Short term cadmium administration dose dependently elicits immediate biochemical, neurochemical and neurobehavioral dysfunction in male rats.

abstract：UNLABELLED:Some subjects with multiple sclerosis (MS) present with low blood iron parameters. Anecdotal reports and a single patient study suggest that iron supplementation may be beneficial in these subjects. Myelin is regenerated continually, but prerequisites for this process are iron and a functional folate-vitamin...

journal_title：Metabolic brain disease

authors： van Rensburg SJ,Kotze MJ,Hon D,Haug P,Kuyler J,Hendricks M,Botha J,Potocnik FC,Matsha T,Erasmus RT

更新日期：2006-09-01 00:00:00

abstract：:Parkinson's disease is a neurodegenerative disease whose hallmark pathological features include a selective loss of dopaminergic neurons in the midbrain. Ciclooxygenase-2 activity induction and oxidative stress have been implicated in the aetiology of Parkinson's disease and in the 1-methyl-4-phenyl-1,2,3,6-tetrahydro...

journal_title：Metabolic brain disease

authors： Ortiz GG,Pacheco-Moisés FP,Gómez-Rodríguez VM,González-Renovato ED,Torres-Sánchez ED,Ramírez-Anguiano AC

更新日期：2013-12-01 00:00:00

abstract：:At the present time alcoholism is recognized as a metabolic disease exhibiting the clinical features of craving for alcohol, loss of control over drinking, tolerance and physical dependence on alcohol, while both epidemiological and experimental studies have demonstrated that genetic factors may be important in determ...

journal_title：Metabolic brain disease

authors： Gianoulakis C,de Waele JP

更新日期：1994-06-01 00:00:00

abstract：:The sprouting of new blood vessels from pre-existing vasculature (angiogenesis) is essential for tumour survival, influenced by tumour cell-endothelial cell interactions and is tightly regulated by biochemical cues including the kallikrein-kinin system (KKS). We examined the structural interaction between neuroblastom...

journal_title：Metabolic brain disease

authors： Naidoo S,Raidoo DM

更新日期：2006-09-01 00:00:00

abstract：:Increased benzodiazepine (BZ) receptor density has been reported in brains of rabbits with hepatic encephalopathy (HE) due to galactosamine (GalN)-induced fulminant hepatic failure (FHF). These data were generated using detergent-Triton X-100-treated neural membranes. While performing further studies it was noted that...

journal_title：Metabolic brain disease

authors： Rössle M,Mullen KD,Jones EA

更新日期：1989-09-01 00:00:00

abstract：:We investigated the biochemical alterations of the striatum of mice subjected to seven experimental schedules with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride (MPTP) treatment. The mice were treated intraperitoneally (i.p.) with MPTP (20 mg/kg in saline) four times a day at 2-hr intervals showed severe ...

journal_title：Metabolic brain disease

authors： Kuroiwa H,Yokoyama H,Kimoto H,Kato H,Araki T

更新日期：2010-06-01 00:00:00

abstract：:The enzyme nitric oxide synthase has been associated with suicide behavior. NOS1, NOS2 and NOS3 genes are implicated in the production of nitric oxide. However, the association between NOS genes and suicide behavior has not yet been established. To assess the association of Nitric Oxide Synthase (NOS) genes and suicid...

journal_title：Metabolic brain disease

authors： González-Castro TB,Genis-Mendoza AD,Tovilla-Zárate CA,Juárez-Rojop IE,López-Narvaez ML,Pérez-Hernández N,Rodríguez-Pérez JM,Martínez-Magaña JJ

更新日期：2019-08-01 00:00:00

abstract：:As studies of brain metabolism grow in complexity, investigators turn increasingly to nuclear magnetic resonance spectroscopy combined with 13C isotopic labeling. The unique ability to detect labeling non-destructively in specific carbon positions of individual compounds has opened the way to investigate brain metabol...

journal_title：Metabolic brain disease

authors： Mason GF,Behar KL,Lai JC

更新日期：1996-12-01 00:00:00

abstract：:Hepatic encephalopathy (HE) is an important cause of morbidity and mortality in patients with severe liver disease. Although the molecular basis for the neurological disorder in HE remains elusive, elevated ammonia and its chief metabolite glutamine are believed to be important factors responsible for altered cerebral...

journal_title：Metabolic brain disease

authors： Rao KV,Norenberg MD

更新日期：2001-06-01 00:00:00

abstract：:The role of oxidative stress in the pathogenesis of phenylketonuria (PKU)-associated disorders has been implicated. Ischemia modified albumin (IMA) is a modified form of serum albumin, which is produced under the conditions of oxidative stress. The aim of this study was to measure the serum level of IMA in the PKU pat...

journal_title：Metabolic brain disease

authors： Keshavarzi F,Rastegar M,Vessal M,Rafiei Dehbidi G,Khorsand M,Ganjkarimi AH,Takhshid MA

更新日期：2018-06-01 00:00:00

abstract：:Maple syrup urine disease (MSUD) or branched-chain alpha-keto aciduria (BCKA) is an inherited disorder caused by a deficiency of the branched-chain alpha-keto acid dehydrogenase complex (BCKAD) activity. The blockage of this pathway leads to tissue accumulation of the branched-chain amino acids (BCAA) leucine, isoleuc...

journal_title：Metabolic brain disease

authors： Barschak AG,Sitta A,Deon M,de Oliveira MH,Haeser A,Dutra-Filho CS,Wajner M,Vargas CR

更新日期：2006-12-01 00:00:00

abstract：:Attention alterations are reported in cirrhotics. Aiming at clarifying attention functioning in cirrhotics, an inquiry on the functioning of the anterior (AAS) and the posterior (PAS) attention system was performed. Thirty-six cirrhotics without overt hepatic encephalopathy (24 with EEG or TMT-A alterations) and 16 ma...

journal_title：Metabolic brain disease

authors： Amodio P,Schiff S,Del Piccolo F,Mapelli D,Gatta A,Umiltà C

更新日期：2005-06-01 00:00:00

abstract：:Spontaneous intracerebral hemorrhage (ICH) represents a partially-understood cerebrovascular disease of high incidence, morbidity and mortality. We, herein, report the findings of our study concerning the role of two important adenosinetriphosphatases (ATPases) in a porcine model of spontaneous ICH that we have recent...

journal_title：Metabolic brain disease

authors： Bimpis A,Papalois A,Tsakiris S,Kalafatakis K,Zarros A,Gkanti V,Skandali N,Al-Humadi H,Kouzelis C,Liapi C

更新日期：2013-09-01 00:00:00

abstract：:Substantial evidence demonstrated that maternal dietary nutrients can significantly determine the susceptibility to developing metabolic disorders in the offspring. Therefore, we aimed to investigate the later-life effects of maternal and postweaning diets interaction on epigenetic modification of the central nervous ...

journal_title：Metabolic brain disease

authors： Zheng J,Xiao X,Zhang Q,Yu M,Xu J,Wang Z,Qi C,Wang T

更新日期：2015-10-01 00:00:00

abstract：:The mitogen-activated protein kinase (MAP kinase) pathway participates in a number of reactions of the cell when responding to various external stimuli. These stimuli include growth factor binding to its receptor as well as stressful situations such as hypoxia and oxidative stress. It has been postulated that one of t...

journal_title：Metabolic brain disease

authors： Daniels WM,Hendricks J,Salie R,Taljaard JJ

更新日期：2001-12-01 00:00:00

abstract：:To assess whether EGb761 could protect elderly diabetic mice with cognitive disorders and explore the role of beclin-1-mediated autophagy in these protective effects. Two-month-old male db/db-/- mice and wild-type C57/BL6 mice were randomly divided into six groups: db/db-/- control, db/db-/- 50 mg, db/db-/- 100 mg, wi...

journal_title：Metabolic brain disease

authors： Guan ZF,Zhang XM,Tao YH,Zhang Y,Huang YY,Chen G,Tang WJ,Ji G,Guo QL,Liu M,Zhang Q,Wang NN,Yu ZY,Hao-Yang,Wu GF,Tang ZP,Du ZG,Shang XL,Liu YC,Mei GH,Guo JC,Zhou HG

更新日期：2018-12-01 00:00:00

abstract：:To characterize an Egyptian patient with glutaric acidemia type I (GA I) and to identify the causative mutation(s) that may be responsible for the disease phenotype. MRI was performed on the patient using the 1.5 T magnet, biochemical analysis was carried out using gas chromatography/mass spectrometry on the patient's...

journal_title：Metabolic brain disease

authors： Moseilhy A,Hassan MM,El Abd HS,Mohammad SA,El Bekay R,Abdel-Motal UM,Ouhtit A,Zaki OK,Zayed H

更新日期：2017-02-01 00:00:00

abstract：:Mutations in the HTT gene, consisting of expansion of CAG triplets, cause the Huntington's disease (HD), one of the major neurodegenerative disorders. Formation of aggregates of mutant huntingtin (mHTT, the product of the mutant HTT gene) leads to cellular dysfunctions, and subsequent neurodegeneration which manifest ...

journal_title：Metabolic brain disease

authors： Pierzynowska K,Gaffke L,Cyske Z,Węgrzyn G

更新日期：2019-06-01 00:00:00

abstract：:It has been suggested that alterations of GABAergic neurotransmission are implicated in the pathophysiology of hepatic encephalopathy (HE). Increased concentrations of endogenous benzodiazepines with positive allosteric modulatory properties at the GABA-A receptor complex were proposed as a pathophysiological mechanis...

journal_title：Metabolic brain disease

authors： Ahboucha S,Pomier-Layrargues G,Butterworth RF

更新日期：2004-12-01 00:00:00

abstract：:Schizophrenia is one of the most disabling mental disorders that affects up to 1 % of the population worldwide. Although the causes of this disorder remain unknown, it has been extensively characterized by a broad range of emotional, ideational and cognitive impairments. Studies indicate that schizophrenia affects neu...

journal_title：Metabolic brain disease

authors： Zugno AI,Julião RF,Budni J,Volpato AM,Fraga DB,Pacheco FD,Deroza PF,Luca RD,de Oliveira MB,Heylmann AS,Quevedo J

更新日期：2013-09-01 00:00:00

abstract：:Stroke is the leading cause of disability among adults as well as the 2nd leading cause of death globally. Ischemic stroke accounts for about 85% of strokes, and currently, tissue plasminogen activator (tPA), whose therapeutic window is limited to up to 4.5 h for the appropriate population, is the only FDA approved dr...

journal_title：Metabolic brain disease

authors： Sarvari S,Moakedi F,Hone E,Simpkins JW,Ren X

更新日期：2020-08-01 00:00:00

abstract：:Phenylketonuria (PKU) is the most common inborn error of amino acid metabolism. Usually diagnosed within the first month of birth, it is essential that the patient strictly follow the dietary restriction of natural protein intake. Otherwise, PKU impacts the development of the brain severely and may result in microceph...

journal_title：Metabolic brain disease

authors： Bortoluzzi VT,Brust L,Preissler T,de Franceschi ID,Wannmacher CMD

更新日期：2019-12-01 00:00:00

abstract：:Undernourished suckling rats were administered, by gastric intubation, either soy oil (which is rich in both linoleic and linolenic acids) or safflower oil (which is rich in linoleic acid but deficient in linolenic acid) to determine (1) if dietary supplementation would offset the hypomyelination characteristic of the...

journal_title：Metabolic brain disease

authors： Divakaran P,Pavlina T,Johnson RC,Cotter R,Madsen D,Wiggins R

更新日期：1986-06-01 00:00:00

abstract：:The aim of the present work was to investigate the role of ondansetron on the high fat diet (HFD) induced obese mice for behavioral and biochemical alterations using chronic unpredictable mild stress (CUMS) model of depression. Animals were fed with high fat diet for 14 weeks and subjected to different stress procedur...

journal_title：Metabolic brain disease

authors： Kurhe Y,Radhakrishnan M,Gupta D

更新日期：2014-09-01 00:00:00

abstract：:Maternal separation in non-human primates has been proposed as a model of early adversity. The symptoms of separation anxiety were studied in vervet monkeys, during the weaning period, when psychotropic medications were administered. The control group received a normal diet and treatment groups received citalopram, re...

journal_title：Metabolic brain disease

authors： Marais L,Daniels W,Brand L,Viljoen F,Hugo C,Stein DJ

更新日期：2006-09-01 00:00:00

abstract：:Autism spectrum disorder (ASD) is a multifactorial disorder caused by an interaction between environmental risk factors and a genetic background. It is characterized by impairment in communication, social interaction, repetitive behavior, and sensory processing. The etiology of ASD is still not fully understood, and t...

journal_title：Metabolic brain disease

authors： Qasem H,Al-Ayadhi L,Bjørklund G,Chirumbolo S,El-Ansary A

更新日期：2018-08-01 00:00:00

abstract：:Tissue methylmalonic acid (MMA) accumulation is the biochemical hallmark of methylmalonic acidemia. Clinically, the disease is characterized by progressive neurological deterioration and renal failure, whose pathophysiology is still undefined. In the present study we investigated the effect of acute MMA administration...

journal_title：Metabolic brain disease

authors： Affonso AC,Machado DG,Malgarin F,Fraga DB,Ghedim F,Zugno A,Streck EL,Schuck PF,Ferreira GC

更新日期：2013-09-01 00:00:00

abstract：:Hepatic encephalopathy is a common complication of hepatic cirrhosis. The clinical diagnosis is based on two concurrent types of symptoms: impaired mental status and impaired neuromotor function. Impaired mental status is characterized by deterioration in mental status with psychomotor dysfunction, impaired memory, an...

journal_title：Metabolic brain disease

authors： Malaguarnera M

更新日期：2013-06-01 00:00:00

abstract：:α-asarone (ASR) is a major bioactive compound isolated from the rhizome of Acorus tatarinowii Schott and it has extensive biological effects. Clinically, anxiety disorder is a common comorbidity of chronic pain. However, limited information is available regarding the effects of ASR on chronic pain-related anxiety. Thi...

journal_title：Metabolic brain disease

authors： Tian J,Tian Z,Qin SL,Zhao PY,Jiang X,Tian Z

更新日期：2017-12-01 00:00:00

abstract：:The impaired insulin signaling has been recognized as a common pathogenetic mechanism between diabetes and Alzheimer's disease (AD). In the progression of AD, brain is characterized by defective insulin receptor substrate-1 (IRS-1) and increased oxidative stress. Thymol, a monoterpene phenol isolated from medicinal he...

journal_title：Metabolic brain disease

authors： FangFang,Li H,Qin T,Li M,Ma S

更新日期：2017-04-01 00:00:00