Ablation of matrix metalloproteinase-9 gene decreases cerebrovascular permeability and fibrinogen deposition post traumatic brain injury in mice.

abstract：:Allicin, one of the main biologically active compounds derived from garlic, was previously reported to possess multiple pharmacological activities. Whether allicin protected against chronic social defeat stress (CSDS) induced depressive-like behaviors remained unknown. Thus, our present study for the first time invest...

journal_title：Metabolic brain disease

authors： Gao W,Wang W,Liu G,Zhang J,Yang J,Deng Z

更新日期：2019-02-01 00:00:00

abstract：:The enzyme nitric oxide synthase has been associated with suicide behavior. NOS1, NOS2 and NOS3 genes are implicated in the production of nitric oxide. However, the association between NOS genes and suicide behavior has not yet been established. To assess the association of Nitric Oxide Synthase (NOS) genes and suicid...

journal_title：Metabolic brain disease

authors： González-Castro TB,Genis-Mendoza AD,Tovilla-Zárate CA,Juárez-Rojop IE,López-Narvaez ML,Pérez-Hernández N,Rodríguez-Pérez JM,Martínez-Magaña JJ

更新日期：2019-08-01 00:00:00

abstract：:Adult-onset type II citrullinemia (CTLN2), characterized by a liver-specific deficiency of urea cycle enzyme, argininosuccinate synthetase, is caused by mutations in SLC25A13 that encodes a calcium binding mitochondrial solute carrier protein, citrin. Citrin deficiency causes not only CTLN2 but also neonatal intrahepa...

journal_title：Metabolic brain disease

authors： Saheki T,Kobayashi K,Iijima M,Nishi I,Yasuda T,Yamaguchi N,Gao HZ,Jalil MA,Begum L,Li MX

更新日期：2002-12-01 00:00:00

abstract：:Autism spectrum disorder (ASD) is a multifactorial disorder caused by an interaction between environmental risk factors and a genetic background. It is characterized by impairment in communication, social interaction, repetitive behavior, and sensory processing. The etiology of ASD is still not fully understood, and t...

journal_title：Metabolic brain disease

authors： Qasem H,Al-Ayadhi L,Bjørklund G,Chirumbolo S,El-Ansary A

更新日期：2018-08-01 00:00:00

abstract：:Recent evidence has established that consumption of High-fat diet (HFD)-induced obesity is associated with deficits in hippocampus-dependent memory/learning and mood states. Nevertheless the link between obesity and emotional disorders still remains to be elucidated. This issue is of particular interest during adolesc...

journal_title：Metabolic brain disease

authors： Wu H,Liu Q,Kalavagunta PK,Huang Q,Lv W,An X,Chen H,Wang T,Heriniaina RM,Qiao T,Shang J

更新日期：2018-02-01 00:00:00

abstract：:Pipecolic acid (PA) levels are increased in severe metabolic disorders of the central nervous system such as Zellweger syndrome, infantile Refsum disease, neonatal adrenoleukodystrophy and hyperlysinemia. The affected individuals present progressive neurological dysfunction, hypotonia and growth retardation. The mecha...

journal_title：Metabolic brain disease

authors： Dalazen GR,Terra M,Jacques CE,Coelho JG,Freitas R,Mazzola PN,Dutra-Filho CS

更新日期：2014-03-01 00:00:00

abstract：:Thiamine triphosphate (ThTP) was discovered over 60 years ago and it was long thought to be a specifically neuroactive compound. Its presence in most cell types, from bacteria to mammals, would suggest a more general role but this remains undefined. In contrast to thiamine diphosphate (ThDP), ThTP is not a coenzyme. I...

journal_title：Metabolic brain disease

authors： Bettendorff L,Lakaye B,Kohn G,Wins P

更新日期：2014-12-01 00:00:00

abstract：:Mitochondrial dysfunction is observed in brains of Alzheimer's Disease patients as well as many rodent model systems including those modeling mutations in preseinilin 1 (PSEN1). The aim of our study was to characterize mitochondrial function and number in fibroblasts from AD patients with PSEN1 mutations. We used bioc...

journal_title：Metabolic brain disease

authors： Gray NE,Quinn JF

更新日期：2015-10-01 00:00:00

abstract：:Hyperammonemia is necessary for development of the cerebral complications to liver disease including hepatic encephalopathy and cerebral edema but the mechanisms are unclear. Ammonia is taken up by the brain in proportion to its arterial concentration. The flux into the brain is most likely by both diffusion of NH3 an...

journal_title：Metabolic brain disease

authors： Ott P,Vilstrup H

更新日期：2014-12-01 00:00:00

abstract：:Iron is an important micronutrient for neuronal function and survival. It plays an essential role in DNA and protein synthesis, neurotransmission and electron transport chain due to its dual redox states. On the contrary, iron also catalyses the production of free radicals and hence, causes oxidative stress. Therefore...

journal_title：Metabolic brain disease

authors： Minhas G,Modgil S,Anand A

更新日期：2014-09-01 00:00:00

abstract：:Increasing evidence indicates that excessive drug consumption is sufficient for the transition from recreational and controlled drug use to uncontrolled use and addiction. However, the underlying mechanisms are debated. Some neurobehavioral and neuroimaging evidence indicates that dorsolateral striatum (dlStr)-depende...

journal_title：Metabolic brain disease

authors： Shi JJ,Cao DN,Liu HF,Wang ZY,Lu GY,Wu N,Zhou WH,Li J

更新日期：2019-08-01 00:00:00

abstract：:To investigate the pattern of brain volume changes in patients with end-stage renal disease (ESRD) using voxel-based morphometry (VBM) and correlation with clinical and neuropsychological (NP) tests. Fifty seven ESRD patients with no anatomical abnormalities in conventional magnetic resonance imaging [24 patients with...

journal_title：Metabolic brain disease

authors： Zhang LJ,Wen J,Ni L,Zhong J,Liang X,Zheng G,Lu GM

更新日期：2013-12-01 00:00:00

abstract：:Schizophrenia is known to be associated with metabolic disturbances including diabetes mellitus, obesity and cardiovascular diseases. A growing body of evidence has suggested abnormal cytokine levels in schizophrenia. In the present study, we explored the effects of low-grade chronic inflammation on behavioral stereot...

journal_title：Metabolic brain disease

authors： Erbaş O,Akseki HS,Aktuğ H,Taşkıran D

更新日期：2015-06-01 00:00:00

abstract：:Stroke is the leading cause of disability among adults as well as the 2nd leading cause of death globally. Ischemic stroke accounts for about 85% of strokes, and currently, tissue plasminogen activator (tPA), whose therapeutic window is limited to up to 4.5 h for the appropriate population, is the only FDA approved dr...

journal_title：Metabolic brain disease

authors： Sarvari S,Moakedi F,Hone E,Simpkins JW,Ren X

更新日期：2020-08-01 00:00:00

abstract：:The sprouting of new blood vessels from pre-existing vasculature (angiogenesis) is essential for tumour survival, influenced by tumour cell-endothelial cell interactions and is tightly regulated by biochemical cues including the kallikrein-kinin system (KKS). We examined the structural interaction between neuroblastom...

journal_title：Metabolic brain disease

authors： Naidoo S,Raidoo DM

更新日期：2006-09-01 00:00:00

abstract：:The present study analyses the potential role of MTHFR gene polymorphism, folate supplementation and dietary pattern among the mothers of NTD neonates and controls in heterogeneous populations of North India, with the special focus on their ethnic labels. Results indicated significant increased risk for neural tube de...

journal_title：Metabolic brain disease

authors： Deb R,Arora J,Meitei SY,Gupta S,Verma V,Saraswathy KN,Saran S,Kalla AK

更新日期：2011-09-01 00:00:00

abstract：:Lead exposure has negative effects on developing nervous system and induces apoptosis in newly generated neurons. Natural antioxidants (i.e. Ascorbic acid and Garlic) might protect against lead-induced neuronal cell damage. The aim of the present study was to investigate the protective effects of Ascorbic acid and Gar...

journal_title：Metabolic brain disease

authors： Ebrahimzadeh-Bideskan AR,Hami J,Alipour F,Haghir H,Fazel AR,Sadeghi A

更新日期：2016-10-01 00:00:00

abstract：:The mitogen-activated protein kinase (MAP kinase) pathway participates in a number of reactions of the cell when responding to various external stimuli. These stimuli include growth factor binding to its receptor as well as stressful situations such as hypoxia and oxidative stress. It has been postulated that one of t...

journal_title：Metabolic brain disease

authors： Daniels WM,Hendricks J,Salie R,Taljaard JJ

更新日期：2001-12-01 00:00:00

abstract：:The associations of levels of apolipoprotein A1 (ApoA1) and apolipoprotein B and ApoB/A1 ratio and risk of a first stroke have not been reliably documented. We performed a meta-analysis to summarize the relationships and confirmed them in a case-control study. We identified relevant publications in PubMed and Embase d...

journal_title：Metabolic brain disease

authors： Dong H,Chen W,Wang X,Pi F,Wu Y,Pang S,Xie Y,Xia F,Zhang Q

更新日期：2015-12-01 00:00:00

abstract：:Tyrosinemia type II is a genetic disorder characterized by elevated blood levels of the amino acid tyrosine caused by the deficiency of tyrosine aminotransferase enzyme, resulting in neurologic and developmental difficulties in the patients. Although neurological sequelae are common in Tyrosinemia type II patients, th...

journal_title：Metabolic brain disease

authors： Carvalho-Silva M,Gomes LM,de Prá SD,Wessler LB,Schuck PF,Scaini G,de Bem AF,Blum-Silva CH,Reginatto FH,de Oliveira J,Streck EL

更新日期：2020-01-01 00:00:00

abstract：:The current study evaluated the protective and therapeutic potency of bee pollen in ameliorating the toxic effects of methylmercury (MeHg), by measuring certain biochemical parameters related to neurotransmission, neuroinflammation, apoptosis, and glutamate excitotoxicity in the male neonate brain. Healthy, pregnant f...

journal_title：Metabolic brain disease

authors： Ben Bacha A,Norah AO,Al-Osaimi M,Harrath AH,Mansour L,El-Ansary A

更新日期：2020-01-01 00:00:00

abstract：:Tyrosinemia type II is an inborn error of metabolism caused by a deficiency in hepatic cytosolic aminotransferase. Affected patients usually present a variable degree of mental retardation, which may be related to the level of plasma tyrosine. In the present study we evaluated effect of chronic administration of L-tyr...

journal_title：Metabolic brain disease

authors： Ferreira GK,Carvalho-Silva M,Gomes LM,Scaini G,Teixeira LJ,Mota IT,Schuck PF,Ferreira GC,Streck EL

更新日期：2015-02-01 00:00:00

abstract：:Increasing evidence indicates that fetal metabolic stress may result in a variety of post-natal perturbations during brain development. The goal of the study was to determine the duration of hypoxia/ischemia that would elicit a demonstrable regional depression of metabolism in the fetal brain and further to examine se...

journal_title：Metabolic brain disease

authors： Pundik S,Robinson S,Lust WD,Zechel J,Buczek M,Selman WR

更新日期：2006-12-01 00:00:00

abstract：:Betanin, a natural food colorant with powerful antioxidative properties, has not been studied in terms of neurodegenerative disease intervention. Therefore, the present study aimed to investigate the neuroprotective effects of betanin against trimethyltin chloride (TMT) -induced neurodegeneration in mice. Forty male I...

journal_title：Metabolic brain disease

authors： Thong-Asa W,Prasartsri S,Klomkleaw N,Thongwan N

更新日期：2020-12-01 00:00:00

abstract：:This study aimed to examine the neuroprotective effects of Nigella sativa (N. sativa) in the hippocampus of propylthiouracil (PTU)-induced hypothyroid rats during neonatal and juvenile growth. Twenty- five pregnant rats from early gestation (GD 0) were divided into five groups: (1) control (received drinking water), (...

journal_title：Metabolic brain disease

authors： Asiaei F,Fazel A,Rajabzadeh AA,Hosseini M,Beheshti F,Seghatoleslam M

更新日期：2017-10-01 00:00:00

abstract：:Attention alterations are reported in cirrhotics. Aiming at clarifying attention functioning in cirrhotics, an inquiry on the functioning of the anterior (AAS) and the posterior (PAS) attention system was performed. Thirty-six cirrhotics without overt hepatic encephalopathy (24 with EEG or TMT-A alterations) and 16 ma...

journal_title：Metabolic brain disease

authors： Amodio P,Schiff S,Del Piccolo F,Mapelli D,Gatta A,Umiltà C

更新日期：2005-06-01 00:00:00

abstract：:Intracerebroventricular (ICV) injection of streptozotocin (STZ) is a well established procedure to induce neuroinflammation leading to dementia in experimental animals. However, the optimal dose of STZ has not been determined. In the present study, rats were ICV injected with 1.5, 3 and 6 mg of STZ per kg of body weig...

journal_title：Metabolic brain disease

authors： Ghosh R,Sil S,Gupta P,Ghosh T

更新日期：2020-12-01 00:00:00

abstract：:A high co-morbidity between Alzheimer's disease (AD) and depression suggests there might be similar mechanisms underlying the course of these diseases. Previous studies have shown that p38MAPK plays a critical role in the pathophysiology of AD and depression. However, little is known about whether SB203580, a selectiv...

journal_title：Metabolic brain disease

authors： Guo J,Chang L,Li C,Li M,Yan P,Guo Z,Wang C,Zha Q,Wang Q

更新日期：2017-02-01 00:00:00

abstract：:Autism (MIM 209850) is a heterogeneous neurodevelopmental disease that manifests within the first 3 years of life. Numerous articles reported that dysfunctional folate-methionine pathway enzymes may play an important role in the pathophysiology of autism. Methylenetetrahydrofolate reductase (MTHFR) is a critical enzym...

journal_title：Metabolic brain disease

authors： Rai V

更新日期：2016-08-01 00:00:00

abstract：:Methamphetamine (METH) is a highly addictive psycho-stimulant that induces behavioral changes due to high level of METH-induced dopamine in the brain. Nucleus accumbens (NAc) plays an important role in these changes, especially in drug addiction. However, little is known about the underlying molecular mechanisms of ME...

journal_title：Metabolic brain disease

authors： Sim MS,Soga T,Pandy V,Wu YS,Parhar IS,Mohamed Z

更新日期：2017-12-01 00:00:00