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Brain edema: a valid endpoint for measuring hepatic encephalopathy?

Abstract：

:Hepatic encephalopathy (HE) is a major complication of liver failure/disease which frequently develops during the progression of end-stage liver disease. This metabolic neuropsychiatric syndrome involves a spectrum of symptoms, including cognition impairment, attention deficits and motor dysfunction which eventually can progress to coma and death. Pathologically, HE is characterized by swelling of the astrocytes which consequently leads to brain edema, a common feature found in patients with acute liver failure (ALF) as well as in cirrhotic patients suffering from HE. The pathogenic factors involved in the onset of astrocyte swelling and brain edema in HE are unresolved. However, the role of astrocyte swelling/brain edema in the development of HE remains ambiguous and therefore measuring brain edema as an endpoint to evaluate HE is questioned. The following review will determine the effect of astrocyte swelling and brain edema on neurological function, discuss the various possible techniques to measure brain edema and lastly to propose a number of neurobehavioral tests to evaluate HE.

journal_name

Metab Brain Dis

journal_title

Metabolic brain disease

authors

Bémeur C,Cudalbu C,Dam G,Thrane AS,Cooper AJ,Rose CF

doi

10.1007/s11011-016-9843-9

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

1249-1258

issue

6

eissn

0885-7490

issn

1573-7365

pii

10.1007/s11011-016-9843-9

journal_volume

31

pub_type

杂志文章,评审

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