Southern Brazilian native fruit shows neurochemical, metabolic and behavioral benefits in an animal model of metabolic syndrome.

Abstract:

:In this work, we evaluated the effects of Psidium cattleianum (Red Type) (PcRT) fruit extract on metabolic, behavioral, and neurochemical parameters in rats fed with a highly palatable diet (HPD) consisted of sucrose (65% carbohydrates being 34% from condensed milk, 8% from sucrose and 23% from starch, 25% protein and 10% fat). Animals were divided into 4 groups: standard chow, standard chow + PcRT extract (200 mg/Kg/day by gavage), HPD, HPD + extract. The animals were treated for 150 days. Concerning chemical profiling, LC/PDA/MS/MS analysis revealed cyanidin-3-O-glucoside as the only anthocyanin in the PcRT extract. Our results showed that the animals exposed to HPD presented glucose intolerance, increased weight gain and visceral fat, as well as higher serum levels of glucose, triacylglycerol, total cholesterol, LDL-cholesterol and interleukin-6. These alterations were prevented by PcRT. In addition, HPD caused an increase in immobility time in a forced swimming test and the fruit extract prevented this alteration, indicating an antidepressant-like effect. PcRT treatment also prevented increased acetylcholinesterase activity in the prefrontal cortex caused by HPD consumption. Moreover, PcRT extract was able to restore Ca2+-ATPase activity in the prefrontal cortex, hippocampus, and striatum, as well as Na+,K+-ATPase activity in the prefrontal cortex and hippocampus. PcRT treatment decreased thiobarbituric acid-reactive substances, nitrite, and reactive oxygen species levels and prevented the reduction of superoxide dismutase activity in all cerebral structures of the HPD group. Additionally, HPD decreased catalase in the hippocampus and striatum. However, the extract prevented this change in the hippocampus. Our results showed that this berry extract has antihyperglycemic and antihyperlipidemic effects, and neuroprotective properties, proving to be a potential therapeutic agent for individuals with metabolic syndrome.

journal_name

Metab Brain Dis

journal_title

Metabolic brain disease

authors

Oliveira PS,Chaves VC,Soares MSP,Bona NP,Mendonça LT,Carvalho FB,Gutierres JM,Vasconcellos FA,Vizzotto M,Vieira A,Spanevello RM,Reginatto FH,Lencina CL,Stefanello FM

doi

10.1007/s11011-018-0262-y

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

1551-1562

issue

5

eissn

0885-7490

issn

1573-7365

pii

10.1007/s11011-018-0262-y

journal_volume

33

pub_type

杂志文章
  • Pretreatment with vitamins E and C prevent the impairment of memory caused by homocysteine administration in rats.

    abstract::Homocystinuria is a metabolic disorder caused by deficiency of cystathione beta-synthase activity leading to tissue accumulation of homocysteine (Hcy); affected patients present neurological dysfunction. Considering that Hcy induces free radical formation and that memory is impaired by oxidative stress, in the present...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章

    doi:10.1023/a:1019982223034

    authors: Reis EA,Zugno AI,Franzon R,Tagliari B,Matté C,Lammers ML,Netto CA,Wyse AT

    更新日期:2002-09-01 00:00:00

  • Glucose transporters and glucose utilization in rat brain after acute ethanol administration.

    abstract::In the normal adult brain, glucose provides 90% of the energy requirements as well as substrate for nucleic acid and lipid synthesis. In the present study, effects of ethanol on glucose transporters (GLUT) and glucose utilization were examined in rat brain. Male Sprague-Dawley rats weighing 250-300 gms were given eith...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章

    doi:10.1007/BF02674530

    authors: Handa RK,DeJoseph MR,Singh LD,Hawkins RA,Singh SP

    更新日期:2000-09-01 00:00:00

  • Antioxidant treatment strategies for hyperphenylalaninemia.

    abstract::Hyperphenylalaninemia (HPA) leads to increased oxidative stress in patients with phenylketonuria (PKU) and in animal models of PKU. Early diagnosis and immediate adherence to a phenylalanine-restricted diet prevents HPA and, consequently, severe brain damage. However, treated adolescent and adult PKU patients have dif...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章,评审

    doi:10.1007/s11011-013-9414-2

    authors: Mazzola PN,Karikas GA,Schulpis KH,Dutra-Filho CS

    更新日期:2013-12-01 00:00:00

  • The blood-brain barrier and selective vulnerability in experimental thiamine-deficiency encephalopathy in the mouse.

    abstract::The integrity of the blood-brain barrier (BBB) is an important aspect of normal central nervous system (CNS) function. Recently, it was shown that the BBB breakdown is one of the predisposing factors in the pathogenesis of thiamine-deficiency encephalopathy. The result is discussed along with some reviews on previous ...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章,评审

    doi:10.1007/BF02080931

    authors: Harata N,Iwasaki Y

    更新日期:1996-03-01 00:00:00

  • Evidence of hippocampal astrogliosis and antioxidant imbalance after L-tyrosine chronic administration in rats.

    abstract::Tyrosinemia type II is a genetic disorder characterized by elevated blood levels of the amino acid tyrosine caused by the deficiency of tyrosine aminotransferase enzyme, resulting in neurologic and developmental difficulties in the patients. Although neurological sequelae are common in Tyrosinemia type II patients, th...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章

    doi:10.1007/s11011-019-00511-3

    authors: Carvalho-Silva M,Gomes LM,de Prá SD,Wessler LB,Schuck PF,Scaini G,de Bem AF,Blum-Silva CH,Reginatto FH,de Oliveira J,Streck EL

    更新日期:2020-01-01 00:00:00

  • Young coconut water ameliorates depression via modulation of neurotransmitters: possible mechanism of action.

    abstract::In the current era, plants are frequently tested for its antidepressant potential. Therefore young coconut water, a commonly used plant based beverage, was selected to explore its antidepressant potential. Rodents were selected for this study and forced swim test was conducted to explore antidepressant activity. Analy...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章

    doi:10.1007/s11011-016-9866-2

    authors: Rao SS,Najam R

    更新日期:2016-10-01 00:00:00

  • Correction to: Shuangxia decoction alleviates p-chlorophenylalanine induced insomnia through the modification of serotonergic and immune system.

    abstract::The original article contains mistake. The authors want to add Wenhui Pei as first co-author and Fang Fang as co-corresponding author. ...

    journal_title:Metabolic brain disease

    pub_type: 已发布勘误

    doi:10.1007/s11011-020-00612-4

    authors: Sun Y,Pei W,Zhang N,Qu Y,Cao Y,Li J,Yang Y,Yang T,Fang F,Sun Y

    更新日期:2020-12-01 00:00:00

  • Improvement of memory and neurological deficit with Ocimum basilicum L. extract after ischemia reperfusion induced cerebral injury in mice.

    abstract::Oxidative stress is strongly implicated in the pathogenesis of stroke. Strategies using antioxidants to improve neurological functions after stroke have, thus, gained significant attention. Ocimum basilicum L. is used traditionally to treat CNS disorders. Its antioxidant capacity is well established. Our laboratory ha...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章

    doi:10.1007/s11011-018-0215-5

    authors: Singh V,Krishan P,Shri R

    更新日期:2018-08-01 00:00:00

  • Metabolic changes in axotomized fetal and early postnatal hamster facial motoneurons: an autoradiographic study.

    abstract::The developing facial neurons of a series of hamsters ranging in age from the 14-day fetus to the 9 day postnatal were axotomized. Postoperative times were graded for each age so that the retrograde response could be observed before any significant amount of cell degeneration or death occurred. The incorporation of tr...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章

    doi:10.1007/BF00996894

    authors: Clark P,Jones KJ,LaVelle A

    更新日期:1993-06-01 00:00:00

  • Microglia.

    abstract::Microglia--the macrophage equivalent of the CNS--safeguards and supports neuronal functions. Threats to the CNS homeostasis can trigger a rapid transformation of these cells from a normally "resting" into alerted and "activated" states. Microglia primarily serves the tissue defence and protection when participating in...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章,评审

    doi:10.1023/b:mebr.0000043984.73063.d8

    authors: van Rossum D,Hanisch UK

    更新日期:2004-12-01 00:00:00

  • Effects of acidic oligosaccharide sugar chain on amyloid oligomer-induced impairment of synaptic plasticity in rats.

    abstract::Soluble amyloid-β protein (Aβ) oligomers have been recognized to be early and key intermediates in Alzheimer's disease-related synaptic dysfunction. In this study, using in vitro electrophysiology, we investigated interactions of the acidic oligosaccharide sugar chain (AOSC), a marine-derived acidic oligosaccharide, w...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章

    doi:10.1007/s11011-014-9521-8

    authors: Chang L,Li F,Chen X,Xu S,Wang C,Chen H,Wang Q

    更新日期:2014-09-01 00:00:00

  • Mild hypothermia in the prevention of brain edema in acute liver failure: mechanisms and clinical prospects.

    abstract::Mild hypothermia (32 degrees C-35 degrees C) reduces intracranial pressure in patients with acute liver failure and may offer an effective adjunct therapy in the management of these patients. Studies in experimental animals suggest that this beneficial effect of hypothermia is the result of a decrease in blood-brain a...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章

    doi:10.1023/a:1021982523691

    authors: Chatauret N,Rose C,Butterworth RF

    更新日期:2002-12-01 00:00:00

  • Central pontine myelinolysis: historical and mechanistic considerations.

    abstract::Central pontine myelinolysis (CPM) is a demyelinating condition affecting not only the pontine base, but also involving other brain areas. It usually occurs on a background of chronic systemic illness, and is commonly observed in individuals with alcoholism, malnutrition and liver disease. Studies carried out 25-30 ye...

    journal_title:Metabolic brain disease

    pub_type: 历史文章,杂志文章

    doi:10.1007/s11011-010-9175-0

    authors: Norenberg MD

    更新日期:2010-03-01 00:00:00

  • Acquired hepatocerebral degeneration (AHD): a peculiar neurological impairment in advanced chronic liver disease.

    abstract::We discuss the case of a rare and often unrecognized neurologic syndrome, called Acquired Hepatocerebral Degeneration (AHD), observed in patients with advanced liver disease and portosystemic shunts. The clinical manifestations can be very heterogeneous and in our case included a combination of cerebellar and extrapyr...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章

    doi:10.1007/s11011-017-0107-0

    authors: Pigoni A,Iuculano F,Saetti C,Airaghi L,Burdick L,Spreafico S,Curioni M,Lombardi R,Valenti L,Fracanzani AL,Fargion S

    更新日期:2018-02-01 00:00:00

  • Anxiolytic-like effects of α-asarone in a mouse model of chronic pain.

    abstract::α-asarone (ASR) is a major bioactive compound isolated from the rhizome of Acorus tatarinowii Schott and it has extensive biological effects. Clinically, anxiety disorder is a common comorbidity of chronic pain. However, limited information is available regarding the effects of ASR on chronic pain-related anxiety. Thi...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章

    doi:10.1007/s11011-017-0108-z

    authors: Tian J,Tian Z,Qin SL,Zhao PY,Jiang X,Tian Z

    更新日期:2017-12-01 00:00:00

  • Decreased expression of myelin gene regulatory factor in Niemann-Pick type C 1 mouse.

    abstract::Niemann-Pick type C 1 (NPC1) disease is an autosomal recessive cholesterol transport defect resulting in a neurodegenerative process in patients mainly at an early age, although some patients may start with manifestation in adult. Since loss of myelin is considered as a main pathogenetic factor, the precise mechanism ...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章

    doi:10.1007/s11011-011-9263-9

    authors: Yan X,Lukas J,Witt M,Wree A,Hübner R,Frech M,Köhling R,Rolfs A,Luo J

    更新日期:2011-12-01 00:00:00

  • Regional metabolic status of the E-18 rat fetal brain following transient hypoxia/ischemia.

    abstract::Increasing evidence indicates that fetal metabolic stress may result in a variety of post-natal perturbations during brain development. The goal of the study was to determine the duration of hypoxia/ischemia that would elicit a demonstrable regional depression of metabolism in the fetal brain and further to examine se...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章

    doi:10.1007/s11011-006-9031-4

    authors: Pundik S,Robinson S,Lust WD,Zechel J,Buczek M,Selman WR

    更新日期:2006-12-01 00:00:00

  • Phosphodiesterase 4B2 gene is an effector of Toll-like receptor signaling in astrocytes.

    abstract::Cyclic AMP is part of an endogenous mechanism that downregulates inflammatory response, and its intracellular concentration is regulated chiefly by cyclic nucleotide phosphodiesterases type 4. The goal of the present study was to determine whether phosphodiesterases 4 are involved in the inflammatory response of astro...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章

    doi:10.1007/s11011-009-9150-9

    authors: Borysiewicz E,Fil D,Dlaboga D,O'Donnell JM,Konat GW

    更新日期:2009-09-01 00:00:00

  • Phenotype, biochemical features, genotype and treatment outcome of pyridoxine-dependent epilepsy.

    abstract::We report treatment outcome of eleven patients with pyridoxine-dependent epilepsy caused by pathogenic variants in ALDH7A1 (PDE-ALDH7A1). We developed a clinical severity score to compare phenotype with biochemical features, genotype and delays in the initiation of pyridoxine. Clinical severity score included 1) globa...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章

    doi:10.1007/s11011-016-9933-8

    authors: Al Teneiji A,Bruun TU,Cordeiro D,Patel J,Inbar-Feigenberg M,Weiss S,Struys E,Mercimek-Mahmutoglu S

    更新日期:2017-04-01 00:00:00

  • Neuro- and nephrotoxicity of subchronic cadmium chloride exposure and the potential chemoprotective effects of selenium nanoparticles.

    abstract::Cadmium (Cd) exposure leads to production of reactive oxygen species (ROS), which are associated with Cd-induced neurotoxicity and nephrotoxicity. Selenium nanoparticles (Se-NPs) have high bioavailability and antioxidant activities so it attracted wide spread attention. The present study examined the possible ameliora...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章

    doi:10.1007/s11011-017-0053-x

    authors: Sadek KM,Lebda MA,Abouzed TK,Nasr SM,Shoukry M

    更新日期:2017-10-01 00:00:00

  • Ameliorative effect of kolaviron, a biflavonoid complex from Garcinia kola seeds against scopolamine-induced memory impairment in rats: role of antioxidant defense system.

    abstract::In Alzheimer's disease (AD) basal forebrain cholinergic neurons appear to be targeted primarily in early stages of the disease. Scopolamine (muscarinic receptor antagonist) has been used for decades to induce working and reference memory impairment in rodents. In this study, we evaluated the protective effect of kolav...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章

    doi:10.1007/s11011-016-9902-2

    authors: Ishola IO,Adamson FM,Adeyemi OO

    更新日期:2017-02-01 00:00:00

  • Normal diet Vs High fat diet - A comparative study: Behavioral and neuroimmunological changes in adolescent male mice.

    abstract::Recent evidence has established that consumption of High-fat diet (HFD)-induced obesity is associated with deficits in hippocampus-dependent memory/learning and mood states. Nevertheless the link between obesity and emotional disorders still remains to be elucidated. This issue is of particular interest during adolesc...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章

    doi:10.1007/s11011-017-0140-z

    authors: Wu H,Liu Q,Kalavagunta PK,Huang Q,Lv W,An X,Chen H,Wang T,Heriniaina RM,Qiao T,Shang J

    更新日期:2018-02-01 00:00:00

  • Neuron-glial relationship during regeneration of motorneurons.

    abstract::Following axonal interruption, structural, metabolic and physiological parameters change in motorneurons. Also, glial cells are involved in this process. Microglia proliferate and express new proteins such as vimentin or MHC antigens. Astrocytes show hypertrophy, increased GFAP synthesis, and formation of lamellae. Bo...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章,评审

    doi:10.1007/BF00999498

    authors: Kreutzberg GW,Graeber MB,Streit WJ

    更新日期:1989-03-01 00:00:00

  • Erratum to: Treadmill exercise alters ecstasy- induced long- term potentiation disruption in the hippocampus of male rats.

    abstract::In the original publication of the article, author name Masoumeh Asadbegi was incorrectly written as Masoumeh Asadbeigi. The authors regret the oversight. ...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s11011-017-0114-1

    authors: Sajadi A,Amiri I,Gharebaghi A,Komaki A,Asadbegi M,Shahidi S,Mehdizadeh M,Asl SS

    更新日期:2017-12-01 00:00:00

  • Changing metabolic and energy profiles in fetal, neonatal, and adult rat brain.

    abstract::The regional energy status and the availability of metabolic substrates during brain development are important, since a variety of fetal metabolic insults have been increasingly implicated in the evolution of neonatal brain disorders. The response of the brain to a metabolic insult is determined, in large part, by the...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章

    doi:10.1023/a:1025503115837

    authors: Lust WD,Pundik S,Zechel J,Zhou Y,Buczek M,Selman WR

    更新日期:2003-09-01 00:00:00

  • Advances in intervention methods and brain protection mechanisms of in situ and remote ischemic postconditioning.

    abstract::Ischemic postconditioning (PostC) conventionally refers to a series of brief blood vessel occlusions and reperfusions, which can induce an endogenous neuroprotective effect and reduce cerebral ischemia/reperfusion (I/R) injury. Depending on the site of adaptive ischemic intervention, PostC can be classified as in situ...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章,评审

    doi:10.1007/s11011-020-00562-x

    authors: Li CY,Ma W,Liu KP,Yang JW,Wang XB,Wu Z,Zhang T,Wang JW,Liu W,Liu J,Liang Y,Zhang XK,Li JJ,Guo JH,Li LY

    更新日期:2021-01-01 00:00:00

  • Association of genetic variants of ABCA1 with susceptibility to dementia: (SADEM study).

    abstract::Because of the importance of cholesterol metabolism in the physiopathogenesis of dementia, and knowing the function of ATP-binding cassette A1 transporter (ABCA1) as a cholesterol flow pump at the cellular and cerebral level, it has been noted that the ABCA1 gene may be a good candidate for disease study. In order to ...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章

    doi:10.1007/s11011-020-00577-4

    authors: Teresa JC,Fernado C,Nancy MR,Gilberto VA,Alberto CR,Roberto RR

    更新日期:2020-08-01 00:00:00

  • Brain edema: a valid endpoint for measuring hepatic encephalopathy?

    abstract::Hepatic encephalopathy (HE) is a major complication of liver failure/disease which frequently develops during the progression of end-stage liver disease. This metabolic neuropsychiatric syndrome involves a spectrum of symptoms, including cognition impairment, attention deficits and motor dysfunction which eventually c...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章,评审

    doi:10.1007/s11011-016-9843-9

    authors: Bémeur C,Cudalbu C,Dam G,Thrane AS,Cooper AJ,Rose CF

    更新日期:2016-12-01 00:00:00

  • Tissue kallikrein and kinin receptor expression in an angiogenic co-culture neuroblastoma model.

    abstract::The sprouting of new blood vessels from pre-existing vasculature (angiogenesis) is essential for tumour survival, influenced by tumour cell-endothelial cell interactions and is tightly regulated by biochemical cues including the kallikrein-kinin system (KKS). We examined the structural interaction between neuroblastom...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章

    doi:10.1007/s11011-006-9008-3

    authors: Naidoo S,Raidoo DM

    更新日期:2006-09-01 00:00:00

  • Acute liver failure and the brain: a look through the crystal ball.

    abstract::Over the past 35 years, the outlook for a patient presenting with acute liver failure (ALF) has changed beyond all recognition. A patient presenting in 1984 had an 80 % likelihood of succumbing to intracranial hypertension. Today due to dramatic improvements in intensive care in dedicated liver transplant units, this ...

    journal_title:Metabolic brain disease

    pub_type: 杂志文章,评审

    doi:10.1007/s11011-012-9363-1

    authors: Ryan JM,Tranah T,Mitry RR,Wendon JA,Shawcross DL

    更新日期:2013-03-01 00:00:00