Abstract:
:Interferons inhibit the replication of vesicular stomatitis virus (VSV), but not of encephalomyocarditis virus (EMCV), in mouse JLSV-11 cells. We report the isolation of clonal derivatives from this cell line in which the replication of both viruses is impaired by interferons. These clones were selected from the parental line by virtue of their rescue by interferon treatment from the cytopathic effects of EMCV infection. In one such clone, RK8, the replication of VSV and EMCV and the production of resident murine leukemia virus were inhibited by interferon. On the other hand, in clone RK6, which was isolated without any selection, the replication of VSV, but not of EMCV, was impaired by interferons. The levels of 2'-5'-oligoadenylate synthetase mRNA and enzyme activity were similarly elevated upon interferon treatment in the two clones. However, the level of RNase L, as determined by binding and cross-linking of a radiolabeled 2'-5'-oligoadenylate derivative, was much lower in RK6 cells than in RK8 cells. In accord with this observation, the introduction of 2'-5'-oligoadenylates into cells inhibited protein synthesis much less strongly in RK6 cells than in RK8 cells. These results are consistent with the notion that the 2'-5'-oligoadenylate-dependent RNase L may be a mediator of the inhibition of EMCV replication by interferons.
journal_name
J Viroljournal_title
Journal of virologyauthors
Kumar R,Choubey D,Lengyel P,Sen GCdoi
10.1128/JVI.62.9.3175-3181.1988subject
Has Abstractpub_date
1988-09-01 00:00:00pages
3175-81issue
9eissn
0022-538Xissn
1098-5514journal_volume
62pub_type
杂志文章abstract::Herpes simplex virus 1 (HSV-1) establishes lifelong latent infections in neurons. Reactivation from latency can lead to serious recurrent disease, including stromal keratitis, corneal scarring, blindness, and encephalitis. Although numerous studies link stress to an increase in the incidence of reactivation from laten...
journal_title:Journal of virology
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journal_title:Journal of virology
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doi:10.1128/JVI.73.3.2270-2279.1999
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.66.1.341-348.1992
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1128/JVI.73.9.7599-7606.1999
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.78.22.12438-12445.2004
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journal_title:Journal of virology
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pub_type: 杂志文章
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journal_title:Journal of virology
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pub_type: 杂志文章
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journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.63.6.2798-2812.1989
更新日期:1989-06-01 00:00:00
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journal_title:Journal of virology
pub_type: 杂志文章
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更新日期:1990-08-01 00:00:00