Post-occlusion treatment with BDNF reduces infarct size in a model of permanent occlusion of the middle cerebral artery in rat.

abstract：:Mutations in NADH dehydrogenase (ND) subunits of complex I lead to mitochondrial encephalomyopathies associated with various phenotypes. This report aims to present the patient's clinical symptomatology in the context of a very rare 13042G>A de novo mutation and with an emphasis on changing phenotypic expression and p...

journal_title：Metabolic brain disease

authors： Schinwelski M,Kierdaszuk B,Dulski J,Tońska K,Kodroń A,Sitek EJ,Bartnik E,Kamińska A,Kwieciński H,Sławek J

更新日期：2015-08-01 00:00:00

abstract：:Although gaseous ammonia (NH3) can freely enter cells through the plasma membrane where NH3 is cyto(neuro)toxic, NH3 and ionic ammonia (NH4+) contents have not been studied in biological materials. We developed a new method for measurement of expiratory NH3 concentration, which may reflect blood NH3 concentrations. Th...

journal_title：Metabolic brain disease

authors： Wakabayashi H,Kuwabara Y,Murata H,Kobashi K,Watanabe A

更新日期：1997-06-01 00:00:00

abstract：:Overwhelming evidence suggests that microglia play an important role in ischemic injury and they polarize into two different phenotypes with distinct functions after ischemic stroke. We performed the present study to investigate whether L-3-n butylphthalide (NBP) has an effect on microglial polarization. Mice were sub...

journal_title：Metabolic brain disease

authors： Li F,Ma Q,Zhao H,Wang R,Tao Z,Fan Z,Zhang S,Li G,Luo Y

更新日期：2018-12-01 00:00:00

abstract：:Mobile phone providers use electromagnetic radiation (EMR) with frequencies ranging from 900 to 1800 MHz. The increasing use of mobile phones has been accompanied by several potentially pathological consequences, such as neurological diseases related to hippocampal (HIPPON) and dorsal root ganglion neuron (DRGN). The ...

journal_title：Metabolic brain disease

authors： Ertilav K,Uslusoy F,Ataizi S,Nazıroğlu M

更新日期：2018-06-01 00:00:00

abstract：:Although the key contributors of altering neurological function in hepatic encephalopathy are relatively well known, the electrophysiological mechanism of CA1 damage, a key vulnerable area during hyperammonemia, have not yet been defined. Therefore, here we focus on the electrophysiological mechanisms of cognitive imp...

journal_title：Metabolic brain disease

authors： Tahamtan M,Aghaei I,Pooladvand V,Sheibani V,Khaksari M,Shabani M

更新日期：2017-06-01 00:00:00

abstract：:Hepatic encephalopathy (HE) is an important cause of morbidity and mortality in patients with severe liver disease. Although the mechanisms responsible for HE remain elusive, ammonia is generally considered to be involved in its pathogenesis, and astrocytes are thought to be the principal target of ammonia neurotoxici...

journal_title：Metabolic brain disease

authors： Rama Rao KV,Jayakumar AR,Norenberg DM

更新日期：2003-06-01 00:00:00

abstract：:Levels of high mobility group box 1 (HMGB1), an important inflammatory mediator, are high in the serum of febrile seizure (FS) patients. However, its roles in FS and secondary epilepsy after prolonged FS are poorly understood. We demonstrate HMGB1's role in the pathogenesis of hyperthermia-induced seizures (HS) and se...

journal_title：Metabolic brain disease

authors： Ito M,Takahashi H,Yano H,Shimizu YI,Yano Y,Ishizaki Y,Tanaka J,Ishii E,Fukuda M

更新日期：2017-12-01 00:00:00

abstract：:Traumatic brain injury (TBI) is accompanied with enhanced matrix metalloproteinase-9 (MMP-9) activity and elevated levels of plasma fibrinogen (Fg), which is a known inflammatory agent. Activation of MMP-9 and increase in blood content of Fg (i.e. hyperfibrinogenemia, HFg) both contribute to cerebrovascular disorders ...

journal_title：Metabolic brain disease

authors： Muradashvili N,Benton RL,Saatman KE,Tyagi SC,Lominadze D

更新日期：2015-04-01 00:00:00

abstract：:Brain glucose uptake is usually reduced in type 2 diabetes owing to downregulation of brain glucose transporters. The ability of Vernonia amygdalina to stimulate glucose uptake as well as ameliorate glucose-induced oxidative stress and proinflammation were investigated in rat brain. Hot infusion of V. amygdalina leave...

journal_title：Metabolic brain disease

authors： Erukainure OL,Oyebode OA,Ibeji CU,Koorbanally NA,Islam MS

更新日期：2019-06-01 00:00:00

abstract：:Increasing evidence indicates that fetal metabolic stress may result in a variety of post-natal perturbations during brain development. The goal of the study was to determine the duration of hypoxia/ischemia that would elicit a demonstrable regional depression of metabolism in the fetal brain and further to examine se...

journal_title：Metabolic brain disease

authors： Pundik S,Robinson S,Lust WD,Zechel J,Buczek M,Selman WR

更新日期：2006-12-01 00:00:00

abstract：UNLABELLED:Some subjects with multiple sclerosis (MS) present with low blood iron parameters. Anecdotal reports and a single patient study suggest that iron supplementation may be beneficial in these subjects. Myelin is regenerated continually, but prerequisites for this process are iron and a functional folate-vitamin...

journal_title：Metabolic brain disease

authors： van Rensburg SJ,Kotze MJ,Hon D,Haug P,Kuyler J,Hendricks M,Botha J,Potocnik FC,Matsha T,Erasmus RT

更新日期：2006-09-01 00:00:00

abstract：:Hepatic encephalopathy (HE) represents a nervous system disorder caused due to liver dysfunction. HE is broadly classified as acute/overt and moderate-minimal HE. Since HE syndrome severely affects quality of life of the patients and it may be life threatening, it is important to develop effective therapeutic strategy...

journal_title：Metabolic brain disease

authors： Mondal P,Trigun SK

更新日期：2014-12-01 00:00:00

abstract：:Chronic neuroinflammation is strongly associated with AD and altered peripheral and central levels of chemokines and cytokines have been frequently described in those with AD. Given the increasing evidence of ethnicity-related differences in AD, it was of interest to determine if those altered chemokine and cytokine l...

journal_title：Metabolic brain disease

authors： Ferguson SA,Varma V,Sloper D,Panos JJ,Sarkar S

更新日期：2020-01-01 00:00:00

abstract：:The lifetime prevalence rate for major depressive disorder (MDD) is approximately 17 % for most developed countries around the world. Dietary polyphenols are currently used as an adjuvant therapy to accelerate the therapeutic efficacy on depression. Ferulic acid (FA) or 4-hydroxy-3-methoxy-cinnamic acid (Fig. 1a) is a...

journal_title：Metabolic brain disease

authors： Li G,Ruan L,Chen R,Wang R,Xie X,Zhang M,Chen L,Yan Q,Reed M,Chen J,Xu Y,Pan J,Huang W

更新日期：2015-12-01 00:00:00

abstract：:As feared and deadly human diseases globally, Rabies virus contrived mechanisms to escape early immune recognition via suppression of the interferon response. This study, preliminarily investigated whether Rabies virus employs epigenetic mechanism for the suppression of the interferon using the Challenge virus standar...

journal_title：Metabolic brain disease

authors： Abdulazeez M,Kia GSN,Abarshi MM,Muhammad A,Ojedapo CE,Atawodi JC,Dantong D,Kwaga JKP

更新日期：2020-06-01 00:00:00

abstract：:D-Galactose (D-gal) chronic administration via intraperitoneal and subcutaneous routes has been used as a model of aging and Alzheimer disease in rodents. Intraperitoneal and subcutaneous administration of D-gal causes memory impairments, a reduction in the neurogenesis of adult mice, an increase in the levels of the ...

journal_title：Metabolic brain disease

authors： Budni J,Garcez ML,Mina F,Bellettini-Santos T,da Silva S,Luz APD,Schiavo GL,Batista-Silva H,Scaini G,Streck EL,Quevedo J

更新日期：2017-06-01 00:00:00

abstract：:A study evaluating zinc supplementation in patients with Alzheimer's disease yielded variable zinc plasma levels in spite of positive cognitive and physiological results. In an attempt to raise and sustain plasma zinc levels, a single patient was given 15 mg zinc/day with various combinations of vitamins. A sustained ...

journal_title：Metabolic brain disease

authors： Potocnik FC,van Rensburg SJ,Hon D,Emsley RA,Moodie IM,Erasmus RT

更新日期：2006-09-01 00:00:00

abstract：:Over the past 35 years, the outlook for a patient presenting with acute liver failure (ALF) has changed beyond all recognition. A patient presenting in 1984 had an 80 % likelihood of succumbing to intracranial hypertension. Today due to dramatic improvements in intensive care in dedicated liver transplant units, this ...

journal_title：Metabolic brain disease

authors： Ryan JM,Tranah T,Mitry RR,Wendon JA,Shawcross DL

更新日期：2013-03-01 00:00:00

abstract：:Multiple sclerosis (MS) is a demyelinating and degenerative disease of the central nervous system (CNS) with a strong inflammatory component that affects more than 2 million people worldwide (and at least 400,000 in the United States). In MS, macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (D...

journal_title：Metabolic brain disease

authors： Meza-Romero R,Benedek G,Gerstner G,Kent G,Nguyen H,Offner H,Vandenbark AA

更新日期：2019-02-01 00:00:00

abstract：:Tyrosinemia type II is a genetic disorder characterized by elevated blood levels of the amino acid tyrosine caused by the deficiency of tyrosine aminotransferase enzyme, resulting in neurologic and developmental difficulties in the patients. Although neurological sequelae are common in Tyrosinemia type II patients, th...

journal_title：Metabolic brain disease

authors： Carvalho-Silva M,Gomes LM,de Prá SD,Wessler LB,Schuck PF,Scaini G,de Bem AF,Blum-Silva CH,Reginatto FH,de Oliveira J,Streck EL

更新日期：2020-01-01 00:00:00

abstract：:Semi-chronic exposure of ICR male Mice to Aflatoxin B1 (AFB1) in non-toxic doses decreased brain serotonin (5-hydroxytryptamine, 5-HT), 5-hydroxyindole-3-acetic acid (5-HIAA) and catecholamines without altering tryptophan (TRP) or tyrosine (TYR) levels. A TRP load (300 mg/kg, i.p. x 2 hours) slightly increased brain T...

journal_title：Metabolic brain disease

authors： Kimbrough TD,Llewellyn GC,Weekley LB

更新日期：1992-12-01 00:00:00

abstract：:Sevoflurane, one of the most commonly used volatile anesthetics in clinical treatment, has been shown to induce a widespread increase in brain apoptosis. However, the underlying mechanism is still unknown. Sestrin 2 has been recently shown to regulate intracellular reactive oxygen species (ROS) levels and play a cruci...

journal_title：Metabolic brain disease

authors： Yi W,Zhang Y,Guo Y,Li D,Li X

更新日期：2015-10-01 00:00:00

abstract：:The associations of levels of apolipoprotein A1 (ApoA1) and apolipoprotein B and ApoB/A1 ratio and risk of a first stroke have not been reliably documented. We performed a meta-analysis to summarize the relationships and confirmed them in a case-control study. We identified relevant publications in PubMed and Embase d...

journal_title：Metabolic brain disease

authors： Dong H,Chen W,Wang X,Pi F,Wu Y,Pang S,Xie Y,Xia F,Zhang Q

更新日期：2015-12-01 00:00:00

abstract：:Mutations in the HTT gene, consisting of expansion of CAG triplets, cause the Huntington's disease (HD), one of the major neurodegenerative disorders. Formation of aggregates of mutant huntingtin (mHTT, the product of the mutant HTT gene) leads to cellular dysfunctions, and subsequent neurodegeneration which manifest ...

journal_title：Metabolic brain disease

authors： Pierzynowska K,Gaffke L,Cyske Z,Węgrzyn G

更新日期：2019-06-01 00:00:00

abstract：:Hepatic encephalopathy (HE) is an important cause of morbidity and mortality in patients with severe liver disease. Although the molecular basis for the neurological disorder in HE remains elusive, elevated ammonia and its chief metabolite glutamine are believed to be important factors responsible for altered cerebral...

journal_title：Metabolic brain disease

authors： Rao KV,Norenberg MD

更新日期：2001-06-01 00:00:00

abstract：:We aimed to evaluate the effect of in vitro galactosaemia on acetylcholinesterase (AChE) activity in different suckling rat brain regions. Various concentrations of galactose (Gal), galactose-1-phosphate (Gal-1-P) and/or galactitol (Galtol) were preincubated for 1 h with homogenates from frontal cortex, hippocampus an...

journal_title：Metabolic brain disease

authors： Marinou K,Tsakiris S,Tsopanakis C,Schulpis KH,Behrakis P

更新日期：2005-09-01 00:00:00

abstract：:Depression is a complex progressive disorder accompanied by activation of inflammatory and Th-1 driven pathways, oxidative and nitrosative stress (O&NS), lowered antioxidant levels, mitochondrial dysfunctions, neuroprogression and increased bacterial translocation. In depression, activation of immuno-inflammatory path...

journal_title：Metabolic brain disease

authors： Maes M

更新日期：2012-12-01 00:00:00

abstract：:Phenylketonuria (PKU) is the most common inborn error of amino acid metabolism. Usually diagnosed within the first month of birth, it is essential that the patient strictly follow the dietary restriction of natural protein intake. Otherwise, PKU impacts the development of the brain severely and may result in microceph...

journal_title：Metabolic brain disease

authors： Bortoluzzi VT,Brust L,Preissler T,de Franceschi ID,Wannmacher CMD

更新日期：2019-12-01 00:00:00

abstract：:Hypoxic-ischemia (HI) is a widely used animal model to mimic the preterm or perinatal sublethal hypoxia, including hypoxic-ischemic encephalopathy. It causes diffuse neurodegeneration in the brain and results in mental retardation, hyperactivity, cerebral palsy, epilepsy and neuroendocrine disturbances. Herein, we exa...

journal_title：Metabolic brain disease

authors： Kartal Ö,Aydınöz S,Kartal AT,Kelestemur T,Caglayan AB,Beker MC,Karademir F,Süleymanoğlu S,Kul M,Yulug B,Kilic E

更新日期：2016-08-01 00:00:00

abstract：:Menkes disease is a very rare X-linked copper metabolism disorder that results from an ATP7A gene mutation. With the advent of subcutaneous copper-histidine therapy, the early diagnosis of Menkes disease becomes of utmost importance for patients' prognosis. In the present study, the clinical characteristics of 12 Kore...

journal_title：Metabolic brain disease

authors： Kim JH,Lee BH,Kim YM,Choi JH,Kim GH,Cheon CK,Yoo HW

更新日期：2015-02-01 00:00:00