Abstract：
:Increasing evidence indicates that excessive drug consumption is sufficient for the transition from recreational and controlled drug use to uncontrolled use and addiction. However, the underlying mechanisms are debated. Some neurobehavioral and neuroimaging evidence indicates that dorsolateral striatum (dlStr)-dependent habit learning plays a key role in excessive drug intake and the transition to addiction, but little is known about the molecular events. The present study investigated whether dlStr miR-134, an important regulator of synaptic transmission and plasticity, is involved in excessive methamphetamine intake. We established excessive and uncontrolled methamphetamine self-administration model in rats by permitting animals extended access to drug (6 h/session/d, LgA group), whereas animals that were limited to access to drug (2 h/session/d, ShA group) exhibited low and controlled self-administration. miR-134 expression in dlStr was significantly increased and its target LIMK1 expression was decreased in the LgA group, but not in the ShA group, compared with the saline control group. However, passive methamphetamine exposure did not alter miR-134 and LIMK1 levels in dlStr. We also found that down-regulation of miR-134 in dlStr through local microinjection of a lentivirus carrying miR-134 sponge (LV-miR-134-Sil) significantly reduced methamphetamine infusions and excessive consumption in LgA group, rather than ShA group. These results indicated that dlStr miR-134, perhaps via its target LIMK1, contributed to excessive and uncontrolled methamphetamine intake, supporting the hypothesis that stimulus-response habit formation is an important mechanism underlying the transition from controlled drug use to uncontrolled drug use and addiction.
journal_name
Metab Brain Disjournal_title
Metabolic brain diseaseauthors
Shi JJ,Cao DN,Liu HF,Wang ZY,Lu GY,Wu N,Zhou WH,Li Jdoi
10.1007/s11011-019-00430-3subject
Has Abstractpub_date
2019-08-01 00:00:00pages
1029-1041issue
4eissn
0885-7490issn
1573-7365pii
10.1007/s11011-019-00430-3journal_volume
34pub_type
杂志文章abstract：:Transient cerebral ischemia causes long-lasting inhibition of protein synthesis despite recovery of energy metabolism. We investigated the question if this inhibition is due to the formation of a suppression factor which interferes with the function of the protein synthesizing machinery. For this purpose rats were sub...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/BF01001061
更新日期：1993-12-01 00:00:00
abstract：:Isolated Methylmalonic acidemia/aciduria (MMA) is a group of inborn errors of metabolism disease which is caused by defect in methylmalonyl-CoA mutase (MCM) enzyme. The enzyme has a key function in the catabolism of branched chain amino acids (BCAA, isoleucine, and valine), methionine, and threonine. MCM is encoded by...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-018-0277-4
更新日期：2018-10-01 00:00:00
abstract：:The regional energy status and the availability of metabolic substrates during brain development are important, since a variety of fetal metabolic insults have been increasingly implicated in the evolution of neonatal brain disorders. The response of the brain to a metabolic insult is determined, in large part, by the...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1023/a:1025503115837
更新日期：2003-09-01 00:00:00
abstract：:Minimal hepatic encephalopathy (MHE) is the earliest form of hepatic encephalopathy (HE) and affects up to 80 % of patients with liver cirrhosis. By definition, MHE is characterized by psychomotor slowing and subtle cognitive deficits, but obvious clinical manifestations are lacking. Given its covert nature, MHE is o...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-016-9848-4
更新日期：2016-10-01 00:00:00
abstract：:Artificial sweeteners are mainly used as substitutes for sucrose derivates. In this study, we analyzed if the chronic consumption of aspartame or acesulfame potassium at an early age, produces histological alterations, astrogliosis and decreased neuronal viability, in hippocampus, prefrontal cortex, amygdala and hypot...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-018-0310-7
更新日期：2018-12-01 00:00:00
abstract：:Intracerebroventricular (ICV) injection of streptozotocin (STZ) is a well established procedure to induce neuroinflammation leading to dementia in experimental animals. However, the optimal dose of STZ has not been determined. In the present study, rats were ICV injected with 1.5, 3 and 6 mg of STZ per kg of body weig...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-020-00588-1
更新日期：2020-12-01 00:00:00
abstract：:Following axonal interruption, structural, metabolic and physiological parameters change in motorneurons. Also, glial cells are involved in this process. Microglia proliferate and express new proteins such as vimentin or MHC antigens. Astrocytes show hypertrophy, increased GFAP synthesis, and formation of lamellae. Bo...
journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
doi：10.1007/BF00999498
更新日期：1989-03-01 00:00:00
abstract：:Cyclic AMP is part of an endogenous mechanism that downregulates inflammatory response, and its intracellular concentration is regulated chiefly by cyclic nucleotide phosphodiesterases type 4. The goal of the present study was to determine whether phosphodiesterases 4 are involved in the inflammatory response of astro...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-009-9150-9
更新日期：2009-09-01 00:00:00
abstract：:Spontaneous intracerebral hemorrhage (ICH) represents a partially-understood cerebrovascular disease of high incidence, morbidity and mortality. We, herein, report the findings of our study concerning the role of two important adenosinetriphosphatases (ATPases) in a porcine model of spontaneous ICH that we have recent...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-013-9380-8
更新日期：2013-09-01 00:00:00
abstract：:The original article contains mistake. The authors want to add Wenhui Pei as first co-author and Fang Fang as co-corresponding author. ...
journal_title：Metabolic brain disease
pub_type： 已发布勘误
doi：10.1007/s11011-020-00612-4
更新日期：2020-12-01 00:00:00
abstract：:Glutamate neurotoxicity was studied in primary neuronal cultures prepared from rat cerebral cortex and hippocampal CA1 sector. Neurons were cultivated with 5% native horse serum and then exposed to 0.1 or 1.0 mM glutamate for 5 min. Subsequently, neurons were allowed to recover for 24 hours either in the presence or i...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/BF02098880
更新日期：1994-12-01 00:00:00
abstract：:We aimed to evaluate the effect of in vitro galactosaemia on acetylcholinesterase (AChE) activity in different suckling rat brain regions. Various concentrations of galactose (Gal), galactose-1-phosphate (Gal-1-P) and/or galactitol (Galtol) were preincubated for 1 h with homogenates from frontal cortex, hippocampus an...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-005-7210-3
更新日期：2005-09-01 00:00:00
abstract：:D-glycerate 2 kinase (DGK) is an enzyme that mediates the conversion of D-glycerate, an intermediate metabolite of serine and fructose metabolism, to 2-phosphoglycerate. Deficiency of DGK leads to accumulation of D-glycerate in various tissues and its massive excretion in urine. D-glyceric aciduria (DGA) is an autosom...
journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
doi：10.1007/s11011-019-0384-x
更新日期：2019-04-01 00:00:00
abstract：:There is abundant evidence showing that repeated use of MDMA (3, 4-Methylenedioxymethamphetamine, ecstasy) has been associated with depression, anxiety and deficits in learning and memory, suggesting detrimental effects on hippocampus. Adenosine is an endogenous purine nucleoside that has a neuromodulatory role in the...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-012-9334-6
更新日期：2012-12-01 00:00:00
abstract：:Heart failure patients often manifest white matter hyperintensites on brain magnetic resonance imaging (MRI). White matter hyperintnsities have also been linked with cognitive problems in patients with heart failure. Sleep disordered breathing may contribute to structural brain changes in heart failure. The purpose of...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-018-0309-0
更新日期：2018-12-01 00:00:00
abstract：:The current study evaluated the protective and therapeutic potency of bee pollen in ameliorating the toxic effects of methylmercury (MeHg), by measuring certain biochemical parameters related to neurotransmission, neuroinflammation, apoptosis, and glutamate excitotoxicity in the male neonate brain. Healthy, pregnant f...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-019-00496-z
更新日期：2020-01-01 00:00:00
abstract：:Chronic exposure to stress amplifies locomotor deficits and exacerbates dopamine neuron loss in an animal model for Parkinson's disease. The release of neurotrophic factors such as glial cell-line derived neurotrophic factor (GDNF) and neurotrophin-3 (NT-3) following neuronal injury attenuates exacerbated degeneration...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-017-9988-1
更新日期：2017-08-01 00:00:00
abstract：:Thyroid hormone insufficiency during neurodevelopment can result into significant structural and functional changes within the developing central nervous system (CNS), and is associated with the establishment of serious cognitive impairment and neuropsychiatric symptomatology. The aim of the present study was to shed ...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-014-9581-9
更新日期：2015-02-01 00:00:00
abstract：:Overwhelming evidence suggests that microglia play an important role in ischemic injury and they polarize into two different phenotypes with distinct functions after ischemic stroke. We performed the present study to investigate whether L-3-n butylphthalide (NBP) has an effect on microglial polarization. Mice were sub...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-018-0307-2
更新日期：2018-12-01 00:00:00
abstract：:We have described the occurrence in freely moving gerbils of slow potential changes (SPC) in two different models of experimental epilepsy: 1) maximal electroshock and 2) bilateral epileptic foci induced by penicillin. SPC is considered a by-product of epileptiform activity in both models and correlates to the SPC whi...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/BF01000149
更新日期：1992-06-01 00:00:00
abstract：:The effects of chronic and repeated radiofrequency electromagnetic radiation (RFEMR) exposure on spatial cognition and hippocampal architecture were investigated in prepubescent rats. Four weeks old male Wistar rats were exposed to RF-EMR (900 MHz; SAR-1.15 W/kg with peak power density of 146.60 μW/cm(2)) for 1 h/day,...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-015-9689-6
更新日期：2015-10-01 00:00:00
abstract：:We investigated the effects of age and nitric oxide synthase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME), on protein kinase C (PKC), adenylyl cyclase, calcium/calmodulin-independent cyclic-AMP phosphodiesterase (cyclic-AMP PDE) and voltage-dependent L-type calcium channels in Fischer rat brain using autoradio...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/BF02676356
更新日期：1997-03-01 00:00:00
abstract：:Lactic acid accumulation has been implicated in the evolution of brain damage after ischemia. Since compartmentation of lactate may play a role in acid-base balance, lactate release from gerbil hippocampal slices was examined during a number of metabolic stresses including elevated [K+]e, ischemia, anoxia, and aglycem...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/BF00999841
更新日期：1990-09-01 00:00:00
abstract：:The present work was carried out to study the influence of ammonia and factors from sera and cerebrospinal fluid (CSF) from patients with different degrees of chronic liver diseases on [3H]D-aspartate (Asp) and [3H]L-glutamate (Glu) high-affinity uptake into the rat hippocampal formation. For comparison, high-affinity...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/BF00996975
更新日期：1990-03-01 00:00:00
abstract：:Wilson disease (WD) is an autosomal recessive inherited disorder of copper metabolism, resulting in pathological accumulation of copper in many organs and tissues. The hallmarks of the disease are the presence of liver disease, neurologic symptoms, and Kayser-Fleischer corneal rings. The leading neurologic symptoms in...
journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
doi：10.1007/s11011-005-7910-8
更新日期：2005-12-01 00:00:00
abstract：:Rare metabolic diseases may sometimes arise acutely and endanger human life if not immediately recognized and treated. Marchiafava Bignami disease is an uncommon neurologic disorder described in alcohol abusers and characterized by an acute severe damage of brain white matter. Even more rarely, it has been reported in...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-016-9893-z
更新日期：2017-02-01 00:00:00
abstract：:Semi-chronic exposure of ICR male Mice to Aflatoxin B1 (AFB1) in non-toxic doses decreased brain serotonin (5-hydroxytryptamine, 5-HT), 5-hydroxyindole-3-acetic acid (5-HIAA) and catecholamines without altering tryptophan (TRP) or tyrosine (TYR) levels. A TRP load (300 mg/kg, i.p. x 2 hours) slightly increased brain T...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/BF01000244
更新日期：1992-12-01 00:00:00
abstract：:In Alzheimer's disease (AD) basal forebrain cholinergic neurons appear to be targeted primarily in early stages of the disease. Scopolamine (muscarinic receptor antagonist) has been used for decades to induce working and reference memory impairment in rodents. In this study, we evaluated the protective effect of kolav...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-016-9902-2
更新日期：2017-02-01 00:00:00
abstract：:This study presents further research into the spectrum of variants in genes responsible for the development of phenylketonuria (PKU) and hyperphenylalaninemia (HPA) in patients in Russia. After a study of 25 frequent variants, 293 patients (327 chromosomes without detected variants) from among 1265 probands still had ...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-019-00461-w
更新日期：2019-12-01 00:00:00
abstract：:Ischemic postconditioning (IPostC) has been reported to have neuroprotection against ischemic diseases, and one cycle of IPostC induces neurogenesis when treated nearby. To expanding these effects, we explored the effects of repetitively remote IPostC (NRIPostC) on neurogenesis in the subgranular zone (SGZ) and subent...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-017-0068-3
更新日期：2017-12-01 00:00:00
