Possible cause for altered spatial cognition of prepubescent rats exposed to chronic radiofrequency electromagnetic radiation.

abstract：:Previous studies have been conducted to explore the association between proline dehydrogenase gene (PRODH) polymorphisms and schizophrenia (SZ) susceptibility, but providing the controversial results. Here we performed this meta-analysis to determine whether PRODH variants were associated with SZ risk. Relevant studie...

journal_title：Metabolic brain disease

authors： Guo X,Tang P,Yang C,Li R

更新日期：2018-02-01 00:00:00

abstract：:A rat model of glucose-precipitated Wernicke's encephalopathy (WE) has been developed in which glucose loading (10 g/kg, i.p.) of ataxic thiamin-deficient (TD) rats induced episodes of gross neurological dysfunction and sometimes death. The acute effects of a glucose load on the neurological state of thiamin-replete c...

journal_title：Metabolic brain disease

authors： Zimitat C,Nixon PF

更新日期：1999-03-01 00:00:00

abstract：:Chronic neuroinflammation is strongly associated with AD and altered peripheral and central levels of chemokines and cytokines have been frequently described in those with AD. Given the increasing evidence of ethnicity-related differences in AD, it was of interest to determine if those altered chemokine and cytokine l...

journal_title：Metabolic brain disease

authors： Ferguson SA,Varma V,Sloper D,Panos JJ,Sarkar S

更新日期：2020-01-01 00:00:00

abstract：:Hepatic encephalopathy (HE) is an important cause of morbidity and mortality in patients with severe liver disease. Although the mechanisms responsible for HE remain elusive, ammonia is generally considered to be involved in its pathogenesis, and astrocytes are thought to be the principal target of ammonia neurotoxici...

journal_title：Metabolic brain disease

authors： Rama Rao KV,Jayakumar AR,Norenberg DM

更新日期：2003-06-01 00:00:00

abstract：:Fenproporex (Fen) is an amphetamine-based anorectic; amphetamine use causes a broad range of severe cognitive deficits and anxiogenic-like effects. In this study we evaluated pharmacological effects of the chronic administration of Fen on cognitive and non-cognitive behaviors. Male adult Wistar rats received intraperi...

journal_title：Metabolic brain disease

authors： Gonçalves CL,Furlanetto CB,Valvassori SS,Bavaresco DV,Varela RB,Budni J,Quevedo J,Streck EL

更新日期：2015-04-01 00:00:00

abstract：:Maple Syrup Urine Disease (MSUD) is biochemically characterized by elevated levels of leucine, isoleucine and valine, as well as their corresponding transaminated branched-chain α-keto acids in tissue and biological fluids. Neurological symptoms and cerebral abnormalities, whose mechanisms are still unknown, are typic...

journal_title：Metabolic brain disease

authors： Taschetto L,Scaini G,Zapelini HG,Ramos ÂC,Strapazzon G,Andrade VM,Réus GZ,Michels M,Dal-Pizzol F,Quevedo J,Schuck PF,Ferreira GC,Streck EL

更新日期：2017-10-01 00:00:00

abstract：:The availability of an animal model is crucial in studying the pathophysiological mechanisms of disease and to test possible therapies. Now, there are several models for the study of liver diseases, but there still remains a lack of a satisfactory animal model of chronic liver disease with hepatic encephalopathy (HE) ...

journal_title：Metabolic brain disease

authors： Jover R,Madaria E,Felipo V,Rodrigo R,Candela A,Compañ A

更新日期：2005-12-01 00:00:00

abstract：:Hepatic encephalopathy (HE) is a neuropsychiatric syndrome which develops in patients with severe liver diseases and/or portal-systemic shunting. Minimal HE, the earliest manifestation of HE, has drawn increasing attention in the last decade. Minimal HE is associated with a series of brain functional changes, such as ...

journal_title：Metabolic brain disease

authors： Zhang LJ,Wu S,Ren J,Lu GM

更新日期：2014-09-01 00:00:00

abstract：:gamma-Hydroxybutyric acid (GHB) is a naturally occurring compound in the central nervous system (CNS) whose tissue concentration are highly increased in the neurometabolic-inherited deficiency of succinic semialdehyde dehydrogenase (SSADH) activity or due to intoxication. SSADH deficiency is biochemically characterize...

journal_title：Metabolic brain disease

authors： Sgaravatti AM,Magnusson AS,Oliveira AS,Mescka CP,Zanin F,Sgarbi MB,Pederzolli CD,Wyse AT,Wannmacher CM,Wajner M,Dutra-Filho CS

更新日期：2009-06-01 00:00:00

abstract：:The regional energy status and the availability of metabolic substrates during brain development are important, since a variety of fetal metabolic insults have been increasingly implicated in the evolution of neonatal brain disorders. The response of the brain to a metabolic insult is determined, in large part, by the...

journal_title：Metabolic brain disease

authors： Lust WD,Pundik S,Zechel J,Zhou Y,Buczek M,Selman WR

更新日期：2003-09-01 00:00:00

abstract：:Overwhelming evidence suggests that microglia play an important role in ischemic injury and they polarize into two different phenotypes with distinct functions after ischemic stroke. We performed the present study to investigate whether L-3-n butylphthalide (NBP) has an effect on microglial polarization. Mice were sub...

journal_title：Metabolic brain disease

authors： Li F,Ma Q,Zhao H,Wang R,Tao Z,Fan Z,Zhang S,Li G,Luo Y

更新日期：2018-12-01 00:00:00

abstract：:This study was performed to analyze the mutational spectrum of the phenylalanine hydroxylase (PAH) gene in phenylketonuria (PKU) patients in Northwest China, to identify mutational hot spots, and to determine the correlation between variants and clinical phenotypes of PKU. A large cohort of 475 PKU families in Northwe...

journal_title：Metabolic brain disease

authors： Yan Y,Zhang C,Jin X,Zhang Q,Zheng L,Feng X,Hao S,Gao H,Ma X

更新日期：2019-06-01 00:00:00

abstract：:Glutamate neurotoxicity was studied in primary neuronal cultures prepared from rat cerebral cortex and hippocampal CA1 sector. Neurons were cultivated with 5% native horse serum and then exposed to 0.1 or 1.0 mM glutamate for 5 min. Subsequently, neurons were allowed to recover for 24 hours either in the presence or i...

journal_title：Metabolic brain disease

authors： Uto A,Dux E,Hossmann KA

更新日期：1994-12-01 00:00:00

abstract：:Depression, common in chronic medical conditions, and hepatic encephalopathy (HE), a reversible neuropsychiatric syndrome due to liver dysfunction, are associated with impaired health-related quality of life (HRQOL) in cirrhosis and hepatitis C (HCV). This study investigated the impact of depression and HE on HRQOL in...

journal_title：Metabolic brain disease

authors： Barboza KC,Salinas LM,Sahebjam F,Jesudian AB,Weisberg IL,Sigal SH

更新日期：2016-08-01 00:00:00

abstract：:The developing facial neurons of a series of hamsters ranging in age from the 14-day fetus to the 9 day postnatal were axotomized. Postoperative times were graded for each age so that the retrograde response could be observed before any significant amount of cell degeneration or death occurred. The incorporation of tr...

journal_title：Metabolic brain disease

authors： Clark P,Jones KJ,LaVelle A

更新日期：1993-06-01 00:00:00

abstract：:Hepatic encephalopathy (HE) represents a nervous system disorder caused due to liver dysfunction. HE is broadly classified as acute/overt and moderate-minimal HE. Since HE syndrome severely affects quality of life of the patients and it may be life threatening, it is important to develop effective therapeutic strategy...

journal_title：Metabolic brain disease

authors： Mondal P,Trigun SK

更新日期：2014-12-01 00:00:00

abstract：:Stress-induced activation of the expression of the endoplasmic reticulum (ER)-resident chaperon and member of the protein disulfide isomerase family erp72 was studied after transient cerebral ischemia in vivo using the four-vessel occlusion method and experimental depletion of ER calcium stores in primary neuronal cel...

journal_title：Metabolic brain disease

authors： Paschen W,Gissel C,Linden T,Doutheil J

更新日期：1998-03-01 00:00:00

abstract：:Attention alterations are reported in cirrhotics. Aiming at clarifying attention functioning in cirrhotics, an inquiry on the functioning of the anterior (AAS) and the posterior (PAS) attention system was performed. Thirty-six cirrhotics without overt hepatic encephalopathy (24 with EEG or TMT-A alterations) and 16 ma...

journal_title：Metabolic brain disease

authors： Amodio P,Schiff S,Del Piccolo F,Mapelli D,Gatta A,Umiltà C

更新日期：2005-06-01 00:00:00

abstract：:Schizophrenia is one of the most disabling mental disorders that affects up to 1 % of the population worldwide. Although the causes of this disorder remain unknown, it has been extensively characterized by a broad range of emotional, ideational and cognitive impairments. Studies indicate that schizophrenia affects neu...

journal_title：Metabolic brain disease

authors： Zugno AI,Julião RF,Budni J,Volpato AM,Fraga DB,Pacheco FD,Deroza PF,Luca RD,de Oliveira MB,Heylmann AS,Quevedo J

更新日期：2013-09-01 00:00:00

abstract：:At the present time alcoholism is recognized as a metabolic disease exhibiting the clinical features of craving for alcohol, loss of control over drinking, tolerance and physical dependence on alcohol, while both epidemiological and experimental studies have demonstrated that genetic factors may be important in determ...

journal_title：Metabolic brain disease

authors： Gianoulakis C,de Waele JP

更新日期：1994-06-01 00:00:00

abstract：:In this work, we evaluated the effects of Psidium cattleianum (Red Type) (PcRT) fruit extract on metabolic, behavioral, and neurochemical parameters in rats fed with a highly palatable diet (HPD) consisted of sucrose (65% carbohydrates being 34% from condensed milk, 8% from sucrose and 23% from starch, 25% protein and...

journal_title：Metabolic brain disease

authors： Oliveira PS,Chaves VC,Soares MSP,Bona NP,Mendonça LT,Carvalho FB,Gutierres JM,Vasconcellos FA,Vizzotto M,Vieira A,Spanevello RM,Reginatto FH,Lencina CL,Stefanello FM

更新日期：2018-10-01 00:00:00

abstract：:We discuss the case of a rare and often unrecognized neurologic syndrome, called Acquired Hepatocerebral Degeneration (AHD), observed in patients with advanced liver disease and portosystemic shunts. The clinical manifestations can be very heterogeneous and in our case included a combination of cerebellar and extrapyr...

journal_title：Metabolic brain disease

authors： Pigoni A,Iuculano F,Saetti C,Airaghi L,Burdick L,Spreafico S,Curioni M,Lombardi R,Valenti L,Fracanzani AL,Fargion S

更新日期：2018-02-01 00:00:00

abstract：:Near infrared radiation (NIR) is known to penetrate and affect biological systems in multiple ways. Recently, a series of experimental studies suggested that low intensity NIR may protect neuronal cells against a wide range of insults that mimic diseases such as stroke, brain trauma and neurodegeneration. However, the...

journal_title：Metabolic brain disease

authors： Yu Z,Liu N,Zhao J,Li Y,McCarthy TJ,Tedford CE,Lo EH,Wang X

更新日期：2015-04-01 00:00:00

abstract：:Sevoflurane, one of the most commonly used volatile anesthetics in clinical treatment, has been shown to induce a widespread increase in brain apoptosis. However, the underlying mechanism is still unknown. Sestrin 2 has been recently shown to regulate intracellular reactive oxygen species (ROS) levels and play a cruci...

journal_title：Metabolic brain disease

authors： Yi W,Zhang Y,Guo Y,Li D,Li X

更新日期：2015-10-01 00:00:00

abstract：:Studies have shown that oxidative stress is involved in the pathophysiology of bipolar disorder (BD). It is suggested that omega-3 (ω3) fatty acids are fundamental to maintaining the functional integrity of the central nervous system. The animal model used in this study displayed fenproporex-induced hyperactivity, a s...

journal_title：Metabolic brain disease

authors： Gomes LM,Carvalho-Silva M,Teixeira LJ,Rebelo J,Mota IT,Bilesimo R,Michels M,Arent CO,Mariot E,Dal-Pizzol F,Scaini G,Quevedo J,Streck EL

更新日期：2017-04-01 00:00:00

abstract：:Depression is a complex progressive disorder accompanied by activation of inflammatory and Th-1 driven pathways, oxidative and nitrosative stress (O&NS), lowered antioxidant levels, mitochondrial dysfunctions, neuroprogression and increased bacterial translocation. In depression, activation of immuno-inflammatory path...

journal_title：Metabolic brain disease

authors： Maes M

更新日期：2012-12-01 00:00:00

abstract：:Hepatic encephalopathy can be a life-threatening complication of fulminant hepatic failure. By understanding the pathophysiology involved in the induction of this neuropsychiatric disorder, future therapeutic and/or preventive attempts could be considered. In this study, an attempt has been made in order to shed more ...

journal_title：Metabolic brain disease

authors： Zarros A,Theocharis S,Skandali N,Tsakiris S

更新日期：2008-09-01 00:00:00

abstract：:Thyroid hormone insufficiency during neurodevelopment can result into significant structural and functional changes within the developing central nervous system (CNS), and is associated with the establishment of serious cognitive impairment and neuropsychiatric symptomatology. The aim of the present study was to shed ...

journal_title：Metabolic brain disease

authors： Koromilas C,Tsakiris S,Kalafatakis K,Zarros A,Stolakis V,Kimpizi D,Bimpis A,Tsagianni A,Liapi C

更新日期：2015-02-01 00:00:00

abstract：:There is abundant evidence showing that repeated use of MDMA (3, 4-Methylenedioxymethamphetamine, ecstasy) has been associated with depression, anxiety and deficits in learning and memory, suggesting detrimental effects on hippocampus. Adenosine is an endogenous purine nucleoside that has a neuromodulatory role in the...

journal_title：Metabolic brain disease

authors： Kermanian F,Mehdizadeh M,Soleimani M,Ebrahimzadeh Bideskan AR,Asadi-Shekaari M,Kheradmand H,Haghir H

更新日期：2012-12-01 00:00:00

abstract：:Mild hypothermia (32 degrees C-35 degrees C) reduces intracranial pressure in patients with acute liver failure and may offer an effective adjunct therapy in the management of these patients. Studies in experimental animals suggest that this beneficial effect of hypothermia is the result of a decrease in blood-brain a...

journal_title：Metabolic brain disease

authors： Chatauret N,Rose C,Butterworth RF

更新日期：2002-12-01 00:00:00