Abstract：
:Statins or HMG-CoA reductase inhibitors have been shown to be effective at lowering cholesterol levels, and the application of these molecules has gradually emerged as an attractive therapeutic strategy for neurodegenerative diseases. Epidemiological studies suggest that statin use is associated with a decreased incidence of Alzheimer's disease (AD). Thus, statins may play a beneficial role in reducing amyloid β (Aβ) toxicity, the most relevant pathological feature and pathogenesis of AD. However, the precise mechanisms involved in statin-inhibited Aβ toxicity remain unclear. In the present study, we report that mevastatin significantly protects against Aβ-induced neurotoxicity in SK-N-MC neuronal cells by restoring impaired insulin signaling. This protection appears to be associated with the activation of AMP-activated protein kinase (AMPK), which has long been known to increase insulin sensitivity. Our results also indicate that high levels of cholesterol likely underlie Aβ-induced neurotoxicity and that activation of AMPK by mevastatin alleviates insulin resistance. Signaling through the insulin receptor substrate-1/Akt pathway appears to lead to cell survival. These findings demonstrate that mevastatin plays a potential therapeutic role in targeting Aβ-mediated neurotoxicity. The molecule presents a novel therapeutic strategy for further studies in AD prevention and therapeutics.
journal_name
Metab Brain Disjournal_title
Metabolic brain diseaseauthors
Kornelius E,Li HH,Peng CH,Hsiao HW,Yang YS,Huang CN,Lin CLdoi
10.1007/s11011-017-0091-4subject
Has Abstractpub_date
2017-12-01 00:00:00pages
1999-2007issue
6eissn
0885-7490issn
1573-7365pii
10.1007/s11011-017-0091-4journal_volume
32pub_type
杂志文章abstract：:The blood-brain barrier and the intestinal barrier show signs of disruption in patients with idiopathic Parkinson's disease (PD) and animal models of nigrostriatal degeneration, and likewise in amyotrophic lateral sclerosis (ALS) models. A substantial body of evidence shows that defects in epithelial membrane barriers...
journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
doi：10.1007/s11011-018-0239-x
更新日期：2018-08-01 00:00:00
abstract：:Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system which causes chronic demyelination. Hydroxychloroquine (HCQ) possess immunosuppressive and anti-inflammatory properties. The aim of this study was to investigate the effect of HCQ on miR-219 and miR-155-3p expression changes in MS-...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-020-00609-z
更新日期：2020-12-01 00:00:00
abstract：:Thyroid hormone insufficiency during neurodevelopment can result into significant structural and functional changes within the developing central nervous system (CNS), and is associated with the establishment of serious cognitive impairment and neuropsychiatric symptomatology. The aim of the present study was to shed ...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-014-9581-9
更新日期：2015-02-01 00:00:00
abstract：:Today, neurological disorders such as epilepsy, depression, tardive dyskinesia, and stress, and neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, dementia, and Huntington's disease affect millions of people all over the world. Existing pharmacological interventions do not meet the desired t...
journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
doi：10.1007/s11011-019-00400-9
更新日期：2019-08-01 00:00:00
abstract：:Schizophrenia (SCZ) and bipolar disorder (BD) are severe psychiatric disorders that share many genetic risk factors. This study aimed to investigate the association of phosphoinositide-3-kinase regulatory subunit1 (PIK3R1) gene rs3756668 and rs3730089 polymorphisms with SCZ and BD risks and determine the expression le...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-020-00552-z
更新日期：2020-06-01 00:00:00
abstract：:It has been suggested that antidepressants, including the selective serotonin reuptake inhibitors have neurotrophic effects. Nevertheless, the impact of treatment with a selective serotonin re-uptake inhibitor on regional brain volumes in social anxiety disorder has not been studied. 11 subjects with social anxiety di...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-010-9218-6
更新日期：2010-12-01 00:00:00
abstract：:Semi-chronic exposure of ICR male Mice to Aflatoxin B1 (AFB1) in non-toxic doses decreased brain serotonin (5-hydroxytryptamine, 5-HT), 5-hydroxyindole-3-acetic acid (5-HIAA) and catecholamines without altering tryptophan (TRP) or tyrosine (TYR) levels. A TRP load (300 mg/kg, i.p. x 2 hours) slightly increased brain T...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/BF01000244
更新日期：1992-12-01 00:00:00
abstract：:Chronic ethanol ingestion results in an "up-regulation" of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor in mouse brain. This increase in receptors is associated with ethanol withdrawal seizures, which can be attenuated by NMDA receptor antagonists. Chronic exposure to ethanol (3 days) of rat cerebella...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/BF01991784
更新日期：1995-03-01 00:00:00
abstract：:Autism (MIM 209850) is a heterogeneous neurodevelopmental disease that manifests within the first 3 years of life. Numerous articles reported that dysfunctional folate-methionine pathway enzymes may play an important role in the pathophysiology of autism. Methylenetetrahydrofolate reductase (MTHFR) is a critical enzym...
journal_title：Metabolic brain disease
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s11011-016-9815-0
更新日期：2016-08-01 00:00:00
abstract：:In patients with hepatic encephalopathy (HE) the blood concentration of ammonia is usually highly elevated. Ammonia readily enters brain cells from the blood, and toxic effects of ammonia on brain metabolism and neurotransmission are believed to play a key role in the pathogenesis of HE. It has, however, been a matter...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-008-9126-1
更新日期：2009-03-01 00:00:00
abstract：:Hyperphenylalaninemia (HPA) leads to increased oxidative stress in patients with phenylketonuria (PKU) and in animal models of PKU. Early diagnosis and immediate adherence to a phenylalanine-restricted diet prevents HPA and, consequently, severe brain damage. However, treated adolescent and adult PKU patients have dif...
journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
doi：10.1007/s11011-013-9414-2
更新日期：2013-12-01 00:00:00
abstract：:In view of the protective effect of brain derived neurotrophic factor (BDNF) against metabolic/excitotoxic insults in vitro, we investigated whether BDNF could limit infarct size after permanent occlusion of the middle cerebral artery in rat (MCAO). BDNF was delivered into the territory of the middle cerebral artery v...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/BF02674671
更新日期：1997-12-01 00:00:00
abstract：:D-glycerate 2 kinase (DGK) is an enzyme that mediates the conversion of D-glycerate, an intermediate metabolite of serine and fructose metabolism, to 2-phosphoglycerate. Deficiency of DGK leads to accumulation of D-glycerate in various tissues and its massive excretion in urine. D-glyceric aciduria (DGA) is an autosom...
journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
doi：10.1007/s11011-019-0384-x
更新日期：2019-04-01 00:00:00
abstract：:Due to the high ability of cadmium to cross the blood-brain barrier, cadmium (Cd) causes severe neurological damages. Hence, the purpose of this study was to investigate the possible protective effect of Mangifera indica leaf extract (MLE) against Cd-induced neurotoxicity. Rats were divided into eight groups. Group 1 ...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-018-0222-6
更新日期：2018-08-01 00:00:00
abstract：:gamma-Hydroxybutyric acid (GHB) is a naturally occurring compound in the central nervous system (CNS) whose tissue concentration are highly increased in the neurometabolic-inherited deficiency of succinic semialdehyde dehydrogenase (SSADH) activity or due to intoxication. SSADH deficiency is biochemically characterize...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-009-9136-7
更新日期：2009-06-01 00:00:00
abstract：:In Alzheimer's disease (AD) basal forebrain cholinergic neurons appear to be targeted primarily in early stages of the disease. Scopolamine (muscarinic receptor antagonist) has been used for decades to induce working and reference memory impairment in rodents. In this study, we evaluated the protective effect of kolav...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-016-9902-2
更新日期：2017-02-01 00:00:00
abstract：:Menkes disease is a very rare X-linked copper metabolism disorder that results from an ATP7A gene mutation. With the advent of subcutaneous copper-histidine therapy, the early diagnosis of Menkes disease becomes of utmost importance for patients' prognosis. In the present study, the clinical characteristics of 12 Kore...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-014-9569-5
更新日期：2015-02-01 00:00:00
abstract：:Heart failure patients often manifest white matter hyperintensites on brain magnetic resonance imaging (MRI). White matter hyperintnsities have also been linked with cognitive problems in patients with heart failure. Sleep disordered breathing may contribute to structural brain changes in heart failure. The purpose of...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-018-0309-0
更新日期：2018-12-01 00:00:00
abstract：:The associations between thyroid auto-immunity and neuro-psychiatric disorders are well-documented. However, there exists limited literature specifically linking auto-immune thyroid disease (AITD) to bipolar disorder (BD). Thus, we investigated the likely association between Hashimoto's disease and BD through the extr...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-019-00437-w
更新日期：2019-10-01 00:00:00
abstract：:The associations of levels of apolipoprotein A1 (ApoA1) and apolipoprotein B and ApoB/A1 ratio and risk of a first stroke have not been reliably documented. We performed a meta-analysis to summarize the relationships and confirmed them in a case-control study. We identified relevant publications in PubMed and Embase d...
journal_title：Metabolic brain disease
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s11011-015-9732-7
更新日期：2015-12-01 00:00:00
abstract：:Effects of sertraline, haloperidol or olanzapine administration on ketamine-induced behaviours in mice were examined. The aim was to ascertain the degree of reversal of such behaviours by sertraline, and compare its effectiveness to haloperidol and olanzapine. Ten-week old mice (N = 120) were equally divided into main...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-017-0031-3
更新日期：2017-10-01 00:00:00
abstract：:The sprouting of new blood vessels from pre-existing vasculature (angiogenesis) is essential for tumour survival, influenced by tumour cell-endothelial cell interactions and is tightly regulated by biochemical cues including the kallikrein-kinin system (KKS). We examined the structural interaction between neuroblastom...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-006-9008-3
更新日期：2006-09-01 00:00:00
abstract：:The present experiments were conducted to investigate the direct effects of ethanol on the energy metabolism of astrocytes and C6-glioma cells. Primary astrocytes were prepared from cerebral cortices of neonatal rats, and C6-glioma cells were purchased from American Type Culture Collection (ATCC). These cells were exp...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1023/a:1020606607729
更新日期：1999-09-01 00:00:00
abstract：:We discuss the case of a rare and often unrecognized neurologic syndrome, called Acquired Hepatocerebral Degeneration (AHD), observed in patients with advanced liver disease and portosystemic shunts. The clinical manifestations can be very heterogeneous and in our case included a combination of cerebellar and extrapyr...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-017-0107-0
更新日期：2018-02-01 00:00:00
abstract：:Traumatic brain injury (TBI) results in severe neurological impairments without effective treatments. Inflammation appears to be an important contributor to key pathogenic events such as secondary brain injury following TBI and therefore serves as a promising target for novel therapies. We have recently demonstrated t...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-017-9991-6
更新日期：2017-10-01 00:00:00
abstract：:The effect of factors released from N2A neuroblastoma cells on the expression of myelin protein genes in glioma C6 cells, i.e., proteolipid protein (PLP) and myelin-associated glycoprotein (MAG), was studied. Both cells lines were propagated in serum-free DMEM-F10 (1:1) medium. The addition of 50% N2A conditioned medi...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/BF01000160
更新日期：1992-09-01 00:00:00
abstract：:Calotropis procera (CP; Apocynaceae) is reported to have several neuroprotective activities however it's anti-depressant activity yet to be established. Therefore, the present study was proposed to evaluate the anti-depressant activity of the standardized ethanolic extract of CP (ECP) in chronic unpredictable mild str...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-019-00471-8
更新日期：2019-12-01 00:00:00
abstract：:Glutamate neurotoxicity was studied in primary neuronal cultures prepared from rat cerebral cortex and hippocampal CA1 sector. Neurons were cultivated with 5% native horse serum and then exposed to 0.1 or 1.0 mM glutamate for 5 min. Subsequently, neurons were allowed to recover for 24 hours either in the presence or i...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/BF02098880
更新日期：1994-12-01 00:00:00
abstract：:Over the past 35 years, the outlook for a patient presenting with acute liver failure (ALF) has changed beyond all recognition. A patient presenting in 1984 had an 80 % likelihood of succumbing to intracranial hypertension. Today due to dramatic improvements in intensive care in dedicated liver transplant units, this ...
journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
doi：10.1007/s11011-012-9363-1
更新日期：2013-03-01 00:00:00
abstract：:The current study evaluated the protective and therapeutic potency of bee pollen in ameliorating the toxic effects of methylmercury (MeHg), by measuring certain biochemical parameters related to neurotransmission, neuroinflammation, apoptosis, and glutamate excitotoxicity in the male neonate brain. Healthy, pregnant f...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-019-00496-z
更新日期：2020-01-01 00:00:00
