Abstract：
:Fenproporex (Fen) is an amphetamine-based anorectic; amphetamine use causes a broad range of severe cognitive deficits and anxiogenic-like effects. In this study we evaluated pharmacological effects of the chronic administration of Fen on cognitive and non-cognitive behaviors. Male adult Wistar rats received intraperitoneal administration of vehicle (control group) or Fen (6.25, 12.5 or 25 mg/kg) for 14 days; the animals were then subjected to habituation and object recognition tasks in open-field apparatus, and elevated plus-maze task. The administration of Fen (12.5 and 25 mg/kg) impaired habituation during the second exposure to the habituation task. In addition, the same doses of Fen also impaired the performance in object recognition task. In elevated plus-maze task, the administration of Fen (in all doses tested) induced anxiogenic-like effects in rats. Our results suggest that chronic Fen administration alters memory and induces anxiogenic-like effects in rats.
journal_name
Metab Brain Disjournal_title
Metabolic brain diseaseauthors
Gonçalves CL,Furlanetto CB,Valvassori SS,Bavaresco DV,Varela RB,Budni J,Quevedo J,Streck ELdoi
10.1007/s11011-014-9617-1subject
Has Abstractpub_date
2015-04-01 00:00:00pages
583-8issue
2eissn
0885-7490issn
1573-7365journal_volume
30pub_type
杂志文章abstract：:Increased benzodiazepine (BZ) receptor density has been reported in brains of rabbits with hepatic encephalopathy (HE) due to galactosamine (GalN)-induced fulminant hepatic failure (FHF). These data were generated using detergent-Triton X-100-treated neural membranes. While performing further studies it was noted that...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/BF01000296
更新日期：1989-09-01 00:00:00
abstract：:There is abundant evidence showing that repeated use of MDMA (3, 4-Methylenedioxymethamphetamine, ecstasy) has been associated with depression, anxiety and deficits in learning and memory, suggesting detrimental effects on hippocampus. Adenosine is an endogenous purine nucleoside that has a neuromodulatory role in the...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-012-9334-6
更新日期：2012-12-01 00:00:00
abstract：:Adult-onset type II citrullinemia (CTLN2), characterized by a liver-specific deficiency of urea cycle enzyme, argininosuccinate synthetase, is caused by mutations in SLC25A13 that encodes a calcium binding mitochondrial solute carrier protein, citrin. Citrin deficiency causes not only CTLN2 but also neonatal intrahepa...
journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
doi：10.1023/a:1021961919148
更新日期：2002-12-01 00:00:00
abstract：:Increasing evidence indicates that excessive drug consumption is sufficient for the transition from recreational and controlled drug use to uncontrolled use and addiction. However, the underlying mechanisms are debated. Some neurobehavioral and neuroimaging evidence indicates that dorsolateral striatum (dlStr)-depende...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-019-00430-3
更新日期：2019-08-01 00:00:00
abstract：:Phenylketonuria (PKU) is the most common inborn error of amino acid metabolism. Usually diagnosed within the first month of birth, it is essential that the patient strictly follow the dietary restriction of natural protein intake. Otherwise, PKU impacts the development of the brain severely and may result in microceph...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-019-00472-7
更新日期：2019-12-01 00:00:00
abstract：:Substantial evidence demonstrated that maternal dietary nutrients can significantly determine the susceptibility to developing metabolic disorders in the offspring. Therefore, we aimed to investigate the later-life effects of maternal and postweaning diets interaction on epigenetic modification of the central nervous ...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-015-9678-9
更新日期：2015-10-01 00:00:00
abstract：:Although gaseous ammonia (NH3) can freely enter cells through the plasma membrane where NH3 is cyto(neuro)toxic, NH3 and ionic ammonia (NH4+) contents have not been studied in biological materials. We developed a new method for measurement of expiratory NH3 concentration, which may reflect blood NH3 concentrations. Th...
journal_title：Metabolic brain disease
pub_type： 临床试验,杂志文章
doi：
更新日期：1997-06-01 00:00:00
abstract：:Sepsis is a major clinical challenge that is associated with encephalopathy and multi-organ dysfunction. Current therapeutic interventions are relatively ineffective and the development of novel treatments is hampered by the lack of a well-characterised animal model. Therefore, the behavioural, metabolic, physiologica...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-007-9058-1
更新日期：2007-12-01 00:00:00
abstract：:The role of oxidative stress in the pathogenesis of phenylketonuria (PKU)-associated disorders has been implicated. Ischemia modified albumin (IMA) is a modified form of serum albumin, which is produced under the conditions of oxidative stress. The aim of this study was to measure the serum level of IMA in the PKU pat...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-017-0165-3
更新日期：2018-06-01 00:00:00
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journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-018-0262-y
更新日期：2018-10-01 00:00:00
abstract：:It has been suggested that alterations of GABAergic neurotransmission are implicated in the pathophysiology of hepatic encephalopathy (HE). Increased concentrations of endogenous benzodiazepines with positive allosteric modulatory properties at the GABA-A receptor complex were proposed as a pathophysiological mechanis...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1023/b:mebr.0000043974.89820.22
更新日期：2004-12-01 00:00:00
abstract：:It has been suggested that antidepressants, including the selective serotonin reuptake inhibitors have neurotrophic effects. Nevertheless, the impact of treatment with a selective serotonin re-uptake inhibitor on regional brain volumes in social anxiety disorder has not been studied. 11 subjects with social anxiety di...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-010-9218-6
更新日期：2010-12-01 00:00:00
abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disorder, characterized by accumulation and deposition of Aβ peptide in human brain. The present study aimed to determine the protective effect of catechin rich extract of MERM (methanolic extract of Rhizophora mucronata) on Aβ (25-35) induced cognitive impai...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-016-9831-0
更新日期：2016-08-01 00:00:00
abstract：:A structured analytic approach was developed to evaluate enzyme kinetic parameters using non-linear least-squares fitting. The approach was implemented in a software package called KinSim and designed to run on Windows 95, 98, and NT platforms. The software and the theoretical approach were tested using kinetic data o...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/BF02679980
更新日期：2000-06-01 00:00:00
abstract：:Homocystinuria is an inborn error of sulfur amino acid metabolism characterized predominantly by vascular and nervous system dysfunction. In this study we determined the in vitro effects of homocysteine and methionine, metabolites which accumulate in homocystinuria, on Na+, K+-ATPase, and Mg2+-ATPase activities in syn...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1023/a:1015594111778
更新日期：2002-06-01 00:00:00
abstract：:We report treatment outcome of eleven patients with pyridoxine-dependent epilepsy caused by pathogenic variants in ALDH7A1 (PDE-ALDH7A1). We developed a clinical severity score to compare phenotype with biochemical features, genotype and delays in the initiation of pyridoxine. Clinical severity score included 1) globa...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-016-9933-8
更新日期：2017-04-01 00:00:00
abstract：:There is substantial clinical and experimental evidence that ammonia is a major factor in the pathogenesis of hepatic encephalopathy. In the article is demonstrated that in hepatocellular dysfunction, ammonia detoxification to glutamine (GLN) in skeletal muscle, brain, and likely the lungs, is activated. In addition t...
journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
doi：10.1007/s11011-013-9428-9
更新日期：2014-03-01 00:00:00
abstract：PURPOSE:To analyze brain metabolite changes in HIV-1-seropositive subjects in order to define whether the neuronal impairment is a localized or more diffuse process. MATERIALS AND METHODS:15 patients and 18 volunteers underwent multivoxel proton magnetic resonance (MR) spectroscopy at 1.5T. Nine patients were classifi...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1023/a:1020609213664
更新日期：1998-06-01 00:00:00
abstract：:The radiological spectrum of neuromyelitis optica has become broader since the detection of aquaporin4 antibodies. We report a case of neuromyelitis optica patient with pseudotumoral encephalic lesion. A 66 year-old woman presented with sudden left lateral homonymous hemianopsia. A brain MRI showed an isolated and ext...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-017-0141-y
更新日期：2018-02-01 00:00:00
abstract：:Mild hypothermia (32 degrees C-35 degrees C) reduces intracranial pressure in patients with acute liver failure and may offer an effective adjunct therapy in the management of these patients. Studies in experimental animals suggest that this beneficial effect of hypothermia is the result of a decrease in blood-brain a...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1023/a:1021982523691
更新日期：2002-12-01 00:00:00
abstract：:Near infrared radiation (NIR) is known to penetrate and affect biological systems in multiple ways. Recently, a series of experimental studies suggested that low intensity NIR may protect neuronal cells against a wide range of insults that mimic diseases such as stroke, brain trauma and neurodegeneration. However, the...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-014-9515-6
更新日期：2015-04-01 00:00:00
abstract：:Traumatic brain injury (TBI) is accompanied with enhanced matrix metalloproteinase-9 (MMP-9) activity and elevated levels of plasma fibrinogen (Fg), which is a known inflammatory agent. Activation of MMP-9 and increase in blood content of Fg (i.e. hyperfibrinogenemia, HFg) both contribute to cerebrovascular disorders ...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-014-9550-3
更新日期：2015-04-01 00:00:00
abstract：:Hereditary tyrosinemia type I (HT1) is caused by mutations in the fumarylacetoacetate hydrolase (FAH) gene, the template for the final enzyme in the tyrosine catabolism pathway. If left untreated this deficiency of functional FAH leads to a buildup of toxic metabolites that can cause liver disease, kidney dysfunction ...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-017-0071-8
更新日期：2017-12-01 00:00:00
abstract：:Depression, common in chronic medical conditions, and hepatic encephalopathy (HE), a reversible neuropsychiatric syndrome due to liver dysfunction, are associated with impaired health-related quality of life (HRQOL) in cirrhosis and hepatitis C (HCV). This study investigated the impact of depression and HE on HRQOL in...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-016-9817-y
更新日期：2016-08-01 00:00:00
abstract：:Hyperammonemia is necessary for development of the cerebral complications to liver disease including hepatic encephalopathy and cerebral edema but the mechanisms are unclear. Ammonia is taken up by the brain in proportion to its arterial concentration. The flux into the brain is most likely by both diffusion of NH3 an...
journal_title：Metabolic brain disease
pub_type： 杂志文章,评审
doi：10.1007/s11011-014-9494-7
更新日期：2014-12-01 00:00:00
abstract：:The selective vulnerability of pyramidal neurons in the CA1 hippocampal region in ischemic rat brain may be preceded by regional alterations of energy metabolism during early reperfusion. We measured ATP, phosphocreatine (PCr), and glucose in paramedian and lateral CA1 and in an area showing little postischemic cell l...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/BF00999235
更新日期：1988-09-01 00:00:00
abstract：:Hepatic encephalopathy (HE) represents a nervous system disorder caused due to liver dysfunction. HE is broadly classified as acute/overt and moderate-minimal HE. Since HE syndrome severely affects quality of life of the patients and it may be life threatening, it is important to develop effective therapeutic strategy...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-014-9556-x
更新日期：2014-12-01 00:00:00
abstract：:In Alzheimer's disease (AD) basal forebrain cholinergic neurons appear to be targeted primarily in early stages of the disease. Scopolamine (muscarinic receptor antagonist) has been used for decades to induce working and reference memory impairment in rodents. In this study, we evaluated the protective effect of kolav...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-016-9902-2
更新日期：2017-02-01 00:00:00
abstract：:A rat model of glucose-precipitated Wernicke's encephalopathy (WE) has been developed in which glucose loading (10 g/kg, i.p.) of ataxic thiamin-deficient (TD) rats induced episodes of gross neurological dysfunction and sometimes death. The acute effects of a glucose load on the neurological state of thiamin-replete c...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1023/a:1020653312697
更新日期：1999-03-01 00:00:00
abstract：:The impaired insulin signaling has been recognized as a common pathogenetic mechanism between diabetes and Alzheimer's disease (AD). In the progression of AD, brain is characterized by defective insulin receptor substrate-1 (IRS-1) and increased oxidative stress. Thymol, a monoterpene phenol isolated from medicinal he...
journal_title：Metabolic brain disease
pub_type： 杂志文章
doi：10.1007/s11011-016-9921-z
更新日期：2017-04-01 00:00:00
