyketide-amino acid/peptide hybrid molecules that incorporate both acyl and aminoacyl building blocks into their products. Their combined functionalities expand the biological activities of these molecules by mixing their chemical properties. Protein-protein interactions are necessary within PKS-NRPS hybrid assembly lines to achieve accurate linkage between the PKS and NRPS systems. This review summarizes the current understanding of the roles and importance of the protein-protein interactions in various PKS-NRPS hybrid assembly lines.
journal_name
Nat Prod Repjournal_title
Natural product reportsauthors
Miyanaga A,Kudo F,Eguchi Tdoi
10.1039/c8np00022ksubject
Has Abstractpub_date
2018-11-14 00:00:00pages
1185-1209issue
11eissn
0265-0568issn
1460-4752journal_volume
35pub_type
杂志文章,评审abstract::Dinoflagellates produce unique polyketides characterized by their size and complexity. The biosynthesis of a limited number of such metabolites has been reported, with studies largely hampered by the low yield of compounds and the severe scrambling of label in the isotopically-labeled precursors. Nonetheless, of the s...
journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c4np00016a
更新日期:2014-09-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1039/d0np00021c
更新日期:2020-07-16 00:00:00
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pub_type: 杂志文章,评审
doi:10.1039/c3np70122k
更新日期:2014-09-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1039/c7np00034k
更新日期:2017-08-30 00:00:00
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pub_type: 杂志文章,评审
doi:10.1039/b705652b
更新日期:2008-04-01 00:00:00
abstract::Covering: 1958 to June 2018 Phenyl-γ-valerolactones (PVLs) and their related phenylvaleric acids (PVAs) are the main metabolites of flavan-3-ols, the major class of flavonoids in the human diet. Despite their presumed importance, these gut microbiota-derived compounds have, to date, in terms of biological activity, be...
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pub_type: 杂志文章,评审
doi:10.1039/c8np00062j
更新日期:2019-05-22 00:00:00
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pub_type: 杂志文章,评审
doi:10.1039/c7np00047b
更新日期:2018-03-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1039/b311170a
更新日期:2004-08-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1039/c7np00019g
更新日期:2017-07-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1039/b610767b
更新日期:2006-10-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1039/b811227b
更新日期:2009-05-01 00:00:00
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journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c4np00029c
更新日期:2014-09-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1039/c0np00047g
更新日期:2011-06-01 00:00:00
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journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b513232k
更新日期:2007-02-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1039/c4np00101j
更新日期:2015-02-01 00:00:00
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journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c9np00029a
更新日期:2019-09-01 00:00:00
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journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c8np00076j
更新日期:2019-12-11 00:00:00
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journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c6np00070c
更新日期:2016-10-26 00:00:00
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pub_type: 杂志文章,评审
doi:10.1039/c4np00110a
更新日期:2015-05-01 00:00:00
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journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b906678k
更新日期:2010-05-01 00:00:00
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journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b800165k
更新日期:2009-07-01 00:00:00
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journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/b212061p
更新日期:2003-06-01 00:00:00
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journal_title:Natural product reports
pub_type: 杂志文章,评审
doi:10.1039/c1np00033k
更新日期:2011-10-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1039/c7np00023e
更新日期:2017-07-06 00:00:00
abstract::This review will detail progress made in the previous decade on the chemistry and bioactivity of birch bark extractive products. Current and future applications of birch bark natural products in pharmaceuticals, cosmetics, and dietary supplements for the prevention and treatment of cancer, HIV,and other human pathogen...
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pub_type: 杂志文章,评审
doi:10.1039/b606816b
更新日期:2006-12-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1039/c5np00090d
更新日期:2016-01-01 00:00:00
abstract::The fungal genus Trichoderma has various applications in industry and in medicine, and several species have economic importance as sources of enzymes, antibiotics, plant growth promoters, decomposers of xenobiotics, and as commercial biofungicides. Peptaibiotics and peptaibols are a class of linear peptides synthesize...
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pub_type: 杂志文章,评审
doi:10.1039/b618086h
更新日期:2007-10-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1039/c8np00045j
更新日期:2018-12-12 00:00:00
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pub_type: 杂志文章,评审
doi:10.1039/c5np00125k
更新日期:2016-02-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1039/c0np00027b
更新日期:2011-01-01 00:00:00