Correction to: Shuangxia decoction alleviates p-chlorophenylalanine induced insomnia through the modification of serotonergic and immune system.

abstract：:Due to the high ability of cadmium to cross the blood-brain barrier, cadmium (Cd) causes severe neurological damages. Hence, the purpose of this study was to investigate the possible protective effect of Mangifera indica leaf extract (MLE) against Cd-induced neurotoxicity. Rats were divided into eight groups. Group 1 ...

journal_title：Metabolic brain disease

authors： Al Omairi NE,Radwan OK,Alzahrani YA,Kassab RB

更新日期：2018-08-01 00:00:00

abstract：:The commonly used volatile anesthetic sevoflurane has been shown to induce widespread apoptosis in the developing brain, yet the underlying molecular mechanisms are not fully understood. Accumulating research has demonstrated that long noncoding RNAs (lncRNAs) regulate multiple biological processes, including neural d...

journal_title：Metabolic brain disease

authors： Chen X,Zhou X,Lu D,Yang X,Zhou Z,Chen X,Chen Y,He W,Feng X

更新日期：2016-10-01 00:00:00

abstract：:Stroke is an increasingly prevalent clinical condition and second leading cause of death globally. The present study evaluated the therapeutic potential of Indian Ginseng, also known as Withania somnifera (WS), supplementation on middle cerebral artery occlusion (MCAO) induced mitochondrial dysfunctions in experimenta...

journal_title：Metabolic brain disease

authors： Sood A,Mehrotra A,Dhawan DK,Sandhir R

更新日期：2018-08-01 00:00:00

abstract：:It has been suggested that antidepressants, including the selective serotonin reuptake inhibitors have neurotrophic effects. Nevertheless, the impact of treatment with a selective serotonin re-uptake inhibitor on regional brain volumes in social anxiety disorder has not been studied. 11 subjects with social anxiety di...

journal_title：Metabolic brain disease

authors： Cassimjee N,Fouche JP,Burnett M,Lochner C,Warwick J,Dupont P,Stein DJ,Cloete KJ,Carey PD

更新日期：2010-12-01 00:00:00

abstract：:Glutaric aciduria type 1 is a neurometabolic disorder, caused by riboflavin-dependent glutaryl-CoA dehydrogenase deficiency. As its consequence, accumulation of the putatively neurotoxic metabolites (glutaric and 3-hydroxyglutaric acids) in body tissues, but especially within the brain, is observed. Estimated incidenc...

journal_title：Metabolic brain disease

authors： Pokora P,Jezela-Stanek A,Różdżyńska-Świątkowska A,Jurkiewicz E,Bogdańska A,Szymańska E,Rokicki D,Ciara E,Rydzanicz M,Stawiński P,Płoski R,Tylki-Szymańska A

更新日期：2019-04-01 00:00:00

abstract：:Menkes disease is a very rare X-linked copper metabolism disorder that results from an ATP7A gene mutation. With the advent of subcutaneous copper-histidine therapy, the early diagnosis of Menkes disease becomes of utmost importance for patients' prognosis. In the present study, the clinical characteristics of 12 Kore...

journal_title：Metabolic brain disease

authors： Kim JH,Lee BH,Kim YM,Choi JH,Kim GH,Cheon CK,Yoo HW

更新日期：2015-02-01 00:00:00

abstract：:Hepatic encephalopathy (HE) represents a nervous system disorder caused due to liver dysfunction. HE is broadly classified as acute/overt and moderate-minimal HE. Since HE syndrome severely affects quality of life of the patients and it may be life threatening, it is important to develop effective therapeutic strategy...

journal_title：Metabolic brain disease

authors： Mondal P,Trigun SK

更新日期：2014-12-01 00:00:00

abstract：:The aim of the present work was to investigate the role of ondansetron on the high fat diet (HFD) induced obese mice for behavioral and biochemical alterations using chronic unpredictable mild stress (CUMS) model of depression. Animals were fed with high fat diet for 14 weeks and subjected to different stress procedur...

journal_title：Metabolic brain disease

authors： Kurhe Y,Radhakrishnan M,Gupta D

更新日期：2014-09-01 00:00:00

abstract：:Traumatic brain injury (TBI) is accompanied with enhanced matrix metalloproteinase-9 (MMP-9) activity and elevated levels of plasma fibrinogen (Fg), which is a known inflammatory agent. Activation of MMP-9 and increase in blood content of Fg (i.e. hyperfibrinogenemia, HFg) both contribute to cerebrovascular disorders ...

journal_title：Metabolic brain disease

authors： Muradashvili N,Benton RL,Saatman KE,Tyagi SC,Lominadze D

更新日期：2015-04-01 00:00:00

abstract：:The sprouting of new blood vessels from pre-existing vasculature (angiogenesis) is essential for tumour survival, influenced by tumour cell-endothelial cell interactions and is tightly regulated by biochemical cues including the kallikrein-kinin system (KKS). We examined the structural interaction between neuroblastom...

journal_title：Metabolic brain disease

authors： Naidoo S,Raidoo DM

更新日期：2006-09-01 00:00:00

abstract：:There is abundant evidence showing that repeated use of MDMA (3, 4-Methylenedioxymethamphetamine, ecstasy) has been associated with depression, anxiety and deficits in learning and memory, suggesting detrimental effects on hippocampus. Adenosine is an endogenous purine nucleoside that has a neuromodulatory role in the...

journal_title：Metabolic brain disease

authors： Kermanian F,Mehdizadeh M,Soleimani M,Ebrahimzadeh Bideskan AR,Asadi-Shekaari M,Kheradmand H,Haghir H

更新日期：2012-12-01 00:00:00

abstract：:MRPS22 gene defect is a very rare newly discovered mitochondrial disorder. We report a 4-month-old severely affected male infant with MRPS22 mutation. Whole exome sequencing revealed a novel homozygous splicing mutation c.339 + 5 G > A in MRPS22 gene. He has mild dysmorphism, hypotonia, developmental delay but not hyp...

journal_title：Metabolic brain disease

authors： Kılıç M,Oğuz KK,Kılıç E,Yüksel D,Demirci H,Sağıroğlu MŞ,Yücel-Yılmaz D,Özgül RK

更新日期：2017-10-01 00:00:00

abstract：:Susceptibility to Wilson's disease (WD) and its clinical manifestations are thought to be affected by genetic factors, including polymorphisms. The role of brain-derived neurotrophic factor (BDNF) in the pathogenesis of neurodegenerative diseases is now widely discussed. The aim of the present study was to evaluate th...

journal_title：Metabolic brain disease

authors： Mirowska-Guzel D,Litwin T,Gromadzka G,Czlonkowski A,Czlonkowska A

更新日期：2013-09-01 00:00:00

abstract：:Isolated Methylmalonic acidemia/aciduria (MMA) is a group of inborn errors of metabolism disease which is caused by defect in methylmalonyl-CoA mutase (MCM) enzyme. The enzyme has a key function in the catabolism of branched chain amino acids (BCAA, isoleucine, and valine), methionine, and threonine. MCM is encoded by...

journal_title：Metabolic brain disease

authors： Shafaat M,Alaee MR,Rahmanifar A,Setoodeh A,Razzaghy-Azar M,Bagherian H,Bagheri SD,Zafarghandi Motlagh F,Hashemi M,Abiri M,Zeinali S

更新日期：2018-10-01 00:00:00

abstract：:Acute and chronic administration of Al-gluconate (12.7% Al) at the concentration of 1 mg/kg produces edema in the rat brain, as reflected by the increase in water and Na+ content. The permeability for Evans blue is also increased, which indicates the opening of the blood-brain barrier. Higher concentrations of the Al-...

journal_title：Metabolic brain disease

authors： Stefanovich V,Joó F

更新日期：1990-03-01 00:00:00

abstract：:Thyroid hormone insufficiency during neurodevelopment can result into significant structural and functional changes within the developing central nervous system (CNS), and is associated with the establishment of serious cognitive impairment and neuropsychiatric symptomatology. The aim of the present study was to shed ...

journal_title：Metabolic brain disease

authors： Koromilas C,Tsakiris S,Kalafatakis K,Zarros A,Stolakis V,Kimpizi D,Bimpis A,Tsagianni A,Liapi C

更新日期：2015-02-01 00:00:00

abstract：:Cystinosis is a systemic genetic disease caused by a lysosomal transport deficiency accumulating cystine in most tissues. Tissue damage depends on cystine accumulation, but the mechanisms of this damage are still obscure. Cysteamine administration depletes cystine accumulated, increasing survive of affected patients. ...

journal_title：Metabolic brain disease

authors： Kessler A,Biasibetti M,Feksa LR,Rech VC,Melo DA,Wajner M,Dutra-Filho CS,Wyse AT,Wannmacher CM

更新日期：2008-03-01 00:00:00

abstract：:Ischemic postconditioning (PostC) conventionally refers to a series of brief blood vessel occlusions and reperfusions, which can induce an endogenous neuroprotective effect and reduce cerebral ischemia/reperfusion (I/R) injury. Depending on the site of adaptive ischemic intervention, PostC can be classified as in situ...

journal_title：Metabolic brain disease

authors： Li CY,Ma W,Liu KP,Yang JW,Wang XB,Wu Z,Zhang T,Wang JW,Liu W,Liu J,Liang Y,Zhang XK,Li JJ,Guo JH,Li LY

更新日期：2021-01-01 00:00:00

abstract：:While risk factors for konzo are known, determinants of cognitive impairment in konzo-affected children remain unknown. We anchored cognitive performance (KABC-II scores) to serum levels of free-thyroxine (free-T4), thyroid-stimulating hormone (TSH), albumin, and motor proficiency (BOT-2 scores) in 40 children includi...

journal_title：Metabolic brain disease

authors： Bumoko GM,Sombo MT,Okitundu LD,Mumba DN,Kazadi KT,Tamfum-Muyembe JJ,Lasarev MR,Boivin MJ,Banea JP,Tshala-Katumbay DD

更新日期：2014-06-01 00:00:00

abstract：:Oral glutamine challenge is a method to increase blood ammonia and may be used to study the ammonia lowering effect of drugs potentially useful in hepatic encephalopathy (HE). We tested its influence on the psychometric performance of 18 cirrhotic patients without HE. Twelve nonencephalopatic cirrhotic patients were s...

journal_title：Metabolic brain disease

authors： Masini A,Efrati C,Merli M,Nicolao F,Amodio P,Del Piccolo F,Riggio O

更新日期：2003-03-01 00:00:00

abstract：:The associations of levels of apolipoprotein A1 (ApoA1) and apolipoprotein B and ApoB/A1 ratio and risk of a first stroke have not been reliably documented. We performed a meta-analysis to summarize the relationships and confirmed them in a case-control study. We identified relevant publications in PubMed and Embase d...

journal_title：Metabolic brain disease

authors： Dong H,Chen W,Wang X,Pi F,Wu Y,Pang S,Xie Y,Xia F,Zhang Q

更新日期：2015-12-01 00:00:00

abstract：:The permeability of the blood-brain barrier to glutamate was measured by quantitative autoradiography in brains of 7-day-old rats (average plasma glutamate 114 microM) and rats injected subcutaneously with glutamate (average plasma glutamate 2,670 microM). Measurements of glutamate permeability were initiated by the i...

journal_title：Metabolic brain disease

authors： Viña JR,DeJoseph MR,Hawkins PA,Hawkins RA

更新日期：1997-09-01 00:00:00

abstract：:Hepatic encephalopathy (HE) is a major complication of liver failure/disease which frequently develops during the progression of end-stage liver disease. This metabolic neuropsychiatric syndrome involves a spectrum of symptoms, including cognition impairment, attention deficits and motor dysfunction which eventually c...

journal_title：Metabolic brain disease

authors： Bémeur C,Cudalbu C,Dam G,Thrane AS,Cooper AJ,Rose CF

更新日期：2016-12-01 00:00:00

abstract：:Substantial evidence demonstrated that maternal dietary nutrients can significantly determine the susceptibility to developing metabolic disorders in the offspring. Therefore, we aimed to investigate the later-life effects of maternal and postweaning diets interaction on epigenetic modification of the central nervous ...

journal_title：Metabolic brain disease

authors： Zheng J,Xiao X,Zhang Q,Yu M,Xu J,Wang Z,Qi C,Wang T

更新日期：2015-10-01 00:00:00

abstract：:Chronic exposure to stress amplifies locomotor deficits and exacerbates dopamine neuron loss in an animal model for Parkinson's disease. The release of neurotrophic factors such as glial cell-line derived neurotrophic factor (GDNF) and neurotrophin-3 (NT-3) following neuronal injury attenuates exacerbated degeneration...

journal_title：Metabolic brain disease

authors： Ngema PN,Mabandla MV

更新日期：2017-08-01 00:00:00

abstract：:In this work, we evaluated the effects of Psidium cattleianum (Red Type) (PcRT) fruit extract on metabolic, behavioral, and neurochemical parameters in rats fed with a highly palatable diet (HPD) consisted of sucrose (65% carbohydrates being 34% from condensed milk, 8% from sucrose and 23% from starch, 25% protein and...

journal_title：Metabolic brain disease

authors： Oliveira PS,Chaves VC,Soares MSP,Bona NP,Mendonça LT,Carvalho FB,Gutierres JM,Vasconcellos FA,Vizzotto M,Vieira A,Spanevello RM,Reginatto FH,Lencina CL,Stefanello FM

更新日期：2018-10-01 00:00:00

abstract：:As studies of brain metabolism grow in complexity, investigators turn increasingly to nuclear magnetic resonance spectroscopy combined with 13C isotopic labeling. The unique ability to detect labeling non-destructively in specific carbon positions of individual compounds has opened the way to investigate brain metabol...

journal_title：Metabolic brain disease

authors： Mason GF,Behar KL,Lai JC

更新日期：1996-12-01 00:00:00

abstract：:The free radical scavenging abilities of the structurally related steroids beta-sitosterol, beta-sitosterol glucoside (plant sterols and sterolins), cholesterol, and dehydroepiandrosterone sulphate (DHEAS) were compared with melatonin (an efficient free radical scavenger) in an in vitro system which measures lipid per...

journal_title：Metabolic brain disease

authors： van Rensburg SJ,Daniels WM,van Zyl JM,Taljaard JJ

更新日期：2000-12-01 00:00:00

abstract：:Glutamate neurotoxicity was studied in primary neuronal cultures prepared from rat cerebral cortex and hippocampal CA1 sector. Neurons were cultivated with 5% native horse serum and then exposed to 0.1 or 1.0 mM glutamate for 5 min. Subsequently, neurons were allowed to recover for 24 hours either in the presence or i...

journal_title：Metabolic brain disease

authors： Uto A,Dux E,Hossmann KA

更新日期：1994-12-01 00:00:00

abstract：:Pipecolic acid (PA) levels are increased in severe metabolic disorders of the central nervous system such as Zellweger syndrome, infantile Refsum disease, neonatal adrenoleukodystrophy and hyperlysinemia. The affected individuals present progressive neurological dysfunction, hypotonia and growth retardation. The mecha...

journal_title：Metabolic brain disease

authors： Dalazen GR,Terra M,Jacques CE,Coelho JG,Freitas R,Mazzola PN,Dutra-Filho CS

更新日期：2014-03-01 00:00:00