Abstract：
:This study aimed to examine the neuroprotective effects of Nigella sativa (N. sativa) in the hippocampus of propylthiouracil (PTU)-induced hypothyroid rats during neonatal and juvenile growth. Twenty- five pregnant rats from early gestation (GD 0) were divided into five groups: (1) control (received drinking water), (2) PTU (received 0.005% PTU in drinking water), (3-5) PTU + NS 0.05%, PTU + NS 0.1%, PTU + NS 0.2% (along with PTU, received 0.05%, 0.1% and 0.2% W/V of N. sativa respectively) and treatment continued until postnatal day 60 (PN 60). The brains of male pups were removed for histological and stereological assessments. N. sativa extract significantly reduced the production of dark neurons and apoptotic cells in different areas of the hippocampus compared to the PTU group. Moreover, it significantly attenuated the effect of hypothyroidism on the volume reduction of the hippocampus. The results of the present study suggested that N. sativa extract has a potential ability to prevent the hippocampal neural damage after inducing hypothyroidism during neonatal and juvenile growth in rats.
journal_name
Metab Brain Disjournal_title
Metabolic brain diseaseauthors
Asiaei F,Fazel A,Rajabzadeh AA,Hosseini M,Beheshti F,Seghatoleslam Mdoi
10.1007/s11011-017-0025-1subject
Has Abstractpub_date
2017-10-01 00:00:00pages
1755-1765issue
5eissn
0885-7490issn
1573-7365pii
10.1007/s11011-017-0025-1journal_volume
32pub_type
杂志文章abstract：:Susceptibility to Wilson's disease (WD) and its clinical manifestations are thought to be affected by genetic factors, including polymorphisms. The role of brain-derived neurotrophic factor (BDNF) in the pathogenesis of neurodegenerative diseases is now widely discussed. The aim of the present study was to evaluate th...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-013-9399-x
更新日期：2013-09-01 00:00:00
abstract：:Rare metabolic diseases may sometimes arise acutely and endanger human life if not immediately recognized and treated. Marchiafava Bignami disease is an uncommon neurologic disorder described in alcohol abusers and characterized by an acute severe damage of brain white matter. Even more rarely, it has been reported in...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-016-9893-z
更新日期：2017-02-01 00:00:00
abstract：:Thyroid hormone insufficiency during neurodevelopment can result into significant structural and functional changes within the developing central nervous system (CNS), and is associated with the establishment of serious cognitive impairment and neuropsychiatric symptomatology. The aim of the present study was to shed ...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-014-9581-9
更新日期：2015-02-01 00:00:00
abstract：:Mobile phone providers use electromagnetic radiation (EMR) with frequencies ranging from 900 to 1800 MHz. The increasing use of mobile phones has been accompanied by several potentially pathological consequences, such as neurological diseases related to hippocampal (HIPPON) and dorsal root ganglion neuron (DRGN). The ...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-017-0180-4
更新日期：2018-06-01 00:00:00
abstract：:Transient bilateral common carotid artery occlusion (tBCCAO), followed by reperfusion, is a model of transient global hypoperfusion. In the present study we aimed to investigate the probable effects of Vanillic acid (VA) on some physiological parameters including cerebral hyperemia, blood-brain barrier (BBB) disruptio...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-018-0187-5
更新日期：2018-06-01 00:00:00
abstract：:Acute and chronic administration of Al-gluconate (12.7% Al) at the concentration of 1 mg/kg produces edema in the rat brain, as reflected by the increase in water and Na+ content. The permeability for Evans blue is also increased, which indicates the opening of the blood-brain barrier. Higher concentrations of the Al-...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/BF00996974
更新日期：1990-03-01 00:00:00
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journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-017-0108-z
更新日期：2017-12-01 00:00:00
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journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-012-9342-6
更新日期：2013-03-01 00:00:00
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journal_title：Metabolic brain disease
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s11011-015-9732-7
更新日期：2015-12-01 00:00:00
abstract：:Methamphetamine (METH) is a highly addictive psycho-stimulant that induces behavioral changes due to high level of METH-induced dopamine in the brain. Nucleus accumbens (NAc) plays an important role in these changes, especially in drug addiction. However, little is known about the underlying molecular mechanisms of ME...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-017-0061-x
更新日期：2017-12-01 00:00:00
abstract：:Sevoflurane, one of the most commonly used volatile anesthetics in clinical treatment, has been shown to induce a widespread increase in brain apoptosis. However, the underlying mechanism is still unknown. Sestrin 2 has been recently shown to regulate intracellular reactive oxygen species (ROS) levels and play a cruci...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-015-9673-1
更新日期：2015-10-01 00:00:00
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journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
doi：10.1007/s11011-020-00562-x
更新日期：2021-01-01 00:00:00
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journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1023/a:1020733024934
更新日期：1999-12-01 00:00:00
abstract：:Oxidative stress is strongly implicated in the pathogenesis of stroke. Strategies using antioxidants to improve neurological functions after stroke have, thus, gained significant attention. Ocimum basilicum L. is used traditionally to treat CNS disorders. Its antioxidant capacity is well established. Our laboratory ha...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-018-0215-5
更新日期：2018-08-01 00:00:00
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journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
doi：10.1007/s11011-013-9414-2
更新日期：2013-12-01 00:00:00
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journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-018-0342-z
更新日期：2019-02-01 00:00:00
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journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
doi：10.1007/s11011-013-9457-4
更新日期：2014-06-01 00:00:00
abstract：:Minimal hepatic encephalopathy (MHE) is the earliest form of hepatic encephalopathy (HE) and affects up to 80 % of patients with liver cirrhosis. By definition, MHE is characterized by psychomotor slowing and subtle cognitive deficits, but obvious clinical manifestations are lacking. Given its covert nature, MHE is o...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-016-9848-4
更新日期：2016-10-01 00:00:00
abstract：:Cadmium is a toxic environmental and industrial pollutant. Cadmium toxicity has been reported to produce biochemical and behavioral dysfunction that may cause adverse effects on several organs including the central nervous system. The present study was designed to investigate the neurotoxic effects of Cadmium Chloride...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-014-9578-4
更新日期：2015-02-01 00:00:00
abstract：:The radiological spectrum of neuromyelitis optica has become broader since the detection of aquaporin4 antibodies. We report a case of neuromyelitis optica patient with pseudotumoral encephalic lesion. A 66 year-old woman presented with sudden left lateral homonymous hemianopsia. A brain MRI showed an isolated and ext...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-017-0141-y
更新日期：2018-02-01 00:00:00
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journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-019-00471-8
更新日期：2019-12-01 00:00:00
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journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-006-9030-5
更新日期：2006-12-01 00:00:00
abstract：:In the normal adult brain, glucose provides 90% of the energy requirements as well as substrate for nucleic acid and lipid synthesis. In the present study, effects of ethanol on glucose transporters (GLUT) and glucose utilization were examined in rat brain. Male Sprague-Dawley rats weighing 250-300 gms were given eith...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/BF02674530
更新日期：2000-09-01 00:00:00
abstract：:In the original publication of the article, author name Masoumeh Asadbegi was incorrectly written as Masoumeh Asadbeigi. The authors regret the oversight. ...
journal_title：Metabolic brain disease
pub_type： 杂志文章,已发布勘误
doi：10.1007/s11011-017-0114-1
更新日期：2017-12-01 00:00:00
abstract：:Mitochondrial dysfunction is observed in brains of Alzheimer's Disease patients as well as many rodent model systems including those modeling mutations in preseinilin 1 (PSEN1). The aim of our study was to characterize mitochondrial function and number in fibroblasts from AD patients with PSEN1 mutations. We used bioc...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-015-9667-z
更新日期：2015-10-01 00:00:00
abstract：:Applying different technologies to monitor disease activity and treatment efficacy are essential in a complex disease such as multiple sclerosis. Combining current assays with flow cytometry could create a powerful tool for such analyses. The cell surface expression level of CD74, the MHC class II invariant chain, is ...
journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
doi：10.1007/s11011-014-9634-0
更新日期：2015-08-01 00:00:00
abstract：:D-Galactose (D-gal) chronic administration via intraperitoneal and subcutaneous routes has been used as a model of aging and Alzheimer disease in rodents. Intraperitoneal and subcutaneous administration of D-gal causes memory impairments, a reduction in the neurogenesis of adult mice, an increase in the levels of the ...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-017-9972-9
更新日期：2017-06-01 00:00:00
abstract：:Near infrared radiation (NIR) is known to penetrate and affect biological systems in multiple ways. Recently, a series of experimental studies suggested that low intensity NIR may protect neuronal cells against a wide range of insults that mimic diseases such as stroke, brain trauma and neurodegeneration. However, the...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-014-9515-6
更新日期：2015-04-01 00:00:00
abstract：:Lead exposure has negative effects on developing nervous system and induces apoptosis in newly generated neurons. Natural antioxidants (i.e. Ascorbic acid and Garlic) might protect against lead-induced neuronal cell damage. The aim of the present study was to investigate the protective effects of Ascorbic acid and Gar...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-016-9837-7
更新日期：2016-10-01 00:00:00
abstract：:Central pontine myelinolysis (CPM) is a demyelinating condition affecting not only the pontine base, but also involving other brain areas. It usually occurs on a background of chronic systemic illness, and is commonly observed in individuals with alcoholism, malnutrition and liver disease. Studies carried out 25-30 ye...
journal_title：Metabolic brain disease
pub_type： 历史文章,杂志文章
doi：10.1007/s11011-010-9175-0
更新日期：2010-03-01 00:00:00
