Abstract:
:Mild hypothermia (32 degrees C-35 degrees C) reduces intracranial pressure in patients with acute liver failure and may offer an effective adjunct therapy in the management of these patients. Studies in experimental animals suggest that this beneficial effect of hypothermia is the result of a decrease in blood-brain ammonia transfer resulting in improvement in brain energy metabolism and normalization of glutamatergic synaptic regulation. Improvement in brain energy metabolism by hypothermia may result from a reduction in ammonia-induced decrease of brain glucose (pyruvate) oxidation. Restoration of normal glutamatergic synaptic regulation by hypothermia may be the consequence of the removal of ammonia-induced decreases in expression of astrocytic glutamate transporters resulting in normal glutamate neurotransmitter inactivation in brain. Randomized controlled clinical trials of hypothermia are required to further evaluate its clinical impact.
journal_name
Metab Brain Disjournal_title
Metabolic brain diseaseauthors
Chatauret N,Rose C,Butterworth RFdoi
10.1023/a:1021982523691subject
Has Abstractpub_date
2002-12-01 00:00:00pages
445-51issue
4eissn
0885-7490issn
1573-7365journal_volume
17pub_type
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