Cerebral energy metabolism in hepatic encephalopathy and hyperammonemia.

abstract：:Niemann-Pick type C 1 (NPC1) disease is an autosomal recessive cholesterol transport defect resulting in a neurodegenerative process in patients mainly at an early age, although some patients may start with manifestation in adult. Since loss of myelin is considered as a main pathogenetic factor, the precise mechanism ...

journal_title：Metabolic brain disease

authors： Yan X,Lukas J,Witt M,Wree A,Hübner R,Frech M,Köhling R,Rolfs A,Luo J

更新日期：2011-12-01 00:00:00

abstract：:There is abundant evidence showing that repeated use of MDMA (3, 4-Methylenedioxymethamphetamine, ecstasy) has been associated with depression, anxiety and deficits in learning and memory, suggesting detrimental effects on hippocampus. Adenosine is an endogenous purine nucleoside that has a neuromodulatory role in the...

journal_title：Metabolic brain disease

authors： Kermanian F,Mehdizadeh M,Soleimani M,Ebrahimzadeh Bideskan AR,Asadi-Shekaari M,Kheradmand H,Haghir H

更新日期：2012-12-01 00:00:00

abstract：:3-Nitropropionic acid (3-NPA) is a toxin sometimes produced on moldy crops (sugarcane, peanuts, etc.) in amounts sufficient to cause severe neurological disorders when consumed by humans. In vitro, 3-NPA irreversibly inactivates SDH, a Complex II respiratory enzyme required for mitochondrial energy production. A singl...

journal_title：Metabolic brain disease

authors： Nony PA,Scallet AC,Rountree RL,Ye X,Binienda Z

更新日期：1999-06-01 00:00:00

abstract：:Long-term or excessive application of morphine leads to tolerance and addiction, which hindered its conventional applications as a drug. Although tremendous progress has been made on the mechanisms of morphine, crucial evidence elaborating the neurobiological basis of tolerance and dependence is still lacking. To furt...

journal_title：Metabolic brain disease

authors： Liu R,Cheng J,Yang J,Ding X,Yang S,Dong F,Guo N,Liu S

更新日期：2015-06-01 00:00:00

abstract：:Fenproporex (Fen) is an amphetamine-based anorectic; amphetamine use causes a broad range of severe cognitive deficits and anxiogenic-like effects. In this study we evaluated pharmacological effects of the chronic administration of Fen on cognitive and non-cognitive behaviors. Male adult Wistar rats received intraperi...

journal_title：Metabolic brain disease

authors： Gonçalves CL,Furlanetto CB,Valvassori SS,Bavaresco DV,Varela RB,Budni J,Quevedo J,Streck EL

更新日期：2015-04-01 00:00:00

abstract：:The availability of an animal model is crucial in studying the pathophysiological mechanisms of disease and to test possible therapies. Now, there are several models for the study of liver diseases, but there still remains a lack of a satisfactory animal model of chronic liver disease with hepatic encephalopathy (HE) ...

journal_title：Metabolic brain disease

authors： Jover R,Madaria E,Felipo V,Rodrigo R,Candela A,Compañ A

更新日期：2005-12-01 00:00:00

abstract：:The integrity of the blood-brain barrier (BBB) is an important aspect of normal central nervous system (CNS) function. Recently, it was shown that the BBB breakdown is one of the predisposing factors in the pathogenesis of thiamine-deficiency encephalopathy. The result is discussed along with some reviews on previous ...

journal_title：Metabolic brain disease

authors： Harata N,Iwasaki Y

更新日期：1996-03-01 00:00:00

abstract：:Menkes disease is a very rare X-linked copper metabolism disorder that results from an ATP7A gene mutation. With the advent of subcutaneous copper-histidine therapy, the early diagnosis of Menkes disease becomes of utmost importance for patients' prognosis. In the present study, the clinical characteristics of 12 Kore...

journal_title：Metabolic brain disease

authors： Kim JH,Lee BH,Kim YM,Choi JH,Kim GH,Cheon CK,Yoo HW

更新日期：2015-02-01 00:00:00

abstract：:Chronic ethanol ingestion results in an "up-regulation" of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor in mouse brain. This increase in receptors is associated with ethanol withdrawal seizures, which can be attenuated by NMDA receptor antagonists. Chronic exposure to ethanol (3 days) of rat cerebella...

journal_title：Metabolic brain disease

authors： Hoffman PL

更新日期：1995-03-01 00:00:00

abstract：:We investigated the biochemical alterations of the striatum of mice subjected to seven experimental schedules with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride (MPTP) treatment. The mice were treated intraperitoneally (i.p.) with MPTP (20 mg/kg in saline) four times a day at 2-hr intervals showed severe ...

journal_title：Metabolic brain disease

authors： Kuroiwa H,Yokoyama H,Kimoto H,Kato H,Araki T

更新日期：2010-06-01 00:00:00

abstract：:Soluble amyloid-β protein (Aβ) oligomers have been recognized to be early and key intermediates in Alzheimer's disease-related synaptic dysfunction. In this study, using in vitro electrophysiology, we investigated interactions of the acidic oligosaccharide sugar chain (AOSC), a marine-derived acidic oligosaccharide, w...

journal_title：Metabolic brain disease

authors： Chang L,Li F,Chen X,Xu S,Wang C,Chen H,Wang Q

更新日期：2014-09-01 00:00:00

abstract：:Minimal hepatic encephalopathy (MHE) is the earliest form of hepatic encephalopathy (HE) and affects up to 80 % of patients with liver cirrhosis. By definition, MHE is characterized by psychomotor slowing and subtle cognitive deficits,  but obvious clinical manifestations are lacking. Given its covert nature, MHE is o...

journal_title：Metabolic brain disease

authors： Nardone R,De Blasi P,Höller Y,Brigo F,Golaszewski S,Frey VN,Orioli A,Trinka E

更新日期：2016-10-01 00:00:00

abstract：:Hepatic encephalopathy (HE) is a neuropsychiatric syndrome which develops in patients with severe liver diseases and/or portal-systemic shunting. Minimal HE, the earliest manifestation of HE, has drawn increasing attention in the last decade. Minimal HE is associated with a series of brain functional changes, such as ...

journal_title：Metabolic brain disease

authors： Zhang LJ,Wu S,Ren J,Lu GM

更新日期：2014-09-01 00:00:00

abstract：:Neuroinflammation has been recognized as a major contributor to brain injury caused by intracerebral hemorrhage (ICH). Nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome acts as an important mediator of inflammatory response in various inflammation-related dis...

journal_title：Metabolic brain disease

authors： Cheng Y,Wei Y,Yang W,Song Y,Shang H,Cai Y,Wu Z,Zhao W

更新日期：2017-08-01 00:00:00

abstract：:Mild hypothermia (32 degrees C-35 degrees C) reduces intracranial pressure in patients with acute liver failure and may offer an effective adjunct therapy in the management of these patients. Studies in experimental animals suggest that this beneficial effect of hypothermia is the result of a decrease in blood-brain a...

journal_title：Metabolic brain disease

authors： Chatauret N,Rose C,Butterworth RF

更新日期：2002-12-01 00:00:00

abstract：:Aberrant brain functional connectivity has been considered as the important mechanism underlying minimal hepatic encephalopathy (MHE); however, little is known about the change in interhemispheric connection in MHE patients. Twenty patients with HBV-related cirrhosis and MHE and 15 healthy controls were included in th...

journal_title：Metabolic brain disease

authors： Chen HJ,Wang Y,Yang M,Zhu XQ,Teng GJ

更新日期：2014-09-01 00:00:00

abstract：:It has been suggested that antidepressants, including the selective serotonin reuptake inhibitors have neurotrophic effects. Nevertheless, the impact of treatment with a selective serotonin re-uptake inhibitor on regional brain volumes in social anxiety disorder has not been studied. 11 subjects with social anxiety di...

journal_title：Metabolic brain disease

authors： Cassimjee N,Fouche JP,Burnett M,Lochner C,Warwick J,Dupont P,Stein DJ,Cloete KJ,Carey PD

更新日期：2010-12-01 00:00:00

abstract：:We have described the occurrence in freely moving gerbils of slow potential changes (SPC) in two different models of experimental epilepsy: 1) maximal electroshock and 2) bilateral epileptic foci induced by penicillin. SPC is considered a by-product of epileptiform activity in both models and correlates to the SPC whi...

journal_title：Metabolic brain disease

authors： de Azeredo FA,Perret ML

更新日期：1992-06-01 00:00:00

abstract：:The free radical scavenging abilities of the structurally related steroids beta-sitosterol, beta-sitosterol glucoside (plant sterols and sterolins), cholesterol, and dehydroepiandrosterone sulphate (DHEAS) were compared with melatonin (an efficient free radical scavenger) in an in vitro system which measures lipid per...

journal_title：Metabolic brain disease

authors： van Rensburg SJ,Daniels WM,van Zyl JM,Taljaard JJ

更新日期：2000-12-01 00:00:00

abstract：:Overwhelming evidence suggests that microglia play an important role in ischemic injury and they polarize into two different phenotypes with distinct functions after ischemic stroke. We performed the present study to investigate whether L-3-n butylphthalide (NBP) has an effect on microglial polarization. Mice were sub...

journal_title：Metabolic brain disease

authors： Li F,Ma Q,Zhao H,Wang R,Tao Z,Fan Z,Zhang S,Li G,Luo Y

更新日期：2018-12-01 00:00:00

abstract：:The synthesis, storage and release of acetylcholine (ACh) requires the expression of several specialized proteins, including choline acetyltransferase (ChAT) and the vesicular ACh transporter (VAChT). The VAChT gene is located within the first intron of the ChAT gene. This unique genomic organization permits coordinat...

journal_title：Metabolic brain disease

authors： Blusztajn JK,Berse B

更新日期：2000-03-01 00:00:00

abstract：:To assess whether EGb761 could protect elderly diabetic mice with cognitive disorders and explore the role of beclin-1-mediated autophagy in these protective effects. Two-month-old male db/db-/- mice and wild-type C57/BL6 mice were randomly divided into six groups: db/db-/- control, db/db-/- 50 mg, db/db-/- 100 mg, wi...

journal_title：Metabolic brain disease

authors： Guan ZF,Zhang XM,Tao YH,Zhang Y,Huang YY,Chen G,Tang WJ,Ji G,Guo QL,Liu M,Zhang Q,Wang NN,Yu ZY,Hao-Yang,Wu GF,Tang ZP,Du ZG,Shang XL,Liu YC,Mei GH,Guo JC,Zhou HG

更新日期：2018-12-01 00:00:00

abstract：:The aim of the present work was to investigate the role of ondansetron on the high fat diet (HFD) induced obese mice for behavioral and biochemical alterations using chronic unpredictable mild stress (CUMS) model of depression. Animals were fed with high fat diet for 14 weeks and subjected to different stress procedur...

journal_title：Metabolic brain disease

authors： Kurhe Y,Radhakrishnan M,Gupta D

更新日期：2014-09-01 00:00:00

abstract：:Oxidative stress is strongly implicated in the pathogenesis of stroke. Strategies using antioxidants to improve neurological functions after stroke have, thus, gained significant attention. Ocimum basilicum L. is used traditionally to treat CNS disorders. Its antioxidant capacity is well established. Our laboratory ha...

journal_title：Metabolic brain disease

authors： Singh V,Krishan P,Shri R

更新日期：2018-08-01 00:00:00

abstract：:Undernourished suckling rats were administered, by gastric intubation, either soy oil (which is rich in both linoleic and linolenic acids) or safflower oil (which is rich in linoleic acid but deficient in linolenic acid) to determine (1) if dietary supplementation would offset the hypomyelination characteristic of the...

journal_title：Metabolic brain disease

authors： Divakaran P,Pavlina T,Johnson RC,Cotter R,Madsen D,Wiggins R

更新日期：1986-06-01 00:00:00

abstract：:Tissue methylmalonic acid (MMA) accumulation is the biochemical hallmark of methylmalonic acidemia. Clinically, the disease is characterized by progressive neurological deterioration and renal failure, whose pathophysiology is still undefined. In the present study we investigated the effect of acute MMA administration...

journal_title：Metabolic brain disease

authors： Affonso AC,Machado DG,Malgarin F,Fraga DB,Ghedim F,Zugno A,Streck EL,Schuck PF,Ferreira GC

更新日期：2013-09-01 00:00:00

abstract：:Autism (MIM 209850) is a heterogeneous neurodevelopmental disease that manifests within the first 3 years of life. Numerous articles reported that dysfunctional folate-methionine pathway enzymes may play an important role in the pathophysiology of autism. Methylenetetrahydrofolate reductase (MTHFR) is a critical enzym...

journal_title：Metabolic brain disease

authors： Rai V

更新日期：2016-08-01 00:00:00

abstract：:Alcohol dependence (AD) has a large heritable component. Genetic variation in genes involved in the absorption and elimination of ethanol have been associated with AD. However, some of these polymorphisms are not present in an African population. Previous studies have reported that a type of AD which is characterized ...

journal_title：Metabolic brain disease

authors： Crawford A,Dalvie S,Lewis S,King A,Liberzon I,Fein G,Koenen K,Ramesar R,Stein DJ

更新日期：2014-06-01 00:00:00

abstract：:Isolated Methylmalonic acidemia/aciduria (MMA) is a group of inborn errors of metabolism disease which is caused by defect in methylmalonyl-CoA mutase (MCM) enzyme. The enzyme has a key function in the catabolism of branched chain amino acids (BCAA, isoleucine, and valine), methionine, and threonine. MCM is encoded by...

journal_title：Metabolic brain disease

authors： Shafaat M,Alaee MR,Rahmanifar A,Setoodeh A,Razzaghy-Azar M,Bagherian H,Bagheri SD,Zafarghandi Motlagh F,Hashemi M,Abiri M,Zeinali S

更新日期：2018-10-01 00:00:00

abstract：:In the current era, plants are frequently tested for its antidepressant potential. Therefore young coconut water, a commonly used plant based beverage, was selected to explore its antidepressant potential. Rodents were selected for this study and forced swim test was conducted to explore antidepressant activity. Analy...

journal_title：Metabolic brain disease

authors： Rao SS,Najam R

更新日期：2016-10-01 00:00:00