Abstract:
PURPOSE:To analyze brain metabolite changes in HIV-1-seropositive subjects in order to define whether the neuronal impairment is a localized or more diffuse process. MATERIALS AND METHODS:15 patients and 18 volunteers underwent multivoxel proton magnetic resonance (MR) spectroscopy at 1.5T. Nine patients were classified as being neuropsychiatrically unimpaired and six as having HIV-1-associated dementia on the basis of a full neuropsychological examination. Spectra were analysed from multiple voxels located in the fronto-parietal cortex and white matter at the level of centrum semiovale. RESULTS:A significant reduction in mean peak area ratios of NAA/Cr (p<0.005 in the grey matter, p<0.01 in the white matter) and an elevation in mean Cho/Cr (p<0.005 in both grey matter and white matter) were observed in patients with HIV-1-associated dementia when compared to healthy volunteers. No significant metabolite abnormalities were detected in the neuropsychiatrically unimpaired group, although there was a similar trend in the metabolite ratios. The changes in metabolite ratios were of the same order of magnitude in the cortical grey matter and subcortical white matter as in the deeper white matter in all patients. There were also no significant regional variations in mean metabolite ratios between right and left hemispheres or anterior and posterior voxels at the level of the brain studied. There were no abnormalities in Glx/Cr in any spectra analysed from either patient group. CONCLUSION:The absence of significant regional variation in metabolite ratios at the level of the centrum semiovale provides some evidence that abnormalities of cerebral metabolites in HIV-infected patients may be part of a diffuse process.
journal_name
Metab Brain Disjournal_title
Metabolic brain diseaseauthors
Marcus CD,Taylor-Robinson SD,Sargentoni J,Ainsworth JG,Frize G,Easterbrook PJ,Shaunak S,Bryant DJdoi
10.1023/a:1020609213664subject
Has Abstractpub_date
1998-06-01 00:00:00pages
123-36issue
2eissn
0885-7490issn
1573-7365journal_volume
13pub_type
杂志文章abstract::D-Galactose (D-gal) chronic administration via intraperitoneal and subcutaneous routes has been used as a model of aging and Alzheimer disease in rodents. Intraperitoneal and subcutaneous administration of D-gal causes memory impairments, a reduction in the neurogenesis of adult mice, an increase in the levels of the ...
journal_title:Metabolic brain disease
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abstract::Sevoflurane, one of the most commonly used volatile anesthetics in clinical treatment, has been shown to induce a widespread increase in brain apoptosis. However, the underlying mechanism is still unknown. Sestrin 2 has been recently shown to regulate intracellular reactive oxygen species (ROS) levels and play a cruci...
journal_title:Metabolic brain disease
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journal_title:Metabolic brain disease
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journal_title:Metabolic brain disease
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abstract::Hepatic encephalopathy is a common complication of hepatic cirrhosis. The clinical diagnosis is based on two concurrent types of symptoms: impaired mental status and impaired neuromotor function. Impaired mental status is characterized by deterioration in mental status with psychomotor dysfunction, impaired memory, an...
journal_title:Metabolic brain disease
pub_type: 杂志文章,评审
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journal_title:Metabolic brain disease
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abstract::Susceptibility to Wilson's disease (WD) and its clinical manifestations are thought to be affected by genetic factors, including polymorphisms. The role of brain-derived neurotrophic factor (BDNF) in the pathogenesis of neurodegenerative diseases is now widely discussed. The aim of the present study was to evaluate th...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-013-9399-x
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journal_title:Metabolic brain disease
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doi:10.1007/s11011-015-9652-6
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journal_title:Metabolic brain disease
pub_type: 杂志文章
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journal_title:Metabolic brain disease
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journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-013-9466-3
更新日期:2014-03-01 00:00:00
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journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-007-9058-1
更新日期:2007-12-01 00:00:00
abstract::Cadmium (Cd) exposure leads to production of reactive oxygen species (ROS), which are associated with Cd-induced neurotoxicity and nephrotoxicity. Selenium nanoparticles (Se-NPs) have high bioavailability and antioxidant activities so it attracted wide spread attention. The present study examined the possible ameliora...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-017-0053-x
更新日期:2017-10-01 00:00:00
abstract::Chronic exposure to stress amplifies locomotor deficits and exacerbates dopamine neuron loss in an animal model for Parkinson's disease. The release of neurotrophic factors such as glial cell-line derived neurotrophic factor (GDNF) and neurotrophin-3 (NT-3) following neuronal injury attenuates exacerbated degeneration...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-017-9988-1
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journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-014-9578-4
更新日期:2015-02-01 00:00:00
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journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/BF02098880
更新日期:1994-12-01 00:00:00
abstract::Mitochondrial dysfunction is observed in brains of Alzheimer's Disease patients as well as many rodent model systems including those modeling mutations in preseinilin 1 (PSEN1). The aim of our study was to characterize mitochondrial function and number in fibroblasts from AD patients with PSEN1 mutations. We used bioc...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-015-9667-z
更新日期:2015-10-01 00:00:00
abstract::The combination of Parkinson syndrome (PS) and prolonged visually evoked potentials (VEPs) in a single patient with hepatic encephalopathy (HE) has not been reported. A 52-year-old male with chronic HE developed PS in early 2001. Treatment with L-DOPA was only of minimal effect. In August 2001 he was admitted because ...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-005-2476-z
更新日期:2005-03-01 00:00:00
abstract::Because of the importance of cholesterol metabolism in the physiopathogenesis of dementia, and knowing the function of ATP-binding cassette A1 transporter (ABCA1) as a cholesterol flow pump at the cellular and cerebral level, it has been noted that the ABCA1 gene may be a good candidate for disease study. In order to ...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-020-00577-4
更新日期:2020-08-01 00:00:00
abstract::In patients with hepatic encephalopathy (HE) the blood concentration of ammonia is usually highly elevated. Ammonia readily enters brain cells from the blood, and toxic effects of ammonia on brain metabolism and neurotransmission are believed to play a key role in the pathogenesis of HE. It has, however, been a matter...
journal_title:Metabolic brain disease
pub_type: 杂志文章
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更新日期:2009-03-01 00:00:00
abstract::Thiamine triphosphate (ThTP) was discovered over 60 years ago and it was long thought to be a specifically neuroactive compound. Its presence in most cell types, from bacteria to mammals, would suggest a more general role but this remains undefined. In contrast to thiamine diphosphate (ThDP), ThTP is not a coenzyme. I...
journal_title:Metabolic brain disease
pub_type: 杂志文章,评审
doi:10.1007/s11011-014-9509-4
更新日期:2014-12-01 00:00:00
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journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-018-0295-2
更新日期:2018-12-01 00:00:00
abstract::The effects of chronic and repeated radiofrequency electromagnetic radiation (RFEMR) exposure on spatial cognition and hippocampal architecture were investigated in prepubescent rats. Four weeks old male Wistar rats were exposed to RF-EMR (900 MHz; SAR-1.15 W/kg with peak power density of 146.60 μW/cm(2)) for 1 h/day,...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-015-9689-6
更新日期:2015-10-01 00:00:00
abstract::In this work, we evaluated the effects of Psidium cattleianum (Red Type) (PcRT) fruit extract on metabolic, behavioral, and neurochemical parameters in rats fed with a highly palatable diet (HPD) consisted of sucrose (65% carbohydrates being 34% from condensed milk, 8% from sucrose and 23% from starch, 25% protein and...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-018-0262-y
更新日期:2018-10-01 00:00:00
abstract::The aim of this study was to explore the neuroprotective effects of active compounds from Schisandra chinensis (Trucz.) Baill. (Magnoliaceae) against the D-galactose (D-gal)-induced neurotoxicity in rat. The Wistar rats were subcutaneously injected with D-gal (150 mg/(kg day)) for six weeks and orally administered wit...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-016-9804-3
更新日期:2016-06-01 00:00:00
abstract::Adult-onset type II citrullinemia (CTLN2), characterized by a liver-specific deficiency of urea cycle enzyme, argininosuccinate synthetase, is caused by mutations in SLC25A13 that encodes a calcium binding mitochondrial solute carrier protein, citrin. Citrin deficiency causes not only CTLN2 but also neonatal intrahepa...
journal_title:Metabolic brain disease
pub_type: 杂志文章,评审
doi:10.1023/a:1021961919148
更新日期:2002-12-01 00:00:00
abstract::Chronic liver disease (CLD) leads to a spectrum of neuropsychiatric disorders named hepatic encephalopathy (HE). Even though brain energy metabolism is believed to be altered in chronic HE, few studies have explored energy metabolism in CLD-induced HE, and their findings were inconsistent. The aim of this study was to...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-015-9715-8
更新日期:2016-12-01 00:00:00
abstract::The commonly used volatile anesthetic sevoflurane has been shown to induce widespread apoptosis in the developing brain, yet the underlying molecular mechanisms are not fully understood. Accumulating research has demonstrated that long noncoding RNAs (lncRNAs) regulate multiple biological processes, including neural d...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-016-9838-6
更新日期:2016-10-01 00:00:00
abstract::In the brain hyperammonemia interferes with ion homeostasis, membrane potentials, neurotransmission, and neurotransmitter recycling and reduces metabolic rates for oxygen and glucose. Because, cerebral blood flow (CBF) is closely coupled to metabolism, CBF is most often reduced in diseases associated with hyperammonem...
journal_title:Metabolic brain disease
pub_type: 杂志文章,评审
doi:10.1023/a:1021941414605
更新日期:2002-12-01 00:00:00
abstract::Several epidemiological studies have shown that Diabetes Mellitus (DM) or Insulin Resistance (IR) increases the risk of dementia. Besides, some authors suggested that poor glucose control to be associated with worse cognitive function. We aimed to assess cognitive functions and IR-degree over time in diabetic. We also...
journal_title:Metabolic brain disease
pub_type: 杂志文章
doi:10.1007/s11011-017-9977-4
更新日期:2017-06-01 00:00:00